Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Djuardi Y., Sartono E., Wibowo H., Supali T., Yazdanbakhsh M.
6507800820;6701506022;57217690943;6602742029;7006269286;
A longitudinal study of BCG vaccination in early childhood: The development of innate and adaptive immune responses
2010
PLoS ONE
5
11
e14066
45
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
Djuardi, Y., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Sartono, E., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Wibowo, H., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Supali, T., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Yazdanbakhsh, M., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD were assessed before vaccination and at ages of 5 months, 1 year, and 2 years, followed by BCG scar measurement at 4 years of age. BCG was shown to induce both Th1 and Th2 type responses against PPD at about 5 months of age after vaccination, and while Th1 response was sustained, Th2 responses declined over time. However, BCG scar size was strongly correlated with Th2 responses to PPD at 5 months of age. Importantly, we observed no clear effects of BCG vaccination on innate immune responses in terms of early IL-10 or TNF-α production whereas some alterations in general adaptive immune responses to PHA were observed. © 2010 Djuardi et al.
BCG vaccine; cytokine; interleukin 10; tuberculin; tumor necrosis factor alpha; BCG vaccine; gamma interferon; interleukin 10; lipopolysaccharide; tumor necrosis factor alpha; adaptive immunity; article; BCG vaccination; cellular immunity; childhood; cohort analysis; cytokine production; female; human; infant; innate immunity; longitudinal study; male; Mycobacterium; newborn; scar; Th1 cell; Th2 cell; adult; clinical trial; immunology; Indonesia; metabolism; methodology; Mycobacterium bovis; pregnancy; pregnancy complication; preschool child; time; tuberculosis; vaccination; Corynebacterineae; Adaptive Immunity; Adult; BCG Vaccine; Child, Preschool; Female; Humans; Immunity, Innate; Indonesia; Infant; Infant, Newborn; Interferon-gamma; Interleukin-10; Lipopolysaccharides; Longitudinal Stud
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Article
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