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No records
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641 |
Rustamadji P., Wiyarta E., Bethania K.A. |
55321572200;57221521342;57226320454; |
CD44 Variant Exon 6 Isoform Expression as a Potential Predictor of Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type |
2021 |
International Journal of Breast Cancer |
2021 |
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1586367 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122178964&doi=10.1155%2f2021%2f1586367&partnerID=40&md5=d1d81f9245419dc6421070e419983e36 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Invasive breast carcinoma of no special type (IBC-NST) is the most widespread invasive carcinoma subtype causing primarily regional metastases of the lymphatic node (LNM). The capacity of CD44 variant exon 6 (CD44v6) expression as an LNM predictor biomarker in IBC-NST was explored. Methods. We conducted a cross-sectional research with 48 paraffin blocks containing IBC-NST primary tumors that were divided into two groups by LNM. The assessment has been carried out in terms of age, tumor size, tumor grade, lymphovascular invasion (LVI), and CD44v6 expression. The expression of CD44v6 was analyzed on the grounds of immunohistochemical (IHC) staining, while other data were taken from archives. Statistical analysis is carried out by univariate, multivariate, and AUROC. Results. CD44v6 exhibits a dominant expression in IBC-NST tumor cells. Univariate analysis revealed a significant association between CD44v6 and LNM status (p=0.001). Multiple logistic regression results showed that CD44v6 expression and LVI were significantly associated with LNM with OR 10.7 (95% CI: 2.43 to 47.08) and 6.22 (95% CI: 1.4 to 27.88), respectively. CD44v6 expression was able to discriminate against LNM with AUROC 0.863±0.053 (95% CI: 0.759 to 0.967) at the H-score cut-off 133.889 (75% sensitivity and 83.3% specificity). Conclusion. CD44v6 expression and LVI are potential predictors of LNM in IBC-NST. The H-score cut-off of the CD44v6 expression can also be used as a threshold for classification in further investigation. © 2021 Primariadewi Rustamadji et al. |
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Hindawi Limited |
20903170 |
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Article |
Q3 |
552 |
9149 |
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643 |
Bangun K., Halim J., Tania V. |
36902624600;57219398869;57394760300; |
Repair of Protruding Bilateral Cleft Lip and Palate With Staged Premaxilla Setback Osteotomy, Cheiloplasty, and Palatoplasty in Trisomy 17p Patient: A Review of Syndromic Clinical Characteristic |
2021 |
Cleft Palate-Craniofacial Journal |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122134129&doi=10.1177%2f10556656211069820&partnerID=40&md5=065c5cf3acef75c03e60e1e90acf33a2 |
Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia |
Bangun, K., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia; Halim, J., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia; Tania, V., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia |
Objective : Chromosome 17 duplication is correlated with an increased risk of developmental delay, birth defects, and intellectual disability. Here, we reported a female patient with trisomy 17 on the whole short arm with bilateral complete cleft lip and palate (BCLP). This study will review the surgical strategies to reconstruct the protruding premaxillary segment, cleft lip, and palate in trisomy 17p patient. Case Presentation : The patient had heterozygous pathogenic duplication of chromosomal region chr17:526-18777088 on almost the entire short arm of chromosome 17. Beside the commonly found features of trisomy 17p, the patient also presented with BCLP with a prominent premaxillary portion. Premaxillary setback surgery was first performed concomitantly with cheiloplasty. The ostectomy was performed posterior to the vomero-premaxillary suture (VPS). The premaxilla was firmly adhered to the lateral segment and the viability of philtral flap was not compromised. Two-flap palatoplasty with modified intravelar veloplasty (IVV) was performed 4 months after. Conclusion : Successful positioning of the premaxilla segment, satisfactory lip aesthetics, and vital palatal flap was obtained from premaxillary setback, primary cheiloplasty, and subsequent palatoplasty in our trisomy 17p patient presenting with BLCP. Postoperative premaxillary stability and patency of the philtral and palatal flap were achieved. Longer follow-up is needed to evaluate the long-term effects of our surgical techniques on inhibition of midfacial growth. However, the benefits that the patient received from the surgery in improving feeding capacity and facial appearance early in life outweigh the cost of possible maxillary retrusion. © 2021, American Cleft Palate-Craniofacial Association. |
bilateral cleft lip and palate; premaxillary osteotomy; trisomy 17 |
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SAGE Publications Ltd |
10556656 |
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Review |
Q2 |
641 |
7859 |
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645 |
Kusmardi K., Azzahra Baihaqi L., Estuningtyas A., Sahar N., Sunaryo H., Tedjo A. |
56966625300;57383198200;55650360200;57212464367;57214674652;57189320451; |
Ethanol Extract of Pomegranate (Punica granatum) Peel in Increasing the Expression of Caspase-3 in DSS-Induced Mice |
2021 |
International Journal of Inflammation |
2021 |
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4919410 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121616606&doi=10.1155%2f2021%2f4919410&partnerID=40&md5=f0575e8e8aafbe4434f9cad30aeabaca |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia; Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia, Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Azzahra Baihaqi, L., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sunaryo, H., Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Tedjo, A., Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Background. Colorectal cancer (CRC) is a malignancy derived from the glandular epithelial cells in the colon. Patients with inflammatory bowel disease (IBD) are more likely to develop CRC. Cancer proliferation is characterized by the loss of inhibition of apoptosis, which involves caspase-3 activation. This study examined the effects of the pomegranate peel extract on the expression of caspase-3 in mice crypt cells induced by dextran sodium sulfate (DSS) 2%. Methods. The experimental study was done in six groups. All treatments were done in 42 days. The groups were all induced by DSS through water drinking, except for the normal group, which was only given water. The treatments given included the pomegranate extract in two doses (240 mg and 480 mg/kg bw/day), aspirin, and ellagic acid. The specimens were then fixated and stained for the immunohistochemistry scoring for the expression of caspase-3, which was then analyzed statistically. Results. The H-scores of each treatment group were 213.23 ± 8.32 (DSS group), 243.81 ± 18.69 (normal group), 226.10 ± 12.38 (pomegranate peel extract of 240 mg/kg/d), 238.84 ± 15.81 (pomegranate peel extract of 480 mg/kg/d), 227.47 ± 12.15 (aspirin), and 224.01 ± 18.39 (ellagic acid). Statistical differences were found in one-way analysis of variance (ANOVA) and post hoc analysis among the DSS group, normal group, and dose 2 group (pomegranate peel extract of 480 mg/kg/day). Conclusions. The ethanol extract of pomegranate was able to induce apoptosis, which was demonstrated by the increase of caspase-3 expression. © 2021 Kusmardi Kusmardi et al. |
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Hindawi Limited |
20908040 |
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Article |
Q2 |
1106 |
3761 |
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646 |
Pudjiadi A.H., Rahayu T., Wijaya S., Alatas F.S. |
18435202300;57382984100;56685332700;57217150164; |
Serum NT-Pro-BNP versus Noninvasive Bedside Inotropic Index in Paediatric Shock: A Contest of Myocardial Performance in Response to Fluid Loading |
2021 |
Critical Care Research and Practice |
2021 |
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7458186 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121597881&doi=10.1155%2f2021%2f7458186&partnerID=40&md5=9e069c0f9739bfd24a6994aa20089bfc |
Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Pasar Rebo Regional General Hospital, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Rahayu, T., Pasar Rebo Regional General Hospital, Jakarta, Indonesia; Wijaya, S., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Alatas, F.S., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia |
Background. Mild elevation of serum amino-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is associated with myocardial dysfunction. A significantly lower Smith-Madigan inotropic index (SMII) has been shown to accurately represent cardiac contractility among heart failure subjects. We aim to monitor the effect of fluid resuscitation on cardiac function among paediatric patients by measuring serum NT-pro-BNP and SMII. Methods. This is an observational study on 70 paediatric shock patients. NT-pro-BNP and noninvasive bedside haemodynamic monitoring were done by using an ultrasonic cardiac output monitor (USCOM, USCOM, Sydney, Australia). The presence of cardiac diseases was excluded. SMII was obtained from the USCOM. An increase in the stroke volume index (SVI) of ≥15% indicates fluid responders. Measurements were taken before and after fluid loading. Results. Preloading NT-pro-BNP and SMII category were significantly different between the fluid responsiveness group, p=0.001 and p=0.004, respectively. Higher median NT-pro-BNP (preloading NT-pro-BNP of 1175.00 (254.50-9965.00) ng/mL vs. 196.00 (65.00-509.00) ng/mL, p=0.002) was associated with fluid nonresponders (subjects >12 months old). Preloading NT-pro-BNP <242.5 ng/mL was associated with fluid responders (AUC: 0.768 (0.615-0.921), p=0.003), 82.1% sensitivity, and 68.7% specificity for subjects >12 years old. Delta NT-pro-BNP in fluid responders (15.00 (-16.00-950.00) ng/mL) did not differ from fluid nonresponders (505.00 (-797.00-1600.00) ng/mL), p=0.456. Postloading SMII >1.25 W·m-2 was associated with fluid responders (AUC: 0.683 (0.553-0.813), p = 0.011), 61.9% sensitivity, and 66.7% specificity, but not preloading SMII. Fluid responders had a higher mean postloading SMII compared to nonresponders (1.36 ± 0.38 vs. 1.10 ± 0.34, p=0.006). Conclusion. Higher NT-pro-BNP and lower SMII in the absence of cardiac diseases were associated with poor response to fluid loading. The SMII is affected by low preload conditions. © 2021 Antonius Hocky Pudjiadi et al. |
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Hindawi Limited |
20901305 |
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Article |
Q2 |
532 |
9497 |
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647 |
Carragher N., Billieux J., Bowden-Jones H., Achab S., Potenza M.N., Rumpf H.-J., Long J., Demetrovics Z., Gentile D., Hodgins D., Aricak O.T., Baigent M., Gandin C., Rahimi-Movaghar A., Scafato E., Assanangkornchai S., Siste K., Hao W., King D.L., Saunders J., Higuchi S., Poznyak V. |
24467456900;57220421868;15834239200;43860942100;7006591634;7004528536;57190689045;55882733400;7004297104;7006685175;22033598100;6602225637;7004229411;8696686900;55644049900;6603003749;55644113100;57226152467;57214845145;7402341830;57383866600;57206524465; |
Brief overview of the WHO Collaborative Project on the Development of New International Screening and Diagnostic Instruments for Gaming Disorder and Gambling Disorder |
2021 |
Addiction |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121573160&doi=10.1111%2fadd.15780&partnerID=40&md5=e4d9f85cf6d05ef0bbd42cad79ab7617 |
Alcohol, Drugs and Addictive Behaviours Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia; Institute of Psychology, University of Lausanne, Lausanne, Switzerland; Centre for Excessive Gambling, Addiction Medicine, Lausanne University Hospitals (CHUV), Lausanne, Switzerland; National Problem Gambling Clinic; National Centre for Gaming Disorders, United Kingdom; Faculty of Brain Sciences, University College London, London, United Kingdom; WHO Collaborating Centre in Research and Training in Mental Health, Faculty of Medicine, University of Geneva, Geneva, 1202, Switzerland; Treatment Facility for Addictive Behaviors, Department of Psychiatry, University Hospitals of Geneva, Switzerland; Department of Psychiatry and Neuroscience, Child Study Center, School of Medicine, Yale University, New Haven, CT, United States; Department of Psychiatry and Psychotherapy, University of Lübeck, Germany; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China; Psychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Centre of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar; Addiction Research Group, ELTE Eötvös Loránd University, Budapest, Hungary; Department of Psychology, Iowa State University, Ames, IA, United States; Department of Psychology, University of Calgary, Calgary, Canada; Hasan Kalyoncu University, Gaziantep, Turkey; Turkish Green Crescent Society, Istanbul, Turkey; Department of Psychiatry, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Statewide Gambling Therapy Service, Flinders Medical Centre, Bedford Park, Australia; National Observatory on Alcohol, National Institute of Health, Rome, Italy; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand; Department of Psychiatry, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mental Health Institute of the Second Xiangya Hospital, Central South University, China; Consortium on Clinical bigdata and Biobank for Addiction Research (3CBAR), Changsha, Hunan, China; College of Education, Psychology, and Social Work, Flinders University, Australia; Department of Public Health Sciences, University of Connecticut School of Medicine, University of Queensland, Australia; National Hospital Organization Kurihama Medical and Addiction Center, Japan |
Carragher, N., Alcohol, Drugs and Addictive Behaviours Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia; Billieux, J., Institute of Psychology, University of Lausanne, Lausanne, Switzerland, Centre for Excessive Gambling, Addiction Medicine, Lausanne University Hospitals (CHUV), Lausanne, Switzerland; Bowden-Jones, H., National Problem Gambling Clinic; National Centre for Gaming Disorders, United Kingdom, Faculty of Brain Sciences, University College London, London, United Kingdom; Achab, S., WHO Collaborating Centre in Research and Training in Mental Health, Faculty of Medicine, University of Geneva, Geneva, 1202, Switzerland, Treatment Facility for Addictive Behaviors, Department of Psychiatry, University Hospitals of Geneva, Switzerland; Potenza, M.N., Department of Psychiatry and Neuroscience, Child Study Center, School of Medicine, Yale University, New Haven, CT, United States; Rumpf, H.-J., Department of Psychiatry and Psychotherapy, University of Lübeck, Germany; Long, J., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China, Psychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Demetrovics, Z., Centre of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar, Addiction Research Group, ELTE Eötvös Loránd University, Budapest, Hungary; Gentile, D., Department of Psychology, Iowa State University, Ames, IA, United States; Hodgins, D., Department of Psychology, University of Calgary, Calgary, Canada; Aricak, O.T., Hasan Kalyoncu University, Gaziantep, Turkey, Turkish Green Crescent Society, Istanbul, Turkey; Baigent, M., Department of Psychiatry, College of Medicine and Public Health, Flinders University, Adelaide, Australia, Statewide Gambling Therapy Service, Flinders Medical Centre, Bedford Park, Australia; Gandin, C., National Observatory on Alcohol, National Institute of Health, Rome, Italy; Rahimi-Movaghar, A., Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Scafato, E., National Observatory on Alcohol, National Institute of Health, Rome, Italy; Assanangkornchai, S., Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand; Siste, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hao, W., Mental Health Institute of the Second Xiangya Hospital, Central South University, China, Consortium on Clinical bigdata and Biobank for Addiction Research (3CBAR), Changsha, Hunan, China; King, D.L., College of Education, Psychology, and Social Work, Flinders University, Australia; Saunders, J., Department of Public Health Sciences, University of Connecticut School of Medicine, University of Queensland, Australia; Higuchi, S., National Hospital Organization Kurihama Medical and Addiction Center, Japan; Poznyak, V., Alcohol, Drugs and Addictive Behaviours Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland |
[No abstract available] |
Addictive behaviours; assessment; diagnosis; gambling; gaming; screening; video games; WHO |
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John Wiley and Sons Inc |
09652140 |
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Letter |
Q1 |
2424 |
961 |
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650 |
Jufri M., Vardhani A., Purwaningsih E. |
55542805100;57372533300;57186723500; |
Evaluating the efficacy of lotion containing black rice bran (Oryza sativa L. indica) extract as skin brightening agent: A clinical trial |
2021 |
Jundishapur Journal of Natural Pharmaceutical Products |
16 |
4 |
e114152 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121121214&doi=10.5812%2fjjnpp.114152&partnerID=40&md5=7475812ecd399617effa3198e4bc8700 |
Faculty of Pharmacy, Universitas Indonesia, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Indonesia |
Jufri, M., Faculty of Pharmacy, Universitas Indonesia, Indonesia; Vardhani, A., Faculty of Pharmacy, Universitas Indonesia, Indonesia; Purwaningsih, E., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Indonesia |
Background: Ultraviolet exposure is an extrinsic factor to initiate melanogenesis, the process of melanin formation in the skin. Nowadays, natural ingredients tend to be more prevalent in cosmetic formulations due to consumers’ concern about synthetic ingredients and the risks they may represent for human health. Rice bran, the outer layer of a rice grain, can be utilized as a skin-lightening agent. Objectives: This study aimed to determine the efficacy of a lotion containing black rice bran (Oryza sativa L. indica) ethanolic extract as a skin lightening agent. Methods: The black rice bran ethanolic extract was formulated into oil in water (o/w) lotion. In this study, 34 women applied the lotion at one side of the forearm and base placebo lotion as control at the other side of forearm. The results were tested with a paired t-test by GraphPad Prism 8.3.0 software. Results: There was a significant decrease in the melanin index and erythema index in the forearm with a lotion containing black rice bran extract (P-value < 0.0001). Conclusions: The lotion containing 10% black rice bran extract was effective as a skin lightener because it effectively reduced skin melanin production when applied topically. Copyright © 2021, Author(s). |
Black Rice Bran; Clinical Trials; Natural Product; Oryza sativa L. indica; Skin Lightening Agent |
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Kowsar Medical Institute |
17357780 |
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Article |
Q3 |
228 |
17746 |
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651 |
Sudarma V., Hegar B., Hidayat A., Agustina R. |
55257657600;6506273944;7006069132;57214141404; |
Human Milk Oligosaccharides as a Missing Piece in Combating Nutritional Issues during Exclusive Breastfeeding |
2021 |
Pediatric Gastroenterology, Hepatology and Nutrition |
24 |
6 |
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501 |
509 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121005273&doi=10.5223%2fpghn.2021.24.6.501&partnerID=40&md5=55bd98613f1bc0613d5d9ff96f327b95 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Public Health, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Human Nutrition Research Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sudarma, V., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Hegar, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hidayat, A., Department of Public Health, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Extensive studies have shown that breast milk is the best source of nutrition for infants, especially during the first six months, because it fulfills almost all of their nutritional needs. Among the many functional building blocks in breast milk, human milk oligosaccharides (HMOs) have been receiving more attention recently. Furthermore, it is the third most common group of compounds in human milk, and studies have demonstrated the health benefits it provides for infants, including improved nutritional status. HMOs were previously known as the ‘bifidus factor' due to their ‘bifidogenic' or prebiotic effects, which enabled the nourishment of the gastrointestinal microbiota. Healthy gastrointestinal microbiota are intestinal health substrates that increase nutrient absorption and reduce the incidence of diarrhea. In addition, HMOs, directly and indirectly, protect infants against infections and strengthen their immune system, leading to a positive energy balance and promoting normal growth. Non-modifiable factors, such as genetics, and modifiable factors (e.g., maternal health, diet, nutritional status, environment) can influence the HMO profile. This review provides an overview of the current understanding of how HMOs can contribute to the prevention and treatment of nutritional issues during exclusive breastfeeding. © 2021. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition. All Rights Reserved. |
Breast feeding; Human milk; Nutritional status; Oligosaccharides |
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Korean Society of Pediartic Gastroenterology, Hepatology and Nutrition |
22348646 |
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Article |
Q3 |
440 |
11229 |
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654 |
Librianto D., Dilogo I.H., Kamal A.F., Saleh I., Ipang F., Aprilya D. |
57192894799;56161962800;56648996700;57191511801;57226749417;57193710642; |
Effectiveness of kyphosis reduction using cantilever method in thoracolumbar spondylitis tuberculosis: A short-term follow-up |
2021 |
Orthopedic Research and Reviews |
13 |
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275 |
280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120573379&doi=10.2147%2fORR.S342365&partnerID=40&md5=36fe8c2722165f6ab5ec3cc315858d37 |
Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Librianto, D., Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kamal, A.F., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saleh, I., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ipang, F., Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Kyphosis in spondylitis tuberculosis (STb) is more than just a cosmetic issue. It has a potentially detrimental effect on both spine-associated structures and cardiopulmonary function. It can be corrected in any stage of STb; however, the corrective surgery is challenging, especially in the late case, in which the additional stiffness of the spine can come into consideration. To date, the cantilever technique is still a gold standard for sagittal plane deformity correction. However, no study to date has explored its effectiveness for thoracolumbar kyphotic deformity, especially that caused by spondylitis tuberculosis. Methods: This is a retrospective study of 16 consecutive cases of spondylitis tuberculosis with thoracolumbar kyphosis that underwent corrective surgery in our center in the period of 2020–2021. We aim to evaluate the effectiveness of the cantilever technique that we use for kyphotic correction in thoracolumbar STb patients. Results: At the 3-months follow-up, the mean Cobb angle was 14.6°±10.27°, with the mean gain of 20.90°±12.00° and positively correlate with the thoracolumbar kyphosis (TLK) correction (68.69%, r = 0.654, p = 0.001). The mean thoracic kyphosis, lumbar lordosis, and sagittal vertebral axis were 30.6°±13.08°, 39.4°±16.02°, and 1.4±4.09 cm, respectively, with sagittal Cobb difference of 12.70±9.85. Conclusion: The kyphotic Cobb angle reduction by cantilever technique in the thoracolumbar area significantly improved the thoracolumbar kyphosis and realign the spinal sagittal axis. Thus, the cantilever technique remains the gold standard for sagittal plane deformity correction which can be applied for kyphotic deformity correction in thoracolumbar STb cases. © 2021 Librianto et al. |
Cantilever technique; Deformity correction; Kyphotic deformity; Spondylitis tuberculosis; Thoracolumbar spine |
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Dove Medical Press Ltd |
11791462 |
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Article |
Q2 |
707 |
7037 |
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655 |
Ota N., Yoshimoto Y., Darwis N.D.M., Sato H., Ando K., Oike T., Ohno T. |
57359393800;36453407100;57200045716;55697961900;55641963900;36453136000;35395665700; |
High tumor mutational burden predicts worse prognosis for cervical cancer treated with radiotherapy |
2021 |
Japanese Journal of Radiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120410945&doi=10.1007%2fs11604-021-01230-5&partnerID=40&md5=4f3db9b90e6b959382e2d0ca7b994c0b |
Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Department of Radiation Oncology, School of Medicine, Fukushima Medical University, 1, Hikarigaoka, Fukushima, 960-1295, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan |
Ota, N., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Yoshimoto, Y., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Department of Radiation Oncology, School of Medicine, Fukushima Medical University, 1, Hikarigaoka, Fukushima, 960-1295, Japan; Darwis, N.D.M., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Sato, H., Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Ando, K., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Oike, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Ohno, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan |
Purpose: Tumor mutational burden (TMB) is a surrogate biomarker of neo-antigens and high TMB status is associated with favorable response to immune-checkpoint inhibitors (ICIs). This study aimed to elucidate the association between TMB and the outcome of definitive radiotherapy in patients with cervical cancer. Materials and methods: TMB and treatment outcome were retrospectively analyzed in patients with newly diagnosed cervical cancer treated with definitive radiotherapy available with somatic mutation data of pre-treatment tumors obtained using a commercially available gene panel. Results: The study enrolled 98 patients (median follow-up period, 61 months). The median TMB was 9.5 mutations per megabase (range, 3.0–35.5 mutations per megabase). After dichotomization based on this median value, the 5-year overall survival (OS) for TMB-high patients was significantly worse than that of TMB-low patients (61.1% vs. 82.2%). Multivariate analysis identified high TMB status as a significant prognostic factor for worse OS, along with advanced stage, para-aortic lymph node involvement, and absence of concurrent chemotherapy. Conclusion: These data indicate that TMB is a potential prognostic factor for worse survival in patients with cervical cancer treated with definitive radiotherapy, thereby providing a rationale for treatment of TMB-high cervical cancers with a combination of ICIs plus radiotherapy. Secondary abstract: This retrospective study of 98 patients demonstrates for the first time that tumor mutational burden (TMB) is an independent prognostic factor for worse overall survival of patients treated with definitive radiotherapy, providing a rationale for treatment of TMB-high cervical cancers with a combination of immune-checkpoint inhibitors plus radiotherapy. © 2021, The Author(s). |
Cervical cancer; Prognosis; Radiotherapy; Tumor mutational burden |
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Springer Japan |
18671071 |
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Article |
Q2 |
616 |
8208 |
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656 |
Marwali E.M., Lopolisa A., Sani A.A., Rayhan M., Roebiono P.S., Fakhri D., Haas N.A., Slee A., Portman M.A. |
36608535400;57358496100;57209881028;57219904946;57192895321;8599513100;7103216848;7004895873;7004985824; |
Indonesian Study: Triiodothyronine for Infants Less than 5 Months Undergoing Cardiopulmonary Bypass |
2021 |
Pediatric Cardiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120384775&doi=10.1007%2fs00246-021-02779-8&partnerID=40&md5=ee32a32dc863edb4c293caf61a4c9fea |
Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiology Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Pediatric Cardiac Surgery Unit, National Cardiovascular Center Harapan Kita, Department of Cardiothoracic Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Axio Research, Seattle Children’s Hospital and Research Institute, Seattle, United States; Seattle Children’s Hospital, University of Washington, Seattle, WA, United States; National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman, Kav 87, Slipi, West Jakarta 11420, Indonesia |
Marwali, E.M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman, Kav 87, Slipi, West Jakarta 11420, Indonesia; Lopolisa, A., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sani, A.A., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Roebiono, P.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Pediatric Cardiology Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fakhri, D., Pediatric Cardiac Surgery Unit, National Cardiovascular Center Harapan Kita, Department of Cardiothoracic Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haas, N.A., Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Slee, A., Axio Research, Seattle Children’s Hospital and Research Institute, Seattle, United States; Portman, M.A., Seattle Children’s Hospital, University of Washington, Seattle, WA, United States |
This study evaluates the efficacy and safety of oral triiodothyronine on time to extubation for infants less than 5 months undergoing heart surgery in Indonesia, and primarily relates to patients in emerging programs with high malnutrition and mortality. In this randomized, double-blind, placebo-controlled trial, oral triiodothyronine (T3, Tetronine®) 1 μg/kg-body weight/dose or placebo (saccharum lactis) was administered via nasogastric tube every 6 h for 60 h to treatment group. A total of 120 patients were randomized into T3 (61 patients) and placebo (59 patients) groups. The majority of the patients had moderate to severe malnutrition (55.83%) with a high post-operative mortality rate of 23.3%. The T3 group showed significantly higher serum FT3 levels from 1 until 48 h post cross-clamp removal (p < 0.0001), lower incidence of low cardiac output syndrome at both 6 h (28 [45.9%] vs. 39 [66.1%] patients, p = 0.03, OR 2.3, 95% CI: 1.10–4.81) and 12 h after cross-clamp removal (25 [41.7%] vs. 36 [63.2%], p = 0.02, OR 2.40, 95% CI: 1.14–5.05). Although not statistically significant, the treatment group had shorter median (IQR) intubation time (2.59 [1.25–5.24] vs. 3.77 [1.28–6.64] days, p = 0.16, HR 1.36, 95% CI: 0.88–2.09)] and lower mortality (10 [16.4%] vs. 18 [30.5%], p = 0.07]. Patients with Aristotle score < 10.0 (low risk) receiving T3 had faster extubation than placebo patients (p = 0.021, HR of 1.90, 95% CI: 1.10–3.28) and were significantly less likely to require CPR or experience infection (p = 0.027, OR 8.56, 95% CI:0.99–73.9 and p = 0.022, OR 4.09 95% CI: 1.16–14.4, respectively). Oral T3 supplementation reduced overall incidence of low cardiac output syndrome and significantly reduced the time to extubation in low-risk patients. Therefore, prophylactic oral T3 administration may be beneficial in these patients. Trial Registration: ClinicalTrials.gov NCT02222532. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Congenital open cardiac surgery; Low cardiac output; Time-to-extubation; Triiodothyronine |
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Springer |
01720643 |
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Article |
Q2 |
646 |
7791 |
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