Publikasi Scopus 926 artikel (Per 14 Maret 2022)

Gunarti D.R., Sukmawati D., Nasser M.K., Ikram T.A.Z., Pribawa R.N., Suryandari D.A.
57196435346;55615650900;57225994342;57225992297;57225996674;6505763338;
Rice bran supplement enhances gsh levels in testis and liver of carbon tetrachloride-induced rats [Pirinç kepeği takviyesi, karbon tetraklorürle İndüklenen sıçanların testis ve karaciğerinde gsh seviyelerini artırır]
2021
Fabad Journal of Pharmaceutical Sciences
46
2
129
138
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Gunarti, D.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sukmawati, D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nasser, M.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikram, T.A.Z., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pribawa, R.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
In the present study, the potency of rice bran as an antioxidant was examined. Rice bran is a by-product of the rice milling process, despite being a rich nutrient, it has limitations in food application. In this study, we used carbon tetrachloride-induced rats (CCl4) as a model of oxidative stress and examined the effect of extract IPB 3S rice bran supplement (RBS) on testis and liver endogenous antioxidant. The testis and liver were used as the representative organs which prone to exposure to reactive oxygen species (ROS). We used 150 and 300 mg.kg-1 Body weight (BW) of RBS. The Concentration of glutathione (GSH) in both organs was measured. All groups administered by RBS had significantly higher GSH levels compared to the CCl4 group, both in testis and liver. The dose of 300 mg.kg-1 BW RBS had a significantly higher GSH level in testis, while 150 mg.kg-1 VA RBS had a significantly higher GSH level in the liver tissue compared to the control group accordingly. Thus, the rice bran supplement enhances GSH levels in rat’s liver and testis which potentially has protective effects. © 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
Antioxidants; CCl4; Glutathione; IPB 3S; Liver; Rice bran; Testis
antioxidant; carbon tetrachloride; glutathione; plant extract; reactive oxygen metabolite; rice bran extract; unclassified drug; animal experiment; animal model; animal tissue; Article; body weight; cell protection; comparative study; controlled study; diet supplementation; drug effect; drug potency; liver tissue; male; nonhuman; oxidative stress; rat; rice bran; testis
Society of Pharmaceutical Sciences of Ankara (FABAD)
13004182
Article
Q3
150
23158