Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Utama A., Tania N.P., Dhenni R., Gani R.A., Hasan I., Sanityoso A., Lelosutan S.A.R., Martamala R., Lesmana L.A., Sulaiman A., Tai S.
6507755893;37027329900;34067588600;23495930300;12776850800;14325717700;35192151700;35192038200;55920139300;57206256978;16176322300;
Genotype diversity of hepatitis C virus (HCV) in HCV-associated liver disease patients in Indonesia
2010
Liver International
30
8
1152
1160
29
Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Tangerang, Banten, Indonesia; Department of Internal Medicine, Hepatology Division, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Gastroentero-Hepatology Division, Gatot Soebroto Hospital, Jakarta, Indonesia; Klinik Hati 'Prof. Ali Sulaiman', Jakarta, Indonesia
Utama, A., Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Tangerang, Banten, Indonesia; Tania, N.P., Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Tangerang, Banten, Indonesia; Dhenni, R., Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Tangerang, Banten, Indonesia; Gani, R.A., Department of Internal Medicine, Hepatology Division, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hasan, I., Department of Internal Medicine, Hepatology Division, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sanityoso, A., Department of Internal Medicine, Hepatology Division, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Lelosutan, S.A.R., Department of Internal Medicine, Gastroentero-Hepatology Division, Gatot Soebroto Hospital, Jakarta, Indonesia; Martamala, R., Department of Internal Medicine, Gastroentero-Hepatology Division, Gatot Soebroto Hospital, Jakarta, Indonesia; Lesmana, L.A., Department of Internal Medicine, Hepatology Division, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sulaiman, A., Klinik Hati 'Prof. Ali Sulaiman', Jakarta, Indonesia; Tai, S., Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Tangerang, Banten, Indonesia
Background: Hepatitis C virus (HCV) genotype distribution in Indonesia has been reported. However, the identification of HCV genotype was based on 5'-UTR or NS5B sequence. Aims: This study was aimed to observe HCV core sequence variation among HCV-associated liver disease patients in Jakarta, and to analyse the HCV genotype diversity based on the core sequence. Methods: Sixty-eight chronic hepatitis (CH), 48 liver cirrhosis (LC) and 34 hepatocellular carcinoma (HCC) were included in this study. HCV core variation was analysed by direct sequencing. Results: Alignment of HCV core sequences demonstrated that the core sequence was relatively varied among the genotype. Indeed, 237 bases of the core sequence could classify the HCV subtype; however, 236 bases failed to differentiate several subtypes. Based on 237 bases of the core sequences, the HCV strains were classified into genotypes 1 (subtypes 1a, 1b and 1c), 2 (subtypes 2a, 2e and 2f) and 3 (subtypes 3a and 3k). The HCV 1b (47.3%) was the most prevalent, followed by subtypes 1c (18.7%), 3k (10.7%), 2a (10.0%), 1a (6.7%), 2e (5.3%), 2f (0.7%) and 3a (0.7%). HCV 1b was the most common in all patients, and the prevalence increased with the severity of liver disease (36.8% in CH, 54.2% in LC and 58.8%in HCC). These results were similar to a previous report based on NS5B sequence analysis. Conclusion: Hepatitis C virus core sequence (237 bases) could identify the HCV subtype and the prevalence of HCV subtype based on core sequence was similar to those based on the NS5B region. © 2010 John Wiley & Sons A/S.
Core region; Genotype; Hepatitis C virus; Indonesia; Liver disease
alpha fetoprotein; adult; article; chronic hepatitis; disease severity; female; genotype; Hepatitis C virus; human; Indonesia; liver cell carcinoma; liver cirrhosis; major clinical study; male; nucleotide sequence; phylogeny; prevalence; sequence analysis; virus core; virus load; virus strain; Base Sequence; Carcinoma, Hepatocellular; Cluster Analysis; DNA Primers; Genetic Variation; Genotype; Hepacivirus; Hepatitis C; Humans; Indonesia; Liver Cirrhosis; Liver Neoplasms; Molecular Sequence Data; Phylogeny; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Statistics, Nonparametric; Viral Core Proteins; Viral Load
14783223
LIINC
20492518
Article
Q1