Publikasi Scopus 926 artikel (Per 14 Maret 2022)

233

Authors

Sunarno S., Puspandari N., Sariadji K., Febriyana D., Saraswati T.F.R.D., Maha M.S., Handayani S., Lestari C.S.W., Fitriana V.S.F., Yuniar Y., Pracoyo N.E., Pradono J., Siswanto S., Multihartina P., Anggraeni N.D., Hidayati L.N., Sukandar A., Safaat H., Karyanti M.R.

Author S Id

57441531200;56786591900;57199654249;57222530233;57462625600;6603127192;26023188400;57194534757;57462459800;57219339473;57273150400;57462947000;56613530000;56708801900;57218324975;57463104500;57463428900;57462459900;56290680800;

Title

Microbiological and Clinical Aspects of Diphtheria-Confirmed Cases from Capital City of Indonesia, Jakarta, and Surrounding Areas in 2017

Year

2021

Source Title

Jundishapur Journal of Microbiology

Volume

Issue

Art No

e118751

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125038649&doi=10.5812%2fJJM.118751&partnerID=40&md5=cd6599282018ea61a451d60e8fe3eb1a

Affiliations

Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; World Health Organization, South-East Asia Regional Office, New Delhi, India; Jakarta Provincial Health Office, Jakarta, Indonesia; West Java Provincial Health Office, Bandung, Indonesia; Banten Provincial Health Office, Serang, Indonesia; Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia

Authors With Affiliations

Sunarno, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Sariadji, K., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Febriyana, D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Saraswati, T.F.R.D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Maha, M.S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Handayani, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Lestari, C.S.W., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Fitriana, V.S.F., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Yuniar, Y., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Pracoyo, N.E., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Pradono, J., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Siswanto, S., World Health Organization, South-East Asia Regional Office, New Delhi, India; Multihartina, P., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Anggraeni, N.D., Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Hidayati, L.N., Jakarta Provincial Health Office, Jakarta, Indonesia; Sukandar, A., West Java Provincial Health Office, Bandung, Indonesia; Safaat, H., Banten Provincial Health Office, Serang, Indonesia; Karyanti, M.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia

Abstract

Background: The World Health Organization reported Indonesia as one of the countries with the most prevalent cases of diphtheria worldwide. The microbiological aspects of diphtheria-inducing bacteria are of great significance in tracing disease transmission and case management. However, clinical aspects are critical for updating clinical features and case management in the field, which may sometimes differ from theoretical foundations. Objectives: This study aimed to identify the microbiological and clinical aspects, including molecular typing and case fatality rates, in diphtheria-confirmed cases from the capital city of Indonesia, Jakarta, and surrounding areas in 2017. Methods: The microbiological aspect of 40 diphtheria-confirmed cases were obtained by re-identify diphtheria-inducing bacteria isolated from the samples, while the clinical aspects of the cases were obtained from the medical records and epidemiological data. The chi-square test was used to examine the correlation between fatal cases and myocarditis and diphtheria antitoxin administra-tion delay. In this study, P ≤ 0.05 was set as the significance level. Results: All 40 diphtheria confirmed cases were induced by toxigenic Corynebacterium diphtheriae with two biotypes, namely inter-medius (60.0%) and mitis (40.0%). There are six sequence types of bacteria with two main sequence types, ie, ST534 (46.4%) and ST377 (35.7%). The proportions of cases that had a fever and sore throat were 72.5% and 77.5%, respectively; however, the prevalence rates of the cases with pseudomembrane and bull neck were 100% and 47%, respectively. Most cases were administered a combination of penicillin or erythromycin with other antibiotics (40%), and 22.5% of the cases only received penicillin. Myocarditis was noticed in three fatal cases, and their relationship was statistically significant (P = 0.000). All five fatal cases (12.5% of cases) received diphtheria antitoxin (DAT) lately or had not received it yet. Conclusions: Toxigenic C. diphtheriae with two biotypes (namely mitis and intermedius) and two main sequence types (ie, ST534 and ST377) was the causative agent of diphtheria-confirmed cases from Jakarta and surrounding areas in 2017. It was also concluded that those fatal cases were correlated with myocarditis complications. © 2021, Author(s).

Author Keywords

Corynebacterium diphtheriae; Diphtheria; Indonesia; Jakarta

Index Keywords

antibiotic agent; antitoxin; erythromycin; glycerol; penicillin G; adolescent; airway obstruction; Article; bacterium identification; bull neck; case fatality rate; child; clinical assessment; clinical feature; conceptual framework; controlled study; correlation analysis; Corynebacterium diphtheriae; Corynebacterium pseudotuberculosis; descriptive research; diphtheria; disease transmission; female; fever; headache; human; Indonesia; intermedius; major clinical study; male; medical record; microbiology; microscopy; mitis; molecular typing; multilocus sequence typing; polymerase chain reaction; preschool child; pseudomembrane; school child; sequence analysis; sore throat; toxicity testing; vaccination; World Health Organization

Publisher

Kowsar Medical Institute

Issn

20083645

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

281

Sjr Rank

15495