Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Freisleben S.K.U., Hidayat J., Freisleben H.-J., Poertadji S., Kurniawan B., Bo N.P., Handayani S., Wahidiyat P.A., Soegianto R.R.
57192904042;56631412600;7003437337;7801639017;57205093077;23108451300;57190983276;24400464000;6507142727;
Plasma lipid pattern and red cell membrane structure in β-thalassemia patients in Jakarta
2011
Medical Journal of Indonesia
20
3
178
184
2
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Thalassemia Center, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Freisleben, S.K.U., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Hidayat, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Freisleben, H.-J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Poertadji, S., Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Kurniawan, B., Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Bo, N.P., Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Handayani, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Wahidiyat, P.A., Department of Child Health, Thalassemia Center, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Soegianto, R.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Background: Over the last 10 years, we have investigated thalassemia patients in Jakarta to obtain a comprehensive picture of iron overload, oxidative stress, and cell damage. Methods: In blood samples from 15 transfusion-dependent patients (group T), 5 non-transfused patients (group N) and 10 controls (group C), plasma lipids and lipoproteins, lipid-soluble vitamin E, malondialdehyde (MDA) and thiol status were measured. Isolated eryhtrocyte membranes were investigated with electron paramagnetic resonance (EPR) spectroscopy using doxyl-stearic acid and maleimido-proxyl spin lables. Data were analyzed statistically with ANOVA. Results: Plasma triglycerides were higher and cholesterol levels were lower in thalassemic patients compared to controls. Vitamin E, group C: 21.8 vs T: 6.2 μmol/L) and reactive thiols (C: 144 vs. T: 61 μmol/L) were considerably lower in transfused patients, who exert clear signs of oxidative stress (MDA, C: 1.96 vs T: 9.2 μmol/L) and of tissue cell damage, i.e., high transaminases plasma levels. Non-transfused thalassemia patients have slight signs of oxidative stress, but no significant indication of cell damage. Erythrocyte membrane parameters from EPR spectroscopy differ considerably between all groups. In transfusion-dependent patients the structure of the erythrocyte membrane and the gradients of polarity and fluidity are destroyed in lipid domains; binding capacity of protein thiols in the membrane is lower and immobilized. Conclusion: In tranfusion-dependent thalassemic patients, plasma lipid pattern and oxidative stress are associated with structural damage of isolated erythrocyte membranes as measured by EPR spectroscopy with lipid and proteinthiol spin labels. © 2011, Faculty of Medicine, Universitas Indonesia. All rights reserved.
Electron paramagnetic resonance spectroscopy; Erythrocyte membrane; Lipoproteins; Oxidative stress; Plasma lipids; Thalassemia
alpha tocopherol; aminotransferase; hemoglobin; lipoprotein; malonaldehyde; membrane protein; stearic acid; thiol; triacylglycerol; adolescent; adult; Article; beta thalassemia; cell damage; cell polarity; child; clinical article; controlled study; electron spin resonance; erythrocyte membrane; female; human; lipid blood level; lipid peroxidation; lipid solubility; male; maximum binding capacity; membrane fluidity; membrane structure; oxidative stress
Faculty of Medicine, Universitas Indonesia
08531773
Article
Q3