Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Rahadiani N., Retnowulan I.A., Stephanie M., Handjari D.R., Krisnuhoni E.
16426455700;57313230400;57192369336;56160657900;35310982200;
β-Catenin Expression and Its Association with Prognostic Factors in Hepatocellular Carcinoma: A Study on Alpha-fetoprotein, Histologic Grade, and Microvascular Invasion
2021
Open Access Macedonian Journal of Medical Sciences
9
887
893
Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia
Rahadiani, N., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Retnowulan, I.A., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Stephanie, M., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Handjari, D.R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver cancer. In addition to its high incidence, the disease burden is high due to its poor prognosis and high recurrence rate. Some of the currently known clinicopathologic prognostic factors include alpha-fetoprotein (AFP) level, histologic grade, and microvascular invasion. At the molecular level, β-catenin is one of the most common driver mutations found in HCC. The Wnt/β-catenin pathway regulates cellular processes related to initiation, growth, survival, migration, differentiation, and apoptosis. Although the underlying pathogenesis of hepatocarcinogenesis is known, clinical application warrants a greater understanding of the molecular characteristics and tumor phenotype, especially for determining the prognosis. AIM: This study aims to analyze the expression of β-catenin and its association with AFP, histologic grade, and microvascular invasion. METHODS: Thirty-five samples of surgically resected HCCs at Cipto Mangunkusumo National Referral Hospital were examined. Diagnoses were made based on histopathological and immunohistochemical findings followed by β-catenin staining. β-catenin expression was analyzed to determine difference between variables. RESULTS: Here, we show that β-catenin expression is significantly associated with low serum AFP and well to moderate differentiation implications. Strong nuclear β-catenin expression implies better prognosis in HCC. CONCLUSION: β-catenin expression is significantly associated with low serumAFP and well-to-moderate differentiation, but not with microvascular invasion. Strong nuclear β-catenin expression implies better prognosis in HCC. © 2021 Nur Rahadiani, Ignasia Andhini Retnowulan, Marini Stephanie, Diah Rini Handjari, Ening Krisnuhoni.
Alpha-fetoprotein; Hepatocellular carcinoma; Microvascular invasion; Tumor grade; β-catenin
alpha fetoprotein; beta catenin; adult; aged; alpha fetoprotein blood level; Article; cancer grading; cancer prognosis; cell invasion; clinical article; controlled study; female; hepatitis B; hepatitis C; histology; histopathology; human; human tissue; immunohistochemistry; liver cell carcinoma; liver cirrhosis; lymph vessel; male; microvasculature; prevalence; protein expression; risk factor; tumor growth; tumor volume
Scientific Foundation SPIROSKI
18579655
Article
Q3
288
15252