Publikasi Scopus 926 artikel (Per 14 Maret 2022)

122

Authors

Panigoro S.S., Sutandyo N., Witjaksono F., Siregar N.C., Ramli R., Hariani R., Pangarsa E.A., Prajoko Y.W., Puruhita N., Hamdani W., Bayu D., Madjid M., Yulidar D., Fransiska J.E., Widyawati R., Tripriadi E.S., Wiwit Ade F.W., Yunda D.K., Pranata R.

Author S Id

56790104300;26028099200;57070455800;6508087790;56126010900;57211658330;57204907532;56050815500;57224902090;57211471316;57193199487;57311861300;57312306100;57197735128;57312525600;57312968000;57312306200;57312748700;57201973901;

Title

The Association Between Triglyceride-Glucose Index as a Marker of Insulin Resistance and the Risk of Breast Cancer

Year

2021

Source Title

Frontiers in Endocrinology

Volume

Issue

Art No

745236

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117891585&doi=10.3389%2ffendo.2021.745236&partnerID=40&md5=7c6ce4b0ece5dc9224c11aab644ae33c

Affiliations

Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia

Authors With Affiliations

Panigoro, S.S., Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutandyo, N., Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Witjaksono, F., Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramli, R., Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Hariani, R., Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Pangarsa, E.A., Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Prajoko, Y.W., Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Puruhita, N., Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Hamdani, W., Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Bayu, D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Madjid, M., Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Yulidar, D., Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Fransiska, J.E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Widyawati, R., Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Tripriadi, E.S., Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Wiwit Ade, F.W., Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Yunda, D.K., Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Pranata, R., Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia

Abstract

Background: This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index and breast cancer. Method: This is a multicenter case-control study conducted in six public referral hospitals in Indonesia. Cases are individuals aged 19 years or above who were diagnosed with breast cancer within 1 year of diagnosis, based on histopathology and immunohistochemistry. Controls were recruited from corresponding hospitals. TyG index was determined by the formula: ln (fasting TG [mg/dl] × fasting glucose [mg/dl]). Results: There were 212 participants in the breast cancer group and 212 participants in the control group. TyG index was higher in patients with breast cancer (median 8.65 [7.38, 10.9] vs. 8.30 [7.09, 10.84], p < 0.001). When compared with TyG quartile of Q1, Q4 was associated with an OR of 2.42 (1.77, 3.31), p < 0.001, Q3 was associated with an OR of 1.53 (1.21, 1.93), p < 0.001, Q2 was associated with an OR of 1.39 (1.12, 1.73), p = 0.002 for the risk of breast cancer. The dose-response relationship was nonlinear (p < 0.001). On univariate analysis, smoking (OR 2.15 [1.44, 3.22], p < 0.001), use of contraception (1.73 [1.15, 2.60], p = 0.008), alcohol consumption (OR 2.04 [0.96, 4.35], p = 0.064), and TyG Index >8.87 (OR 3.08 [1.93, 4.93], p < 0.001) were associated with risk of breast cancer. Independently associated with increased risk of breast cancer included smoking (OR 1.93 [1.23, 3.01], p = 0.004), use of contraception (OR 1.59 [1.02, 2.48], p = 0.039), and TyG Index >8.87 (OR 2.93 [1.72, 4.98], p < 0.001) Conclusion: TyG index was associated with breast cancer in a nonlinear dose-response fashion. © Copyright © 2021 Panigoro, Sutandyo, Witjaksono, Siregar, Ramli, Hariani, Pangarsa, Prajoko, Puruhita, Hamdani, Bayu, Madjid, Yulidar, Fransiska, Widyawati, Tripriadi, F. W., Yunda and Pranata.

Author Keywords

breast cancer; glucose; insulin; insulin resistance; triglyceride

Index Keywords

insulin; triacylglycerol; adult; aged; alcohol consumption; Article; breast cancer; breast feeding; case control study; contraception; controlled study; dose response; female; glucose blood level; histopathology; human; human tissue; immunohistochemistry; major clinical study; multicenter study; nutrient uptake; obesity; questionnaire; smoking; triacylglycerol blood level; underweight; univariate analysis

Publisher

Frontiers Media S.A.

Issn

16642392

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

1518

Sjr Rank

2233