Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)

Palupi-Baroto R., Hermawan K., Murni I.K., Nurlitasari T., Prihastuti Y., Sekali D.R.K., Ambarsari C.G.
56495463300;57224908584;55734483200;57224895124;57224909176;57224897130;57211850895;
High fibroblast growth factor 23 as a biomarker for severe cardiac impairment in children with chronic kidney disease: A single tertiary center study
2021
International Journal of Nephrology and Renovascular Disease
14
165
171
Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Palupi-Baroto, R., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Hermawan, K., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Murni, I.K., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Nurlitasari, T., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Prihastuti, Y., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Sekali, D.R.K., Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ambarsari, C.G., Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Introduction: Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in chronic kidney disease (CKD). Changes in cardiac geometry and functions may occur in an early stage and worsen as CKD progresses. Recently, the role of fibroblast growth factor 23 (FGF23) is being highlighted and investigated in CKD-related cardiomyopathy. However, only a few studies have reviewed the utilization of FGF23 as a diagnostic biomarker in the pediatric CKD population. Purpose: This study aimed to identify the role of FGF23 as a biomarker in assessing cardiac changes in children with CKD. Patients and Methods: We conducted a cross-sectional study that involved children aged 2 to 18 years old with CKD stages 2 to 5D in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The level of FGF23 was measured using an immunometric enzyme-linked immunosorbent assay. LVMI, RWT, and left ventricular ejection fraction (LVEF) were assessed with echocardiography. Receiver-operating characteristic (ROC) analyses were conducted to assess the diagnostic performance of FGF23 in detecting LVH with impaired contractility. Results: A total of 43 children with CKD stages 2 to 5D were included, among whom the prevalence of LVH diagnosis was 95.35%. The area under the curve (AUC) of FGF23 to assess LVH and systolic dysfunction was 0.82 (95% CI 0.62–1.0), and the optimal cutoff point was 1413 RU/mL (sensitivity 80%, specificity 78.95%). The median concentration of FGF23 increased with the decreasing eGFR and the increasing LVMI although the systolic and diastolic functions were preserved. Conclusion: FGF23 might be used as an early biomarker to detect cardiac changes in pediatric CKD patients, particularly for LVH and impaired systolic function among children with CKD stage 2 and higher. © 2021 Palupi-Baroto et al.
Dialysis; End-stage kidney disease; FGF23; Left ventricular hypertrophy; Ventricular ejection fraction
biological marker; fibroblast growth factor 23; adolescent; adult; anemia; area under the curve; Article; child; chronic kidney failure; clinical article; cross-sectional study; diabetic nephropathy; diagnostic test accuracy study; diagnostic value; disease severity; echocardiography; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; glomerulonephritis; heart left ventricle contractility; heart left ventricle contraction; heart left ventricle ejection fraction; heart left ventricle filling; heart left ventricle mass; heart ventricle hypertrophy; human; hypertension; Indonesia; kidney agenesis; kidney calcification; kidney dysplasia; kidney hypoplasia; lupus erythematosus nephritis; male; nephrotic syndrome; obstructive uropathy; preschool child; prevalence; r
Dove Medical Press Ltd
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Article
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