Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Agustina R., Syam A.F., Wirawan F., Widyahening I.S., Rahyussalim A.J., Yusra Y., Rianda D., Burhan E., Salama N., Daulay R., Halim A.R.V., Shankar A.H.
57214141404;8443384400;57205313463;54893154400;55212166100;57220998367;57214119630;36058554600;57219411020;57226811488;57226806443;7005442634;
Integration of symptomatic, demographical and diet-related comorbidities data with SARS-CoV-2 antibody rapid diagnostic tests during epidemiological surveillance: A cross-sectional study in Jakarta, Indonesia
2021
BMJ Open
11
8
e047763
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syam, A.F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wirawan, F., Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widyahening, I.S., Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Rianda, D., Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Salama, N., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Daulay, R., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Halim, A.R.V., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Shankar, A.H., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Affordable options for COVID-19 epidemiological surveillance are needed. Virus detection by reverse transcription-PCR (RT-PCR) is sensitive but costly, and antigen-based rapid diagnostic tests (RDTs) are cheap but with reduced sensitivity; both detect current infection but not exposure. RDT-IgM/IgG antibodies to SARS-CoV-2 detect exposure but have poor sensitivity for current infection. We investigated if the integration of symptomatic, demographical and diet-related comorbidities data with antibody RDTs improves their potential to assess infection rates in addition to exposure, thereby broadening their utility for surveillance. We conducted a cross-sectional study using data from community surveillance for SARS-CoV-2. Health workers collected nasopharyngeal swabs for RT-PCR and RDT antigen assessments and venous blood for RDT-IgM/IgG from symptomatic and asymptomatic persons. Data on age, gender, contact history, symptoms (ie, fever, cough, runny nose, sore throat, headache, dyspnoea and diarrhoea), diet-related comorbidities (ie, diabetes and hypertension) and chest radiology were collected. High-risk communities in Jakarta, Indonesia, in May 2020. 343 community members’ data were included. RDT-IgM/IgG sensitivity, specificity and predictive values and area under receiver operating characteristic curve for RT-PCR positivity using RDT results alone and in combination with other predictors, including symptom components derived from principal component analysis. There were 24 PCR-confirmed infections. RDT-IgM/IgG-positive tests were associated with infection (OR 10.8, 95% CI 4.43 to 26.4, p<0.001) with an area under the curve (AUC) of 0.708% and 50% sensitivity, 91.5% specificity, 30.8% positive predictive value (PPV) and 96.1% negative predictive value (NPV). RDT results combined with age, gender, contact history, symptoms and comorbidities increased the AUC to 0.787 and yielded 62.5% sensitivity, 87.0% specificity, 26.6% PPV and 96.9% NPV. SARS-CoV-2 RDT-IgM/IgG results integrated with other predictors may be an affordable tool for epidemiological surveillance for population-based COVID-19 exposure and current infection, especially in groups with outbreaks or high transmission. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
COVID-19; epidemiology; public health
immunoglobulin G; immunoglobulin M; SARS-CoV-2 antibody; virus antibody; adolescent; adult; aged; area under the curve; Article; child; community; comorbidity; coronavirus disease 2019; coughing; cross-sectional study; demography; diagnostic test; diagnostic test accuracy study; diet; female; health care personnel; human; Indonesia; major clinical study; male; nasopharyngeal swab; predictive value; receiver operating characteristic; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat; thorax radiography; diagnostic test; diet; epidemiology; Antibodies, Viral; COVID-19; Cross-Sectional Studies; Diagnostic Tests, Routine; Diet; Humans; Indonesia; SARS-CoV-2; Sensitivity and Specificity
BMJ Publishing Group
20446055
34376448
Article
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