Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Bangun K., Sukasah C.L., Dilogo I.H., Indrani D.J., Siregar N.C., Pandelaki J., Iskandriati D., Kekalih A., Halim J.
36902624600;57218391534;56161962800;6602774472;6508087790;35759266900;6507742011;55633562200;57219398869;
Bone Growth Capacity of Human Umbilical Cord Mesenchymal Stem Cells and BMP-2 Seeded Into Hydroxyapatite/Chitosan/Gelatin Scaffold in Alveolar Cleft Defects: An Experimental Study in Goat
2021
Cleft Palate-Craniofacial Journal
58
6
707
717
1
Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Unit Pelayanan Terpadu Teknologi Kedokteran Sel Punca (Stem Cell Research Center), Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Dental Material Science and Technology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Anatomical Pathology Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Radiology Department of Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Primate Research Center of Bogor Agricultural Institute, Bogor, Indonesia; Community Medicine Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Bangun, K., Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sukasah, C.L., Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dilogo, I.H., Unit Pelayanan Terpadu Teknologi Kedokteran Sel Punca (Stem Cell Research Center), Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Indrani, D.J., Department of Dental Material Science and Technology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Siregar, N.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Anatomical Pathology Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pandelaki, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Radiology Department of Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Iskandriati, D., Primate Research Center of Bogor Agricultural Institute, Bogor, Indonesia; Kekalih, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Community Medicine Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Halim, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Objective: To evaluate bone regeneration in alveolar defects treated with human umbilical cord–derived mesenchymal stem cells (hUCMSCs), hydroxyapatite/chitosan/gelatin (HA/CS/Gel) scaffold, and bone morphogenic protein-2 (BMP-2) in Capra hircus models. Design: Randomized posttest-only control group design. Setting: Animal Hospital at Bogor Agricultural Institute. Participants: Healthy and equally treated 24 female Capra hircus/goats. Intervention: Animals were randomly assigned to 3 experimental group design (iliac crest alveolar bone graft/ICABG [control], HA/Cs/Gel+BMP-2 [Novosys], and HA/Cs/Gel+BMP-2+UCMSCs). Graft materials were implanted in surgically made alveolar defects. Main Outcome Measures: Postoperative functional score and operating time were assessed. New bone growth, bone density, inflammatory cells recruitment, and neoangiogenesis were evaluated based on radiological and histological approach at 2 time points, week 4 and 12. Statistical analysis was done between treatment groups. Results: Operating time was 34% faster and functional score 94.5% more superior in HA/Cs/Gel+BMP-2+hUCMSC group. Bone growth capacity in HA/Cs/Gel+BMP-2+UCMSCs mimicked ICABG, but ICABG showed possibility of bone loss between week 4 and 12. The HA/Cs/Gel+BMP-2+UCMSCs showed early bone repopulation and unseen inflammatory cells and angiogenesis on week 12. Discussion and Conclusion: The HA/Cs/Gel+BMP-2+hUCMSCs were superior in enhancing new bone growth without donor site morbidity compared to ICABG. The presence of hUCMSCs in tissue-engineered alveolar bone graft (ABG), supported with paracrine activity of the resident stem cells, initiated earlier new bone repopulation, and completed faster bone regeneration. The HA/Cs/Gel scaffold seeded with UCMSCs+BMP-2 is a safe substitute of ICABG to close alveolar bone defects suitable for patients with cleft lip, alveolus, and palate. © American Cleft Palate-Craniofacial Association. All rights reserved 2020.
alveolar bone grafts; bone regeneration; hydroxyapatite/chitosan/gelatin scaffold; iliac crest bone graft; mesenchymal stem cells; tissue engineering
bone morphogenetic protein 2; chitosan; gelatin; hydroxyapatite; gelatin; hydroxyapatite; adult; alveolar bone; alveolar bone grafting; angiogenesis; animal experiment; animal model; animal tissue; Article; bone density; bone graft; bone growth; bone regeneration; controlled study; domestic goat; donor site; female; histology; human; human cell; iliac crest; inflammatory cell; jaw malformation; morbidity; nonhuman; operation duration; osteolysis; outcome assessment; paracrine signaling; umbilical cord mesenchymal stem cell; animal; bone development; goat; mesenchymal stem cell; tissue scaffold; umbilical cord; Animals; Bone Development; Bone Regeneration; Chitosan; Durapatite; Female; Gelatin; Goats; Humans; Mesenchymal Stem Cells; Tissue Scaffolds; Umbilical Cord
SAGE Publications Ltd
10556656
34047209
Article
Q2
641
7859