Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)

Umbarawan Y., Enoura A., Ogura H., Sato T., Horikawa M., Ishii T., Sunaga H., Matsui H., Yokoyama T., Kawakami R., Maeno T., Setou M., Kurabayashi M., Iso T.
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Fabp5 is a sensitive marker for lipid-rich macrophages in the luminal side of atherosclerotic lesions
2021
International Heart Journal
62
3
666
676
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Hiroshima, Japan; Center for Liberal Arts and Sciences, Ashikaga University, Ashikaga, Japan; Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Department of Systems Molecular Anatomy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu, Japan
Umbarawan, Y., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan, Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Enoura, A., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Ogura, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Sato, T., Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan, International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan; Horikawa, M., Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan, International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan, Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Hiroshima, Japan; Ishii, T., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Sunaga, H., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan, Center for Liberal Arts and Sciences, Ashikaga University, Ashikaga, Japan; Matsui, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Yokoyama, T., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Kawakami, R., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Maeno, T., Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Setou, M., Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan, International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan, Department of Systems Molecular Anatomy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu, Japan; Kurabayashi, M., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Iso, T., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
Lipid-rich macrophages in atherosclerotic lesions are thought to be derived from myeloid and vascular smooth muscle cells. A series of studies with genetic and pharmacological inhibition of fatty acid binding protein 4 (FABP4) and FABP5 and bone marrow transplant experiments with FABP4/5 deficient cells in mice have demonstrated that these play an important role in the development of atherosclerosis. However, it is still uncertain about the differential cell-type specificity and distribution between FABP4- and FABP5-expressing cells in early- and late-stage atherosclerotic lesions. In this study, we first explored spatial distribution of FABP4/5 in atherosclerotic lesions in apolipoprotein E deficient (ApoE-/-) mice. FABP4 was only marginally detected in early and advanced lesions, whereas FABP5 was abundantly expressed in these lesions. In advanced lesions, the FABP5-positive area was mostly restricted to the foam cell layer adjacent to the lumen above collagen and elastic fibers with a high signal/noise ratio. Oil red O (ORO) staining revealed that FABP5-positive cells were lipidrich in early and advanced lesions. Together, most of lipid-rich FABP5-positive cells reside adjacent to the lumen above collagen and elastic fibers. We next studied involvement of FABP5 in lesion formation of atherosclerosis using ApoE-/- FABP5-/- mice. However, deletion of FABP5 did not affect the development of atherosclerosis. These findings, along with previous reports, suggest a novel notion that FABP5 is a sensitive marker for bone marrow-derived lipid-rich macrophages in the luminal side of atherosclerotic lesions, although its functional significance remains elusive. © 2021, International Heart Journal Association. All rights reserved.
Apolipoprotein E knockout mice; Atherosclerosis; Foam cell; Oil red O staining
apolipoprotein E; CD68 antigen; collagen; fatty acid binding protein 4; fatty acid binding protein 5; Ki 67 antigen; Mac 3; smooth muscle actin; unclassified drug; Fabp4 protein, mouse; Fabp5 protein, mouse; fatty acid binding protein; tumor protein; adipogenesis; animal cell; animal experiment; animal model; animal tissue; apolipoprotein E knockout mouse; Article; atherosclerotic plaque; blood vessel wall; bone marrow transplantation; electrospray mass spectrometry; foam cell; image analysis; immunohistochemistry; lipid rich macrophage; lipid storage; macrophage; mouse; nonhuman; oil red O staining; signal noise ratio; staining; tissue preparation; vascular smooth muscle cell; animal; atherosclerosis; immunology; metabolism; Animals; Atherosclerosis; Fatty Acid-Binding Proteins; Foam Cell
International Heart Journal Association
13492365
33994513
Article
Q2
555
9100