Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Karyanti M.R., Uiterwaal C.S.P.M., Hadinegoro S.R., Jansen M.A.C., Heesterbeek J.A.P.H., Hoes A.W., Bruijning-Verhagen P.
56290680800;7006033434;56893685800;57189994541;57211847433;35370614300;55175644800;
Clinical Course and Management of Dengue in Children Admitted to Hospital: A 5 Years Prospective Cohort Study in Jakarta, Indonesia
2020
Pediatric Infectious Disease Journal
E314
E319
Department of Child Health, Medical Faculty University of Indonesia, Division of Infection and Tropical Pediatrics, Dr. Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Theoretical Epidemiology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, Netherlands
Karyanti, M.R., Department of Child Health, Medical Faculty University of Indonesia, Division of Infection and Tropical Pediatrics, Dr. Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Uiterwaal, C.S.P.M., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Hadinegoro, S.R., Department of Child Health, Medical Faculty University of Indonesia, Division of Infection and Tropical Pediatrics, Dr. Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Jansen, M.A.C., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Heesterbeek, J.A.P.H., Theoretical Epidemiology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, Netherlands; Hoes, A.W., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Bruijning-Verhagen, P., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
Background: Dengue incidence is rising globally which was estimated 100 million per year, whereas in Indonesia was estimated 7.5 million per year. Dengue clinical course varies from mild dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Patients, clinicians and care facilities would benefit if reliable predictors can determine at admission which cases with clinically suspected dengue will progress to DHF or DSS. Methods: From 2009 through 2013, a cohort of 494 children admitted with clinically suspected dengue at a tertiary care hospital in Jakarta, Indonesia, was followed until discharge. We evaluated the clinical course and disease outcome of admitted patients and estimated the burden of dengue cases hospitalized over time. Results: Of all 494 children, 185 (37%) were classified at admission as DF, 158 (32%) as DHF and 151 (31%) as DSS. Of DF patients, 52 (28%) progressed to DHF or DSS, 10 (5%) had other viral diseases. Of DHF patients, 9(6%) progressed to DSS. Of 33 routinely collected parameters at admission, duration of fever ≤4 days was the only significant predictor of disease progression (P = 0.01). Five cases (3%) admitted with DSS died. Between 2009 and 2013, annual dengue admissions declined, while distribution of disease severity remained stable. Conclusions: Almost a third of children admitted to tertiary care with clinically suspected DF progress to DHF or DSS. Among routinely collected parameters at admission, only fever duration was significantly associated with clinical progression, emphasizing unpredictability of dengue disease course from parameters currently routinely collected. © 2020 Lippincott Williams and Wilkins. All rights reserved.
children; clinical progression; dengue infection
adolescent; child; dengue; disease exacerbation; disease management; epidemic; female; fever; hospitalization; human; Indonesia; infant; male; pathophysiology; preschool child; prospective study; severe dengue; tertiary care center; treatment outcome; virology; Adolescent; Child; Child, Preschool; Dengue; Disease Management; Disease Outbreaks; Disease Progression; Female; Fever; Hospitalization; Humans; Indonesia; Infant; Male; Prospective Studies; Severe Dengue; Tertiary Care Centers; Treatment Outcome
Lippincott Williams and Wilkins
08913668
PIDJE
31738330
Article
Q1