Publikasi Scopus FKUI 2021 per tanggal 31 Mei 2021 (358 artikel)

Ariyanto I.A., Lee S., Estiasari R., Edmands J., Bela B., Soebandrio A., Price P.
57193538110;56272877300;55240204000;57207355582;24723637900;8602893200;57201814264;
Understanding the effects of CMV on γδ T-cell populations in HIV patients starting antiretroviral therapy
2021
Clinical Immunology
226
108696
Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia; School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Ariyanto, I.A., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lee, S., Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia, School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Estiasari, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Edmands, J., School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Bela, B., Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Price, P., Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia
Cytomegalovirus (CMV) affects γδ T-cell profiles in healthy individuals and transplant recipients, but the effects of HIV and CMV have not been distinguished in HIV patients. CMV-seropositive Indonesian HIV patients (n = 40) were studied before ART and after six months, alongside healthy controls (n = 20). 50% of patients started ART with detectable CMV DNA. Proportions of Vδ2− γδ T-cells were high in patients and declined on ART, whilst proportions of Vδ2+ γδ T-cells were uniformly low, and correlated inversely with levels of CMV DNA and CMV-reactive antibody. Residual Vδ2+ cells were enriched for markers of terminal differentiation, but this did not associate with CMV metrics. Patients with CMV DNA at baseline showed a direct correlation between CMV reactive-antibody and CD8+ γδ T-cells. Our data are consistent with a role for CMV in the depletion of Vδ2+ γδ T-cells in HIV patients beginning ART, with no consistent evidence of a role for CMV in γδ T-cell activation or differentiation. © 2021
Antiretroviral therapy; CMV; HIV; γδ T-cells
adult; antiretroviral therapy; article; cell population; clinical article; controlled study; Cytomegalovirus; female; gamma delta T lymphocyte; human; human cell; Human immunodeficiency virus infected patient; male; nonhuman; T lymphocyte activation
Academic Press Inc.
15216616
33621667
Article
Q2
1217
3173