Publikasi Scopus 926 artikel (Per 14 Maret 2022)

464

Authors

Cahyono A.T., Louisa M., Mayang Permata T.B., Handoko, Nuryadi E., Kodrat H., Wibowo H., Hariandy Hamid A.R.A., Sekarutami S.M., Gondhowiardjo S.A.

Author S Id

57222900545;41461551400;57197808751;57209984822;57197806814;57210639849;57217690943;57202054669;56576294500;6508327402;

Title

The potential of gallic acid as a radiosensitizer on human prostate cancer: A systematic review of preclinical studies

Year

2021

Source Title

Malaysian Journal of Medicine and Health Sciences

Volume

Issue

Art No

Page Start

246

Page End

254

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104201486&partnerID=40&md5=aff7e4b57216dc4b88ee83f02823372e

Affiliations

Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Authors With Affiliations

Cahyono, A.T., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, H., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hariandy Hamid, A.R.A., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Abstract

Prostate adenocarcinoma accounts for majority of prostate cancer cases, and it was found to be highly radioresistant. Gallic acid is a phenolic acid naturally occurring in many plants, reported to exhibit biological activities in eliminating cancer cell lines and xenografts. The purpose of this study is to review gallic acid as a potential radiosensitizer agent in prostate cancer treatment. Article search was conducted in PubMed, EBSCO, and Scopus. 11 studies using different cell lines including DU145, PC-3, LNCaP, and 22Rv1 xenograft of human prostate cancer were reviewed in this paper. Gallic acid acts as a radiosensitizer mainly by increasing caspase-3 and caspase-9 activation resulting in apoptosis, while also reducing intracellular CDKs, cyclins, and cdc25 phosphatases ultimately causing G2-M cell cycle arrest. Gallic acid has a potential to be a new radiosensitizer compound in prostate cancer treatment. Additional clinical studies using gallic acid derivatives with lower hydrophilicity are needed. © 2021 UPM Press. All rights reserved.

Author Keywords

Apoptosis; Gallic acid; Prostate cancer; Radiobiology; Radiotherapy

Index Keywords

Publisher

Universiti Putra Malaysia Press

Issn

16758544

Isbn

Pubmed Id

Document Type

Review

Sjr Best Quartile

Sjr

144

Sjr Rank

23823