Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Sipilä P., Krutskikh A., Pujianto D.A., Poutanen M., Huhtaniemi I.
7007060324;6506856483;8745734300;57203174768;7102262318;
Regional expression of androgen receptor coregulators and androgen action in the mouse epididymis
2011
Journal of Andrology
32
6
711
717
11
Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland; Turku Center for Disease Modeling, University of Turku, Turku, Finland; Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, United Kingdom; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta Pusat, Indonesia
Sipilä, P., Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland, Turku Center for Disease Modeling, University of Turku, Turku, Finland; Krutskikh, A., Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, United Kingdom; Pujianto, D.A., Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland, Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta Pusat, Indonesia; Poutanen, M., Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland, Turku Center for Disease Modeling, University of Turku, Turku, Finland; Huhtaniemi, I., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta Pusat, Indonesia
Endocrine regulation of the mouse initial segment (IS) and distal caput epididymides was studied using genome-wide profiling of gene expression. Among the IS-enriched genes, 29% were significantly down-regulated 1 day after gonadectomy. Of those genes, dihydrotestosterone (DHT) supplementation was not sufficient to maintain their pregonadectomy level of expression in 70%. Of the caput-enriched genes, 16% were significantly down-regulated after gonadectomy, and of those genes, DHT supplementation did not maintain the initial level of expression in 28%. Identical data were obtained by clustering analyses performed for the expression data of epididymal genes. Furthermore, the microarray data revealed that 26 androgen receptor coregulators were expressed in the epididymis, of which several were confirmed by quantitative reverse transcriptase polymerase chain reaction analysis. This suggests putative involvement of these proteins in the segment-specific regulation of the epididymal genes. The pattern of epididymal gene expression in the novel proximal epididymis-specific androgen receptor knockout mouse ProxE-ARKO, with severe hypotrophy and hypoplasia of the caput epithelium, furthermore suggested that a subset of genes whose expression cannot be maintained by systemic androgen alone still require either direct lumicrine androgen action or a permissive effect of circulating testosterone. It is evident that testicular factors, one ofwhich could be the high-concentration luminal androgen, are important for the expression of IS-enriched genes, whereas the expression of distal caput-enriched genes is typically regulated by systemic androgens. © American Society of Andrology.
Androgens; AR coregulators; Testicular lumicrine factors
aminoterminal enhancer of split; androgen receptor; androstanolone; beta catenin; BRCA1 associated protein; caveolin 1; Cbp p300 interacting transactivator with glutamic acid aspartic acid carboxy terminal domain 1; cyclin D1; cyclin E2; Daxx protein; DnaJ homolog subfamily A member 1; four and a half LIM domain 2; gelsolin; NEDD8 protein; nuclear receptor binding SET domain protein 1; nuclear receptor NR2C1; pleiomorphic adenoma gene like 1; protein inhibitor of activated STAT1; protein inhibitor of activated STAT2; protein inhibitor of activated STAT3; Ran protein; receptor interacting protein 140; ring finger protein 4; silencing mediator of retinoid and thyroid hormone receptor; STAT1 protein; steroid receptor coactivator 1; steroid receptor RNA activator 1; testosterone; unclassified
01963635
JOAND
21764902
Article
Q1