Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Lalisang T.J.M., Sjamsuhidajat R., Siregar N.C., Taher A.
36623976300;6505812851;6508087790;7005269743;
Profile of hepatocyte apoptosis and bile lakes before and after bile duct decompression in severe obstructive jaundice patients
2010
Hepatobiliary and Pancreatic Diseases International
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5
520
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Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Urology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Lalisang, T.J.M., Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sjamsuhidajat, R., Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Siregar, N.C., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
BACKGROUND: Excessive hepatocyte apoptosis and bile lakes in severe obstructive jaundice might impair liver functions. Although decompression of the bile duct has been reported to improve liver functions in animal studies, the mechanism of obstruction differs from that in humans. This study aimed to determine the profiles of hepatocyte apoptosis and bile lakes following bile duct decompression in patients with severe obstructive jaundice in the clinical setting. METHODS: We conducted a "before and after study" on severe obstructive jaundice patients as a model of inhibition of the excessive process by bile duct decompression. Specimens of liver biopsies were taken before and after decompression of the bile duct and then stained by terminal deoxynucleotide transferase-mediated dUTP nick end-labeling (TUNEL) to identify hepatocyte apoptosis and by hematoxilin-eosin (HE) to identify bile lakes. All measurements were independently done by 2 observers. RESULTS: Twenty-one severe obstructive jaundice patients were included. In all patients, excessive hepatocyte apoptosis and bile lakes were apparent. After decompression, the hepatocyte apoptosis index decreased from 53.1 (SD 105) to 11.7 (SD 13.6) (P<0.05), and the bile lakes from 23.6 (SD 14.8) to 10.9 (SD 6.9) (P<0.05). CONCLUSION: Bile duct decompression improves hepatocyte apoptosis and bile lakes in cases of severe obstructive jaundice, similar to the findings in animal studies. © 2010, Hepatobiliary Pancreat Dis Int. All rights reserved.
Bile duct decompression; Bile lakes; Hepatocyte apoptosis; Obstructive jaundice; TUNEL
deoxyuridine triphosphate pyrophosphatase; eosin; hematoxylin; adult; aged; apoptosis; article; bile; bile duct; bile duct reconstruction; biliary tract drainage; clinical article; disease severity; female; human; liver biopsy; liver cell; male; nick end labeling; obstructive jaundice; Adult; Aged; Apoptosis; Bile; Bile Ducts; Cholecystostomy; Cholestasis; Chronic Disease; Decompression, Surgical; Female; Hepatocytes; Humans; Jaundice, Obstructive; Liver Diseases; Male; Middle Aged; Neoplasms
14993872
HPDIA
20943462
Article
Q2