Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Yurnadi, Soeharso P., Suryandari D.A., Moeloek N., Susworo R.
57197805109;6506418980;6505763338;55979524100;8438653400;
Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients
2011
Medical Journal of Indonesia
20
3
171
177
Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiotherapy, Faculty of Medicine Universitas Indonesia and Ciptomangunkusumo Hospital, Jakarta, Indonesia
Yurnadi, Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soeharso, P., Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Moeloek, N., Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Susworo, R., Department of Radiotherapy, Faculty of Medicine Universitas Indonesia and Ciptomangunkusumo Hospital, Jakarta, Indonesia
Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-β gene contribute to the incidence of NPC. This study investigates the association of TCR-β gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups. Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-β gene. The PCR-RFLP analysis of TCR-β gene was used to determine allotypes of TCR-β gene in NPC patients and control among ethnic Chinese and indigenous groups in the population of Indonesia. Results: The results indicate that the distribution of TCR-β gene allotypes between NPC patients and controls are not significantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution of TCR-β gene allotypes between Chinese ethnic group was not significantly different from indigenous groups (p > 0.05). Conclusion: The distribution of TCR-β gene allele between NPC group and control groups showed no difference. The distribution of TCR-β gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-β gene are not associated with NPC and ethnic groups in Indonesian population. © 2011, Faculty of Medicine, Universitas Indonesia. All rights reserved.
EBV; NPC; Polymorphism; Susceptibility; TCR-ß gene
T lymphocyte receptor beta chain; allele; allotype; Article; cancer risk; controlled study; ethnic group; gene; gene frequency; genetic association; genetic polymorphism; genotype; geographic distribution; human; Indonesia; nasopharynx carcinoma; polymerase chain reaction; restriction fragment length polymorphism; T cell receptor beta gene
Faculty of Medicine, Universitas Indonesia
08531773
Article
Q3