Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)

Rizka A., Setiati S., Sadikin M., Mansur I.G.
57203243658;14325991900;36981411100;6603222374;
Immunomodulatory effect of in vitro calcitriol in fit and frail elderly
2021
International Immunopharmacology
96
107737
Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia
Rizka, A., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia, Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Sadikin, M., Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Mansur, I.G., Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia
Introduction: Effect of calcitriol on PBMCs of healthy adults have been well studied but not much is known about its effect on the PBMCs of elderly patients with various degree of frailty syndrome and immune senescence. This study was aimed to assess the effect of in vitro calcitriol immunomodulatory effect on IL-6, IL-10 and IFN-γ in elderly patients who were fit, pre-frail and frail to see which group of patients might get the most benefit of calcitriol. Methods: This study was an experimental study on the PBMCs of 24 elderly people, of which 8 subjects each were in fit, pre-frail and frail categories based on the Cardiovascular Health Study criteria. IL-6, IL-10, and IFN-γ were examined by ELISA, before and after administration of lipopolysaccharide and 100 pg/mL calcitriol into PBMC cultures in vitro. Result: The mean serum vitamin D level was 26.2 (2.4) ng/ml. Vitamin D level is decreasing along with worsening of frailty status. After LPS induction, calcitriol did not reduce IL-6 and IFN-γ in all the groups. Calcitriol increased IL-10 in all groups, with the most observed change in the pre-frail group. Conclusion: In vitro administration of calcitriol showed anti-inflammatory potential by increasing IL-10 mainly in pre-frail subjects. © 2021 Elsevier B.V.
Calcitriol; Elderly; Frail; In vitro
Elsevier B.V.
15675769
33965881
Article
Q1
992
4398