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645 |
Kusmardi K., Azzahra Baihaqi L., Estuningtyas A., Sahar N., Sunaryo H., Tedjo A. |
56966625300;57383198200;55650360200;57212464367;57214674652;57189320451; |
Ethanol Extract of Pomegranate (Punica granatum) Peel in Increasing the Expression of Caspase-3 in DSS-Induced Mice |
2021 |
International Journal of Inflammation |
2021 |
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4919410 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121616606&doi=10.1155%2f2021%2f4919410&partnerID=40&md5=f0575e8e8aafbe4434f9cad30aeabaca |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia; Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia, Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Azzahra Baihaqi, L., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sunaryo, H., Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Tedjo, A., Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Background. Colorectal cancer (CRC) is a malignancy derived from the glandular epithelial cells in the colon. Patients with inflammatory bowel disease (IBD) are more likely to develop CRC. Cancer proliferation is characterized by the loss of inhibition of apoptosis, which involves caspase-3 activation. This study examined the effects of the pomegranate peel extract on the expression of caspase-3 in mice crypt cells induced by dextran sodium sulfate (DSS) 2%. Methods. The experimental study was done in six groups. All treatments were done in 42 days. The groups were all induced by DSS through water drinking, except for the normal group, which was only given water. The treatments given included the pomegranate extract in two doses (240 mg and 480 mg/kg bw/day), aspirin, and ellagic acid. The specimens were then fixated and stained for the immunohistochemistry scoring for the expression of caspase-3, which was then analyzed statistically. Results. The H-scores of each treatment group were 213.23 ± 8.32 (DSS group), 243.81 ± 18.69 (normal group), 226.10 ± 12.38 (pomegranate peel extract of 240 mg/kg/d), 238.84 ± 15.81 (pomegranate peel extract of 480 mg/kg/d), 227.47 ± 12.15 (aspirin), and 224.01 ± 18.39 (ellagic acid). Statistical differences were found in one-way analysis of variance (ANOVA) and post hoc analysis among the DSS group, normal group, and dose 2 group (pomegranate peel extract of 480 mg/kg/day). Conclusions. The ethanol extract of pomegranate was able to induce apoptosis, which was demonstrated by the increase of caspase-3 expression. © 2021 Kusmardi Kusmardi et al. |
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Hindawi Limited |
20908040 |
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Article |
Q2 |
1106 |
3761 |
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646 |
Pudjiadi A.H., Rahayu T., Wijaya S., Alatas F.S. |
18435202300;57382984100;56685332700;57217150164; |
Serum NT-Pro-BNP versus Noninvasive Bedside Inotropic Index in Paediatric Shock: A Contest of Myocardial Performance in Response to Fluid Loading |
2021 |
Critical Care Research and Practice |
2021 |
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7458186 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121597881&doi=10.1155%2f2021%2f7458186&partnerID=40&md5=9e069c0f9739bfd24a6994aa20089bfc |
Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Pasar Rebo Regional General Hospital, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Rahayu, T., Pasar Rebo Regional General Hospital, Jakarta, Indonesia; Wijaya, S., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Alatas, F.S., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia |
Background. Mild elevation of serum amino-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is associated with myocardial dysfunction. A significantly lower Smith-Madigan inotropic index (SMII) has been shown to accurately represent cardiac contractility among heart failure subjects. We aim to monitor the effect of fluid resuscitation on cardiac function among paediatric patients by measuring serum NT-pro-BNP and SMII. Methods. This is an observational study on 70 paediatric shock patients. NT-pro-BNP and noninvasive bedside haemodynamic monitoring were done by using an ultrasonic cardiac output monitor (USCOM, USCOM, Sydney, Australia). The presence of cardiac diseases was excluded. SMII was obtained from the USCOM. An increase in the stroke volume index (SVI) of ≥15% indicates fluid responders. Measurements were taken before and after fluid loading. Results. Preloading NT-pro-BNP and SMII category were significantly different between the fluid responsiveness group, p=0.001 and p=0.004, respectively. Higher median NT-pro-BNP (preloading NT-pro-BNP of 1175.00 (254.50-9965.00) ng/mL vs. 196.00 (65.00-509.00) ng/mL, p=0.002) was associated with fluid nonresponders (subjects >12 months old). Preloading NT-pro-BNP <242.5 ng/mL was associated with fluid responders (AUC: 0.768 (0.615-0.921), p=0.003), 82.1% sensitivity, and 68.7% specificity for subjects >12 years old. Delta NT-pro-BNP in fluid responders (15.00 (-16.00-950.00) ng/mL) did not differ from fluid nonresponders (505.00 (-797.00-1600.00) ng/mL), p=0.456. Postloading SMII >1.25 W·m-2 was associated with fluid responders (AUC: 0.683 (0.553-0.813), p = 0.011), 61.9% sensitivity, and 66.7% specificity, but not preloading SMII. Fluid responders had a higher mean postloading SMII compared to nonresponders (1.36 ± 0.38 vs. 1.10 ± 0.34, p=0.006). Conclusion. Higher NT-pro-BNP and lower SMII in the absence of cardiac diseases were associated with poor response to fluid loading. The SMII is affected by low preload conditions. © 2021 Antonius Hocky Pudjiadi et al. |
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Hindawi Limited |
20901305 |
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Article |
Q2 |
532 |
9497 |
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663 |
Mangunatmadja I., Indra R.M., Widodo D.P., Rafli A. |
57195717216;57222298152;57215087823;57210824944; |
Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study |
2021 |
Behavioural Neurology |
2021 |
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9092824 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119934233&doi=10.1155%2f2021%2f9092824&partnerID=40&md5=74ddaa54df43f8e9dd4e310b0bf1246c |
Department of Child Health, Dr. Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Mohammad Hoesin General Hospital, Universitas Sriwijaya, Medical School, Palembang, Indonesia |
Mangunatmadja, I., Department of Child Health, Dr. Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indra, R.M., Department of Child Health, Mohammad Hoesin General Hospital, Universitas Sriwijaya, Medical School, Palembang, Indonesia; Widodo, D.P., Department of Child Health, Dr. Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rafli, A., Department of Child Health, Dr. Cipto Mangunkusumo Tertiary General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Children with epilepsy with onset above five years encompass distinct epidemiological and clinical characteristics that may have specific risk factors for resistance to antiseizure medications (ASMs). Studies on this age group are limited. Purpose. To identify risk factors for drug resistance in children with epilepsy with the age of onset above five years. Methods. A case-control study was conducted on children with epilepsy with the age of onset above five years visiting the Pediatric Neurology Clinic of Cipto Mangunkusumo and Mohammad Hoesin Hospital between September 2015 and August 2016. Cases consisted of drug-resistant children while control consisted of drug-responsive children according to 2010 ILAE classification. Risk factors studied include onset, number of seizures, illness duration before treatment, cause, seizure type, status epilepticus, initial and evolution of EEG, brain imaging, and initial treatment response. Results. Thirty-two pairs of children were included in the study. After logistic regression analysis, symptomatic etiology and failure to achieve early response to treatment were found to be associated with drug resistance with adjusted OR of 84.71 (95% CI: 5.18-1359.15) and 72.55 (95% CI: 7.08-743.85), respectively. Conclusion. Poor initial response to ASM and symptomatic etiology are independent risk factors for drug resistance in children with epilepsy with the age of onset above five years. © 2021 Irawan Mangunatmadja et al. |
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anticonvulsive agent; case control study; child; drug resistance; epilepsy; human; onset age; preschool child; risk factor; Age of Onset; Anticonvulsants; Case-Control Studies; Child; Child, Preschool; Drug Resistance; Epilepsy; Humans; Risk Factors |
Hindawi Limited |
09534180 |
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34804259 |
Article |
Q2 |
859 |
5468 |
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671 |
Irawan C., Rachman A., Rahman P., Mansjoer A. |
28767651600;15056701600;57336745700;24335647800; |
Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients |
2021 |
Journal of Cancer Epidemiology |
2021 |
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1103631 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118993816&doi=10.1155%2f2021%2f1103631&partnerID=40&md5=82e487803fe00d9c97bbac4301d585e1 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology Unit, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Irawan, C., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahman, P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mansjoer, A., Clinical Epidemiology Unit, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. The three-year survival rate of locally advanced nasopharyngeal carcinoma (NPC) patients in Indonesia is lower than in other Asian countries. Calculation of hemoglobin-to-platelet ratio (HPR) may become a more practical predictor than the ratios using leukocyte cell components. Yet, no study has been conducted to investigate the potential of HPR in predicting survival outcomes in locally advanced nasopharyngeal cancer patients. Objective. To determine the role of pretreatment hemoglobin-to-platelet ratio in predicting the three-year overall survival (OS) of locally advanced NPC. Method. A retrospective cohort study followed up on 289 locally advanced NPC patients who had undergone therapy at the Dr. Cipto Mangunkusumo National General Hospital between January 2012 and October 2016. HPR cut-off was determined using ROC. Subjects were classified into two groups according to the HPR value. Kaplan-Meier curve was utilized to illustrate patients' three-year survival, and Cox regression test analyzed confounding variables to yield an adjusted hazard ratio (HR). Results. The optimal cut-off for HPR was 0.362 (AUC 0.6228, 95% CI: 0.56-0.69, sensitivity 61.27%, specificity 60.34%). Of the subjects, 48.44% had HPR≤0.362, and they had a higher three-year mortality rate than those with HPR>0.362 (50% vs. 31.54%). In bivariate analysis, HPR≤0.362 and age≥60 significantly showed a worse three-year OS (p value = 0.003 and 0.075, respectively). In multivariate analysis, we concluded that a pretreatment HPR≤0.362 was an independent negative predictor of three-year OS in locally advanced NPC patients (adjusted HR 1.82; 95% CI: 1.25-2.65). Conclusion. Pretreatment HPR≤0.362 was a negative predictor of three-year OS in locally advanced nasopharyngeal cancer patients. © 2021 Cosphiadi Irawan et al. |
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antineoplastic agent; hemoglobin; adjuvant therapy; adult; advanced cancer; area under the curve; Article; cancer chemotherapy; cancer mortality; cancer patient; cancer prognosis; cancer radiotherapy; cancer survival; clinical outcome; cohort analysis; conformal radiotherapy; controlled study; female; follow up; general hospital; hematological parameters; hemoglobin blood level; hemoglobin to platelet ratio; human; human cell; intensity modulated radiation therapy; locally advanced nasopharyngeal carcinoma; major clinical study; male; middle aged; multiple cycle treatment; nasopharynx carcinoma; neoadjuvant chemotherapy; nutritional status; overall survival; platelet count; receiver operating characteristic; reference value; retrospective study; sensitivity and specificity; survival predic |
Hindawi Limited |
16878558 |
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Article |
Q2 |
783 |
6201 |
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672 |
Tunjungputri R.N., Tetrasiwi E.N., Veronica M., Pandelaki J., Ibrahim F., Nelwan E.J. |
56342194400;57267704700;57268337000;35759266900;54886001500;14527452900; |
Vaccine-Associated Disease Enhancement (VADE): Considerations in Postvaccination COVID-19 |
2021 |
Case Reports in Medicine |
2021 |
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9673453 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118971098&doi=10.1155%2f2021%2f9673453&partnerID=40&md5=ddb9dd4ce5b8de10f0e4c9c43c6cd496 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Infectious Disease and Immunology Research Center - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tunjungputri, R.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tetrasiwi, E.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Veronica, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ibrahim, F., Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Infectious Disease and Immunology Research Center - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction. The COVID-19 pandemic has entered a new phase with the roll-out of several vaccines worldwide at an accelerated phase. The occurrence of a more severe presentation of COVID-19 after vaccination may affect policymakers' decision-making and vaccine uptake by the public. Vaccine-associated disease enhancement (VADE) is the modified presentation of infections in individuals after having received a prior vaccination. Currently, little is known about the potential of vaccine-associated disease enhancement (VADE) following COVID-19 immunization. Case Illustration. We herewith report two patients admitted with confirmed COVID-19 pneumonia with a history of CoronaVac vaccination. The first patient with a relatively milder course of the disease had received two doses of CoronaVac, whereas the second patient with a more progressive course of the disease received only one dose before developing symptoms and being admitted to the hospital. Our observations suggest that vaccination could act in boosting the inflammatory process and reveal the previously asymptomatic COVID-19 illness. Theoretically, vaccines could induce VADE, where only suboptimal, nonprotective titers of neutralizing antibodies were produced or proinflammatory T-helper type 2 response was induced. Secondly, enhanced respiratory disease (ERD) could manifest, where pulmonary symptoms are more severe due to peribronchial monocytic and eosinophilic infiltration. Understanding VADE is important for the decision-making by the public, clinicians, and policymakers and is warranted for successful vaccination uptake. Conclusion. We report two cases of patients developing COVID-19 shortly after CoronaVac vaccination in which VADE is likely. We recommend that current vaccination strategies consider the measurement of neutralizing antibody titer as a guide in ensuring the safest strategy for mass immunization. Studies are needed to investigate the true incidence of VADE on vaccinated individuals as well as on how to differentiate between VADE and severe manifestations of COVID-19 that are unrelated to vaccination. © 2021 Rahajeng N. Tunjungputri et al. |
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C reactive protein; coronavac; D dimer; fibrinogen; hemoglobin; neutralizing antibody; procalcitonin; adult; antibody titer; Article; asymptomatic coronavirus disease 2019; blood pressure; calcitonin blood level; case report; clinical article; coronavirus disease 2019; COVID-19 testing; electrocardiography; fibrinogen blood level; heart right bundle branch block; hemoglobin blood level; hospital admission; human; hyperglycemia; hypokalemia; hyponatremia; hypoosmolarity; inflammation; laboratory test; leukocyte count; lung examination; male; medical history; middle aged; physical examination; platelet count; protein blood level; real time polymerase chain reaction; thorax radiography; vaccination; vaccine associated disease enhancement; vaccine associated disease enhancement; young adult |
Hindawi Limited |
16879627 |
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Article |
Q4 |
200 |
19317 |
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686 |
Muharam R., Febri R.R., Prabowo K.A., Bustami A., Mansur I.G. |
57191492732;57195941864;57224859187;57192888839;6603222374; |
Increased Levels of CD107a and Intracellular Cytokines in IL-2 Stimulated PBMCs from Endometriosis Patients |
2021 |
International Journal of Inflammation |
2021 |
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5760959 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117385290&doi=10.1155%2f2021%2f5760959&partnerID=40&md5=016a37c79309194717aea380b260bb3e |
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia; Integrated Laboratory of Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia; Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Muharam, R., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia; Febri, R.R., Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Prabowo, K.A., Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Bustami, A., Integrated Laboratory of Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia, Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Mansur, I.G., Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
It has been postulated that the immune system is impaired in individuals with endometriosis, with attention directed to natural killer (NK) cells. Specifically, it has been hypothesized that altered numbers of peripheral NK cells in blood are associated with the presence of endometriotic lesions. This study aimed to evaluate the level of the peripheral NK cell surface marker CD107a in endometriosis in the presence of IL-2 stimulation. Peripheral blood mononuclear cells (PBMCs) were obtained from 7 women with endometriosis and 7 women without endometriosis. The PBMCs were divided into two groups and either treated with recombinant IL-2 or left untreated. The cytotoxic activity of the PBMCs toward target cells (K562) was evaluated. Then, both groups were cocultured for 4 days. The expressions of CD107a, TNF-α, and IFN-γ were determined using flow cytometry analysis. There was no difference in the expression of CD107a prior to IL-2 stimulation in PBMCs from women with endometriosis compared to those from women without endometriosis. However, we observed upregulation of the expression of the surface marker CD107a after treatment in the endometriosis group. In addition, there was a significant difference in CD107a expression in the endometriosis group before versus after stimulation with IL-2 (p < 0.01). We also found no difference in the production of TNF-α and IFN-γ before versus after treatment with IL-2 in either groups. The levels of CD107a were significantly enhanced in peripheral blood taken from women with endometriosis after treatment with IL-2. © 2021 R. Muharam et al. |
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gamma interferon; interleukin 2; lysosome associated membrane protein 1; tumor necrosis factor; adult; Article; cell activation; cell culture; cell isolation; cell stimulation; clinical article; coculture; controlled study; cytokine production; cytotoxicity; endometriosis; female; flow cytometry; human; human cell; immune response; K-562 cell line; pathogenesis; peripheral blood mononuclear cell; protein expression; upregulation |
Hindawi Limited |
20908040 |
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Article |
Q2 |
1106 |
3761 |
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700 |
Rinaldi I., Prasetyawaty F., Fazlines S., Winston K., Samudera Nurrobi Y.A., Leoni J., Restu Tulus Maha I.H., Wicaksono S., Wicaksono A.Y., Aslani A.O., Ikhsani R. |
23475122400;57285017300;57284131900;57224165400;57283687900;57285017400;57285017500;57204717310;57283688000;57283914100;57283688100; |
Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review |
2021 |
Case Reports in Medicine |
2021 |
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5554664 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116367653&doi=10.1155%2f2021%2f5554664&partnerID=40&md5=dd3f8e177d1b2f8c901c2f67e106f921 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasetyawaty, F., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fazlines, S., Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Samudera Nurrobi, Y.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Leoni, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Restu Tulus Maha, I.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, A.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aslani, A.O., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikhsani, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Acquired hemophilia A (AHA) is a potentially life-threatening autoimmune hemostatic disorder where autoantibodies that disrupt the functions of factor VIII (FVIII) are present in the circulation. The early diagnosis of AHA is difficult since the symptoms of AHA differ from those of congenital hemophilia A. Furthermore, the management of AHA is also more complex due to the presence of autoantibodies against FVIII (FVIII inhibitors). Here, we present three case reports and conduct a literature review of AHA with the aim to increase awareness and knowledge regarding the diagnosis and treatment of AHA. Case Presentations. We present three patients diagnosed with AHA in these case reports. The first patient was a young female, while the second and third patients were middle-aged and elderly males, respectively. All patients presented with a chief complaint of bruises without hemarthrosis and a history of bleeding. Laboratory examinations of the patients revealed isolated prolonged aPTT, normal PT, and the presence of autoantibodies against factor VIII, which are characteristics of AHA. Patients were then treated with corticosteroids to reduce the titer level of autoantibodies and received factor VIII transfusion to stop bleeding. Conclusion. AHA can be suspected in patients presenting with symptoms of bruises without hemarthrosis and without the history of bleeding. Isolated aPTT elevation with normal PT should raise high suspicion of AHA. The presence of FVIII inhibitors can help to confirm the diagnosis of AHA. Treatment consists of factor VIII transfusion and corticosteroid therapy. Bypassing agents are recommended as an alternative to FVIII transfusion. © 2021 Ikhwan Rinaldi et al. |
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autoantibody; blood clotting factor 8; blood clotting factor 8 antibody; blood clotting factor 8 inhibitor; cyclophosphamide; fresh frozen plasma; methylprednisolone; mycophenolate mofetil; prednisone; prothrombin; recombinant blood clotting factor 8; tranexamic acid; acquired hemophilia A; activated partial thromboplastin time; adult; aged; antibody titer; bleeding; blood cell count; case report; chronic kidney failure; clinical article; contusion; corticosteroid therapy; drug dose reduction; erythrocyte concentrate; erythrocyte transfusion; female; follow up; hand swelling; hemarthrosis; hemophilia A; human; laboratory test; male; medical history; middle aged; ovariectomy; ovary cyst; physical examination; prothrombin time; Review; surgical wound; treatment duration; very elderly; young |
Hindawi Limited |
16879627 |
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Review |
Q4 |
200 |
19317 |
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703 |
Massenburg B.B., Hopper R.A., Crowe C.S., Morrison S.D., Alonso N., Calis M., Donkor P., Kreshanti P., Yuan J. |
55859007400;57277146200;55976347800;45661573100;7004026436;53263345100;15063876600;36192866200;57278294200; |
Global Burden of Orofacial Clefts and the World Surgical Workforce |
2021 |
Plastic and Reconstructive Surgery |
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568E |
580E |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115936193&doi=10.1097%2fPRS.0000000000008334&partnerID=40&md5=b6aab0e1c64506de878c4f09a9d86d70 |
Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Division of Craniofacial and Plastic Surgery, Seattle Children's Hospital, Division of Plastic Surgery, Department of Surgery, University of São Paulo, São Paulo, Brazil; Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital; and School of Medicine, Shanghai Jiao Tong University, Shanghai, China |
Massenburg, B.B., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Hopper, R.A., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Crowe, C.S., Division of Craniofacial and Plastic Surgery, Seattle Children's Hospital, Division of Plastic Surgery, Department of Surgery, University of São Paulo, São Paulo, Brazil; Morrison, S.D., Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Alonso, N., Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Calis, M., Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Donkor, P., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kreshanti, P., Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital; and School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Yuan, J., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States |
Background: Orofacial clefts are one of the most common congenital anomalies, but this disease burden is unevenly distributed worldwide. The authors hypothesize that this burden falls disproportionately on the countries with the smallest surgical workforce or lowest Socio-Demographic Index, rather than those with the highest prevalence of disease. Methods: The authors estimated the prevalence and disease burden of orofacial clefting from 1990 to 2017 in 195 countries using the Global Burden of Disease methodology. Prevalence and disability-adjusted life-years were compared geographically, temporally, and against the size of the national surgical workforce, Socio-Demographic Index, and income status. Linear and logarithmic regressions were performed. Results: In 2017, the prevalence of orofacial clefting was estimated to be 10.8 million people, representing a disease burden of 652,084 disability-adjusted life-years, with most of this disease burden experienced by low- and middle-income countries (94.1%). From 1990 to 2017, there was a decrease in disease burden (-70.2%) and prevalence (-4.9%). There was negative logarithmic association between surgical workforce size and disease burden, with a surgical workforce of greater than six providers per 100,000 population (3.6 disability-adjusted life-years versus 22.4 disability-adjusted life-years per 100,000 population; p < 0.0001). Conclusions: Burden of orofacial clefting has a strong negative association with the size of the surgical workforce, suggesting that strengthening the surgical workforce will help alleviate this burden. Epidemiologic data on countries and regions with inadequate surgical workforces and high disease burden should guide future research efforts and allocation of resources, and guide the treatment and educational goals of international charitable organizations. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
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cleft lip; cleft palate; global disease burden; global health; health service; human; organization and management; prevalence; reconstructive surgery; Cleft Lip; Cleft Palate; Global Burden of Disease; Global Health; Health Services Needs and Demand; Health Workforce; Humans; Prevalence; Reconstructive Surgical Procedures |
Lippincott Williams and Wilkins |
00321052 |
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34550940 |
Article |
Q1 |
1841 |
1560 |
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707 |
Aulia I., Mustika R., Menaldi S.L. |
57204495153;57220273147;57192918198; |
Impact of Women's Domination in Plastic Surgery Residency Program in Indonesia |
2021 |
Plastic and Reconstructive Surgery - Global Open |
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e3757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115629156&doi=10.1097%2fGOX.0000000000003757&partnerID=40&md5=de23c6b8c2c9f64536023cb3cf54a1f3 |
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, RSCM Gedung A, Jalan Diponegoro No. 71, DKI Jakarta, Jakarta Pusat, 10430, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cluster of Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Aulia, I., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, RSCM Gedung A, Jalan Diponegoro No. 71, DKI Jakarta, Jakarta Pusat, 10430, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cluster of Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Menaldi, S.L., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: A shift in gender dominance from man to woman in the medical field has occurred from time to time globally, including in Indonesia's plastic surgery community. This shift may alter the education and clinical settings of plastic surgery. This study aimed to explore the effect of the phenomenon of women's dominance in plastic surgery residency programs in Indonesia. Methods: This qualitative study was conducted using a phenomenological approach on three plastic surgery residency programs in Indonesia. Academic report review, focus group discussions, and in-depth interviews of residents, lecturers, residency program managers, and alumni user groups were selected using the maximum variation sampling method. Data obtained were analyzed and processed thematically. Results: Three themes emerged based on the educational process timeline: pre-education, intra-education, and post-education. Each timeline had several themes that mutually influenced the educational process. In the pre-educational process, residents' personal characters were affected by societies' positive and negative perceptions. The working environment, impact of women's dominance, and cultural dimension affected the intra-educational process. When entering the career life, residents expected an ideal working environment and had particular workplace preferences to achieve their well-being. Conclusions: The impact of women's dominance during the educational program affected residents' daily dynamics. However, this dominance did not affect the quality of education and workloads. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
759 |
6437 |
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714 |
S. Sitohang I.B., Legiawati L., Suseno L.S., Safira F.D. |
56734569200;57202804484;57202804092;57261863100; |
Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review |
2021 |
Dermatology Research and Practice |
2021 |
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3085670 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115103407&doi=10.1155%2f2021%2f3085670&partnerID=40&md5=9d2fa9a3d858b06aaf4bba3cc0802e10 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
S. Sitohang, I.B., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Legiawati, L., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suseno, L.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Safira, F.D., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesis of photoaged facial skin. Low concentration is effective for superficial sun damage. Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. Some adverse effects may occur but usually resolve within weeks. Overall patients were satisfied with the treatment result. An equivalent basic skin preparation such as topical retinoic acid skin priming prior to intervention is necessary for more objective comparison. Further research studies with a larger sample size and longer follow-up period are required. This evidence suggests that TCA peeling is effective in photoaging treatment, either as monotherapy or as combination therapy with other modalities. © 2021 Irma Bernadette S. Sitohang et al. |
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melanin; trichloroacetic acid; actinic keratosis; adult; bacterial superinfection; burning sensation; chemexfoliation; cohort analysis; edema; erythema; female; human; hydration status; hyperpigmentation; hypopigmentation; male; monotherapy; outcome assessment; pain; patient satisfaction; photoaging; quality of life; randomized controlled trial (topic); Review; systematic review; treatment outcome; wrinkle |
Hindawi Limited |
16876113 |
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Review |
Q3 |
456 |
10893 |
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