Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Sormin I.P., Lukito W., Wijaya A., As’ad S.
57192906237;6701622348;57218177969;6505510738;
Negative impact of imflammation and insulin resistance on the biogenesis of HDL-c in indonesian men with metabolic syndrome
2010
Medical Journal of Indonesia
19
1
36
45
Faculty of Medicine, University of Hassanuddin, Makassar, Indonesia; Prodia Clinical Laboratory, Jakarta, Indonesia; SEAMEO-TROPMED Regional Center for Community Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Sormin, I.P., Faculty of Medicine, University of Hassanuddin, Makassar, Indonesia, Prodia Clinical Laboratory, Jakarta, Indonesia; Lukito, W., SEAMEO-TROPMED Regional Center for Community Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wijaya, A., Faculty of Medicine, University of Hassanuddin, Makassar, Indonesia, Prodia Clinical Laboratory, Jakarta, Indonesia; As’ad, S., Faculty of Medicine, University of Hassanuddin, Makassar, Indonesia
Aim To find out the relationship between inflammation and insulin resistance with impaired HDL biogenesis that cause low HDL-c concentration Methods Using a cross-sectional design, this study involved 163 adult men, aged 25-60 years old with metabolic syndrome (IDF criteria, 2005), without liver and kidney dysfunction. This study was undertaken in Jakarta in the year 2007-2009. Measured indicators were serum apolipoprotein A-1 (apoA-1), prebeta-1 HDL, cholesteryl ester transfer protein (CETP), HDL cholesterol (HDL-c), body weight, height, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), and triglyceride. The apoA-1/HDL-c ratios were taken as indicator of HDL maturation, whereas CETP/HDL-c and CETP/TG ratios were indicated HDL catabolism. high-sensitivity CRP (hsCRP) and HOMA-IR were taken as indicator of inflammation and insulin resistance, respectively. Data were analyzed by using univariate, bivariate, and multivariate analysis. Results Positive correlations were found between hsCRP and CETP (rs= 0.200, p= 0.042), and CETP/HDL-c ratios (rs= 0.188, p= 0.013). HOMA-IR positively correlated with apoA-1/HDL-c ratios (rs= 0.190, p= 0.016) and negatively correlated with the CETP/TG ratios (rs= -0.162, p= 0.04). Results of general linear model analysis showed that serum hsCRP concentration had the highest contribution to CETP/HDL-c ratios, apoA-1, dan CETP (p= 0.009; 0.016; 0.054, respectively). Conclusions Inflammation and insulin resistance related to dysfunction of HDL biogenesis in men with metabolic syndrome. The inflammation correlated with increased HDL catabolism, whereas the insulin resistance correlated with decreased HDL maturation and increased HDL catabolism. These may lead to low HDL-c concentration. Inflammation had higher contribution to HDL biogenesis factors than insulin resistance. © 2010, Faculty of Medicine, Universitas Indonesia. All rights reserved.
ApoA-1; CETP; HDL-c and metabolic syndrome; HOMA-IR; hsCRP; Prebeta-1 HDL
alanine aminotransferase; apolipoprotein A1; aspartate aminotransferase; bilirubin; C reactive protein; cholesterol ester transfer protein; creatinine; high density lipoprotein cholesterol; triacylglycerol; very low density lipoprotein; adult; Article; biogenesis; body mass; chemiluminescence immunoassay; cross-sectional study; diastolic blood pressure; enzyme linked immunosorbent assay; glucose blood level; homeostasis model assessment; human; inflammation; insulin resistance; major clinical study; male; metabolic syndrome X; systolic blood pressure; waist circumference
Faculty of Medicine, Universitas Indonesia
08531773
Article
Q4