Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Utami P.D., Hadi U., Dachlan Y.P., Suryokusumo G., Loeki Enggar Fitri R., Yudo V.
57221766908;55804160500;6602868510;57205444996;57226796443;57226798501;
Protection against brain histopathological damage in experimental cerebral malaria models after exposure to hyperbaric oxigent
2021
Research Journal of Pharmacy and Technology
14
7
3833
3838
Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia
Utami, P.D., Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Hadi, U., Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Dachlan, Y.P., Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Suryokusumo, G., Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Loeki Enggar Fitri, R., Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Yudo, V., Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia
In this study, brain damage caused by cerebral malaria was induced by parasitized erythrocyte rupture and sequestration, which led to inflammation and blood vessel damage. Therefore, this research objective to determine the effect of oxygen administration on the histopathological features and sequestration of CD3 lymphocyte T cells on Plasmodium berghei ANKA/PbA-infected vascular endothelial brain tissue of mice. The study samples consisted of 39 C57BL/6 mice, which were divided into 3 groups: G1 contained normal mice; G2 contained PbA-infected mice; G3 were mice infected with PbA, and administered HBO 2.4 ATA for 10 days straight. Histopathological examination of the of brain tissue and CD3 lymphocyte T cell expression was carried out using immuno-histochemical at the end of the study. Therefore, the results of this study indicate that HBO administration can reduce the level of parasites, can improve the histopathological features of the brain, and can reduce the sequestration of CD3 cells in the brain's blood vessels. According to the results, it can be concluded that 10 sessions of HBO 2.4 ATA exposure can reduce the level of parasites, enhance the histopathological features of brain tissue and decrease the sequestration of CD3 lymphocyte T cells. © RJPT All right reserved.
CD3 cells; Cerebral malaria; Endothel; Histopathological; Hyperbaric oxygen
CD3 antigen; cytotoxic T lymphocyte antigen 4; ketamine; reactive oxygen metabolite; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; blood smear; blood vessel injury; brain damage; brain protection; brain tissue; CD4+ T lymphocyte; CD8+ T lymphocyte; cell adhesion; cerebral malaria; consciousness; controlled study; endothelium; endothelium cell; erythrocyte count; female; gene expression; hematological parameters; histochemistry; histopathology; hyperbaric oxygen therapy; immunohistochemistry; inflammation; leukocyte count; malaria; mortality rate; neutrophil lymphocyte ratio; nonhuman; oxygen therapy; parasitemia; phagocytosis; Plasmodium berghei ANKA; protein expression; T lymphocyte
Research Journal of Pharmacy and Technology
09743618
Article
Q3
225
17916