Publikasi Scopus FKUI 2021 per tanggal 30 November 2021 (817 artikel)

Authors_(Last_Name)

Al-Jawadi A.A., Priliani L., Oktavianthi S., Febinia C.A., Daya M., Artika I.M., Malik S.G.

Author S Id

57327931000;57203360168;38361976900;55195897900;57208032155;57194561825;7402973374;

Title

Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

Year

2021

Source Title

BMC Research Notes

Volume

Issue

Art No

411

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118749881&doi=10.1186%2fs13104-021-05823-1&partnerID=40&md5=c2e5f8f0c5b077d184062624f315d2dc

Affiliations

Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia; Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia

Authors With Affiliations

Al-Jawadi, A.A., Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia; Priliani, L., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Oktavianthi, S., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Febinia, C.A., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Daya, M., Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Artika, I.M., Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia, Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia

Abstract

Objective: Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results: Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight. © 2021, The Author(s).

Author Keywords

Fat intake; Fatty acid; FTO; Indonesia; Obesity; rs1421085

Index Keywords

Publisher

BioMed Central Ltd

Issn

17560500

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

608

Sjr Rank

8303