Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Marofi F., Kozlitina I.A., Margiana R., Bahramali M., Suksatan W., Abdelbasset W.K., Chupradit S., Nasimi M., Maashi M.S.
57199650994;57428645300;56685900600;57365531600;57219950613;57208873763;57211329338;57189347372;57220613490;
MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
2021
Stem Cell Research and Therapy
12
1
597
1
Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Sechenov First Moscow State Medical University, Moscow, Russian Federation; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biotechnology Department, University of Tehran, Tehran, Iran; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Tehran University of Medical Sciences, Tehran, Iran; Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia
Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Kozlitina, I.A., Sechenov First Moscow State Medical University, Moscow, Russian Federation; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bahramali, M., Biotechnology Department, University of Tehran, Tehran, Iran; Suksatan, W., Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Nasimi, M., Tehran University of Medical Sciences, Tehran, Iran; Maashi, M.S., Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports. © 2021, The Author(s).
Cutaneous wounds; Differentiation; Exosome; Mesenchymal stem/stromal stem cell (MSC); Paracrine factors
angiopoietin 1; angiopoietin 2; biomaterial; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CXCR1; chemokine receptor CXCR4; collagen type 1; collagen type 3; elastin; fibroblast growth factor 2; gelatinase B; immunoglobulin enhancer binding protein; interleukin 1; interleukin 6; microRNA; microRNA 21 5p; mitogen activated protein kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; platelet derived growth factor beta receptor; platelet endothelial cell adhesion molecule 1; stromal cell derived factor 1; toll like receptor 4; tumor necrosis factor; unclassified drug; vasculotropin; vasculotropin C; angiogenesis; biogenesis; cell differentiation; cell migration; cell proliferation; diabetic foot; endothelium cell; exosome; extracellular matrix; fibroblast; h
BioMed Central Ltd
17576512
34863308
Review
Q1
1599
2021