Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Hardiany N.S., Kirana A.N., Prafiantini E.
57192910605;57222361321;57193088368;
Oxidative Stress in the Elderly with Hypertension: A Cross-Sectional Study
2021
Journal of International Dental and Medical Research
14
3
1246
1250
Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Hardiany, N.S., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kirana, A.N., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Hypertension is a major health problem, especially in the elderly, because it serves as a risk I factor for cardio- and cerebrovascular diseases. The involvement of oxidative stress in hypertension I has been shown in animal studies. However, the data about oxidative stress in humans with I hypertension, especially in the elderly, are still limited. The aim of this study is to analyze oxidative stress by measuring carbonyl and superoxide I dismutase (SOD) in hypertensive elderly. It was a cross-sectional study conducted on 70 elderly I subjects, 35 subjects with hypertension and 35 subjects with normotension, in Jakarta, Indonesia. I Subjects were classified into the hypertensive group if their systolic blood pressure was > 130 I mmHg or their diastolic blood pressure was > 80 mmHg according to American guidelines. Plasma I carbonyl and SOD were measured using a spectrophotometer. Correlation analysis and I Independent T-test were used for statistical analysis. Carbonyl was significantly higher, while SOD I was significantly lower in hypertensive elderly compared to the control. There was a negative I correlation between SOD and systolic blood pressure, as well as a weak positive correlation I between carbonyl and mean arterial pressure. In conclusion, a significant increase of carbonyl and decrease of SOD were detected in I hypertensive elderly, reflecting oxidative stress. © 2021. All Rights Reserved.
Carbonyl; elderly; hypertension; superoxide dismutase
University of Dicle
1309100X
Article
Q3
259
16312