Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Background: Obesity is a cause of FGF21 resistance, which affects the browning and thermogenesis process of the adipose tissue. Decreased receptor expression is influenced by miR-34a, whose expression is increased in obesity. While FGF21-based therapies have been widely investigated, the potential activity of Hibiscus sabdariffa Linn. extract (HSE) against FGF21 resistance is unknown. Objective: This study aims to determine the effects of HSE on the expression of miR-34a and FGF21 receptors in white adipose tissue. Methods: This experimental study used 24 male Sprague-Dawley rats and divided into four groups: Control (N); diet-induced-obesity rats (DIO); DIO rats with HSE 200?mg/kgBW/day and DIO rats with HSE 400?mg/kgBW/day. Rats were fed a high-fat diet for 17?weeks. HSE was administered daily for 5 weeks. The administration of HSE 400?mg/kgBW/day resulted in the equivalent expression of miR-34a to that of the control (p?>?0.05). Results: FGFR1 receptor expression was also similar to controls (p?>?0.05). Beta-klotho expression was significantly lower than that of control (p?