Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Wiria A.E., Prasetyani M.A., Hamid F., Wammes L.J., Lell B., Ariawan I., Uh H.W., Wibowo H., Djuardi Y., Wahyuni S., Sutanto I., May L., Luty A.J.F., Verweij J.J., Sartono E., Yazdanbakhsh M., Supali T.
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Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
2010
BMC Infectious Diseases
10
77
77
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Department of Biostatistics, School of of Public Health, University of Indonesia, Jakarta, Indonesia; Department of Biostatistics, Leiden University Medical Centre, Leiden, Netherlands; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Wiria, A.E., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Prasetyani, M.A., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hamid, F., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Wammes, L.J., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Lell, B., Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon, Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Ariawan, I., Department of Biostatistics, School of of Public Health, University of Indonesia, Jakarta, Indonesia; Uh, H.W., Department of Biostatistics, Leiden University Medical Centre, Leiden, Netherlands; Wibowo, H., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Djuardi, Y., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wahyuni, S., Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Sutanto, I., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; May, L., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Luty, A.J.F., Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; Verweij, J.J., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Sartono, E., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Yazdanbakhsh, M., Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Supali, T., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Background: Given that helminth infections are thought to have strong immunomodulatory activity, the question whether helminth infections might affect responses to malaria antigens needs to be addressed. Different cross-sectional studies using diverse methodologies have reported that helminth infections might either exacerbate or reduce the severity of malaria attacks. The same discrepancies have been reported for parasitemia.Methods/Design: To determine the effect of geohelminth infections and their treatment on malaria infection and disease outcome, as well as on immunological parameters, the area of Nangapanda on Flores Island, Indonesia, where malaria and helminth parasites are co-endemic was selected for a longitudinal study. Here a Double-blind randomized trial will be performed, incorporating repeated treatment with albendazole (400 mg) or placebo at three monthly intervals. Household characteristic data, anthropometry, the presence of intestinal helminth and Plasmodium spp infections, and the incidence of malaria episodes are recorded. In vitro cultures of whole blood, stimulated with a number of antigens, mitogens and toll like receptor ligands provide relevant immunological parameters at baseline and following 1 and 2 years of treatment rounds. The primary outcome of the study is the prevalence of Plasmodium falciparum and P. vivax infection. The secondary outcome will be incidence and severity of malaria episodes detected via both passive and active follow-up. The tertiary outcome is the inflammatory cytokine profile in response to parasite antigens. The project also facilitates the transfer of state of the art methodologies and technologies, molecular diagnosis of parasitic diseases, immunology and epidemiology from Europe to Indonesia.Discussion: The study will provide data on the effect of helminth infections on malaria. It will also give information on anthelminthic treatment efficacy and effectiveness and could help develop evidence-based policymaking. © 2010 Wiria et al; licensee BioMed Central Ltd.
albendazole; cytokine; parasite antigen; placebo; albendazole; anthelmintic agent; cytokine; placebo; adolescent; adult; aged; anthropometry; article; Ascaris lumbricoides; blood culture; child; clinical effectiveness; clinical trial; controlled clinical trial; controlled study; cytokine release; disease severity; double blind procedure; evidence based medicine; feces analysis; female; follow up; helminthiasis; human; in vitro study; incidence; Indonesia; infant; intestine infection; longitudinal study; major clinical study; malaria; male; outcomes research; Plasmodium falciparum; Plasmodium vivax; prevalence; randomized controlled trial; single drug dose; treatment response; Trichuris; animal; helminthiasis; immunology; Indonesia; intestine infection; isolation and purification; malaria f
14712334
BIDMB
20338054
Article
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