Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Muliaty D., Yusuf I., Setiabudy R., Wanandi S.I.
36120774200;8109514400;6602316235;36099320700;
CYP2A6 gene polymorphisms impact to nicotine metabolism
2010
Medical Journal of Indonesia
19
1
46
51
Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Physiology Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Pharmacology Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Biochemistry Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Muliaty, D., Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Yusuf, I., Department of Physiology Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Setiabudy, R., Department of Pharmacology Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wanandi, S.I., Department of Biochemistry Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensive nicotine metabolism. In the CYP2A6 gene, several polymorphic alleles have been reported such as CYP2A6*4, CYP2A6*7, CYP2A6*9, and CYP2A6*10 which are related to decreasing nicotine metabolism activity. The variation of nicotine metabolism activity could alter nicotine plasma levels. Smokers need a certain level of nicotine in their brain and must smoke regularly because of nicotine’s short half-life; this increases the number of smoked cigarettes in extensive metabolizers. Meanwhile, in slow metabolizers, nicotine plasma level may increase and results in nicotine toxicity. This will eventually lower the risk of dependence. © 2010, Faculty of Medicine, Universitas Indonesia. All rights reserved.
Cotinine; Hepatic cytochrome P450 2A6; Smoking behavior
cotinine; cytochrome P450 2A6; nicotine; amino acid substitution; Article; crossing over; cytochrome P450 2A6 gene; distribution half-life; DNA polymorphism; enzyme activity; frameshift mutation; gene; gene conversion; gene frequency; genetic variation; genotype; human; metabolic activity assay; phenotype; single nucleotide polymorphism; smoking; tissue distribution; tobacco dependence
Faculty of Medicine, Universitas Indonesia
08531773
Article
Q4