Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)

Lilihata G., Saputra C., Yaniarti D., Soerarso R.
57223977510;57223988357;57223991240;57192913673;
Hyperthyroidism in severe mitral regurgitation post mechanical mitral valve replacement: The effect on warfarin anticoagulation
2021
Cardiovascular Endocrinology and Metabolism
146
148
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia
Lilihata, G., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Saputra, C., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Yaniarti, D., Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Soerarso, R., Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia
A 24-year-old male patient came to the emergency room with melena, gum bleeding and nosebleeds. This patient has a history of mechanical prosthetic mitral valve replacement for severe mitral regurgitation (MR) and consumed warfarin irregularly, but did not come back for regular check-up. Investigations showed greatly increased thyroid function and international normalised ratio (INR) was 15.8. Patients were diagnosed with thyroid storm and bleeding due to prolongation of INR. His hyperthyroid state might have caused increased rate of degradation of vitamin K-dependent clotting factor thereby increased sensitivity to warfarin. Concomitant acute decompensated heart failure, thrombocytopenia and hypoalbuminemia also contributed to his risk of bleeding. Treatment included anti-thyroid therapy as well as warfarin reversal therapy by stopping warfarin, low-dose intravenous vitamin K due to his mechanical prosthetic valve and fresh frozen plasma. In conclusion, hyperthyroidism could increase the response to warfarin so close monitoring is needed to balance the risk of bleeding and thromboembolism. © 2021 Lippincott Williams and Wilkins. All rights reserved.
anticoagulation; bleeding; hyperthyroidism; mechanical valve; prosthetic valve; warfarin
Lippincott Williams and Wilkins
25740954
Article
Q3
498
10107