Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Hee H.T., Ismail H.D., Lim C.T., Goh J.C.H., Wong H.K.
7003808455;56161962800;35574057500;7102139532;7402865054;
Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc
2010
Journal of Bone and Joint Surgery - Series B
92
5
726
736
36
National University Hospital, Singapore; Department of Orthopaedic Surgery, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore; Department of Orthopaedic and Traumatology, Faculty of Medicine, University of Indonesia, Salemba 6, Jakarta 10430, Indonesia
Hee, H.T., Department of Orthopaedic Surgery, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore; Ismail, H.D., National University Hospital, Singapore, Department of Orthopaedic and Traumatology, Faculty of Medicine, University of Indonesia, Salemba 6, Jakarta 10430, Indonesia; Lim, C.T., Department of Orthopaedic Surgery, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore; Goh, J.C.H., Department of Orthopaedic Surgery, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore; Wong, H.K., Department of Orthopaedic Surgery, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Although success has been achieved with implantation of bone marrow mesenchymal stem cells (bMSCs) in degenerative discs, its full potential may not be achieved if the harsh environment of the degenerative disc remains. Axial distraction has been shown to increase hydration and nutrition. Combining both therapies may have a synergistic effect in reversing degenerative disc disease. In order to evaluate the effect of bMSC implantation, axial distraction and combination therapy in stimulating regeneration and retarding degeneration in degenerative discs, we first induced disc degeneration by axial loading in a rabbit model. The rabbits in the intervention groups performed better with respect to disc height, morphological grading, histological scoring and average dead cell count. The groups with distraction performed better than those without on all criteria except the average dead cell count. Our findings suggest that bMSC implantation and distraction stimulate regenerative changes in degenerative discs in a rabbit model. ©2010 British Editorial Society of Bone and Joint Surgery.
animal experiment; animal model; animal tissue; article; axial distraction; cell count; cell death; controlled study; height; histopathology; intervertebral disk degeneration; mesenchymal stem cell transplantation; morphology; nonhuman; orthopedic surgery; priority journal; rabbit; scoring system; surgical technique; Animals; Biomechanics; Bone Marrow Transplantation; Bone Wires; Cell Count; Cell Culture Techniques; Combined Modality Therapy; Disease Models, Animal; Intervertebral Disk; Intervertebral Disk Degeneration; Lumbar Vertebrae; Mesenchymal Stem Cell Transplantation; Osteogenesis, Distraction; Rabbits; Radiographic Image Enhancement; Random Allocation; Regeneration; Weight-Bearing; X-Ray Microtomography
0301620X
JBSUA
20436013
Article
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