Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Miftahussurur M., Agung Waskito L., Aftab H., Vilaichone R., Subsomwong P., Nusi I.A., Syam A.F., Ratanachu-Ek T., Doohan D., Siregar G., Rezkitha Y.A.A., Fauzia K.A., Mahachai V., Yamaoka Y.
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Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations
2020
PLoS ONE
15
4
e0230064
Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, Japan; Department of Gastroenterology, Dhaka Medical College and Hospital, Dhaka, Bangladesh; Gastroenterology Unit, Digestive Diseases Research Center (DRC), Thammasat University Hospital, Pathumthani, Thailand; Department of Medicine, Chulabhorn International College of Medicine (CICM), Thammasat University, Pathumthani, Thailand; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Surgery, Rajavithi Hospital, Bangkok, Thailand; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara, Medan, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia; GI and Liver Center, Bangkok Medical Center, Bangkok, Thailand; Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States; Global Oita Medical Advanced Research Center for Health, Yufu, Japan
Miftahussurur, M., Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Agung Waskito, L., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, Japan; Aftab, H., Department of Gastroenterology, Dhaka Medical College and Hospital, Dhaka, Bangladesh; Vilaichone, R., Gastroenterology Unit, Digestive Diseases Research Center (DRC), Thammasat University Hospital, Pathumthani, Thailand, Department of Medicine, Chulabhorn International College of Medicine (CICM), Thammasat University, Pathumthani, Thailand; Subsomwong, P., Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, Japan; Nusi, I.A., Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ratanachu-Ek, T., Department of Surgery, Rajavithi Hospital, Bangkok, Thailand; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, Japan; Siregar, G., Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara, Medan, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, Japan; Mahachai, V., GI and Liver Center, Bangkok Medical Center, Bangkok, Thailand; Yamaoka, Y., Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, Japan, Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States, Global Oita Medical Advanced Research Center for Health, Yufu, Japan
Serum pepsinogens have been widely acknowledged as gastric mucosal biomarkers; however, a multicountry report on the benefits of pepsinogens as biomarkers has not yet been published. We analyzed 1,206 sera and gastric mucosal samples collected from Bangladesh, Bhutan, Indonesia, Myanmar, Nepal and Thailand then assessed the association between gastric mucosal changes and Helicobacter pylori infection. The new cutoff values for serum pepsinogen values were evaluated using a receiver operating characteristic analysis. The participants with H. pylori infection had significantly lower pepsinogen I and higher pepsinogen II values, but a lower pepsinogen I/II ratio than participants without the infection (all P < .001). The pepsinogen I and pepsinogen I/II values were significantly higher and lower, respectively, in individuals with atrophic gastritis than in those without (both P < .001). Among uninfected individuals, only the pepsinogen I/II ratio was significantly lower in atrophic individuals. Pepsinogen I/II ratio also were significantly different between disease among H. pylori-positive and H. pylori-negative individuals, suggesting the pepsinogen I/II ratio is a robust biomarker for determining both chronic and atrophic gastritis. The cutoffs for detecting chronic and atrophic gastritis for the pepsinogen I/II ratio were 4.65 and 4.95, respectively. In conclusion, pepsinogen levels are useful biomarker for both chronic gastritis and atrophic gastritis, but they should be used with caution. Population-based validation is necessary to determine the best cutoff values. Among all pepsinogen values, the pepsinogen I/II ratio was the most reliable gastric mucosal-change biomarker. © 2020 Miftahussurur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
pepsinogen I; pepsinogen II; biological marker; pepsinogen; pepsinogen II; virulence factor; adolescent; adult; aged; Article; atrophic gastritis; Bangladesh; Bhutan; cancer risk; chronic gastritis; controlled study; cross-sectional study; disease association; enzyme linked immunosorbent assay; female; Helicobacter infection; Helicobacter pylori; human; immunohistochemistry; Indonesia; major clinical study; male; Myanmar; Nepal; nonhuman; pathogenesis; population research; predictive value; protein blood level; receiver operating characteristic; sensitivity and specificity; South Asian; Southeast Asian; stomach cancer; Thailand; validation study; Asia; atrophic gastritis; blood; chronic disease; gastritis; metabolism; middle aged; pathogenicity; physiology; risk factor; stomach tumor; very
Public Library of Science
19326203
POLNC
32271765
Article
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