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830 |
Wicaksono I., Rahardjo H.E. |
57217251974;37762030000; |
Diagnostic Value of PCR compared to Urine Culture for Urinary Tuberculosis in Adult Women: An Evidence-Based Case Report |
2021 |
Acta medica Indonesiana |
53 |
1 |
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108 |
118 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993519&partnerID=40&md5=7a612f7f41fa8ec9b31840cc9700f185 |
Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Wicaksono, I., Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Rahardjo, H.E. |
BACKGROUND: genitourinary tuberculosis (GUTB) refers to a Mycobacterium tuberculosis infection of the urinary tract with clinical manifestation masquerading as various urological diagnostic entities. With an incidence rate of 192-232 per 100,000 individuals, current diagnoses have fallen short in comparison to the total incidence. Combined with an atypical and non-specific manifestation, a high false negative rate of acid-fast bacilli (AFB) staining, and long AFB culture duration has made diagnosis difficult. We aim to gather current available evidence regarding the diagnostic performance of polymerase chain reaction (PCR) in the diagnosis of GUTB. METHODS: a literature search was conducted in four different, well-known databases using a predetermined PICO, keywords, and Boolean operators. All included articles will be subjected to rigorous appraisal according the University of Oxford's Centre for Evidence-Based Medicine (CEBM) Diagnostic Variability Criteria. Review and meta-analysis will be subjected to the QFAITH appraisal checklist to assess its quality. RESULTS: out of a total of 243 initial search results, 11 relevant studies were determined after title and abstract screening. Additionally, nine articles were excluded based on the predetermined criteria. Two fully appraised articles were included in the study: one systematic review article, revealing a heterogenous (I2 = unstated; p = unstated) result of sensitivity mean above 85% and specificity above 75%; and one cross-sectional diagnostic study that reported the use of two different PCR primers: IS6110-PCR and 16SrRNA-PCR primer with a sensitivity of 95.99% and 87.05% and specificity of 98.11% and 98.9%, respectively. CONCLUSION: current limited evidence showed that PCR could not be solely used for the diagnosis of GUTB, but its use is recommended to guide patient treatment and monitoring. |
acid-fast bacilli; diagnosis; genitourinary tuberculosis; polymerase chain reaction; urine culture |
adult; case report; comparative study; evidence based practice; female; genetics; human; isolation and purification; meta analysis; microbiology; Mycobacterium tuberculosis; polymerase chain reaction; sensitivity and specificity; urine; urogenital tuberculosis; Adult; Evidence-Based Practice; Female; Humans; Mycobacterium tuberculosis; Polymerase Chain Reaction; Sensitivity and Specificity; Tuberculosis, Urogenital; Urine |
NLM (Medline) |
01259326 |
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33818414 |
Article |
Q3 |
321 |
14162 |
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831 |
William W., Ascobat P., Instiaty I., Agustin H. |
57222750602;55795863600;55703138400;56135125000; |
Outcomes of Daily Dose versus Part-daily Dose Treatment for Lung Tuberculosis: A Real-World Database Study in an Indonesian Hospital |
2021 |
Acta medica Indonesiana |
53 |
1 |
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18 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993218&partnerID=40&md5=8b5b59f2fda6442613cb3b59085dcbde |
1. Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Indonesia. 2. Department of Pharmacology, Faculty of Medicine, University of Christian Krida WacanaJakarta, Indonesia |
William, W., 1. Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Indonesia. 2. Department of Pharmacology, Faculty of Medicine, University of Christian Krida WacanaJakarta, Indonesia; Ascobat, P.; Instiaty, I.; Agustin, H. |
BACKGROUND: a meta-analysis of randomized control trials (RCTs) on category I pulmonary tuberculosis (PTB) treatments showed that either part-daily (2RHZE/4R3H3) or daily dose (2RHZE/4RH) had the same failure and recurrence rates. However, the World Health Organization (WHO) concluded that the part-daily dose had higher failure and recurrence rates. Therefore, this study was conducted to compare the treatment outcomes between both regimens, whether daily dose regimen has a better treatment outcome than part-daily dose regimen, and the adverse effects between both regimens. METHODS: this was an analytic cross-sectional study of patients at the Persahabatan General Hospital, over the period of January 2015-June 2018. Data were taken from medical records and supported by telephone interviews, each regimen group had 175 patients. RESULTS: there were no significant differences for success rates (p=0.470), lost to follow up rates (p=0.659), failure rates (p=1.000), death rates (p=1.000), and adverse effects in the continuation phase (p=0.324) between the groups. There were, however, significant differences in cure rates (p < 0.001) and complete treatment rates (p<0.001) between the groups. CONCLUSION: the cure rate and complete treatment rate were found to be better for the part-daily than the daily doses. The success rate of both regimens were the same as Indonesia's target (90%). In the continuation phase, there were no significant difference of adverse effects between both regimens. |
Adverse effects; dose regimen; pulmonary tuberculosis; treatment outcomes |
tuberculostatic agent; adolescent; adult; cross-sectional study; drug administration; female; follow up; human; Indonesia; lung tuberculosis; male; middle aged; recurrent disease; treatment outcome; young adult; Adolescent; Adult; Antitubercular Agents; Cross-Sectional Studies; Drug Administration Schedule; Female; Humans; Indonesia; Lost to Follow-Up; Male; Middle Aged; Recurrence; Treatment Outcome; Tuberculosis, Pulmonary; Young Adult |
NLM (Medline) |
01259326 |
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33818403 |
Article |
Q3 |
321 |
14162 |
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832 |
Shidiq K.M., Nelwan E.J., Yunihastuti E., Harimurti K., Pohan H.T. |
57222751395;14527452900;57221273925;23473513200;23474782900; |
Clinical Evaluation of HIV/AIDS Patients on Antiretroviral Therapy using HIV Symptoms Index: A reliability and Applicability Evaluation using Indonesian Language |
2021 |
Acta medica Indonesiana |
53 |
1 |
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52 |
59 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103992672&partnerID=40&md5=4dc758f0ec746e017c56b0c1bf8c2fdf |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia |
Shidiq, K.M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia; Nelwan, E.J.; Yunihastuti, E.; Harimurti, K.; Pohan, H.T. |
BACKGROUND: HIV/AIDS is a chronic, lifelong disease with a wide clinical spectrum which could decrease the quality of life. Objective symptoms measurement is important because it is correlated to treatment adherence and progressivity of the disease. Currently, there is no clinical tool available to evaluate symptoms of HIV infection and the treatment's side effect for the outpatient setting. This study aimed is to assess the reliability of the Indonesian version of HIV Symptom Index for measuring symptoms of HIV/AIDS patients, and use it for assessment of their symptom profile. METHODS: this is a cross sectional study in outpatient HIV/AIDS subjects (n=87) recruited in Cipto Mangunkusumo Hospital's HIV clinic from September-November 2018. The HIV Symptom Index consisted of 20 items evaluating somatic, psychologic, and the combination of both symptoms, and its' language adaptation to Indonesian was done with Beaton and Guillemin method. Reliability of the Indonesian version of HIV Symptom Index was tested by alpha cronbach's a coefficient analysis, and the internal validity was tested with multitrait scaling analysis before being used to profile the symptom pattern of HIV/AIDS patients. RESULTS: Indonesian version of HIV Symptom Index is reliable (cronbach alpha 0.76) and valid (multitrait correlation >0.4) for measuring symptoms of HIV/AIDS patients. The most common symptom is fatigue (55.7%), followed by insomnia (43.3%), dizziness and lightheadedness (42.3%), skin problems (42.3%), and pain, numbness, or tingling in the hands or feet (39.2%). CONCLUSION: Indonesian version of HIV symptom Index is reliable and valid to measure symptoms of HIV/AIDS patiens objectively. |
clinical evaluation; HIV/AIDS; symptom |
antiretrovirus agent; acquired immune deficiency syndrome; adult; cross-sectional study; female; human; Human immunodeficiency virus infection; Indonesia; language; male; middle aged; quality of life; questionnaire; reproducibility; severity of illness index; Acquired Immunodeficiency Syndrome; Adult; Anti-Retroviral Agents; Cross-Sectional Studies; Female; HIV Infections; Humans; Indonesia; Language; Male; Middle Aged; Quality of Life; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires |
NLM (Medline) |
01259326 |
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33818407 |
Article |
Q3 |
321 |
14162 |
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833 |
Kaligis F., Ismail R.I., Wiguna T., Prasetyo S., Indriatmi W., Gunardi H., Pandia V., Magdalena C.C. |
36604651700;55996895500;24367785700;56879108300;57189888041;56510252700;57208206604;57222744289; |
Mental health problems and needs among transitional-age youth in Indonesia |
2021 |
International Journal of Environmental Research and Public Health |
18 |
8 |
4046 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103933053&doi=10.3390%2fijerph18084046&partnerID=40&md5=5f79eeea8b723a621bb8c21de80ea384 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Public Health, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Padjajaran, Bandung, West Java, 40115, Indonesia |
Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Prasetyo, S., Faculty of Public Health, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Indriatmi, W., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Gunardi, H., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pandia, V., Department of Psychiatry, Faculty of Medicine, Universitas Padjajaran, Bandung, West Java, 40115, Indonesia; Magdalena, C.C., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
“Transitional-age youth” describes those whose ages range from 16–24 years old. In this phase, the youth face new challenges and new experiences which may increase the risk for having mental health problems, yet not very many seek help from mental health professionals. In Indone-sia, no data are available about mental health problems and the needs of transitional-age youth. This study explores common mental health problems experienced during this stage and assesses how they cope with problems and their expectations from health services. This was a cross-sectional study involving 393 Indonesians aged 16–24 years in May 2020. More than 90% of students had financial and academic difficulties and felt lonely. The most prevalent mental health problem among students was anxiety (95.4%). Most of the students, ranging from 90% to 96.4%, had positive coping strategies. However, around 50% of respondents reported self-harming and having suicidal thoughts. The results of subcategories analysis between ages and faculties were similar. Their most important expectations from mental health services included confidentiality (99.2%) and being wel-coming and friendly (99.2%). In conclusion, this study highlighted the most common problems tran-sitional-age youth experience in Indonesia. While some of them already knew how to deal with their problems, not all the participants had good coping mechanisms. Their healthcare expectations were also explored, thereby providing a useful background to revise and amend the current condi-tions. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Adolescence; Coping mechanisms; Health service expectation; Mental health needs; Mental health problems; Transitional-age youth |
academic performance; coping strategy; finance; health services; mental health; student; young population; adolescent; adult; age; anxiety; Article; automutilation; confidentiality; coping behavior; cross-sectional study; female; financial stress; health care access; health care need; health care quality; human; Indonesia; juvenile; loneliness; male; mental health; mental health service; prevalence; risk factor; school stress; suicidal ideation; transitional age youth; young adult; epidemiology; mental health service; Indonesia; Adolescent; Adult; Cross-Sectional Studies; Humans; Indonesia; Mental Health; Mental Health Services; Suicidal Ideation; Young Adult |
MDPI AG |
16617827 |
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33921344 |
Article |
Q2 |
747 |
6560 |
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834 |
Ibrahim F., Natasha A., Saharman Y.R., Yasmon A., Fithriyah F., Karuniawati A., Ganiesa S., Sudarmono P. |
54886001500;57211428938;55980934300;41462004500;57210142453;54886816200;57222740114;6507855437; |
Consideration of the Cycle Threshold Values from Real-Time RT-PCR SARS-CoV-2 Interpretation for the Clinicians: Analysis of 339 Positive Cases from a Referral Laboratory in Jakarta, Indonesia |
2021 |
Acta medica Indonesiana |
53 |
1 |
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13 |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921764&partnerID=40&md5=34f56312ba1b549b121d030e28212342 |
Clinical Microbiology Department, faculty of medicine, University of Indonesia |
Ibrahim, F., Clinical Microbiology Department, faculty of medicine, University of Indonesia; Natasha, A.; Saharman, Y.R.; Yasmon, A.; Fithriyah, F.; Karuniawati, A.; Ganiesa, S.; Sudarmono, P. |
BACKGROUND: real-time RT-PCR was recommended by WHO for COVID-19 diagnosis. The cycle threshold (Ct) values were expected to have an association with clinical manifestation. However, the diagnostic modalities such as quantitative molecular detection and virus isolation were not yet available for the routine test. This study has been conducted to analyze the relationship between the Ct values of qualitative rRT-PCR and the clinical manifestation and to describe the factors determining the result. METHODS: from March to April 2020, specimens were sent to our laboratory from different healthcare centers in Jakarta. The patient's characteristic and clinical manifestation were extracted from the specimen's epidemiology forms. The specimens extracted and tested using rRT-PCR, and the Ct value were collected. The data were analyzed using the appropriate statistic test. RESULTS: from 339 positive results, the mild to moderate case was 176 (52%) and the severe cases was 163 (48%). Female was dominant in the mild to moderate cases (58%), while the male was prevalent in the severe cases (60%). The median age for mild to moderate case was 35 years old and severe cases was 49 years old. Statistical analysis found relationship between both group with gender (p = 0.001) and age (p < 0.001), but not with the Ct value. CONCLUSION: many variables in specimen sampling and processing could affect the Ct value result. In addition, the disease's severity was depended with the host immune response, regardless the number of virus. There was suggested no significant difference between the Ct values of mild-moderate and severe COVID-19, and thus should not be loosely interpreted. |
clinical interpretation; Cycle Threshold; rRT-PCR; SARS-Cov-2 |
adult; age; diagnosis; epidemiology; female; human; Indonesia; isolation and purification; male; middle aged; observer variation; pathophysiology; physiology; procedures; real time polymerase chain reaction; reproducibility; severity of illness index; sex factor; symptom assessment; virus load; Adult; Age Factors; Correlation of Data; COVID-19; COVID-19 Nucleic Acid Testing; Female; Humans; Indonesia; Male; Middle Aged; Observer Variation; Real-Time Polymerase Chain Reaction; Reproducibility of Results; SARS-CoV-2; Severity of Illness Index; Sex Factors; Symptom Assessment; Viral Load |
NLM (Medline) |
01259326 |
|
33818402 |
Article |
Q3 |
321 |
14162 |
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835 |
Loho T., Widodo D. |
55624513300;8231822900; |
Rapid Antigen Detection Test for Severe Acute Respiratory Syndrome Coronavirus 2: How to Use It Properly? |
2021 |
Acta medica Indonesiana |
53 |
1 |
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119 |
131 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921511&partnerID=40&md5=d85899546f23d6d70bd458483c6c9ac1 |
Department of Clinical Pathology, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Loho, T., Department of Clinical Pathology, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Widodo, D. |
Cases of coronavirus disease 2019 (COVID-19) in Indonesia are still increasing and even higher in the last few weeks. Contact tracing and surveillance are important to locate cases in the community, including asymptomatic individuals. Diagnosis of COVID-19 depends on the detection of viral RNA, viral antigen, or indirectly, viral antibodies. Molecular diagnosis, using real time, reverse transcriptase polymerase chain reaction (RT-PCR), is the common standard method; however, it is not widely available in Indonesia and requires a high standard laboratory. Rapid, point-of-care antibody testing has been widely used as an alternative; however, interpretation of the results is not simple and now it is no longer used by the Indonesian government as a screening test for people travelling between locations. Thus, the rapid antigen detection test (Ag-RDT) is used by the Indonesian government as a screening test for travellers. As a result, many people buy the kit online and perform self-Ag-RDT at home. This raises the question of how safe and accurate it is to perform self-Ag-RDT at home. Before a test is applied, it is suggested to research its sensitivity and specificity, as compared to gold standard, and its limitations. In this article, laboratory diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is discussed, with an emphasis on Ag-RDT and the recommendation to use it properly in daily practice. |
antigen testing; COVID-19; SARS-CoV-2 |
virus antibody; virus RNA; diagnosis; epidemiology; human; immunology; isolation and purification; physiology; prevention and control; procedures; reproducibility; sensitivity and specificity; Antibodies, Viral; COVID-19; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing; Humans; Reproducibility of Results; RNA, Viral; SARS-CoV-2; Sensitivity and Specificity |
NLM (Medline) |
01259326 |
|
33818415 |
Article |
Q3 |
321 |
14162 |
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836 |
Nelwan E.J., Tunjungputri R.N., Tunjung N., Widodo D. |
14527452900;56342194400;57208446370;8231822900; |
Hospital-acquired Skin and Skin-structure Infection in COVID-19 Infected Patient with Prolonged Hospitalization |
2021 |
Acta medica Indonesiana |
53 |
1 |
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105 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921503&partnerID=40&md5=23cf0f1fefa15f3ad7ca5a2fea78cdeb |
Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nelwan, E.J., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Tunjungputri, R.N.; Tunjung, N.; Widodo, D. |
Acute bacterial skin and skin-structure infections (ABSSSI) is defined in 2013 by the US Food and Drug Administration as a bacterial cellulitis/erysipelas, major skin abscesses, and wound infections. The Infectious Diseases Society of America (IDSA) in 2014 classifies skin and soft-tissue infection (SSTI) as either non-purulent (which includes cellulitis, erysipelas, and necrotizing infection) or purulent (including furuncle, carbuncle, and abscess). Among hospitalized patients with SSTI, healthcare-associated infections account for 73.5% of all cases. Notably, skin and skin-structure infections caused by Pseudomonas aeruginosa, a common hospital pathogen, was reported to cause higher total cost and longer hospital length of stay compared to non-P. aeruginosa cases, despite causing only approximately 5.7% of all healthcare-associated SSTIs. Infection with P. aeruginosa should always be considered in non-healing skin infections in patients with prolonged hospitalization and antibiotic exposure. Tissue culture, preferably taken by surgical debridement, should be promptly performed; and when hospital-infection is suspected, appropriate antibiotics should be started along with removal of all devitalized tissue and to promote skin and soft tissue healing. Expedited discharge should be considered when possible, with adequate antibiotic treatment and follow up for definitive wound treatment. |
COVID-19; Hospital-acquired skin; prolonged hospitalization; skin-structure infection |
antiinfective agent; linezolid; case report; complication; debridement; female; hospitalization; human; iatrogenic disease; isolation and purification; microbiology; middle aged; pathology; pathophysiology; procedures; skin; skin infection; treatment outcome; Anti-Bacterial Agents; COVID-19; Debridement; Female; Hospitalization; Humans; Iatrogenic Disease; Linezolid; Middle Aged; SARS-CoV-2; Skin; Skin Diseases, Infectious; Treatment Outcome |
NLM (Medline) |
01259326 |
|
33818413 |
Article |
Q3 |
321 |
14162 |
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837 |
Setiati S., Marsigit J. |
14325991900;57218912589; |
COVID-19 Vaccine for Elderly: Should We Be Reactive or Proactive? |
2021 |
Acta medica Indonesiana |
53 |
1 |
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1 |
4 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921302&partnerID=40&md5=6cdc928dd1802691cbcb0d3e3aa26a36 |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia. 2. Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo HospitalJakarta, Indonesia |
Setiati, S., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia. 2. Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo HospitalJakarta, Indonesia; Marsigit, J. |
It has been a year since the Indonesian government announced its first COVID-19 identified in Jakarta. Since then, there have been more than 900,000 cases in Indonesia with case fatality rate (CFR) of 2.9%. The number of new cases per day is now ranging from 9,000 cases to almost 13,000 cases. Not only in Indonesia, but the number of new cases along with the mortality rate in other countries, such as Malaysia, Japan, United States, and Europe region also increased dramatically. COVID-19 vaccines are being investigated and the world hopes that vaccines will be the answer to tackle this pandemic. Is it really so? Immunization is an effort to induce immunity in individuals to prevent a disease or the complication related to the diseases that may be catastrophic. Immunization can be divided into passive, which is by giving certain type of antibody and active, which means that either we get the disease, or we get the antigen injected into our body.Having prior vaccination or past COVID-19 does not mean that someone is totally immune to COVID-19 as a recent study suggested that the antibody related to COVID-19 past infection is significantly decreasing after 3 months post-infection. Compliance to implementation of health protocol remained the most crucial strategy during this pandemic. |
COVID-19; COVID-19 vaccine; elderly; vaccine |
administration and dosage; adverse event; aged; female; frail elderly; frailty; geriatric assessment; human; Indonesia; male; organization and management; prevention and control; procedures; risk assessment; risk factor; seroconversion; vaccination; Aged; COVID-19; COVID-19 Vaccines; Female; Frail Elderly; Frailty; Geriatric Assessment; Humans; Indonesia; Male; Risk Adjustment; Risk Factors; SARS-CoV-2; Seroconversion; Vaccination |
NLM (Medline) |
01259326 |
|
33818400 |
Article |
Q3 |
321 |
14162 |
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838 |
Ginanjar E., Alwi I., Lydia A., Immanuel S., Yamin M., Indrajaya T., Harimurti K. |
23472616600;15055173800;8451287200;12777341300;23475706300;54994136500;23473513200; |
The Association of β2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease |
2021 |
Acta medica Indonesiana |
53 |
1 |
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5 |
12 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921128&partnerID=40&md5=095d67ad322b9a2d7ea79b6dde38e4cd |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Ginanjar, E., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Alwi, I.; Lydia, A.; Immanuel, S.; Yamin, M.; Indrajaya, T.; Harimurti, K. |
BACKGROUND: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. METHODS: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox's Proportional Hazard Regression. RESULTS: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15-4.05; p = 0.017). CONCLUSION: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect. |
Acute Coronary Syndrome; Beta2-Microglobulin; Fibrioblast Growth Factor 23; Major Adverse Cardiac Event |
beta 2 microglobulin; biological marker; fibroblast growth factor; fibroblast growth factor 23; acute coronary syndrome; aged; blood; chronic kidney failure; complication; cross-sectional study; female; human; Indonesia; male; middle aged; mortality; multivariate analysis; predictive value; prognosis; retrospective study; risk factor; survival analysis; Acute Coronary Syndrome; Aged; beta 2-Microglobulin; Biomarkers; Cross-Sectional Studies; Female; Fibroblast Growth Factors; Humans; Indonesia; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Renal Insufficiency, Chronic; Retrospective Studies; Risk Factors; Survival Analysis |
NLM (Medline) |
01259326 |
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33818401 |
Article |
Q3 |
321 |
14162 |
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839 |
Ayuandari S., Khasanah N., Riyanti I., Dewanto A., Enisar Sangun D., Wiweko B. |
56231262400;57222708996;57222710738;57190580042;57222709491;43061741400; |
Current awareness and attitude toward fertility preservation in Indonesia: A nationwide survey among health-care providers |
2021 |
Journal of Human Reproductive Sciences |
14 |
1 |
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81 |
86 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103760305&doi=10.4103%2fjhrs.jhrs_239_20&partnerID=40&md5=10c9f18d628ded6d4e5658e52f96eb59 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Ayuandari, S., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Khasanah, N., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Riyanti, I., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Dewanto, A., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Enisar Sangun, D., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Context: Fertility preservation (FP) is necessary for cancer patients who develop infertility due to chemotherapy and radiotherapy. In Indonesia, many systematic steps and long-Term continued actions must be taken to establish FP units since there has been an increasing incidence of cancer among people under 45 years old. Aims: This study aimed at a comprehensive evaluation on the awareness and practices of health-care providers (HCPs) toward FP. Settings and Design: This was a descriptive cross-sectional study. Subjects and Methods: A validated nationwide online survey was completed by 160 HCPs as a representative sample from 11 provinces in 2017 that provide medical care to cancer patients at hospitals or clinics. Statistical Analysis Used: Descriptive statistics, analysis of variance, logistic regression, and Pearson correlation tests were used for the statistical analysis. Results: Respondents were specialists (59.4%) and other HCPs (40.6%). Around 60% of the HCPs who performed cancer therapies already discussed the fertility issues with their patients. Meanwhile, the HCPs (60.7%) also tended not to consult and refer their patients to fertility experts (P < 0.05). However, those who discussed the risk of infertility with patients tended to consult with and refer them to a fertility consultant for further FP procedure as the follow-up for their discussions (odds ratio = 8.98, confidence interval 95%, P < 0.05). Conclusions: In Indonesia, FP awareness of the HCPs who performed cancer therapy was high. Nevertheless, attitudes to refer patients to fertility experts for possible FP management still need to be improved. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Attitude; awareness; fertility preservation; health-care providers |
adult; analysis of variance; article; awareness; cancer patient; cancer therapy; controlled study; cross-sectional study; female; fertility preservation; fertility specialist; follow up; health survey; human; human tissue; Indonesia; male; medical care; risk assessment |
Wolters Kluwer Medknow Publications |
09741208 |
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Article |
Q3 |
484 |
10359 |
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