Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)

Elhidsi M., Rasmin M., Prasenohadi
57203157152;15754578700;55758911100;
In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors
2021
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
23
100236
Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
Elhidsi, M., Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Rasmin, M., Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Prasenohadi, Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
Background/objective: Data on acute respiratory failure (ARF) in pulmonary tuberculosis (PTB) patients is limited. This study aims to investigate in-hospital mortality, its clinical risk factors and the accuracy of the existing scoring system in predicting in-hospital mortality. Methods: An observational prospective cohort study involving PTB patients with ARF in tertiary hospital, between January 2017 and December 2018, was conducted. The in-hospital mortality was predicted using the National Early Warning Score 2 (NEWS2), quick Sequential Organ Failure Assessment (qSOFA) and CRB-65. Regression models were run to analyze the clinical risk factors for in-hospital Mortality. Sensitivity and specificity of scoring systems were calculated using a Wilson score interval. Results: A total of 111 subjects were included. Most of subjects were hypoxemic type respiratory failure (68.5%), advanced lesions (62.2%), new cases (70.3%) and pneumonia co-infection (72.1%) patients. Invasive mechanical ventilation was utilized for 29.73% of cases. There were 53 (47.75%) in-hospital mortality cases and its risk factors were intensive phase treatment (3.34 OR; CI95% 1.27–8.78), P/F ratio < 100 (OR 4.30; CI 95% 1.75–10.59) and renal insufficiency (4.09 OR; CI95% 1.46–11.49). The sensitivity and specificity of NEWS2 ≥ 6, qSOFA ≥ 2 and CRB-65 ≥ 2 were 62.26% and 67.24%; 60.38% and 72.41%; 41.51% and 84.48% respectively. Conclusions: Most of PTB with ARF were new cases, advanced lesion and hypoxemic type respiratory failure. Intensive phase treatment, severe hypoxemia and renal insufficiency are independent predictors of in-hospital mortality in PTB patients with ARF. NEWS2, qSOFA and CRB-65 scores were poor to predict the in-hospital mortality. © 2021 The Author(s)
Acute respiratory failure; In-hospital mortality; Pulmonary tuberculosis; Tuberculosis
Elsevier Ltd
24055794
Article
Q3
585
8643