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810 |
Suwantika A.A., Zakiyah N., Abdulah R., Sitohang V., Tandy G., Anartati A., Hidayatullah T., Herliana P., Hadinegoro S.R. |
55757798100;56073623400;9244834900;57201802658;57208105012;35602938500;35117792500;57203394399;57226218772; |
Cost-Effectiveness and Budget Impact Analyses of Pneumococcal Vaccination in Indonesia |
2021 |
Journal of Environmental and Public Health |
2021 |
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7494965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105700019&doi=10.1155%2f2021%2f7494965&partnerID=40&md5=bbd858611fb710b7cc2cabf814a8c66b |
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia; Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
Suwantika, A.A., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Zakiyah, N., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Abdulah, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Sitohang, V., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Tandy, G., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Anartati, A., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hidayatullah, T., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Herliana, P., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hadinegoro, S.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
As a country with the high number of deaths due to pneumococcal disease, Indonesia has not yet included pneumococcal vaccination into the routine program. This study aimed to analyse the cost-effectiveness and the budget impact of pneumococcal vaccination in Indonesia by developing an age-structured cohort model. In a comparison with no vaccination, the use of two vaccines (PCV10 and PCV13) within two pricing scenarios (UNICEF and government contract price) was taken into account. To estimate the cost-effectiveness value, a 5-year time horizon was applied by extrapolating the outcome of the individual in the modelled cohort until 5 years of age with a 1-month analytical cycle. To estimate the affordability value, a 6-year period (2019-2024) was applied by considering the government's strategic plan on pneumococcal vaccination. In a comparison with no vaccination, the results showed that vaccination would reduce pneumococcal disease by 1,702,548 and 2,268,411 cases when using PCV10 and PCV13, respectively. Vaccination could potentially reduce the highest treatment cost from the payer perspective at $53.6 million and $71.4 million for PCV10 and PCV13, respectively. Applying the UNICEF price, the incremental cost-effectiveness ratio (ICER) from the healthcare perspective would be $218 and $162 per QALY-gained for PCV10 and PCV13, respectively. Applying the government contract price, the ICER would be $987 and $747 per QALY-gained for PCV10 and PCV13, respectively. The result confirmed that PCV13 was more cost-effective than PCV10 with both prices. In particular, introduction cost per child was estimated to be $0.91 and vaccination cost of PCV13 per child (3 doses) was estimated to be $16.61 and $59.54 with UNICEF and government contract prices, respectively. Implementation of nationwide vaccination would require approximately $73.3-$75.0 million (13-14% of routine immunization budget) and $257.4-$263.5 million (45-50% of routine immunization budget) with UNICEF and government contract prices, respectively. Sensitivity analysis showed that vaccine efficacy, mortality rate, and vaccine price were the most influential parameters affecting the ICER. In conclusion, pneumococcal vaccination would be a highly cost-effective intervention to be implemented in Indonesia. Yet, applying PCV13 with UNICEF price would give the best cost-effectiveness and affordability values on the routine immunization budget. © 2021 Auliya A. Suwantika et al. |
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pcv 10; Pneumococcus vaccine; Pneumococcus vaccine; Article; budget; budget impact analysis; case control study; case fatality rate; child; cohort analysis; comparative effectiveness; contract; controlled study; cost effectiveness analysis; drug cost; drug efficacy; economic evaluation; government; health care cost; human; incidence; incremental cost effectiveness ratio; Indonesia; infection prevention; mortality rate; outcome assessment; pneumococcal infection; price; quality adjusted life year; sensitivity analysis; strategic planning; Streptococcus pneumonia; United Nations Children's Fund; vaccination; cost benefit analysis; economics; Budgets; Child; Cost-Benefit Analysis; Humans; Indonesia; Pneumococcal Vaccines; Vaccination |
Hindawi Limited |
16879805 |
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33995536 |
Article |
Q2 |
869 |
5372 |
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811 |
Dinarti L.K., Anggrahini D.W., Lilyasari O., Siswanto B.B., Hartopo A.B. |
57192908812;35285645700;57192914838;14422648800;36056281100; |
Pulmonary arterial hypertension in Indonesia: Current status and local application of international guidelines |
2021 |
Global Heart |
16 |
1 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105601627&doi=10.5334%2fGH.944&partnerID=40&md5=a344de6f2ae7c858408e0bbec6a2f09e |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia; Department Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Dinarti, L.K., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia; Anggrahini, D.W., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia; Lilyasari, O., Department Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Siswanto, B.B., Department Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Hartopo, A.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia |
Recent advances in the diagnosis and management of pulmonary arterial hypertension (PAH) have led to a significant improvement in the outcomes for patients with PAH. However, prompt and accurate diagnosis of PAH remains an unmet challenge due to lack of awareness and lack of meticulous data to profile the etiology and pathophysiology of this rare progressive disease, especially in low- and middle-income country. In Indonesia, the true prevalence and incidence of different subtypes of PAH in general population is still unknown. The Congenital HeARt Disease in adult and Pulmonary Hypertension (COHARD-PH) registry was the first single-center prospective registry in Indonesia, which indicated that almost 80% of adult patients with congenital heart disease (CHD) had experienced PAH and even Eisenmenger syndrome due to delayed diagnosis. Screening for early detection of asymptomatic CHD in children is yet to be systematically established in Indonesia, leading to undiagnosed and uncorrected CHD in adulthood. There are no specific national guidelines focusing on diagnostic workup and treatment of PAH in Indonesia. Furthermore, the lack of adequate diagnostic facilities, limited treatment availability, and limited drug coverage under the National Health Insurance Scheme are key issues that remain unaddressed. This review focuses on the diagnosis, treatment, and management of PAH associated with CHD in Indonesia as per international guidelines. We have proposed recommendations to effectively control and prevent PAH associated with CHD in Indonesia. The paper should be of interest to readers in the area of medical management and policy makers especially in low- and middle-income countries. © 2021 The Author(s). |
Congenital heart disease (CHD); Etiology; Indonesia; International guideline; Lower middle-income region; Pulmonary arterial hypertension (PAH) |
antihypertensive agent; vasodilator agent; clinical research; congenital heart disease; early diagnosis; health care policy; human; Indonesia; maternal mortality; practice guideline; priority journal; prognostic assessment; pulmonary hypertension; Review; risk assessment; adult; congenital heart malformation; Eisenmenger complex; female; pregnancy; pulmonary hypertension; Adult; Eisenmenger Complex; Female; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Indonesia; Pregnancy; Pulmonary Arterial Hypertension |
Web Portal Ubiquity Press |
22118160 |
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34040936 |
Review |
Q1 |
1012 |
4314 |
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812 |
Abadi M.R., Widyahening I.S., Sudarsono N.C., Tobing A.J. |
57223256005;54893154400;57201862518;57195719588; |
Incidence rate of musculoskeletal injuries among professional tennis players during 2019 international tournaments in Indonesia |
2021 |
Journal of Sports Science and Medicine |
20 |
2 |
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268 |
274 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105367811&doi=10.52082%2fjssm.2021.268&partnerID=40&md5=084058e65a62004039937034c05f34a7 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization (SEAMEO-RECFON) – Regional Centre for Food and Nutrition, Universitas Indonesia, Jakarta, Indonesia |
Abadi, M.R., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Southeast Asian Ministers of Education Organization (SEAMEO-RECFON) – Regional Centre for Food and Nutrition, Universitas Indonesia, Jakarta, Indonesia; Sudarsono, N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tobing, A.J., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Several studies have indicated that musculoskeletal injuries are common during a professional tennis competition. However, data from a tropical country like Indonesia is lacking. This study aimed to obtain the incidence rate and injury characteristics and identify risk factors of musculoskeletal injuries among professional tennis players competing in Indonesia under the International Tennis Federation (ITF). The study was a prospective cohort during professional tennis tournaments in Jakarta, Indonesia in 2019, consisting of the ITF Women’s Circuit Indonesia (two weeks) and ITF Men’s Future Indonesia (three weeks). All athletes were enrolled in this study. Injuries were assessed based on the ITF Consensus Statement. Incidence rate was the number of injuries per 1000 player hours (i.e., the total duration from before the match starts to completion of the match after the final point). The magnitude of risk was expressed as a relative risk (RR) and its 95% confidence interval (CI). Independent risk factors were identified using multivariate analyses. A total of 161 tennis players were enrolled; 71 (44.1%) were men. Their mean age was 22 years old. The incidence rate of musculoskeletal injuries was 30.8 injuries per 1000 player hours (95% CI: 28.2–33.5). The most common onset was acute injuries (61.1%), while the most common location and type of injury was the trunk (38.9%) and muscle strain (61.1%). Risk factors associated with musculoskeletal injury were higher body height, skill level, history of previous in-jury, and wet bulb globe temperature (WBGT) zone. There was no injury during the doubles matches. Previous injury was an independent risk factor (adjusted RR: 48.1 (95% CI: 11.3–155.0; p < 0.001). The incidence of musculoskeletal injuries among professional tennis player is considerably high. Factors associated with injury are body height, skill level, previous injury, and WBGT zone. Future injury prevention programmes should incor-porate the management of previous injuries and take into account the effect of environmental temperature. © Journal of Sports Science and Medicine (2021). |
Epidemiology; Incidence; Injury; Risk factors; Tennis; Tropical climate |
body height; competitive behavior; female; human; incidence; Indonesia; injury; male; motor performance; musculoskeletal system; physiology; prospective study; risk factor; skeletal muscle; tennis; tropic climate; trunk; young adult; Body Height; Competitive Behavior; Female; Humans; Incidence; Indonesia; Male; Motor Skills; Muscle, Skeletal; Musculoskeletal System; Prospective Studies; Risk Factors; Sprains and Strains; Tennis; Torso; Tropical Climate; Young Adult |
Journal of Sport Science and Medicine |
13032968 |
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34211319 |
Article |
Q1 |
815 |
5901 |
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813 |
Azmi L., Rukmana A., Sjatha F. |
57223235228;35491487100;55372815000; |
Cloning of the pe11 (LipX, Rv1169c) gene of a mycobacterium tuberculosis beijing strain into the pcDNA3.1 plasmid vector |
2021 |
Makara Journal of Science |
25 |
1 |
6 |
35 |
42 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105345058&doi=10.7454%2fmss.v25i1.1206&partnerID=40&md5=15f89692c545a91386310b30b135be6b |
Biomedical Student, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Azmi, L., Biomedical Student, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Rukmana, A., Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Sjatha, F., Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. It is a persistent global health problem with a high mortality rate. Currently, TB is controlled by administering the Bacillus Calmette-Guerin (BCG) vaccine, but the effectiveness of its protection varies among individuals in a population. The pe/ppe gene family comprises a typical group of genes that play a role in avoiding the host immune response and inducing persistent TB infection. Based on in silico analysis, the pe11 gene has estimated immunogenicity and potential as a TB seed vaccine candidate. The pe11 gene from an Indonesian isolate of an M. tuberculosis Beijing strain was amplified by polymerase chain reaction (PCR) and inserted into the mammalian expression vector pcDNA3.1. The recombinant vector pcDNA3.1-pe11 was used to transform Top10 competent Escherichia coli. Clones from the transformation were subjected to colony PCR to confirm the direction of the insert. Sequencing was performed to confirm the correctness of the insert sequence. In this study, the pe11 gene was successfully cloned into the pcDNA3.1 vector in the correct direction to assure PE11 expression. No mutations were found in the pe11 gene insert, compared with the M. tuberculosis H37Rv sequence as the standard. A pcDNA3.1 vector contain-ing the pe11 gene derived from an M. tuberculosis Beijing strain was successfully constructed. © 2021, Universitas Indonesia. All rights reserved. |
M. tuberculosis; PcDNA3.1; Pe11; Tuberculosis |
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Universitas Indonesia |
23391995 |
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Article |
#N/A |
#N/A |
#N/A |
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814 |
Mirtha L.T., Siagian M., Tamin T.Z., Radi B., Soemarko D.S., Prijanti A.R., Irfanuddin M., Pelana R., Mansyur M. |
57193201450;6505956355;23476060900;6603494019;57192889490;57190863386;57223257669;57202117393;37085506800; |
The formula for calculating the predicted value of cardiorespiratory endurance using a foot rest-based cardiorespiratory exercise device |
2021 |
Science Progress |
104 |
2 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105102326&doi=10.1177%2f00368504211010637&partnerID=40&md5=2c4408c0d2414931797e6357c72a1d59 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Faculty of Sports Science, University State of Jakarta, Jakarta, Indonesia |
Mirtha, L.T., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siagian, M., Departement of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tamin, T.Z., Departement of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radi, B., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soemarko, D.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prijanti, A.R., Departement of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irfanuddin, M., Departement of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Pelana, R., Faculty of Sports Science, University State of Jakarta, Jakarta, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
This study developed a formula for calculating the predicted VO2 max value using a prototype model of foot-based cardiorespiratory exercise. Forty sedentary workers (20 men and 20 women) were enrolled via consecutive sampling. They underwent direct measurement of VO2 max using spiroergometry as the gold standard; the predicted VO2 max value was calculated using a prototype model of foot-based cardiorespiratory exercise, which was performed on consecutive days. Multivariate linear regression analysis was used to formulate the equation for the predicted VO2 max value by including potential contributing variables: gender, body height, body weight and heart rate. Bland–Altman test was used for assessing the agreement level for the predicted VO2 max value. The equation for the predicted VO2 max value was formulated as 3.2 + 0.15 optimal exercise heart rate −5.5 sexes (0 for men, 1 for women). The agreement level for the formula was acceptable in all measurement result ranges. The formula developed in this study can be used to measure the predicted VO2 max value with an acceptable agreement level. © The Author(s) 2021. |
Cardiorespiratory endurance; level of agreement; physical exercise; physical fitness; predicted VO2 max; sedentary work; sitting workers; VO2 max |
adult; article; body height; body weight; clinical article; endurance; exercise; female; foot; gender; gold standard; heart rate; human; human experiment; human tissue; linear regression analysis; male; sitting; worker |
SAGE Publications Ltd |
00368504 |
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33913389 |
Article |
Q2 |
310 |
14499 |
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815 |
Permata T.B.M., Sekarutami S.M., Nuryadi E., Giselvania A., Gondhowiardjo S. |
57197808751;56576294500;57197806814;57217201891;6508327402; |
Rapid advancement in cancer genomic big data in the pursuit of precision oncology |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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81 |
85 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105003444&doi=10.13181%2fmji.rev.204250&partnerID=40&md5=ac20a978c8162343bd2dd077ffd5908e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Giselvania, A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
In the current big data era, massive genomic cancer data are available for open access from anywhere in the world. They are obtained from popular platforms, such as The Cancer Genome Atlas, which provides genetic information from clinical samples, and Cancer Cell Line Encyclopedia, which offers genomic data of cancer cell lines. For convenient analysis, user-friendly tools, such as the Tumor Immune Estimation Resource (TIMER), which can be used to analyze tumor-infiltrating immune cells comprehensively, are also emerging. In clinical practice, clinical sequencing has been recommended for patients with cancer in many countries. Despite its many challenges, it enables the application of precision medicine, especially in medical oncology. In this review, several efforts devoted to accomplishing precision oncology and applying big data for use in Indonesia are discussed. Utilizing open access genomic data in writing research articles is also described. © 2021 Authors. |
Cancer genetic database; Oncology; Personalized medicine |
adult; big data; cancer cell line; clinical practice; controlled study; genetic database; human; human cell; immunocompetent cell; Indonesia; personalized medicine; review; writing |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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816 |
Pratomo I.P., Ariane A., Tedjo A., Heryanto R., Paramita R.I. |
57192904477;57210643323;57189320451;23392757600;54882436900; |
Xanthine oxidase inhibition in sars-cov-2 infection: The mechanism and potency of allopurinol and febuxostat in covid-19 management |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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75 |
80 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104949199&doi=10.13181%2fmji.rev.204641&partnerID=40&md5=689e842e1dfa9cde24da9c6f8f7bbee1 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia; Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariane, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Tedjo, A., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia, Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19. © 2020 Authors. |
COVID-19; Free radicals; Uric acid; Xanthine oxidase |
allopurinol; C reactive protein; febuxostat; free radical; gamma interferon; interleukin 2; interleukin 6; reactive oxygen metabolite; uric acid; xanthine oxidase; animal model; coronavirus disease 2019; cytokine production; cytokine storm; drug potency; epithelium; influenza; mouse; neutrophil; nonhuman; oxidative stress; pathogenesis; poultry; respiratory virus; Review; Severe acute respiratory syndrome coronavirus 2; virus infection |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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817 |
Kusumawardani A., Yanfaunnas A.M., Supandi D.P., Inggita R.A.M., Andayani N.G.A.A.P.T., Louisa M., Soetikno V., Burhan E. |
57223083920;57223095441;57222624055;57223087394;57223088955;41461551400;36769252100;36058554600; |
The use of Urinary Lipoarabinomannan (LAM) as a Rapid Diagnostic Test for Adult Pulmonary Tuberculosis in HIV-Positive Patients: An Evidence-based Case Report |
2021 |
Journal of International Dental and Medical Research |
14 |
1 |
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461 |
466 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104790784&partnerID=40&md5=012c79128a2fc69230627fe766651487 |
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia |
Kusumawardani, A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yanfaunnas, A.M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Supandi, D.P., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Inggita, R.A.M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Andayani, N.G.A.A.P.T., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia |
Tuberculosis is a major health concerns around the world as it is causing morbidity and mortality, especially in HIV infected patients. Detection of lipoarabinomannan (LAM) on urine is a non-sputum-based diagnostic test for TB that could accelerate TB case detection in HIV-positive patients. This evidence-based case report was aimed to evaluate the diagnostic value of urinary Lipoarabinomannan (LAM) test in diagnosing pulmonary tuberculosis in HIV-positive patients as compared to sputum culture. Structured literature searching was done on cross-sectional or systematic reviews of diagnostic studies of lipoarabinomannan versus sputum culture in adult HIV-positive patients suspected with pulmonary TB. There were 9 articles that meet the eligibility criteria; 1 systematic review and 8 cross-sectional studies. Two out of nine articles were deemed as not valid due to not using sputum on all samples and the index test and reference test were not carried out on all samples. There were contradictory results regarding the sensitivity, positive predictive values and negative predictive values, meanwhile the specificity showed good results. We conclude that urinary LAM can be used to diagnose pulmonary TB in HIV-positive patients due to its high specificity. However, it could not be used as a stand-alone test, due to its suboptimal sensitivity. © 2021 |
Sputum culture; TB-HIV; tuberculosis; urinary lipoarabinomannan |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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818 |
Sahar N., Birowo P., Kusmardi, Kristianty D., Rahmaningrum K., Miranda A.V., Rasyad A., Prasasty V.D. |
57212464367;6504153311;56966625300;57223024424;57223023016;57222664687;57223027205;56019989700; |
Mucin-1 expression in endometrial tissue of Macaca nemestrina during mid-luteal phase after controlled-ovarian hyperstimulation |
2021 |
Biodiversitas |
22 |
4 |
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1927 |
1933 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104548199&doi=10.13057%2fbiodiv%2fd220440&partnerID=40&md5=436be5fa1fbe0e2157ca68a386731018 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Departement Urology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Biotechnology, Universita Katolik Atma Jaya Indonesia, Jl. Jend. Sudirman No. 51, Jakarta Selatan, Jakarta, 12930, Indonesia |
Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Birowo, P., Departement Urology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Kusmardi, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Kristianty, D., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Rahmaningrum, K., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Rasyad, A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Prasasty, V.D., Faculty of Biotechnology, Universita Katolik Atma Jaya Indonesia, Jl. Jend. Sudirman No. 51, Jakarta Selatan, Jakarta, 12930, Indonesia |
Endometrial receptivity is one of the factors for successful implantation in pregnancy. Controlled ovarian hyperstimulation (COH) is a required step of in vitro fertilization (IVF), one of the standard procedures to overcome infertility. Exogenous gonadotropin hormones from COH provoke the secretion of estrogen and progesterone from the ovaries in higher amounts. The supraphysiological environment could impact the endometrial receptivity of the implantation process. Mucin-1 (MUC1) can be used as a marker to indicate alterations in the endometrial tissue. Therefore, this study aimed to investigate the alteration of mucin-1 expression in endometrial tissue of Macaca nemestrina after COH protocol. This study used endometrium tissue of M. nemestrina embedded with paraffin as tissue blocks. The subjects were 15 female macaques in reproductive age (8-10 years old) with a history of producing offspring. These macaques were classified into four groups based on the COH protocols, which consist of administering gonadotropin-releasing hormone (GnRH) agonist and recombinant FSH (r-FSH) with dosages of 30 IU, 50 IU, 70 IU (intervention groups), and no r-FSH (control group). The stimulations were administered for 14 days during the mid-luteal phase. Moreover, tissue staining was done by using immunohistochemistry. Mucin-1 expression was analyzed manually for glandular and luminal compartments and automatically for the stromal compartment by Red Green Blue (RGB) measure plugin as a color image from ImageJ software. The expression of mucin-1 was counted semi-quantitatively as H-score. Mucin-1 expression differences in endometrial tissue were assessed by one-way ANOVA with a significant difference found in the glandular part and insignificant results found in luminal and stromal parts. Pearson correlation test was also performed to determine the relationship of steroidal hormones and mucin-1 expression in glandular and luminal compartments. Both correlations were statistically insignificant. However, a positive correlation was found with the glandular compartment and a negative correlation with luminal compartment. As the subject species, M. nemestrina is limited for research utilization in our country, small number of subjects becomes a limitation of this study. Further studies need to be conducted to deepen the understanding of the regulation of mucin-1 expression, particularly by the altered concentrations of steroidal hormones as a consequence of COH. © 2021, Society for Indonesian Biodiversity. All rights reserved. |
Controlled ovarian hyperstimulation; Endometrial receptivity; In vitro fertilization; Mucin-1 |
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Society for Indonesian Biodiversity |
1412033X |
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Article |
Q3 |
257 |
16376 |
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819 |
Putri A.S., Soedarsono N., Nehemia B., Atmadja D.S., Ubelaker D.H. |
57223021361;14049161500;57204102056;6507824506;7003416830; |
Age estimation of individuals aged 5–23 years based on dental development of the Indonesian population |
2021 |
Forensic Sciences Research |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104502186&doi=10.1080%2f20961790.2021.1886648&partnerID=40&md5=b3c0a614893fe57774dae608436d737a |
Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Putri, A.S., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Nehemia, B., Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Atmadja, D.S., Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ubelaker, D.H., Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Dental development can be used to estimate age for forensic purposes. However, most of the currently available methods are less reliable for the Indonesian population due to population variability. This study presents a new method and evaluates other methods that utilize dental development to estimate the age of Indonesian people. Panoramic radiographs of 304 young Indonesian people aged 5–23 years old were analysed for deciduous tooth root resorption, permanent tooth calcification, and eruption. The extent of tooth root resorption was determined based on AlQahtani’s modified Moorrees et al. method. Tooth calcification was classified based on a modified Demirjian et al. method. Tooth eruption was evaluated based on AlQahtani’s modified Bengston system. The sequence of tooth root resorption, and permanent tooth calcification and eruption were grouped into 19 age categories (from 5–23 years old) in an atlas. The differences between males and females, between maxillary and mandibular teeth, and between right and left teeth were also analysed. There were minimal significant differences of tooth development between males and females, and between the right and left teeth (P > 0.05), while the maxillary and mandibular dental development was significantly different (P < 0.05). The newly developed atlas showed the development of the right side of maxillary and mandibular tooth of combined sex of Indonesian population. Another 34 panoramic radiographs of known-age and sex individuals from Indonesia were assessed using the newly developed Atlas of Dental Development in the Indonesian Population, Ubelaker’s Dental Development Chart, The London Atlas of Human Tooth Development and Eruption by AlQahtani, and the Age Estimation Guide-Modern Australia population by Blenkin-Taylor. Accuracy was assessed by comparing estimated age to actual chronological age using the Bland-Altmand test. Results show that the smallest range of error was found in the Atlas of Dental Development in the Indonesian Population (−0.969 to 1.210 years), followed by The London Atlas of Human Tooth Development and Eruption by AlQahtani (−2.013 to 1.990 years), the Age Estimation Guide-Modern Australia population by Blenkin-Taylor (−2.495 to 2.598 years), the Dental Development Chart by Ubelaker (−2.960 to 3.289 years). These findings show that the Atlas of Dental Development constructed in this study performs better than the other three methods and presents greater accuracy of age estimation in the Indonesian population. Key points •Dental development such as deciduous tooth root resorption, permanent tooth calcification, and tooth eruption can be used to estimate age for forensic purposes. •The development of the teeth are influenced by genetic, ethnicity, and sex, therefore an age estimation method must be constructed based on the same population. •There were minimal significant differences in tooth development between male and female, and between right and left teeth, but there was significant difference between maxillary and mandibular teeth. •The Atlas of Dental Development in the Indonesian Population constructed in this study allowed more accurate age estimation of the Indonesian sample than the other methods tested. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1886648. © 2021 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science. |
age estimation; forensic odontology; Forensic sciences; root resorption; tooth calcification; tooth eruption |
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Taylor and Francis Ltd. |
20961790 |
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Article |
Q1 |
729 |
6779 |
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