156 |
Yoanita R., Gunardi H., Rohsiswatmo R., Setyanto D.B. |
57257403000;56510252700;55533574600;57203009929; |
Effect of tactile–kinesthetic stimulation on growth, neurobehavior and development among preterm neonates |
2021 |
Journal of Bodywork and Movement Therapies |
28 |
|
|
180 |
186 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114826873&doi=10.1016%2fj.jbmt.2021.06.023&partnerID=40&md5=42e65f10f1f437b31aaa9dd4fdb3559e |
Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Developmental Behavioural & Community Pediatrics Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Neonatology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Pediatric Respirology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Yoanita, R., Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Gunardi, H., Developmental Behavioural & Community Pediatrics Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Setyanto, D.B., Pediatric Respirology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Background: Preterm neonates are at risk of delayed growth and development. Hence, early tactile–kinesthetic stimulation (TKS) is required to improve their growth and development. Objective: To evaluate the effect of TKS on growth, neurobehavior and development among preterm neonates. Method: An interventional study was conducted from August 2015 to July 2017 in the neonatal unit of Dr. Cipto Mangunkusumo Hospital. Preterm neonates were recruited via random sampling and divided into two groups (the intervention group and control group). TKS was performed for 15 min, three times a day, for 10 days. The anthropometric measurements, neurobehavior (Dubowitz score) and development (Capute Scale score) of neonates in both groups were assessed. Results: There were 126 preterm neonates (n = 63 in each group). During the 10-day TKS period, the intervention group had a significant increment in weight and length compared to the control group (p < 0.05) at 11–14 days, at term and 3 months. Moreover, increased tone, reflexes, and improvement in behavior based on the Dubowitz score were observed during monitoring. However, the result did not differ significantly (p > 0.05). There was no significant difference in terms of cognitive and language development in both groups (Developmental Quotient of Clinical Linguistic Adaptive Milestone Scale, Developmental Quotient of Clinical Adaptive Test and Full Scale Developmental Quotient scores, p > 0.05). Conclusion: TKS was significantly effective in promoting growth, particularly weight and length, among preterm neonates. However, it did not significantly influence neurobehavior and development at 3 months of chronological age. © 2021 Elsevier Ltd |
Growth; Infant behavior; Infant development; Preterm infants; Tactile perception |
human; kinesthesia; newborn; prematurity; touch; Humans; Infant, Newborn; Infant, Premature; Kinesthesis; Touch |
Churchill Livingstone |
13608592 |
|
34776139 |
Article |
Q1 |
467 |
10672 |
|
|
161 |
Ramlan A.A., Lestari M.I., Banadji Y., Arif S.K. |
57195941841;57219312983;57225895278;57189846423; |
A national survey of capnography utilization among anaesthesiologists in Indonesia |
2021 |
Trends in Anaesthesia and Critical Care |
40 |
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|
9 |
13 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109639916&doi=10.1016%2fj.tacc.2021.06.004&partnerID=40&md5=b17959a3c3b317991ee9e2a914ec9547 |
Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National HospitalJakarta, Indonesia; Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Sriwijaya, Palembang, Indonesia; Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Hasanuddin, Makassar, Indonesia; Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia |
Ramlan, A.A., Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National HospitalJakarta, Indonesia, Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia; Lestari, M.I., Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Sriwijaya, Palembang, Indonesia, Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia; Banadji, Y., Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia; Arif, S.K., Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Hasanuddin, Makassar, Indonesia, Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia |
Background: Capnography allows health-care providers to continuously monitor the concentration or partial pressure of carbon dioxide in respiratory gas. The American Society of Anaesthesiologists includes end-tidal carbon dioxide monitoring as mandatory monitoring for patients under sedation and anaesthesia. However, capnography is not widely considered for standard patient monitoring in Indonesia. We aim to investigate the utilization of capnography and reasons for lack of use among anaesthesiologists in Indonesia. Methods: An internet-based questionnaire was distributed to participants of an online anaesthesiology national meeting. Data was collected and managed using REDCap electronic data capture tools hosted at Faculty of Medicine Universitas Indonesia. Results: We received 421 respondents' replies nationwide. Replies from anaesthesiologists (n = 367) was used for data analysis. 55.3% (n = 203) reported the availability of capnography in their hospitals. Approximately 77 (21%) of respondents utilize capnography routinely for intraoperative monitoring, 132 (36%) never use capnography. Only 59 (16%) routinely use capnography for intubation confirmation. The utilization of capnography outside the operating theatre was even lower. As many of 249 (67.9%) never use capnography for monitoring during procedural sedation, while 278 (75.8%) do not utilize capnography during patient transfer. Conclusion: The utilization of capnography for intraoperative monitoring is adopted only by half of anaesthesiologists in Indonesia. Outside the operating theatre capnography use is still limited. Capnography as a standard of care should be implemented in all health care institutions in Indonesia. © 2021 Elsevier Ltd |
Capnography; Intra-operative monitoring; Standard monitoring |
anesthesiologist; Article; capnometry; controlled study; health care quality; health care utilization; human; Indonesia; Internet; intraoperative monitoring; patient safety; patient transport; sedation |
Churchill Livingstone |
22108440 |
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|
Article |
Q3 |
213 |
18603 |
|
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402 |
van Crevel R., Avila-Pacheco J., Thuong N.T.T., Ganiem A.R., Imran D., Hamers R.L., Alisjahbana B., Dian S., Estiasari R., Tram T.T.B., Vinh D.N., Hai H.T., Donovan J., Ardiansyah E., Koeken V., Kumar V., Netea M.G., van Laarhoven A., Clish C., Thwaites G., The ULTIMATE consortium |
6603956378;57194750113;16551464800;35145741500;57203976849;23034345900;6506944516;55418398700;55240204000;56426109200;56562746100;57197774138;57203943392;57205617822;57194441324;57222877712;35378641700;55625910500;35460787900;57220045286; |
Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data |
2021 |
Tuberculosis |
128 |
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102085 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106295161&doi=10.1016%2fj.tube.2021.102085&partnerID=40&md5=4ce0f74084aad8c1c23b99ba0823c3f8 |
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia |
van Crevel, R., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Avila-Pacheco, J., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thuong, N.T.T., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ganiem, A.R., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Imran, D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia; Alisjahbana, B., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Dian, S., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Estiasari, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tram, T.T.B., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Vinh, D.N., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Hai, H.T., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Donovan, J., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ardiansyah, E., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koeken, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Kumar, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Netea, M.G., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; van Laarhoven, A., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Clish, C., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thwaites, G., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; The ULTIMATE consortium |
There is a clear need to improve host-directed therapy for tuberculous meningitis (TBM), the most severe and deadly manifestation of tuberculosis. Corticosteroids represent the only host-directed therapy of proven benefit in TBM, yet their effect is modest, the mechanism by which they reduce mortality is unknown, and there is evidence for heterogeneity in their effect. Novel therapeutic approaches are therefore urgently needed. Cellular metabolism is critical for the function of immune cells; through unbiased metabolomics we recently found that high concentrations of cerebrospinal fluid (CSF) tryptophan are associated with increased mortality in Indonesian TBM patients, and that CSF tryptophan concentrations are under strong genetic regulation. Many questions remain. How exactly is tryptophan metabolism altered during TBM? How does it correlate with inflammation, immunopathology, and response to corticosteroids? How is tryptophan metabolism genetically regulated? What is the effect of HIV co-infection on tryptophan metabolism before and during TBM treatment? The ULTIMATE project addresses these questions by integrating data and specimens from large patient studies and clinical trials evaluating the effects of corticosteroids in Vietnam and Indonesia. Through its powerful and unbiased approach, ULTIMATE aims to identify which TBM patients benefit from corticosteroids and if novel therapeutic targets, such as the tryptophan pathway, could be targeted. © 2021 |
Cerebrospinal fluid; Genetics; Host-directed therapy; Meningitis; Metabolomics; Tryptophan; Tuberculosis |
corticosteroid; tryptophan; corticosteroid; tryptophan; tuberculostatic agent; Article; cerebrospinal fluid level; clinical trial (topic); coinfection; corticosteroid therapy; genetic regulation; host-directed therapy; human; Human immunodeficiency virus infection; multiomics; nonhuman; pathogenesis; priority journal; treatment response; tryptophan metabolism; tuberculous meningitis; cerebrospinal fluid; metabolomics; mortality; tuberculous meningitis; Adrenal Cortex Hormones; Antitubercular Agents; Humans; Metabolomics; Tryptophan; Tuberculosis, Meningeal |
Churchill Livingstone |
14729792 |
|
34022506 |
Article |
Q2 |
977 |
4524 |
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