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881 |
Harzif A., Hyaswicaksono P., Kurniawan R., Wiweko B. |
57191493435;57221907604;57196055951;43061741400; |
Heterotopic pregnancy: Diagnosis and pitfall in ultrasonography |
2021 |
Gynecology and Minimally Invasive Therapy |
10 |
1 |
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53 |
56 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100537776&doi=10.4103%2fGMIT.GMIT_92_19&partnerID=40&md5=ba933e51def94298b03a38705981ed87 |
Department of Obstetrics and Gynecology, Reproductive Immunology and Endocrinology Division, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, 10340, Indonesia |
Harzif, A., Department of Obstetrics and Gynecology, Reproductive Immunology and Endocrinology Division, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Hyaswicaksono, P., Department of Obstetrics and Gynecology, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, 10340, Indonesia; Kurniawan, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, 10340, Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Reproductive Immunology and Endocrinology Division, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Heterotopic pregnancy (HP) is the coexistence of extrauterine and intrauterine pregnancies. This case is rare, difficult to diagnose, and threatening if left untreated. Incidental rate is estimated 1 in 30,000 spontaneous pregnancies and higher in assisted reproductive techniques. HP is often missed because of the detection of intrauterine sacs; therefore, comprehensive and systematic ultrasonography (USG) is needed, especially when there is ectopic pregnancy suspicion or when there is free fluid in the pelvis. A 46-year nulligravida with 13-year primary infertility history underwent frozen embryo transfer process with positive beta-human chorionic gonadotropin 2 weeks after the procedure. Clinical pregnancy is expressed by gestational sac findings at 6-week gestation. Two weeks later, she complained of lower right abdominal pain accompanied by spots from the birth canal. USG showed intrauterine pregnancy and sac appropriate to 8-week gestation and adnexal mass accompanied by a ring of fire image. The patient underwent right salpingectomy, recovered well, and continued her pregnancy. In vitro fertilization is the main risk factor for multiple and ectopic pregnancies. Clinical manifestations are similar to pregnancy loss or ectopic pregnancy. Specific risk factor must be acknowledged by the physician prior initial examination to rule out HP. Transvaginal ultrasound is useful in making the diagnosis of HP, especially in early pregnancy. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Heterotopic; laparoscopy; ultrasound |
chorionic gonadotropin beta subunit; progesterone; abdominal pain; adnexa disease; adult; Article; case report; clinical article; ectopic pregnancy; embryo transfer; female; female infertility; first trimester pregnancy; gestational sac; human; in vitro fertilization; middle aged; priority journal; risk factor; salpingectomy; transvaginal echography; uterine adnexa |
Wolters Kluwer Medknow Publications |
22133070 |
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Article |
Q3 |
441 |
11202 |
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887 |
Arliny Y., Yunus F., Burhan E., Andarini S., Jusman S.W.A., Yunir E., Kekalih A., Soeroton A.Y., Nurwidya F. |
57221832635;57194486277;36058554600;8716259500;36518792100;36520254800;55633562200;57221832157;55221773800; |
Diagnostic predictors of active tuberculosis infection in diabetic patients with latent tuberculosis: A review on cathelicidin and 1,25-dihydroxyvitamin d3 |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
1 |
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117 |
123 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100332647&doi=10.4103%2fjnsbm.JNSBM_26_20&partnerID=40&md5=bcbc06659ad7db8063dc7a77d40a3bd0 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia |
Arliny, Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Syiah Kuala, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soeroton, A.Y., Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia; Nurwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia |
Background: Diabetes Mellitus has been identified as one of factors causing increased risks of latent TB infection. The roles of cathelicidin LL-37, 1.25(OH)2D3 as well as their correlation with specific IFN-γ in latent TB has not been extensively identified. Aims and Objectives: Our study was aimed to identify proportion of latent TB infection in patients with DM and to identify the role of cathelicidin, 1.25(OH)2D3, vitamin D and other clinical factors as predictors for active TB infection in diabetic patients with latent TB. Methods: Our study was conducted in 2 stages. The first-stage study was a cross-sectional study to identify the proportion of latent TB infection in patients with DM without any history of TB, which was continued with a case-control study to identify the roles of predictive biomarkers (cathelicidin LL-37, 25(OH) D3, 1.25(OH)2D3 and IFN-γ) as well as clinical predictive factors for active TB infection in diabetic patients with latent TB. Results: Out of 242 diabetic patients without any history of TB who underwent screening test for latent TB, there were 78 (33.2%) subjects with a diagnosis of latent TB and 1 subject was diagnosed with active TB. There was significant association on the level of cathelicidin LL-37 in DM patient with latent TB, active TB and without TB infection (23.49 ng/mL vs. 49.6 ng/mL vs. 10.46 ng/mL, P < 0,005). Almost all of subjects with DM showed low levels of vitamin D, most in subject with active TB (97%). There was no significant association between 1.25(OH)2D3 and 25(OH)D3 in DM patients with latent TB, active TB and without TB infection. There was a significant association on the levels of IFN-γ ((TB1 1.4 IU/mL vs. 0.03 IU/mL P < 0.005; TB2 1.4 IU/mL vs. 0.04 IU/mL P < 0.005) in DM subjects with latent TB and those without TB infection; however, no significant association was found in DM subjects with latent TB and active TB. History of smoking, HbA1C > 9.5% and cathelicidin LL-37 levels of > 30 ng/mL were predictors for latent TB into active TB in DM patients. Conclusion: Cathelicidin LL-37 can serve as a biomarker of latent TB progressiveness in patients with DM. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
1,25 (OH)2D3; cathelicidin; diabetes; latent tuberculosis infection; Vitamin D |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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888 |
Subekti I., Kartiko G.J., Suhardi Z.F., Muhadi, Wisnu W. |
24336854300;57221818935;57221814580;57189615533;57200425452; |
Serum TSH level as predictor of Graves' disease recurrence following antithyroid drug withdrawal: A systematic review |
2021 |
PLoS ONE |
16 |
1 January |
e0245978 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100298149&doi=10.1371%2fjournal.pone.0245978&partnerID=40&md5=68971152ed2933aff2d374d62012a231 |
Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Subekti, I., Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Kartiko, G.J., Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Suhardi, Z.F., Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Muhadi, Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Wisnu, W., Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Graves' disease (GD) has a high recurrence rate despite various and adequate treatment. Numerous studies have been performed to identify the predictor of disease recurrence. This report aims to investigate the role of thyroid stimulating hormone (TSH) level as a thyrotropin in predicting the recurrence of Graves' disease within 1 to 2 years following antithyroid drug (ATD) withdrawal. Literature searching was conducted on PubMed, Scopus, Cochrane, Proquest, EBSCO in August 2019 and Google Scholar in October 2020. The study criteria include the study that evaluates TSH level 4 weeks following ATD withdrawal, with subjects ≥18 years old who are retrospectively or prospectively followed up after 1 to 2 years following ATD withdrawal. Four eligible studies were selected based on inclusion/exclusion criteria, all of which measured TSH level at 4 weeks following ATD withdrawal. All studies had 1 to 2 years follow up. One study was an RCT, two studies were done in prospective cohort and another in retrospective cohort. All studies had comparable validity and applicability. Three out of four studies suggested that low TSH level measured 4 weeks following treatment withdrawal was associated with higher risk of disease recurrence. In conclusion, low TSH level obtained 4 weeks after ATD withdrawal was associated with higher rate of recurrence rate in GD. Copyright: © 2021 Subekti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antithyroid agent; thyrotropin; antithyroid agent; thyrotropin; Article; clinical evaluation; clinical outcome; disease association; drug withdrawal; follow up; Graves disease; human; prospective study; recurrence risk; recurrent disease; risk factor; systematic review; thyrotropin blood level; blood; Graves disease; recurrent disease; treatment withdrawal; Antithyroid Agents; Graves Disease; Humans; Recurrence; Thyrotropin; Withholding Treatment |
Public Library of Science |
19326203 |
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33513181 |
Article |
Q1 |
990 |
4434 |
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889 |
Irdam G.A., Sutojo B., Raharja P.A.R. |
57194729795;57218247988;57201013616; |
Risk Factors of Ureteral Stenosis in Kidney Transplant Recipients: A Retrospective Study in National Referral Hospital in Indonesia |
2021 |
Advances in Urology |
2021 |
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2410951 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100218047&doi=10.1155%2f2021%2f2410951&partnerID=40&md5=8c80f4380c17c32aba39dc8572cc7807 |
Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Irdam, G.A., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sutojo, B., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Ureteral stenosis is one of the most common urological complications following kidney transplantations. It is occurred in 2-10% of patients and poses a significant problem to the patients as it may lead to permanent damage to renal damage. Identification of risk factors is important to prevent the incidence of ureteral stenosis. Thus, we aim to determine the risk factors of ureteral stenosis in the Indonesian population. This is a retrospective analysis of 487 kidney transplant patients performed in Cipto Mangunkusumo Hospital between 2014 and 2018. We collected and compared donor and recipient demography data in recipients who developed ureteral stenosis and recipients who did not develop ureteral stenosis. Ureteral stenosis was defined as the presence of hydronephrosis from ultrasound and increased number of serum creatinine. The overall incidence of ureteral stenosis post-kidney transplantation in our center is 6.6% (32 from 487 patients) from January 2014 until June 2018. We found that older donor and recipient age more frequent in developing ureteral stenosis post-kidney transplantation (p < 0.001). We also found that donors with number of arteries more than 2 (p < 0.001) and prolonged warm ischemic time (p < 0.05) are more frequently to develop ureteral stenosis post-kidney transplantation. There is no association between type II diabetes mellitus and hypertension with ureteral stenosis in this study. Donor age, recipient age, donor number of arteries more than 2, and prolonged warm ischemia time are associated with ureteral stenosis after kidney transplantation. © 2021 Gampo A. Irdam et al. |
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creatinine; adolescent; adult; age; aged; allograft; Article; child; creatinine blood level; disease association; female; graft recipient; human; hydronephrosis; hypertension; Indonesia; ischemia time; kidney donor; kidney graft; kidney transplantation; major clinical study; male; medical history; neurogenic bladder; non insulin dependent diabetes mellitus; postoperative period; retrospective study; risk factor; ureter obstruction; warm ischemia time |
Hindawi Limited |
16876369 |
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Article |
Q1 |
1180 |
3392 |
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892 |
Dwinata M., Putera D.D., Hasan I., Raharjo M. |
57209231012;57210288025;12776850800;57212400550; |
SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review |
2021 |
Clinical and Experimental Hepatology |
6 |
4 |
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339 |
346 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099931230&doi=10.5114%2fceh.2020.102173&partnerID=40&md5=628a477d8f6d02f9de989db2ce816c8c |
Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Dwinata, M., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Putera, D.D., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Raharjo, M., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Aim of the study: To evaluate the efficacy of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in improving hepatic fibrosis and steatosis of non-alcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Material and methods: We searched CENTRAL, MEDLINE, and EMBASE and included any clinical trials involving patients with NAFLD and T2DM aged ≥ 18 years comparing efficacy of SGLT2i and other antidiabetic drugs in improving fibrosis and steatosis, irrespective of publication status, year of publication, and language. Results: Five clinical trials were included. One study reported significant improvements in the controlled attenuation parameter 314.6 ±61.0 dB/m to 290.3 ±72.7 dB/m (p = 0.04) in the SGLT2i group measured by transient elastography. In patients with significant fibrosis, dapagliflozin treatment significantly decreased the liver stiffness measurement from 14.7 ±5.7 kPa at baseline to 11.0 ±7.3 kPa after 24 weeks (p = 0.02). One study reported a significant decrease in liver fat content 16.2% to 11.3% (p < 0.001) in the SGLT2i group compared to the control (p < 0.001). Three studies reported significant improvement in the liver-to-spleen ratio in the SGLT2i group after treatment 0.96 (0.86-1.07) to 1.07 (0.98-1.14), p < 0.01, 0.80 ±0.24 to 1.00 ±0.18, p < 0.001, and 0.91 (0.64-1.04) to 1.03 (0.80-1.20), p < 0.001 respectively. All studies reported a significant decrease in alanine aminotransferase with SGLT2i. Conclusions: SGLT2i is associated with positive effects on hepatic steatosis measured by non-invasive modalities. Further studies are needed to confirm the impact of SGLT2i on hepatic fibrosis and steatosis. © 2020 Termedia Publishing House Ltd.. All rights reserved. |
Diabetes mellitus; Fibrosis; NAFLD; SGLT2 inhibitor; Steatosis |
alanine aminotransferase; dapagliflozin; empagliflozin; ipragliflozin; luseogliflozin; metformin; pioglitazone; sodium glucose cotransporter 2 inhibitor; adult; aged; alanine aminotransferase blood level; Article; comparative effectiveness; controlled study; diabetic patient; drug efficacy; elastography; female; human; liver fibrosis; liver stiffness; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; quasi experimental study; randomized controlled trial; systematic review; transient elastography; treatment outcome |
Termedia Publishing House Ltd. |
23921099 |
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Article |
Q4 |
394 |
12273 |
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893 |
Alkaff F.F., Illavi F., Salamah S., Setiyawati W., Ramadhani R., Purwantini E., Tahapary D.L. |
57208781930;57221732812;57217109015;57221720254;57219870814;57221736394;55944492500; |
The Impact of the Indonesian Chronic Disease Management Program (PROLANIS) on Metabolic Control and Renal Function of Type 2 Diabetes Mellitus Patients in Primary Care Setting |
2021 |
Journal of Primary Care and Community Health |
12 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099918670&doi=10.1177%2f2150132720984409&partnerID=40&md5=6ba221c547d10bfc27fa5120aa56a223 |
Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia; Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Politeknik Elektronika Negeri Surabaya, Surabaya, East Java, Indonesia; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta, Indonesia |
Alkaff, F.F., Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Illavi, F., Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia; Salamah, S., Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Setiyawati, W., Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Ramadhani, R., Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Purwantini, E., Politeknik Elektronika Negeri Surabaya, Surabaya, East Java, Indonesia; Tahapary, D.L., Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta, Indonesia |
Background: Indonesia through its government National Health Insurance System has launched a non-communicable and chronic disease management program named Indonesian Chronic Disease Management Program (PROLANIS), with Type 2 Diabetes Mellitus (T2DM) and hypertension as the main focus. However, study that evaluates the clinical impact of PROLANIS in patients with T2DM is still scarce to this date. This study aims to evaluate the metabolic control and renal function of PROLANIS participants with T2DM every six month within the first 18-months of implementation. Methods: This study was a retrospective cohort study conducted at Wates sub-district, East Java using secondary data from PROLANIS group report from April 2018 to October 2019. The study population was T2DM patients who voluntarily joined the PROLANIS group in April 2018. The six-month-evaluation included metabolic parameters [body mass index (BMI), blood pressure, hemoglobin A1C, total cholesterol, high-density lipid, low-density lipid, and triglyceride (TG)] and renal parameters [blood urea nitrogen (BUN), creatinine serum, and urinary microalbumin]. Paired t-test and wilcoxon signed-rank test was used for the analysis, and the P-value was adjusted using Bonferroni correction. A P-value <.0015 was considered statistically significant, while a P-value between.0015 and.003 was considered as marginally significant. Results: A total of 30 participants were included in the analysis. Following the PROLANIS implementation, the only parameter of metabolic control that showed significant improvement was TG serum level (P <.001). Despite the worsening status of other metabolic parameters, the changes were not statistically significant except for BMI that was marginally significant (P =.002). From renal function, only BUN serum level was significantly deteriorated (P <.001), while the others did not significantly change. Conclusion: PROLANIS implementation in our study population seems to be ineffective. Future study with more primary healthcare centers needs to be done to scrutinize the clinical impact of this program nationwide. © The Author(s) 2021. |
government program; Indonesia; primary healthcare; PROLANIS; type 2 diabetes mellitus |
glycosylated hemoglobin; disease management; human; Indonesia; non insulin dependent diabetes mellitus; primary health care; retrospective study; Diabetes Mellitus, Type 2; Disease Management; Glycated Hemoglobin A; Humans; Indonesia; Primary Health Care; Retrospective Studies |
SAGE Publications Inc. |
21501319 |
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33472499 |
Article |
Q2 |
550 |
9179 |
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896 |
Suraya A., Nowak D., Sulistomo A.W., Icksan A.G., Berger U., Syahruddin E., Bose-O’reilly S. |
57214135787;7201764407;57024018500;57194332884;7101876991;6507688750;55933417800; |
Excess risk of lung cancer among agriculture and construction workers in Indonesia |
2021 |
Annals of Global Health |
87 |
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1 |
14 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099767907&doi=10.5334%2faogh.3155&partnerID=40&md5=01b5a6cafe172bcea089864226c539b6 |
CIHLMU Center for International Health, University Hospital, LMU, Munich, Germany; Universitas Binawan, Jakarta, Indonesia; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), Member, German Center for Lung Research (DZL), Germany; Department of Radiology, Persahabatan Hospital, National Respiratory Referral Hospital, Jakarta, Indonesia; Faculty of Medicine UPN Veteran, Jakarta, Indonesia; IBE – Institute for Medical Information Processing, Biometry and Epidemiology, LMU, Munich, Germany; Division of Thoracic Oncology Department of Pulmonology Faculty of Medicine, Universitas Indonesia Persahabatan hospital, Jakarta, Indonesia; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany; Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT–Private University for Health Sciences, Medical Informatics and Technology, Austria |
Suraya, A., CIHLMU Center for International Health, University Hospital, LMU, Munich, Germany, Universitas Binawan, Jakarta, Indonesia; Nowak, D., Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany, Comprehensive Pneumology Center Munich (CPC-M), Member, German Center for Lung Research (DZL), Germany; Sulistomo, A.W., Universitas Binawan, Jakarta, Indonesia; Icksan, A.G., Department of Radiology, Persahabatan Hospital, National Respiratory Referral Hospital, Jakarta, Indonesia, Faculty of Medicine UPN Veteran, Jakarta, Indonesia; Berger, U., IBE – Institute for Medical Information Processing, Biometry and Epidemiology, LMU, Munich, Germany; Syahruddin, E., Division of Thoracic Oncology Department of Pulmonology Faculty of Medicine, Universitas Indonesia Persahabatan hospital, Jakarta, Indonesia; Bose-O’reilly, S., Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany, Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT–Private University for Health Sciences, Medical Informatics and Technology, Austria |
Background: In Indonesia, many occupations and industries involve a variety of hazardous and toxic materials. The ILO estimates that about 21.1% of the tracheal, bronchial, and lung cancer deaths among men were attributable to workplace hazardous substances. This study investigated the relationship between occupations or workplace exposure and the risk of lung cancer in the country. The results will help determine how Indonesia can best mitigate the risk for its workers. Objectives: This case-control study utilizes the Indonesian Standard of Industrial Classification (IndSIC) 2015 with the aim of exploring the risk of lung cancer among Indonesian workers. Methods: The study included patients aged 35 years old or older receiving thoracic CT at the radiology department of Persahabatan Hospital. The cases were histologicalconfirmed primary lung cancers, while the controls were negative thoracic CT scan for lung cancer. The subjects’ job titles and industries were classified according to IndSIC 2015 and blind to the patient’s grouping as a case or control. Logistic regression was used to determine the odds ratios for lung cancer among all sections and some divisions or groups of IndSIC 2015. Findings: The mean age was 58.1 (±10.23) years for lung cancer patients and 54.5 (±10.23) years for controls. The majority of subjects (19.6%) worked in Section G (Wholesale and retail trade; repair of motor vehicles and motorcycle). After adjusting for age, gender, level of education, and smoking habit, the risk of lung cancer was nearly three-times higher (OR = 2.8, 95% CI = 1.11–7.02) in workers of Division A01 (crop, animal production, and hunting) and two-times higher (OR = 1.9, 95% CI = 1.05–3.46) in workers of Section F (construction) compared to the workers in other sections or divisions. Conclusions: The excess risk of lung cancer among certain categories of workers confirms the need for improved policy, monitoring, and control of occupational exposure for primary cancer prevention and workers’ compensation purposes. © 2021 The Author(s). |
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adult; aged; agricultural worker; Article; cancer prevention; cancer risk; case control study; construction worker; controlled study; educational status; female; human; human tissue; Indonesia; lung cancer; major clinical study; male; medical information; motor vehicle; motorcycle; occupational exposure; occupational health; smoking habit; x-ray computed tomography; adverse event; agriculture; building industry; lung tumor; middle aged; occupation; occupational disease; occupational exposure; risk factor; very elderly; Adult; Aged; Aged, 80 and over; Agriculture; Case-Control Studies; Construction Industry; Female; Humans; Indonesia; Lung Neoplasms; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Occupations; Risk Factors |
Ubiquity Press |
22149996 |
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33505867 |
Article |
Q2 |
602 |
8385 |
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898 |
Dewi B.E., Nainggolan L., Sudiro T.M., Chenderawasi S., Goentoro P.L., Sjatha F. |
24076058600;23498394800;6506414225;57221643087;57212515515;55372815000; |
Circulation of various dengue serotypes in a community-based study in Jakarta, Indonesia |
2021 |
Japanese Journal of Infectious Diseases |
74 |
1 |
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17 |
22 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099705269&doi=10.7883%2fyoken.JJID.2019.431&partnerID=40&md5=d7c98adae43cb2a3728e97343d353000 |
Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia |
Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia; Nainggolan, L., Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sudiro, T.M., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia; Chenderawasi, S., Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Goentoro, P.L., Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sjatha, F., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia |
Dengue virus (DENV) infection remains to be a serious health problem in Indonesia. Community-based dengue studies to determine circulating DENV serotypes based on the geography and season are limited owing to the expensive cost and significant effort required. Many patients with DENV infection are not hospitalized and many visit the hospital in the later phase of the disease. In this study, we performed active DENV surveillance in a community in Jakarta to study the circulating dengue serotypes; adult febrile patients with fever less than 48 hours were recruited. Disease severity was defined using the World Health Organization (WHO) 1997 guidelines. Rapid NS1 dengue antigen detection was used to screen patients with DENV in the community. Viral culture using the C6/36 cell line, an increased antibody titer on hemagglutination inhibition test and enzyme linked immunosorbent assay, or detection of the viral genome on reverse transcription-polymerase chain reaction was used to confirm DENV infection. Of the 102 patients, 68 (66.7%) were confirmed to have DENV infection, with DENV-2 being the most dominant serotype, followed by DENV-3, DENV-1, and DENV-4, in concordance with several reports of mixed DENV infection. Interestingly, in terms of disease severity, although DENV-3 infection was not the predominant circulating serotype, infection with it tended to cause a more severe disease than infection with DENV-2. © 2021, National Institute of Health. All rights reserved. |
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DNA polymerase; nonstructural protein 1; viral protein; virus antibody; adult; antibody titer; antigen detection; Article; Dengue virus; disease severity; enzyme linked immunosorbent assay; female; fever; hemagglutination inhibition test; human; human cell; Indonesia; major clinical study; male; monitoring; reverse transcription polymerase chain reaction; serotype; virus culture; virus genome; World Health Organization; adolescent; dengue; Dengue virus; genetics; isolation and purification; middle aged; molecular epidemiology; severity of illness index; virology; young adult; Adolescent; Adult; Antibodies, Viral; Dengue; Dengue Virus; Enzyme-Linked Immunosorbent Assay; Female; Genome, Viral; Humans; Indonesia; Male; Middle Aged; Molecular Epidemiology; Reverse Transcriptase Polymerase Chai |
National Institute of Health |
13446304 |
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32611971 |
Article |
Q3 |
517 |
9793 |
|
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|
911 |
Kurniawan A., Kodrat E., Gani Y.I. |
57204398223;57191430080;57195936648; |
Effectiveness of granulocyte colony stimulating factor to enhance healing on delayed union fracture model Sprague-Dawley rat |
2021 |
Annals of Medicine and Surgery |
61 |
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54 |
60 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098139356&doi=10.1016%2fj.amsu.2020.12.005&partnerID=40&md5=55751366daec87d69d3f9b7fe9113d43 |
Paediatric Orthopaedic Division, Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Musculoskletal Pathology Division, Departement of Anatomic Phatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kurniawan, A., Paediatric Orthopaedic Division, Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, E., Musculoskletal Pathology Division, Departement of Anatomic Phatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gani, Y.I., Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Delayed union is a problem that can occur after fracture healing. Many studies were conducted based on the diamond concept approach to solve the problem of delayed union. Granulocyte-colony stimulating factor (G-CSF) is one of the various substances known to have a positive role in healing skeletal tissue or adjuvant regeneration. This study was conducted to see the effect of G-CSF in affecting delayed union fracture healing. Materials and method: The experimental study was conducted by randomized posttest only control group design on 24 experimental animals Sprague-Dawley white rats that had experienced delayed union models. The study compared the treatment group injected with subcutaneous G-CSF with a control group and was divided into four groups (n = 6). Harvest and follow-up histomorphometry and immunohistochemistry were performed in the second week and in the fourth week the histomorphometry analysis consisted of the percentage of immature bone area, cartilage, and fibrous area. The semiquantitative evaluation of immunohistochemistry with the expression of BMP-2 through the immunoreactive score (IRS). Result: In the evaluation of histomorphometry and immunohistochemical parameters, there were significantly more woven bone area (p = 0,015), less fibrosis area (p = 0,002) and higher BMP 2 expression (p = 0,004) in treatment group week four compared to control. . Conclusion: G-CSF was shown to increase the speed of healing in Sprague-Dawley rats on delayed union models evaluated from histomorphometry and immunohistochemical aspects. © 2020 The Author(s) |
BMP-2; Delayed union; Fracture healing; Granulocyte-colony stimulating factor; Histomorphometry; Immunohistochemistry |
bone morphogenetic protein 2; CD146 antigen; granulocyte colony stimulating factor; phenobarbital; animal experiment; animal model; animal tissue; Article; cartilage; comparative study; controlled study; fibrosis; follow up; fracture healing; histopathology; immunohistochemistry; immunoreactivity; male; morphometry; nonhuman; osteoblast; osteocyte; osteotomy; outcome assessment; protein expression; quantitative analysis; rat; surgical wound |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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917 |
Aziza Y., Inatomi T., Sotozono C., Kinoshita S. |
57214455776;7003842530;7003976484;7402391671; |
Pterygium excision with modified bare sclera technique combined with mitomycin C |
2021 |
Japanese Journal of Ophthalmology |
65 |
1 |
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89 |
96 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096149087&doi=10.1007%2fs10384-020-00786-5&partnerID=40&md5=184828afad7b83063fe2f20bcb75744d |
Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan; Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Ophthalmology, National Center for Geriatrics and Gerontology, Aichi, Japan; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan |
Aziza, Y., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Inatomi, T., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan, Department of Ophthalmology, National Center for Geriatrics and Gerontology, Aichi, Japan; Sotozono, C., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan; Kinoshita, S., Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan |
Purpose: Numerous surgical methods, with varying rates of recurrence, have been applied for the treatment of pterygium. Adjuvant mitomycin C (MMC) application has shown promising results in the prevention of recurrence. Here we propose and describe modified bare sclera technique combined with the intraoperative application of MMC for pterygium excision. Study design: Retrospective study. Methods: Primary pterygium patients who underwent pterygium excision via the bare sclera combined with 0.04% MMC technique from January 2014 to December 2016 were reviewed. In all patients, the subconjunctival pterygium strand was exposed and then sufficiently excised in combination with the safe use of MMC; i.e., the prevention of MMC dilution and diffusion to surrounding tissue. Surgical complications, recurrence rates, and recurrence onset were recorded. Results: This study involved 32 primary pterygium eyes (grade T1 = 22 eyes; 68.7%). The mean postoperative follow-up period was 26.4 ± 14.5 months (range: 12–60 months). MMC was applied for 1–3 min. The mean complete epithelialization was 12.6 ± 7.6 days and no surgical complications were observed. In 1 patient with double-head primary pterygium, recurrence occurred at 15-months postoperative. Conclusions: The modified bare sclera technique combined with MMC application was found to be safe, effective, and presents good cosmetic appearance for the treatment of primary pterygium when safety points are strictly applied. © 2020, Japanese Ophthalmological Society. |
Bare sclera with MMC; Recurrence rate; Safety profile |
betamethasone; levofloxacin; mitomycin; oxybuprocaine; mitomycin; adult; aged; Article; controlled study; diffusion; dilution; drug safety; epithelization; eye surgery; female; follow up; human; intraoperative period; Japan; major clinical study; male; medical record review; modified bare sclera technique; optical coherence tomography; patient; postoperative complication; postoperative period; priority journal; pterygium; recurrent disease; retrospective study; surgical technique; university hospital; conjunctiva; pterygium; sclera; treatment outcome; Conjunctiva; Follow-Up Studies; Humans; Mitomycin; Pterygium; Recurrence; Retrospective Studies; Sclera; Treatment Outcome |
Springer Japan |
00215155 |
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33205316 |
Article |
Q2 |
934 |
4846 |
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