Publikasi Scopus FKUI 2021 per tanggal 4 Januari 2021 (879 artikel)

Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Bardosono S., Sungkar S., Rachmat J., Hediyati M., Silalahi T.
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;21933841000;57016857300;6507225348;57310558800;56275255400;
Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial
2021
Acta medica Indonesiana
53
3
268
275
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia
Kartika, R.W., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Alwi, I.; Suyatna, F.D.; Yunir, E.; Waspadji, S.; Immanuel, S.; Bardosono, S.; Sungkar, S.; Rachmat, J.; Hediyati, M.; Silalahi, T.
BACKGROUND: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of  PRF autologous consider as adjuvant therapy in DFU treatment. METHODS: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size < 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. RESULTS: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation  of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation  of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). CONCLUSION: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy.
diabetic foot ulcer; hyaluronic acid; platelet-rich fibrin
NLM (Medline)
01259326
34611065
Article
Q3
321
14162