Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Hermansyah T.A., Ginanjar E., Putri V.H.
57428569000;23472616600;57428569100;
Elevation of Cardiac Biomarkers in COVID-19 As a Major Determinant for Mortality: A Systematic Review
2021
Acta medica Indonesiana
53
4
385
396
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia
Hermansyah, T.A., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Ginanjar, E.; Putri, V.H.
BACKGROUND: This study aimed to summarize the prognosis of Corona Virus Disease 2019 (COVID-19) patients with elevated troponin and N-terminal pro brain natriuretic peptide (NT-proBNP) levels and demonstrate the involvement of myocardial injury as a complication in COVID-19. METHODS: A systematic literature search was performed using several databases (PubMed, MEDLINE, PROQUEST and SCOPUS ) for studies published up to August 2020. Observational studies about the mortality outcome of COVID-19 patients who experienced cardiac injury, as defined by the elevation of serum levels of troponin, brain natriuretic peptide (BNP), with NT-proBNP or only BNP or only NT-proBNP, were included. In addition, a critical appraisal was conducted for all included studies using the Critical Appraisal for Prognostic Studies checklist published by the Centre for Evidence-Based Medicine by the University of Oxford. RESULTS: Seven retrospective observational studies fulfilled the inclusion criteria. This study found that there is a higher risk of death in COVID 19 patients with higher levels of troponin and NT-proBNP, indicating the importance of these biomarkers as determinant factors to predict in-hospital deaths. CONCLUSION: Based on the analysis, elevation of troponin  and NT-proBNP levels plays an essential role in determining the patient prognosis because it is shown to be associated with in-hospital mortality. This also supports the involvement of myocardial injury as a prominent fatal complication in COVID-19.
BNP; COVID-19; myocardial injury; NT-proBNP; prognostic factors; troponin
biological marker; brain natriuretic peptide; peptide fragment; pro-brain natriuretic peptide (1-76); troponin; blood; human; mortality; observational study; prognosis; retrospective study; Biomarkers; COVID-19; Humans; Natriuretic Peptide, Brain; Observational Studies as Topic; Peptide Fragments; Prognosis; Retrospective Studies; SARS-CoV-2; Troponin
NLM (Medline)
01259326
35027485
Article
Q3
321
14162