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72 |
Fitriana I., Setiati S., Rizal E.W., Istanti R., Rinaldi I., Kojima T., Akishita M., Azwar M.K. |
55486095900;14325991900;57223021639;23496653300;23475122400;55240575700;7004867426;57202798959; |
Malnutrition and depression as predictors for 30-day unplanned readmission in older patient: a prospective cohort study to develop 7-point scoring system |
2021 |
BMC Geriatrics |
21 |
1 |
256 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104539861&doi=10.1186%2fs12877-021-02198-7&partnerID=40&md5=38aa06ca8c7777764cff2096359b93e7 |
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan |
Fitriana, I., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia, Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rizal, E.W., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Istanti, R., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Rinaldi, I., Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kojima, T., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Akishita, M., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Azwar, M.K., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Background: Readmission is related to high cost, high burden, and high risk for mortality in geriatric patients. A scoring system can be developed to predict the readmission of older inpatients to perform earlier interventions and prevent readmission. Methods: We followed prospectively inpatients aged 60 years and older for 30 days, with initial comprehensive geriatric assessment (CGA) on admission in a tertiary referral centre. Patients were assessed with CGA tools consisting of FRAIL scale (fatigue, resistance, ambulation, illness, loss of weight), the 15-item Geriatric Depression Scale, Mini Nutritional Assessment short-form (MNA-SF), the Barthel index for activities of daily living (ADL), Charlson Comorbidity Index (CCI), caregiver burden based on 4-item Zarit Burden Index (ZBI), and cognitive problem with Abbreviated Mental Test (AMT). Demographic data, malignancy diagnosis, and number of drugs were also recorded. We excluded data of deceased patients and patients transferred to other hospitals. We conducted stepwise multivariate regression analysis to develop the scoring system. Results: Thirty-day unplanned readmission rate was 37.6 %. Among 266 patients, 64.7 % of them were malnourished, and 46.5 % of them were readmitted. About 24 % were at risk for depression or having depressed mood, and 53.1 % of them were readmitted. In multivariate analysis, nutritional status (OR 2.152, 95 %CI 1.151–4.024), depression status (OR 1.884, 95 %CI 1.071–3.314), malignancy (OR 1.863 95 %CI 1.005–3.451), and functional status (OR 1.584, 95 %CI 0.885–2.835) were included in derivation of 7 score system. The scoring system had maximum score of 7 and incorporated malnutrition (2 points), depression (2 points), malignancy (2 points), and dependent functional status (1 point). A score of 3 or higher suggested 82 % probability of readmission within 30 days following discharge. Area under the curve (AUC) was 0.694 (p = 0.001). Conclusions: Malnutrition, depression, malignancy and functional problem are predictors for 30-day readmission. A practical CGA-based 7 scoring system had moderate accuracy and strong calibration in predicting 30-day unplanned readmission for older patients. © 2021, The Author(s). |
Comprehensive geriatric assessment; Depression; Malnutrition; Predictive score; Readmission |
aged; daily life activity; depression; geriatric assessment; hospital readmission; human; malnutrition; middle aged; nutritional assessment; nutritional status; prospective study; risk factor; Activities of Daily Living; Aged; Depression; Geriatric Assessment; Humans; Malnutrition; Middle Aged; Nutrition Assessment; Nutritional Status; Patient Readmission; Prospective Studies; Risk Factors |
BioMed Central Ltd |
14712318 |
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33865312 |
Article |
Q1 |
1414 |
2506 |
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73 |
Kosasih A., Koepfli C., Dahlan M.S., Hawley W.A., Baird J.K., Mueller I., Lobo N.F., Sutanto I. |
56584346800;26536294400;57195937625;7004280510;15921267800;7006910183;35392948100;6603791639; |
Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study |
2021 |
Malaria Journal |
20 |
1 |
177 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104141748&doi=10.1186%2fs12936-021-03709-y&partnerID=40&md5=9c099fec0d8bce6347bf112092d4561b |
PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; PT Epidemiologi Indonesia, Jakarta, Indonesia; UNICEF, Jakarta, Indonesia; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Kosasih, A., PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Koepfli, C., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States, Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Dahlan, M.S., PT Epidemiologi Indonesia, Jakarta, Indonesia; Hawley, W.A., UNICEF, Jakarta, Indonesia; Baird, J.K., Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Mueller, I., Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Lobo, N.F., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; Sutanto, I., Indonesian Medical Education and Research Institute, Jakarta, Indonesia, Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Background: A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas—an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia. Methods: RT-qPCR targeting pfs25 and pvs25 transcripts—gametocyte molecular markers for Plasmodium falciparum and Plasmodium vivax, respectively, was performed to detect and quantify gametocytes in blood samples of P. falciparum and P. vivax-infected subjects over the course of the MST study. The presence of both asexual and sexual parasites in microscopic and submicroscopic infections was compared from the start and end of the MST, using proportion tests as well as parametric and non-parametric tests. Results: Parasite prevalence remained unchanged for P. falciparum (6% = 52/811 versus 7% = 50/740, p = 0.838), and decreased slightly for P. vivax (24% = 192/811 versus 19% = 142/740, p = 0.035) between the MST baseline and endpoint. No significant difference was observed in gametocyte prevalence for either P. falciparum (2% = 19/803 versus 3% = 23/729, p = 0.353, OR = 1.34, 95%CI = 0.69–2.63), or P. vivax (7% = 49/744 versus 5% = 39/704, p = 0.442, OR = 0.83, 95%CI = 0.52–1.31). Even though there was an insignificant difference between the two time points, the majority of parasite positive subjects at the endpoint had been negative at baseline (P. falciparum: 66% = 29/44, P. vivax: 60% = 80/134). This was similarly demonstrated for the transmissible stage—where the majority of gametocyte positive subjects at the endpoint were negative at baseline (P. falciparum: 95% = 20/21, P. vivax: 94% = 30/32). These results were independent of treatment provided during MST activities. No difference was demonstrated in parasite and gametocyte density between both time points either in P. falciparum or P. vivax. Conclusion: In this study area, similar prevalence rates of P. falciparum and P. vivax parasites and gametocytes before and after MST, although in different individuals, points to a negligible impact on the parasite reservoir. Treatment administration based on parasite positivity as implemented in the MST should be reevaluated for the elimination strategy in the community. Trial registration Clinical trials registration NCT01878357. Registered 14 June 2013, https://www.clinicaltrials.gov/ct2/show/NCT01878357. © 2021, The Author(s). |
Gametocyte; Mass screening and treatment; Pfs25; Pvs25 |
dihydroartemisinin plus piperaquine; primaquine; adolescent; Article; blood sampling; cell density; controlled study; disease reservoir; endemic disease; female; gametocyte; gene; gene targeting; genetic transcription; human; Indonesia; longitudinal study; major clinical study; malaria falciparum; male; mass screening; microscopy; parasite clearance; parasite transmission; pfs25 gene; Plasmodium vivax malaria; population structure; prevalence; prospective study; pvs25 gene; randomized controlled trial; real time polymerase chain reaction; adult; aged; child; heterozygote; infant; isolation and purification; malaria falciparum; middle aged; parasitology; Plasmodium falciparum; Plasmodium vivax; Plasmodium vivax malaria; preschool child; very elderly; young adult; Adolescent; Adult; Aged; Ag |
BioMed Central Ltd |
14752875 |
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33836772 |
Article |
Q1 |
1718 |
1764 |
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74 |
Darmadi J., Batubara R.R., Himawan S., Azizah N.N., Audah H.K., Arsianti A., Kurniawaty E., Ismail I.S., Batubara I., Audah K.A. |
57222431230;57220745212;57222422725;57191927056;57222432027;36124567000;57214889313;7103005751;26031903000;15119028200; |
Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug |
2021 |
Scientific Reports |
11 |
1 |
6080 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102715983&doi=10.1038%2fs41598-021-85383-3&partnerID=40&md5=0ea6644166c67e4defd273cae7f6aa43 |
Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia; Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Darmadi, J., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Batubara, R.R., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Himawan, S., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Azizah, N.N., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Audah, H.K., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Arsianti, A., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia, Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Kurniawaty, E., Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Ismail, I.S., Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Batubara, I., Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia, Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Audah, K.A., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia, Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug. © 2021, The Author(s). |
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acetic acid; antineoplastic agent; plant extract; adipose tissue; animal; Artemia; chemistry; drug screening; HeLa cell line; HT-29 cell line; human; MCF-7 cell line; Meliaceae; metabolism; neoplasm; plant leaf; stem cell; Acetates; Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Artemia; Drug Screening Assays, Antitumor; HeLa Cells; HT29 Cells; Humans; MCF-7 Cells; Meliaceae; Neoplasms; Plant Extracts; Plant Leaves; Stem Cells |
Nature Research |
20452322 |
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33727582 |
Article |
Q1 |
1240 |
3130 |
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75 |
Lydia A., Setiati S., Soejono C.H., Istanti R., Marsigit J., Azwar M.K. |
8451287200;14325991900;24472241900;23496653300;57218912589;57202798959; |
Prevalence of prehypertension and its risk factors in midlife and late life: Indonesian family life survey 2014–2015 |
2021 |
BMC Public Health |
21 |
1 |
493 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102501346&doi=10.1186%2fs12889-021-10544-y&partnerID=40&md5=ca5ddee24de31f31b2409c6356d7d7e6 |
Department of Internal Medicine, Division of Nephrology and Hypertension, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Lydia, A., Department of Internal Medicine, Division of Nephrology and Hypertension, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiati, S., Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soejono, C.H., Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Istanti, R., Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Marsigit, J., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Azwar, M.K., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Early detection of prehypertension is important to prevent hypertension-related complications, such as cardiovascular disease, cerebrovascular disease and all-cause mortality. Data regarding the prevalence of prehypertension among mid- and late-life population in Indonesia were lacking. It is crucial to obtain the prevalence data and identify the risk factors for prehypertension in Indonesia, which may differ from that of other countries. Methods: The cross-sectional analysis utilized multicenter data from Indonesian Family Life Survey-5 (IFLS-5) from 13 provinces in 2014–2015. We included all subjects at mid-and late-life (aged ≥40 years old) from IFLS-5 with complete blood pressure data and excluded those with prior diagnosis of hypertension. Prehypertension was defined as high-normal blood pressure according to International Society of Hypertension (ISH) 2020 guideline (systolic 130–139 mmHg and/or diastolic 85–89 mmHg). Sociodemographic factors, chronic medical conditions, physical activity, waist circumference and nutritional status were taken into account. Statistical analyses included bivariate and multivariate analyses. Results: There were 5874 subjects included. The prevalence of prehypertension among Indonesian adults aged > 40 years old was 32.5%. Age ≥ 60 years (adjusted OR 1.68, 95% CI 1.41–2.01, p < 0.001), male sex (adjusted OR 1.65, 95% CI 1.45–1.88, p < 0.001), overweight (adjusted OR 1.44, 95% CI 1.22–1.70, p < 0.001), obesity (adjusted OR 1.77, 95% CI 1.48–2.12, p < 0.001), and raised waist circumference (adjusted OR 1.32, 95% CI 1.11–1.56, p = 0.002) were the significant risk factors associated with prehypertension. Prehypertension was inversely associated with being underweight (adjusted OR 0.74, 95% CI 0.59–0.93, p = 0.009). Conclusions: The prevalence of prehypertension in Indonesian mid- and late-life populations is 32.5%. Age ≥ 60 years, male sex, overweight, obesity, and raised waist circumference are risk factors for prehypertension. © 2021, The Author(s). |
Indonesia; Mid- and late-life; Prehypertension; Risk factors |
adult; blood pressure; clinical trial; cross-sectional study; family size; human; hypertension; Indonesia; male; middle aged; multicenter study; prehypertension; prevalence; risk factor; Adult; Blood Pressure; Cross-Sectional Studies; Family Characteristics; Humans; Hypertension; Indonesia; Male; Middle Aged; Prehypertension; Prevalence; Risk Factors |
BioMed Central Ltd |
14712458 |
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33711980 |
Article |
Q1 |
1230 |
3166 |
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76 |
Lazarus G., Findyartini A., Putera A.M., Gamalliel N., Nugraha D., Adli I., Phowira J., Azzahra L., Ariffandi B., Widyahening I.S. |
57214599425;56543777300;57222064804;57222183873;57221389984;57222181089;57221489618;57222184743;57222178259;54893154400; |
Willingness to volunteer and readiness to practice of undergraduate medical students during the COVID-19 pandemic: a cross-sectional survey in Indonesia |
2021 |
BMC Medical Education |
21 |
1 |
138 |
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14 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101797052&doi=10.1186%2fs12909-021-02576-0&partnerID=40&md5=fe743e7efa2199d87c6345360ad4e627 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Salemba 6, Central, Jakarta, 10430, Indonesia; Medical Education Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Salemba 6, Central, Jakarta, 10430, Indonesia, Medical Education Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putera, A.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gamalliel, N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nugraha, D., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Adli, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Phowira, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahra, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariffandi, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The question to involve or restrict medical students’ involvement in the coronavirus disease 2019 (COVID-19) pandemic response remains contentious. As their state of preparation and perceptions in volunteering during this pandemic have yet to be investigated, this study aims to evaluate Indonesian medical students’ willingness to volunteer and readiness to practice during the COVID-19 pandemic. Methods: A web-based survey was conducted among undergraduate medical students throughout Indonesia. Socio-demographic and social interaction information, in addition to willingness to volunteer and readiness to practice, were obtained using a self-reported questionnaire. The significance level was set at 5%. Results: Among 4870 participants, 2374 (48.7%) expressed their willingness to volunteer, while only 906 (18.6%) had adequate readiness to practice. Male students, students with prior volunteering experience in health or non-health sectors, and students from public universities or living in Central Indonesia (vs Java) had higher scores of willingness and readiness to volunteer. Students from Sumatra also had better preparedness (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.15–2.12, p = 0.004), while the opposite occurred for students from Eastern Indonesia (OR 0.63, 95% CI: 0.44–0.89, p = 0.002)–when compared to students from Java. In addition, compared to students with high family income, students from lower-middle income families were less willing to volunteer (OR 0.76, 95% CI: 0.59–0.98, p = 0.034), though those with low family income had better readiness (OR 1.51, 95% CI: 1.10–2.08, p = 0.011). Shortage of medical personnel, sense of duty, and solicitation by stakeholders were the main reasons increasing the students’ willingness to volunteer; whereas contrarily fear for own’s health, absence of a cure, and fear of harming patients were the primary factors diminishing their willingness to volunteer. Conclusion: Our findings indicated that many Indonesian medical students are willing to volunteer, yet only few of them were ready to practice, indicating that further preparations are required to maximize their potentials and minimize their exposure to hazards. We suggest that their potentials as a firm support system during the pandemic should not be overlooked, and that the integration of relevant courses to the medical curricula are imperative to prepare for future public health emergencies. © 2021, The Author(s). |
COVID-19; Indonesia; Medical students; Readiness to practice; Willingness to volunteer |
clinical competence; curriculum; demography; epidemiology; fear; female; human; income; Indonesia; male; medical education; medical student; motivation; pandemic; psychology; self report; sex factor; volunteer; young adult; Clinical Competence; COVID-19; Curriculum; Education, Medical, Undergraduate; Fear; Female; Humans; Income; Indonesia; Male; Motivation; Pandemics; Residence Characteristics; SARS-CoV-2; Self Report; Sex Factors; Students, Medical; Volunteers; Young Adult |
BioMed Central Ltd |
14726920 |
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33648516 |
Article |
Q1 |
809 |
5954 |
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77 |
Findyartini A., Greviana N., Putera A.M., Sutanto R.L., Saki V.Y., Felaza E. |
56543777300;57197709749;57222064804;57222060277;57222061848;57217487889; |
The relationships between resilience and student personal factors in an undergraduate medical program |
2021 |
BMC Medical Education |
21 |
1 |
113 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101258190&doi=10.1186%2fs12909-021-02547-5&partnerID=40&md5=a9759408209ed0c6e18f2a706196b0ae |
Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Putera, A.M., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sutanto, R.L., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saki, V.Y., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Resilience is an essential aspect of wellbeing that plays a major role in undergraduate medical education. Various personal and social factors are known to affect resilience. Empirical evidence remains limited regarding resilience and the personal factors that affect it among undergraduate medical students in an Asian setting. Therefore, this study aims to identify undergraduate medical students’ level of resilience and its relationships to personal factors in Indonesia. Methods: This cross-sectional study was conducted among undergraduate medical students in years 1–6. Respondents were asked to complete three validated questionnaires: the Connor-Davidson Resilience Scale (CD-RISC) to measure resilience, the Brief-COPE to assess coping mechanisms, and the Big Five Personality Test to measure five personality dimensions. Descriptive and Pearson’s correlation analyses were completed to explore relationships between each variable. Regression analysis was completed to analyze the extent to which coping mechanisms, personality, and academic achievement explained the variation in resilience scores. Results: A total of 1040 respondents completed the questionnaires (a 75.42% response rate). Students in both preclinical and clinical stages had quite good levels of resilience and higher scores on adaptive coping mechanisms than on maladaptive coping mechanisms. Adaptive and maladaptive coping mechanisms, Big Five Personality traits (extraversion, agreeableness, conscientiousness, neuroticism, and openness), and students’ academic achievement explained 46.9% of students’ resilience scores. Conclusions: Although the resilience scores in this study were comparable to resilience scores among undergraduate medical students in other settings, we found that coping mechanisms, personality traits, and academic performance may predict resilience among medical students. © 2021, The Author(s). |
Coping mechanism; Medical students; Personality traits; Resilience; Undergraduate |
cross-sectional study; human; Indonesia; medical education; medical student; personality; Cross-Sectional Studies; Education, Medical, Undergraduate; Humans; Indonesia; Personality; Students, Medical |
BioMed Central Ltd |
14726920 |
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33602176 |
Article |
Q1 |
809 |
5954 |
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78 |
Laurentius A., Mendel B., Prakoso R. |
57213147353;57221914088;57192893243; |
Clinical outcome of renin-angiotensin-aldosterone system blockers in treatment of hypertensive patients with COVID-19: a systematic review and meta-analysis |
2021 |
Egyptian Heart Journal |
73 |
1 |
13 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100576309&doi=10.1186%2fs43044-021-00135-y&partnerID=40&md5=09d9e73f520074123305d8d901cd705f |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Laurentius, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mendel, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prakoso, R., Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Background: Novel coronavirus disease 2019 has been stated as global disease pandemic due to its rapid spread worldwide. Up to 30% of coronavirus disease 2019 patients with hypertension are more susceptible to death. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have been used as primary line of medication for hypertension; nonetheless, conflicting data arises as numerous studies showed contradictory results. Main body: Aiming to show clinical outcome of renin-angiotensin-aldosterone system blockers in hospital treatment of hypertensive patients with coronavirus disease 2019, systematically searched literatures through five databases were intensively appraised using The Grading of Recommendations Assessment, Development and Evaluation checklists for cohort studies. Based on the result evaluation from retrospective cohorts involving more than 15,000 patients across Asia and other regions of the world, ten encompassed studies divided into two subgroups in this meta-review showed that in-hospital hypertensive coronavirus disease 2019 patients receiving antihypertensive drugs were associated with overall risk reduction in subgroup 1 (hazard ratio, HR = 0.96, 95% CI = 0.82–1.12) to no outcome association of all-cause mortalities in subgroup 2 (HR = 0.26, 95% CI = 0.19–0.34). All appraised studies in synergism showed that mortality outcomes were not augmented with the employment of either ACE inhibitor or ARB in subjects. Conclusion: Therefore, the results support recommendation by the American Heart Association not to discontinue angiotensin-converting enzyme inhibitor or angiotensin receptor blocker regimens in coronavirus disease 2019 patients with hypertension. © 2021, The Author(s). |
Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; COVID-19; Hypertension; Outcome |
angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; adult; aged; all cause mortality; clinical outcome; confidence interval; coronavirus disease 2019; data base; female; hazard ratio; human; hypertension; hypertensive patient; male; medical society; meta analysis; mortality; renin angiotensin aldosterone system; Review; risk reduction; systematic review |
Springer Science and Business Media Deutschland GmbH |
11102608 |
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Review |
Q3 |
212 |
18617 |
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79 |
Saharman Y.R., Karuniawati A., Severin J.A., Verbrugh H.A. |
55980934300;54886816200;8700385500;7103296623; |
Infections and antimicrobial resistance in intensive care units in lower-middle income countries: a scoping review |
2021 |
Antimicrobial Resistance and Infection Control |
10 |
1 |
22 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100075262&doi=10.1186%2fs13756-020-00871-x&partnerID=40&md5=137569c4bc3b7584a1b51042515f7130 |
Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands |
Saharman, Y.R., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Severin, J.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands; Verbrugh, H.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, Netherlands |
Background: Intensive care units (ICUs) in lower-middle income countries (LMICs) are suspected to constitute a special risk for patients of acquiring infection due to multiple antibiotic resistant organisms. The aim of this systematic scoping review was to present the data published on ICU-acquired infections and on antimicrobial resistance observed in ICUs in LMICs over a 13-year period. A systematic scoping review was conducted according to the PRISMA extension guideline for scoping reviews and registered in the Open Science Framework. Main body of the abstract: Articles were sought that reported on ICU-acquired infection in LMICs between 2005 and 2018. Two reviewers parallelly reviewed 1961 titles and abstracts retrieved from five data banks, found 274 eligible and finally included 51. Most LMICs had not produced reports in Q1 or Q2 journals in this period, constituting a large gap in knowledge. However, from the reported evidence it is clear that the rate of ICU-acquired infections was comparable, albeit approximately 10% higher, in LMICs compared to high income countries. In contrast, ICU mortality was much higher in LMICs (33.6%) than in high income countries (< 20%). Multidrug-resistant Gram-negative species, especially Acinetobacter baumannii and Pseudomonas aeruginosa, and Klebsiella pneumoniae played a much more dominant role in LMIC ICUs than in those in high income countries. However, interventions to improve this situation have been shown to be feasible and effective, even cost-effective. Conclusions: Compared to high income countries the burden of ICU-acquired infection is higher in LMICs, as is the level of antimicrobial resistance; the pathogen distribution is also different. However, there is evidence that interventions are feasible and may be quite effective in these settings. Protocol Registration The protocol was registered with Open Science Framework (https://osf.io/c8vjk) © 2021, The Author(s). |
Acinetobacter; Bacterial drug resistance; Cross infection; Infection control; Intensive care units |
antibiotic agent; Acinetobacter baumannii; adult; antibiotic resistance; bacterial infection; cross infection; female; high income country; hospital mortality; human; infection control; intensive care unit; Klebsiella pneumoniae; major clinical study; male; middle income country; multidrug resistance; nonhuman; priority journal; Pseudomonas aeruginosa; Review; bacterial infection; cross infection; developing country; Acinetobacter baumannii; Adult; Bacterial Infections; Cross Infection; Developing Countries; Drug Resistance, Bacterial; Humans; Intensive Care Units; Klebsiella pneumoniae; Pseudomonas aeruginosa |
BioMed Central Ltd |
20472994 |
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33514432 |
Review |
Q1 |
1456 |
2381 |
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80 |
Paramita R.I., Nelwan E.J., Fadilah F., Renesteen E., Puspandari N., Erlina L. |
54882436900;14527452900;56966708600;57216633036;56786591900;57190181680; |
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing |
2021 |
PLoS ONE |
15 |
12 December |
e0244358 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099074536&doi=10.1371%2fjournal.pone.0244358&partnerID=40&md5=4997d32055c7a3e5834f747ae4be685e |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia |
Paramita, R.I., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Renesteen, E., Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia; Erlina, L., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia |
Escherichia coli are one of the commonest bacteria causing bloodstream infection (BSI). The aim of the research was to identify the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance of E. coli isolated from bloodstream infection hospitalized patients in Cipto Mangunkusumo National Hospital Jakarta. We used whole genome sequencing methods rather than the conventional one, to characterized the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance (AMR) of E. coli. The composition of E. coli sequence types (ST) was as follows: ST131 (n=5), ST38 (n=3), ST405 (n=3), ST69 (n=3), and other STs (ST1057, ST127, ST167, ST3033, ST349, ST40, ST58, ST6630). Enteroaggregative E. coli (EAEC) and Extra-intestinal pathogenic E. coli (ExPEC) groups were found dominant in our samples. Twenty isolates carried virulence genes for host cells adherence and 15 for genes that encourage E. coli immune evasion by enhancing survival in serum. ESBL-genes were present in 17 E. coli isolates. Other AMR genes also encoded resistance against aminoglycosides, quinolones, chloramphenicol, macrolides and trimethoprim. The phylogeny analysis showed that phylogroup D is dominated and followed by phylogroup B2. The E. coli isolated from 22 patients in Cipto Mangunkusumo National Hospital Jakarta showed high diversity in serotypes, sequence types, virulence genes, and AMR genes. Based on this finding, routinely screening all bacterial isolates in health care facilities can improve clinical significance. By using Whole Genome Sequencing for laboratory-based surveillance can be a valuable early warning system for emerging pathogens and resistance mechanisms. © 2020 Paramita et al. |
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aminoglycoside antibiotic agent; beta lactam antibiotic; chloramphenicol; macrolide; quinoline derived antiinfective agent; trimethoprim; virulence factor; antibiotic resistance; Article; bacterial gene; bacterial genome; bacterial virulence; bacterium isolate; bloodstream infection; cell adhesion; clinical article; DNA isolation; enteroaggregative Escherichia coli; Escherichia coli; extraintestinal pathogenic Escherichia coli; gene isolation; gene sequence; genetic code; high throughput sequencing; hospital patient; host cell; human; Indonesia; multilocus sequence typing; nonhuman; nuclear magnetic resonance; phylogeny; serotype; virulence gene; whole genome sequencing; bacteremia; bacterial genome; classification; Escherichia coli; Escherichia coli infection; genetics; high throughput se |
Public Library of Science |
19326203 |
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33362261 |
Article |
Q1 |
990 |
4434 |
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83 |
Triwidodo A., Rahyussalim A.J., Yulisa N.D., Pandelaki J., Huraiby L.S., Hadi I.A.N., Liosha F.Y., Dilogo I.H. |
57222626174;55212166100;57191033188;35759266900;57410470800;57345259600;57195941059;56161962800; |
Sacrum morphometry and spinopelvic parameters among the Indonesian population using computed tomography scans |
2021 |
Medicine (United States) |
100 |
47 |
e27955 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122758150&doi=10.1097%2fMD.0000000000027955&partnerID=40&md5=fcef27e030576bfa693c1f9a81c6abd9 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Triwidodo, A., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yulisa, N.D., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Huraiby, L.S., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hadi, I.A.N., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Liosha, F.Y., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
This is a cross-sectional study. This study aims to describe the characteristics of sacrum vertebrae and spinopelvic parameters among the Indonesian population and compare them with studies from other populations. This study also intends to determine the sexual dimorphism of sacrum vertebrae and find the correlations between spinopelvic parameters. Morphometry of the sacrum is necessary for designing sacral prosthesis and instrumentations. Knowledge of spinopelvic parameters further supports the prosthesis installation procedure to restore the physiological spinal alignment of the patients. However, previous studies showed varied results among different populations. This is the first study to be conducted among the Indonesian population. Morphometric dimensions of sacrum vertebrae and the spinopelvic parameters (pelvic incidence, pelvic tilt, sacral slope, lumbar lordosis) were analyzed using thin-cut (1 mm) computed tomography images in 150 males and 150 females, aged 25 to 50 years without any spinal pathology. Generally, the size of the sacrum vertebrae was greater in males (P < .05). The sacral index, curvature index, and corporo-basal index were statistically different between genders (P < .001). Lumbar lordosis was the only spinopelvic parameter found significantly greater in females (P < .001). Significant positive correlations between all spinopelvic parameters, except for lumbar lordosis and pelvic tilt, were found in the present study (P < .001). The study serves as the first large series database of sacrum morphometric characteristics and spinopelvic parameters of the Indonesian population. There was significant gender-associated differences in various dimensions of sacrum vertebrae. The sacral index was found to be the most useful parameter for sex determination. There were strong significant positive correlations between various spinopelvic parameters. A comparison of populations revealed morphometric characteristic differences, which is proved to be critical in surgical implications. Copyright © 2021 the Author(s). |
Computed tomography scans; Indonesian population; Morphometry; Sacrum vertebrae; Spinopelvic parameters |
adult; cross-sectional study; diagnostic imaging; female; human; Indonesia; lumbar vertebra; male; middle aged; pelvis; sacrum; sexual characteristics; x-ray computed tomography; Adult; Cross-Sectional Studies; Female; Humans; Indonesia; Lumbar Vertebrae; Male; Middle Aged; Pelvis; Sacrum; Sex Characteristics; Tomography, X-Ray Computed |
Lippincott Williams and Wilkins |
00257974 |
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34964781 |
Article |
Q2 |
590 |
8573 |
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