Publikasi Scopus 926 artikel (Per 14 Maret 2022)

675

Authors

Anton J., Sudibio S., Handoko H., Permata T.B.M., Kodrat H., Nuryadi E., Sofyan H., Susanto E., Mulyadi R., Aman R.A., Gondhowiardjo S.

Author S Id

57328462500;57283461500;57204105168;57197808751;57210639849;57197806814;57328366500;57204423225;56403164500;36848942500;6508327402;

Title

Overexpression of c-Met is Associated with Poor Prognosis in Glioblastoma Multiforme: A Systematic Review and Meta-Analyses

Year

2021

Source Title

Asian Pacific Journal of Cancer Prevention

Volume

Issue

Art No

Page Start

3075

Page End

3080

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118768203&doi=10.31557%2fAPJCP.2021.22.10.3075&partnerID=40&md5=1f49d5bfee87f5293659fdc801e6d63a

Affiliations

Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Authors With Affiliations

Anton, J., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudibio, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handoko, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sofyan, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Susanto, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mulyadi, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aman, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Abstract

Objective: The aim of this study is to evaluate the association of c-Met overexpression with survival of glioblastoma multiforme (GBM) patients. Methods: A systematic review with meta-analyses was conducted on related articles from PubMed, EBSCOhost, Scopus, and Cochrane databases with last updated search on October 31, 2020. A total of 7 studies regarding c-Met overexpression and overall survival (OS) and/or progression free survival (PFS) are included in this study. Results: All studies used immunohistochemistry to examine the expression of c-Met protein. The results showed that the positive rate of c-Met overexpression was detected in approximately 33,9% - 60,5% of GBM patients. c-Met overexpression was related to worse OS (HR: 1,74; 95% CI: 1,482-2,043; Z=6,756; p<0,001) and PFS (HR: 1,66; 95% CI: 1,327-2,066; Z=4,464; p<0,001) in GBM patients. Low heterogeneity of subjects was found in both OS and PFS analyses, I2 values were 7,8% and 0,0%, respectively. Conclusion: In conclusion, c-Met overexpression is significantly related to shorter OS and PFS in GBM patients, so c-Met can be considered as a potential prognostic indicator in GBM. © 2021. All Rights Reserved.

Author Keywords

c-Met; glioblastoma multiforme; prognosis; survival

Index Keywords

MET protein, human; scatter factor receptor; brain tumor; glioblastoma; human; Kaplan Meier method; meta analysis; metabolism; mortality; prognosis; Brain Neoplasms; Glioblastoma; Humans; Kaplan-Meier Estimate; Prognosis; Progression-Free Survival; Proto-Oncogene Proteins c-met

Publisher

Asian Pacific Organization for Cancer Prevention

Issn

15137368

Isbn

Pubmed Id

34710981

Document Type

Article

Sjr Best Quartile

Sjr

512

Sjr Rank

9866