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747 |
Rahyussalim A.J., Sahputra R.E., Yanwirasti, Manjas M., Whulanza Y., Kurniawati T., Aprilya D., Zufar M.L.L. |
55212166100;57212460235;56711920400;24473177100;36807053500;55213290600;57193710642;57216349850; |
The effect of mesenchymal stem cell-enriched scaffolds on mmp-8 and tgf-β levels of vertebrae postlaminoplasty in rabbit model |
2021 |
Stem Cells and Cloning: Advances and Applications |
14 |
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27 |
37 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111052490&doi=10.2147%2fSCCAA.S314107&partnerID=40&md5=6b23d4e3b167216975366ce0f5f83ae6 |
Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, IMERI Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Jakarta, Indonesia |
Rahyussalim, A.J., Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, IMERI Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sahputra, R.E., Department of Surgery, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Yanwirasti, Department of Anatomy, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Manjas, M., Department of Surgery, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Jakarta, Indonesia; Kurniawati, T., Stem Cell and Tissue Engineering Cluster, IMERI Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aprilya, D., Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Zufar, M.L.L., Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Some laminoplasty procedures still have restenosis because of bony-bridging failure of the laminar hinge. The present study aimed to determine the effect of mesenchymal stem cell (MSC)-enriched scaffolds on vertebral regeneration after laminoplasty on the basis of the number of osteoblasts, matrix metalloproteinase-8 (MMP-8), and transforming growth factor-beta (TGF-β) levels. Methods: Laminoplasty procedure using the Hirabayashi technique was conducted at the lumbar level in 32 rabbits that were divided into four and three groups of the control (C) and treatment groups, respectively, with different types of laminoplasty spacer (T1, autograft; T2, scaffold; and T3, scaffold with MSCs). Histopathological studies were conducted to calculate the number of osteoblasts and enzyme-linked immunosorbent assay tests to detect MMP-8 and TGF-β 4 weeks after the surgery. Results: The results showed a significant decrease in MMP-8 level in the T3 group compared with that in the control group (p < 0.05). A significant difference exists between the average number of newly formed osteoblasts in the control group compared with that in the T3 group (p < 0.05) with a higher mean blood TGF-β level of all experimental groups compared with that of the control group (p = 0.58). Conclusion: The significant decrease in MMP-8 levels, increase in TGF-β levels, and increased number of osteoblasts on MSC-seeded polylactic acid scaffolds could be useful to support the laminoplasty procedure to prevent restenosis because it was biocompatible and promoted the bone healing process. © 2021 Rahyussalim et al. |
Hirabayashi technique; Laminoplasty; Mesenchymal stem cells; Scaffolds |
enrofloxacin; eosin; hematoxylin; ketoprofen; liquid nitrogen; neutrophil collagenase; polylactic acid; transforming growth factor beta; animal experiment; animal model; animal tissue; Article; autograft; blood sampling; body weight; bone development; cell suspension; cell viability; cervical spine dislocation; controlled study; cryopreservation; enzyme linked immunosorbent assay; follow up; fracture healing; histopathology; inflammation; injury; laminoplasty; mesenchymal stem cell; neoplasm; nonhuman; nutrition; ossification; osteoblast; restenosis; sample size; spine; umbilical cord |
Dove Medical Press Ltd |
11786957 |
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Article |
Q2 |
606 |
8341 |
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778 |
Miftahussurur M., Windia A., Syam A.F., Nusi I.A., Alfaray R.I., Fauzia K.A., Kahar H., Purbayu H., Sugihartono T., Setiawan P.B., Maimunah U., Kholili U., Thamrin H., Vidyani A., Doohan D., Waskito L.A., Rezkitha Y.A.A., Siregar G.A., Yamaoka Y. |
56323903000;57224923195;8443384400;56543515200;57215962996;57204649404;57218903823;57194162048;57194156387;6507682592;56543645400;57209663659;57204648560;57211316314;57204644036;57192177367;56543533600;56483277100;55183784100; |
Diagnostic value of 14C urea breath test for Helicobacter pylori detection compared by histopathology in indonesian dyspeptic patients |
2021 |
Clinical and Experimental Gastroenterology |
14 |
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291 |
296 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108652378&doi=10.2147%2fCEG.S306626&partnerID=40&md5=ed8411e8e8e3e089aef5e0d750c1da27 |
Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia |
Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Windia, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Alfaray, R.I., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Kahar, H., Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Purbayu, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Setiawan, P.B., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Maimunah, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Kholili, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Thamrin, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Vidyani, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Siregar, G.A., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan |
Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as14C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet. Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and14C-UBT test. We used Heliprobe® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System. Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861–1.000). By applying the optimum cut-off value, Heliprobe® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy. Conclusion: The14C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population. © 2021 Miftahussurur et al. |
Diagnostic; Helicobacter pylori; Infectious disease; UBT |
urea c 14; adult; Article; bacterium identification; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; dyspepsia; female; gastroscopy; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; Indonesian; intermethod comparison; major clinical study; male; May Giemsa staining; middle aged; negative likelihood ratio; nonhuman; positive likelihood ratio; predictive value; receiver operating characteristic; sensitivity and specificity; statistical analysis; stomach antrum; stomach biopsy; stomach corpus; urea breath test; validation study |
Dove Medical Press Ltd |
11787023 |
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Article |
Q2 |
1113 |
3723 |
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782 |
Palupi-Baroto R., Hermawan K., Murni I.K., Nurlitasari T., Prihastuti Y., Sekali D.R.K., Ambarsari C.G. |
56495463300;57224908584;55734483200;57224895124;57224909176;57224897130;57211850895; |
High fibroblast growth factor 23 as a biomarker for severe cardiac impairment in children with chronic kidney disease: A single tertiary center study |
2021 |
International Journal of Nephrology and Renovascular Disease |
14 |
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165 |
171 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108541273&doi=10.2147%2fIJNRD.S304143&partnerID=40&md5=ba9cd0eab6e18711499e83b6c4812aa7 |
Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Palupi-Baroto, R., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Hermawan, K., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Murni, I.K., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Nurlitasari, T., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Prihastuti, Y., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Sekali, D.R.K., Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ambarsari, C.G., Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in chronic kidney disease (CKD). Changes in cardiac geometry and functions may occur in an early stage and worsen as CKD progresses. Recently, the role of fibroblast growth factor 23 (FGF23) is being highlighted and investigated in CKD-related cardiomyopathy. However, only a few studies have reviewed the utilization of FGF23 as a diagnostic biomarker in the pediatric CKD population. Purpose: This study aimed to identify the role of FGF23 as a biomarker in assessing cardiac changes in children with CKD. Patients and Methods: We conducted a cross-sectional study that involved children aged 2 to 18 years old with CKD stages 2 to 5D in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The level of FGF23 was measured using an immunometric enzyme-linked immunosorbent assay. LVMI, RWT, and left ventricular ejection fraction (LVEF) were assessed with echocardiography. Receiver-operating characteristic (ROC) analyses were conducted to assess the diagnostic performance of FGF23 in detecting LVH with impaired contractility. Results: A total of 43 children with CKD stages 2 to 5D were included, among whom the prevalence of LVH diagnosis was 95.35%. The area under the curve (AUC) of FGF23 to assess LVH and systolic dysfunction was 0.82 (95% CI 0.62–1.0), and the optimal cutoff point was 1413 RU/mL (sensitivity 80%, specificity 78.95%). The median concentration of FGF23 increased with the decreasing eGFR and the increasing LVMI although the systolic and diastolic functions were preserved. Conclusion: FGF23 might be used as an early biomarker to detect cardiac changes in pediatric CKD patients, particularly for LVH and impaired systolic function among children with CKD stage 2 and higher. © 2021 Palupi-Baroto et al. |
Dialysis; End-stage kidney disease; FGF23; Left ventricular hypertrophy; Ventricular ejection fraction |
biological marker; fibroblast growth factor 23; adolescent; adult; anemia; area under the curve; Article; child; chronic kidney failure; clinical article; cross-sectional study; diabetic nephropathy; diagnostic test accuracy study; diagnostic value; disease severity; echocardiography; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; glomerulonephritis; heart left ventricle contractility; heart left ventricle contraction; heart left ventricle ejection fraction; heart left ventricle filling; heart left ventricle mass; heart ventricle hypertrophy; human; hypertension; Indonesia; kidney agenesis; kidney calcification; kidney dysplasia; kidney hypoplasia; lupus erythematosus nephritis; male; nephrotic syndrome; obstructive uropathy; preschool child; prevalence; r |
Dove Medical Press Ltd |
11787058 |
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Article |
Q2 |
846 |
5589 |
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798 |
Rinaldi I., Hamonangan R., Azizi M.S., Cahyanur R., Wirawan F., Fatya A.I., Budiananti A., Winston K. |
23475122400;57194734003;57209578916;37066991400;57205313463;57224164794;57224171532;57224165400; |
Diagnostic value of neutrophil lymphocyte ratio and D-Dimer as biological markers of deep vein thrombosis in patients presenting with unilateral limb edema |
2021 |
Journal of Blood Medicine |
12 |
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313 |
325 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107134090&doi=10.2147%2fJBM.S291226&partnerID=40&md5=e8ea48e2b9ed2ba98d1bdc094dbbe4f7 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, PGI Cikini Hospital, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Hamonangan, R., Department of Internal Medicine, PGI Cikini Hospital, Jakarta, Indonesia; Azizi, M.S., Division of Cardiology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Cahyanur, R., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Wirawan, F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fatya, A.I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Budiananti, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Patients with deep vein thrombosis (DVT) pose high morbidity and mortality risk thus needing fast and accurate diagnosis. Wells clinical prediction scores with D-dimer testing are traditionally used to rule out patients with low probability of DVT. However, D-dimer testing has a few limitations regarding its relatively low specificity. Neutrophil-lymphocyte ratio (NLR), a marker of inflammation, was found to increase in DVT. Hence, we aimed to evaluate the role of NLR for DVT diagnosis. Methods: Data were collected from medical records of patients with suspected DVT at Cipto Mangunkusumo National General Hospital during January-December 2014. Diagnosis of DVT was conducted using lower limb ultrasonography. Diagnostic values for NLR, D-dimer, and NLR + D-dimer were determined by receiver operating characteristic (ROC) analysis to obtain area under the curve (AUC), sensitivity, specificity, negative predictive value, and positive predictive values. Sensitivity and specificity analyses of NLR and D-dimer were also conducted based on Wells score and divided into groups of low and high probability of DVT. Results: The AUC values for NLR, D-dimer, and NLR + D-dimer were 72.6%, 70.4%, and 76.1%, respectively. The optimal cut-off value determined for NLR was 5.12 with sensitivity of 67.7%, specificity of 67.9%, PPV of 68.85%, and NPV of 64.91% in differentiating subjects with and without DVT. This study also found that D-dimer had sensitivity of 69.4%, specificity of 71.4%, PPV of 72.88%, and NPV of 67.8%. Meanwhile, the NLR + D-dimer combination had sensitivity of 66.1% and specificity of 72.6%. Multivariate analysis showed that NLR (OR: 2.636; 95% CI: 1.144-6.076; p: 0.023) and D-dimer (OR: 4.175; 95% CI: 1.810-9.633; p: 0.001) were associated with DVT. Conclusion: NLR value has wider AUC than D-Dimer and is relatively easier to obtain and does not require specific assay, thus enabling rapid evaluation of symptomatic patients suspected of having DVT. Adding NLR to D-dimer increased AUC to detect DVT. Therefore, NLR could serve as a complementary diagnostic tool for D-dimer to exclude DVT, especially in low clinical probability patients. © 2021 Rinaldi et al. |
D-dimer; Deep vein thrombosis; Inflammation; Neutrophils lymphocyte ratio; NLR |
biological marker; C reactive protein; D dimer; hemoglobin; adult; Article; atrial fibrillation; cerebrovascular disease; chronic kidney failure; controlled study; deep vein thrombosis; diabetes mellitus; diagnostic test accuracy study; echography; extracellular trap; female; health care facility; heart disease; hematological parameters; human; hypertension; inflammation; internal medicine; lymphocyte count; major clinical study; male; middle aged; nanotechnology; neutrophil lymphocyte ratio; peripheral edema; predictive value; pregnancy; receiver operating characteristic; sensitivity analysis; sensitivity and specificity; venous thromboembolism |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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799 |
Atmakusuma T.D., Lubis A.M. |
57216961785;56702707800; |
Correlation of serum ferritin and liver iron concentration with transient liver elastography in adult thalassemia intermedia patients with blood transfusion |
2021 |
Journal of Blood Medicine |
12 |
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235 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107032322&doi=10.2147%2fJBM.S303703&partnerID=40&md5=408d9c4b4409a7ccccfcbc0f6dca1380 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lubis, A.M., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Iron overload is a common feature of thalassemia intermedia due to regular blood transfusion and increased gastrointestinal iron absorption. Early detection and adequate iron chelator can decrease morbidity and mortality from iron overload. Liver iron concentration (LIC) by MRI T2* is the best non-invasive way to measure body iron stores. However, this method is expensive and not available nationwide in Indonesia. The aim of this study was to identify liver iron overload and correlation of transferrin saturation, serum ferritin, liver MRI T2* and LIC with transient liver elastography in adult thalassemia intermedia patients. Methods: This is a cross-sectional study of 45 patients with thalassemia intermedia with blood transfusion and with and without iron chelator therapy. The study was conducted at Cipto Mangunkusumo Hospital from August through October 2016. We performed measurements of transferrin saturation, serum ferritin level, transient liver elastography and liver MRI T2*. Pearson and Spearman correlation tests were used to evaluate the correlation between transient liver elastography with transferrin saturation, serum ferritin, liver MRI T2*and LIC. Results and Discussion: This study showed that 64.4% of study subjects are β-Hb E thalassemia intermedia. Furthermore, 84.4% of study subjects have regular transfusion. Based on liver MRI T2*all subjects suffered from liver iron overload, 48.9% had severe degree. Median value of liver MRI T2* was 1.6 ms. Mean serum ferritin was 2831 ng/mL, with median transferrin saturation of 66%. Mean of LIC corresponding to liver MRI T2* and mean liver stiffness measurement was 15.36±7.37 mg Fe/gr dry weight and 7.7±3.8 kPa, respectively. Liver stiffness correlated with serum ferritin (r=0.651; p=0.000), liver MRI T2* (r=−0.357; p=0.016), and LIC (r=0.433; p=0.003). No correlation was found between liver elastography and transferrin saturation (r=0.204; p=0.178). Conclusion: Serum ferritin, liver MRI T2*and LIC correlated with liver elastography. No correlation was found between transferrin saturation and liver elastography. © 2021 Atmakusuma and Lubis. |
LIC; Liver MRI T2*; Serum ferritin; Thalassemia intermedia; Transient liver elastography |
alanine aminotransferase; aspartate aminotransferase; bilirubin; C reactive protein; deferasirox; deferiprone; hemoglobin; hemoglobin F; iron; iron chelating agent; adult; alpha thalassemia; Article; beta thalassemia; blood sampling; blood transfusion; capillary electrophoresis; clinical article; concentration (parameter); correlation analysis; cross-sectional study; DNA determination; elastography; female; ferritin blood level; hemoglobin E-beta thalassemia; high performance liquid chromatography; human; hypertransaminasemia; iron overload; liver examination; liver function test; liver hemosiderosis; liver stiffness; male; nuclear magnetic resonance imaging; splenectomy; thalassemia intermedia; transferrin saturation |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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826 |
Irawati Y., Soedarman S., Arianti A., Widyasari A., Reksodiputro M.H. |
57201260313;57222867991;57201999421;57280734100;35090488800; |
Multiple approaches for managing complex ophthalmic blunt trauma: A case report |
2021 |
International Medical Case Reports Journal |
14 |
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205 |
210 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104124100&doi=10.2147%2fIMCRJ.S304193&partnerID=40&md5=1d5a9d9b836b19267fc2e128d84efc72 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soedarman, S., Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Arianti, A., Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Widyasari, A., JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Reksodiputro, M.H., Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Purpose: This report presents a one-step surgery management process for an intricate case of blunt facial trauma with complex ophthalmic and nasal injury. Patients and Methods: A 45-year-old male with blunt force trauma of the left eye from a wooden block, suffered from naso-orbital-ethmoidal fractures, eyelid laceration with canalicular, close-globe injuries of traumatic cataract and vitreous hemorrhage with retinal detachment. A simultaneous one-step surgery was performed by a trauma team of ophthalmological and ENT surgeons during the height of the COVID-19 pandemic to lessen the risk of cross-transmission. After ruling out the possibility of open-globe rupture, traumatic cataract extraction, retinal detachment surgery, the repair of an eyelid laceration with canalicular involvement, and septorhinoplasty were performed on concomitantly. Results: Anatomical success was achieved for the repair of the nasoorbitoethmoidal (NOE) type II fracture and close-globe injuries, including the anatomical reattachment of the retina. However, the functional outcome remained unsatisfactory. Visual acuity failed to show further improvement at a later follow-up. Traumatic optic neuropathy was, at the final follow-up, considered to be the cause of the suboptimal visual acuity. Conclusion: A single-step multi-procedure for a complex ophthalmic blunt trauma, as demonstrated in this case, may be beneficial for reducing the complications that might arise due to treatment delay. The complex nature of the injury, however, creates the higher possibility for residual post-operative complications. Risks of residual functional impairment should be considered in such complex trauma prior to surgery, to determine the surgical prognostic value and provide appropriate consent to the patient. © 2021 Irawati et al. |
Blunt trauma; Canalicular laceration; Closed-globe injury; Facial injury; Nasal fracture; Ocular trauma |
adult; Article; blunt trauma; case report; cataract; clinical article; clinical examination; conjunctival hemorrhage; crackle; epistaxis; ethmoid bone; eye injury; eyelid closure; eyelid disease; eyelid reconstruction; face fracture; human; hyphema; Indonesia; laceration; lens implantation; male; middle aged; nasopharyngeal swab; nose injury; nose septum reconstruction; occupational accident; orbit fracture; postoperative care; retina detachment; ultrasound; visual acuity; vitrectomy; vitreous hemorrhage |
Dove Medical Press Ltd |
1179142X |
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Article |
Q4 |
198 |
19482 |
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844 |
Prihadi J.C., Putra A.C., Wahyudi Y. |
57204771911;36999310900;57215779247; |
Biopsy-confirmed genitourinary tuberculosis in a secondary health care hospital: An evidence-based clinical review |
2021 |
Research and Reports in Urology |
13 |
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133 |
137 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103294921&doi=10.2147%2fRRU.S286899&partnerID=40&md5=762300ffc5d15b605c193bb496ee96d9 |
Department of Surgery, Urology Division, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jakarta, Indonesia; Department of Urology, St. Carolus Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, St. Carolus Hospital, Jakarta, Indonesia |
Prihadi, J.C., Department of Surgery, Urology Division, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jakarta, Indonesia, Department of Urology, St. Carolus Hospital, Jakarta, Indonesia; Putra, A.C., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, St. Carolus Hospital, Jakarta, Indonesia; Wahyudi, Y., Department of Urology, St. Carolus Hospital, Jakarta, Indonesia |
Introduction: Tuberculosis (TB) is a worldwide disease and remains a major public health problem in developing countries, with 95% of cases occurring in developing countries, including Indonesia. It is caused by Mycobacterium tuberculosis, an acid-fast aerobic bacillus. When M. tuberculosis infects other than lung, it is called extrapulmonary tuberculosis (EPTB). Among other organs, genitourinary tuberculosis (GUTB) is responsible for 30– 40% of all EPTB cases. Methods: The study was conducted in a secondary health-care hospital in central Jakarta over a five-year period. We took data from hospital’s medical records and collected all the positive histopathological reports on biopsied tissue of the genitourinary tract from 2014– 2019. Results: Eleven patients showed positive histopathological results for TB on their biopsied genitourinary tissue. The genitourinary tracts involved were as follows: Prostate (n=2), kidney (n=1), ureter (n=2), epididymis (n=1), epididymo-orchitis (n=1), bladder (n=4). All of them presented with specific genitourinary symptoms, such as lower urinary tract symptoms (LUTS) (n=8), dysuria (n=9), urinary retention (n=2), flank pain (n=6), and incontinence (n=1). Nine of 11 patients (81.8%) exhibited systemic manifestations, with fever being the most common (n=8), followed by malaise (n=6), dyspepsia syndrome (n= 4), and weight loss (n=3). Discussion: Consistent with other studies, our research found that the prevalence of GUTB is substantially decreased with advancing age. Kidney is the most common site infected in GUTB infection. GUTB is easily overlooked, because its signs and symptoms are usually typical of a conventional bacterial cystitis. Conclusion: Because of its insidious nature and late-onset symptoms, diagnosis of GUTB is often late to approach, leading to higher morbidity and even mortality rate. This leads into further complications of the disease, which are largely preventable by a correct and timely diagnosis followed by appropriate therapy. © 2021 Prihadi et al. |
Extrapulmonary; Genitourinary; Tuberculosis |
albumin; esterase; abscess; adult; anemia; Article; bladder; body weight loss; clinical article; computer assisted tomography; cystitis; dyspepsia; dysuria; echography; electrolyte disturbance; epididymis; extrapulmonary tuberculosis; female; fever; flank pain; hematuria; histopathology; human; human tissue; hydrocele; hydronephrosis; hydroureter; incontinence; kidney; kidney failure; leukocytosis; leukocyturia; lower urinary tract symptom; malaise; male; morbidity; mortality rate; Mycobacterium tuberculosis; nephrolithiasis; orchitis; prevalence; prostate; proteinuria; public health; pyuria; retrospective study; secondary health care; ureter; urinalysis; urine retention; urogenital tuberculosis |
Dove Medical Press Ltd |
22532447 |
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Article |
Q2 |
506 |
9983 |
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852 |
Birowo P., Raharja P.A.R., Atmoko W., Rasyid N. |
6504153311;57201013616;57193125664;56245069300; |
X-ray-free endoscopic combined intrarenal surgery for complex proximal ureteral stone: A case report |
2021 |
Research and Reports in Urology |
13 |
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121 |
125 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102769053&doi=10.2147%2fRRU.S299707&partnerID=40&md5=032063a30ddb79b23195d2c16a6aaa56 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
X-ray-free endoscopic combined intra renal surgery (ECIRS) is a feasible alternative to avoid radiation exposure to both surgical teams and patients, but has not been reported prior. The aim of this report is to present our first-hand experience of performing X-ray-free ECIRS for complex ureteral stone. A 57-year-old female presented with right flank pain, fever, dysuria, and leukocytosis. The computed tomography scan showed right impacted proximal ureteral stone sized 33 ´17 mm and grade IV hydrone-phrosis. Percutaneous nephrostomy was performed immediately. With improvement of clinical symptoms two days after nephrostomy, X-ray-free ECIRS was performed. The patient was placed in a Galdakao-modified supine position. During ureteroscopy (URS), there was noted right ureteral stenosis in the distal part of the stone, which could be passed. However, the stone was impacted and the semi-rigid URS was not able to push it. Therefore, antegrade approach with percutaneous nephrolithotomy was performed. Previous nephrostomy tract was used as percutaneous access. Tract dilatation was performed under direct visualization from the URS. The 28 Fr rigid nephroscope was used during the ECIRS procedure. The stone was fragmented using shock-pulse litho-tripters. There was no residual stone or infundibular laceration after the procedure. A 6 Fr double J stent was inserted retrogradely due to ureteral stenosis. There was no complication during and after the procedure. The patient was discharged on post-operative day three. X-ray free ECIRS for complex proximal ureteral stone was possible and showed good results. © 2021 Birowo et al. |
ECIRS; Modified procedure; Supine position; Ureterolithiasis |
creatinine; esterase; hemoglobin; levofloxacin; adult; Article; case report; clinical article; computer assisted tomography; creatinine blood level; diagnostic test accuracy study; dysuria; endoscopic surgery; Escherichia coli; female; fever; flank pain; hemoglobin blood level; human; human tissue; hydronephrosis; hydroureter; injection site reaction; kidney calyx; kidney surgery; leukocytosis; middle aged; nausea and vomiting; neutrophil; operation duration; operative blood loss; percussion; percutaneous nephrolithotomy; percutaneous nephrostomy; radiation exposure; supine position; ureter obstruction; ureter stone; ureteroscopy; urinalysis; X ray; x-ray computed tomography |
Dove Medical Press Ltd |
22532447 |
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Article |
Q2 |
506 |
9983 |
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856 |
Rinaldi I., Louisa M., Sari R.M., Arwanih E. |
23475122400;41461551400;57208474079;57222314110; |
Flt3-itd mutation and flt3 ligand plasma level were not associated with one-year survival of Indonesian acute myeloid leukemia patients |
2021 |
OncoTargets and Therapy |
14 |
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1479 |
1486 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102287355&doi=10.2147%2fOTT.S282842&partnerID=40&md5=67e8a263fb7385921e3a50606454ebd6 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, R.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arwanih, E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To analyze the association of FLT3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian acute myeloid leukemia (AML) patients. Methods: A prospective cohort study was conducted to determine the association between FLT-3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian AML patients. In the study, a total of 51 AML patients were obtained from two tertiary hospitals in Indonesia from year 2018 to 2020. Inclusion criteria were de novo AML male and female patients aged ≥18 years old. Exclusion criteria were prior myelodysplastic syndrome and patients that refused to participate in the study. FLT3-ITD genotype of patients was then analyzed using PCR method while FLT3 ligand plasma level was measured using ELISA method. Patients were then followed-up for 1 year or until death occurred with survival as the measured outcome. Association between independent and dependent variable were analyzed by cox regression proportional hazard. Results: Eleven patients (21.5%) in this study had FLT3-ITD mutation. The median age of AML patients was 45 (18–71) years, and the median blast percentage was 50% (5–87%). After one-year follow-up, 33 (64.7%) patients had died. The median survival of AML patients was 6 months. Univariate analysis showed no association between FLT3-ITD mutation status (HR: 1.051; 95% CI: 0.483–2.286; P: 0.901) and FLT3 ligand plasma level (HR: 0.798; 95% CI: 0.347–1.837; p= 0.596), and age (HR: 1.283; 95% CI: 0.575–2.862; p= 0.542) with one-year survival of AML patients, but multivariate analysis showed association between GFR with one-year survival of AML patients in this cohort (HR: 4.053; 95% CI: 1.469–11.183; p= 0.007). Conclusion: One-year survival of AML patients in Indonesia is not affected by FLT3-ITD mutation and FLT3 ligand plasma level. However, GFR showed association with one-year survival of AML patient in this cohort study. © 2021 Rinaldi et al. |
Acute myeloid leukemia; FLT3 Ligand Plasma; FLT3-ITD; One-year survival |
Flt3 ligand; acute myeloid leukemia; adult; age; aged; Article; cancer survival; clinical feature; cohort analysis; comparative study; controlled study; enzyme linked immunosorbent assay; female; follow up; gene mutation; genetic association; genotype; human; Indonesian; kidney function; major clinical study; male; myelodysplastic syndrome; outcome assessment; overall survival; polymerase chain reaction; prevalence; prospective study; protein blood level; survival time |
Dove Medical Press Ltd |
11786930 |
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Article |
Q2 |
1054 |
4053 |
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873 |
Rosdiana D.S., Setiabudy R., Andalusia R., Gatot D., Louisa M., Bardosono S., Instiaty I. |
56955579800;6602316235;57191278723;6508292159;41461551400;21933841000;55703138400; |
Tpmt genetic variability and its association with hematotoxicity in indonesian children with acute lymphoblastic leukemia in maintenance therapy |
2021 |
Pharmacogenomics and Personalized Medicine |
14 |
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199 |
210 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101168492&doi=10.2147%2fPGPM.S288988&partnerID=40&md5=45069dfc59e995d12723c15428e48bcd |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dharmais National Cancer Hospital, Jakarta, Indonesia; Drug Registration Directorate, National Agency for Drug and Food Control, Jakarta, Indonesia; Division of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Rosdiana, D.S., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andalusia, R., Dharmais National Cancer Hospital, Jakarta, Indonesia, Drug Registration Directorate, National Agency for Drug and Food Control, Jakarta, Indonesia; Gatot, D., Division of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Instiaty, I., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: Hematotoxicity monitoring in children with acute lymphoblastic leukemia (ALL) is critical to preventing life-threatening infections and drug discontinuation. The primary drug that causes hematotoxicity in ALL children is 6-mercaptopurine (6-MP). Genetic variability of the drug-metabolizing enzymes of 6-MP, thiopurine S-methyltransferase (TPMT), is one factor that might increase the susceptibility of children to hematotoxicity. The present study aimed to determine the variability in TPMT genotypes and phenotypes and its association with the occurrence of hematotoxicity in ALL children in maintenance therapy. Patients and Methods: A cross-sectional study was conducted at Cipto Mangunkusumo and Dharmais National Cancer Hospital, Jakarta, Indonesia, from June 2017 to October 2018. We included ALL patients, 1–18 years, who were receiving at least one month of 6-MP during maintenance therapy according to the Indonesian protocol for ALL 2013. Direct sequencing was used to determine TPMT*3A, *3B, and *3C genotypes, and LCMS/MS analysis was performed to measure the plasma concentrations of 6-MP and its metabolites. Association analysis between the TPMT genotype and hematotoxicity was evaluated using the unpaired t-test or Mann–Whitney’s test. Results: The prevalence of neutropenia, anemia, and thrombocytopenia in ALL children during maintenance therapy was 51.9%, 44.3%, and 6.6%, respectively. We found a low frequency of TPMT*3C, which is 0.95%. No association was found between hematotoxicity and TPMT genotypes or age, nutritional status, serum albumin levels, risk stratification, the daily dose of 6-MP, and cotrimoxazole co-administration. However, hematotoxicity was associated with 6-methylmercaptopurine (6-MeMP) plasma concentrations and the ratio 6-MeMP/6-thioguanine (6-TGN). We also found no association between TPMT genotypes and TPMT phenotypes. Conclusion: The 6-MeMP/6-TGN ratio is associated with hematotoxicity in ALL children during maintenance therapy but is not strong enough to predict hematotoxicity. © 2021 Rosdiana et al. |
Mercaptopurine; Methylmercaptopurine; Neutropenia; Thioguanine; Thiopurine methyltransferase |
6 methylthioinosine; albumin; cotrimoxazole; dexamethasone; methotrexate; thiopurine methyltransferase; tioguanine; vincristine; acute lymphoblastic leukemia; adolescent; adult; albumin blood level; anemia; Article; blood toxicity; child; cross-sectional study; drug blood level; drug safety; female; gene sequence; genetic variability; groups by age; human; human cell; Indonesia; Indonesian; liquid chromatography-mass spectrometry; maintenance therapy; major clinical study; male; neutropenia; nutritional status; prevalence; risk factor; thrombocytopenia; TPMT gene |
Dove Medical Press Ltd |
11787066 |
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Article |
Q2 |
845 |
5609 |
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