Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Rustamadji P., Wiyarta E., Bethania K.A., Kusmardi K.
55321572200;57221521342;57226320454;56966625300;
Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type
2021
Journal of Pathology and Translational Medicine
51
3
271
278
3
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST. Methods: Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives. Results: Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity). Conclusions: AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies. © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology.
AKT2; Breast neoplasms; Immunohistochemistry; Metastasis
biological marker; protein kinase B beta; adult; aged; Article; breast carcinoma; cancer grading; clinical article; confidence interval; controlled study; female; human; human tissue; immunohistochemistry; lymph vessel metastasis; multivariate logistic regression analysis; odds ratio; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; tumor invasion; tumor volume
Seoul National University
23837837
Article
Q2
684
7312