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840 |
Sihombing A.T., Taher A., Rodjani A., Mochtar C.A., Hakim L., Daryanto B., Danarto H.R., Umbas R. |
57218510635;7005269743;6504653529;6506558321;57200406177;57208512904;57222667970;6602634832; |
Assessing the online objective structured clinical examinations in urology qualifying exam for urology residents in Indonesia during COVID-19 time |
2021 |
MethodsX |
8 |
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101316 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103707591&doi=10.1016%2fj.mex.2021.101316&partnerID=40&md5=493809572dae72b1fbf5b2b8e4d8bf25 |
Department of Urology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Urology, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Department of Urology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Sihombing, A.T., Department of Urology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hakim, L., Department of Urology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Daryanto, B., Department of Urology, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Danarto, H.R., Department of Urology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Umbas, R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
This project aimed to assess the Online National Board of Urology Objective Structured Clinical Examination (OSCE) feasibility in evaluating candidates simultaneously from five urology training centers in Indonesia during the COVID-19 pandemic. Data were collected from two online OSCE simulation trials and the Online National Board of Urology OSCE. A self-administered questionnaire was used to assess examiners and candidates’ perception. The average final score of the Online OSCE was compared to previous face-to-face OSCE results. All candidates and examiners (100%) heard and saw clearly the audio-visual in both OSCE simulation trials. None of the candidates had a failing score on the mock exam from all stations. There was a statistically significant difference between the online OSCE and December 2019 face-to-face OSCE. The Online National Board Urology OSCE was feasible and comparable to face-to-face OSCE in evaluating urology candidates. It may be beneficial for the future OSCE method in the medical education system. • Objective Structured Clinical Examination (OSCE) which assesses a broad range of urology candidates’ high-level clinical skills, is a more valid and reliable assessment instrument than the traditional oral examination • The Online National Board of Urology OSCE method can help evaluate urology candidates, especially during the unprecedented COVID-19 pandemic © 2021 |
COVID-19 Pandemic; Online Examination; Online National Board Examination; Online National Board of Urology Objective Structured Clinical Examination (OSCE); OSCE method; Urology Examination |
academic failure; Article; audiovisual aid; clinical examination; coronavirus disease 2019; e-learning; feasibility study; human; Indonesia; medical education; objective structured clinical examination; pandemic; priority journal; resident; simulation; urology |
Elsevier B.V. |
22150161 |
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Article |
Q2 |
356 |
13209 |
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841 |
Wijaya D.A., Louisa M., Wibowo H., Taslim A., Permata T.B.M., Handoko, Nuryadi E., Kodrat H., Gondhowiardjo S.A. |
57222657856;41461551400;57217690943;57222661883;57197808751;57209984822;57197806814;57210639849;6508327402; |
The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review |
2021 |
Journal of HerbMed Pharmacology |
10 |
2 |
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166 |
178 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103633859&doi=10.34172%2fjhp.2021.18&partnerID=40&md5=810428f36d6d7326990b348f1d1a958a |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Wijaya, D.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Wibowo, H., Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Taslim, A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent. © 2021 Nickan Research Institute. All rights reserved. |
Annona muricata; Bioactive compounds; Plant extract; Radio-sensitivity; Radiotherapy |
acetogenin; Annona muricata extract; annonacin; apoptosome; caspase 9; curcumin; cyclin D1; cyclin D2; death domain receptor signaling adaptor protein; Fas ligand; glucose transporter 4; glycogen synthase kinase; hypoxia inducible factor 1alpha; immunoglobulin light chain; interleukin 13; lactate dehydrogenase; mammalian target of rapamycin; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphatidylserine; procaspase 3; protein Bax; protein bcl 2; protein mcl 1; protein p105; protein p50; protein p53; radiosensitizing agent; reactive oxygen metabolite; STAT3 protein; stress activated protein kinase; transcription factor RelA; transcription factor RelB; tumor necrosis factor; Annona muricata; apoptosis; B cell lymphoma; cell aging; |
Nickan Research Institute |
23455004 |
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Review |
Q3 |
341 |
13610 |
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842 |
Rahyussalim A.J., Marsetio A.F., Kamal A.F., Supriadi S., Setyadi I., Pribadi P.M., Mubarok W., Kurniawati T. |
55212166100;57192180884;56648996700;16040272500;57216397660;57194227346;57208440063;55213290600; |
Synthesis, Structural Characterization, Degradation Rate, and Biocompatibility of Magnesium-Carbonate Apatite (Mg-Co3Ap) Composite and Its Potential as Biodegradable Orthopaedic Implant Base Material |
2021 |
Journal of Nanomaterials |
2021 |
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6615614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103563575&doi=10.1155%2f2021%2f6615614&partnerID=40&md5=071473665891e53e20135fe57fd742de |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Marsetio, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Kamal, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Setyadi, I., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Pribadi, P.M., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Mubarok, W., Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Kurniawati, T., Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Suitable biomechanical properties with a degradation rate parallel to normal bone healing time are vital characteristics for biodegradable implant material in orthopaedics. Magnesium (Mg) is a natural micronutrient as well as biodegradable metal with biomechanical characteristics close to that of the human bone, while carbonate apatite (CO3Ap) is a biological apatite with good osteoconductivity which allows bone healing without forming fibrotic tissue. We fabricated a Mg-CO3Ap composite with various content ratios by powder metallurgy, various milling times (3, 5, and 7 hours) at 200 RPM, warm compaction at 300°C and pressure of 265 MPa, sintering at 550°C, holding time of 1 hour, heating rate of 5°C/minutes, and room atmosphere cooling. Specimens were successfully created and had a density comparable to that of the human bone (1.95-2.13 g/cm3). Good biocompatibility was found on Mg-10% CO3Ap composite (66.67% of viable cells). Nevertheless, its biomechanical properties and corrosion resistance were inferior to the human bone. Additionally, the materials of the composites make the surrounding environment alkaline. Interparticle consolidation and grain size were dissatisfactory due to microstructural pores presumably formed by the Mg(OH)2 layer and oxidation process during sintering. However, alkaline condition caused by the material corrosion by-product might be beneficial for bone healing and wound healing process. Modifications on fabrication parameters are needed to improve interparticle consolidation, refine grain size, improve biomechanical strength, reduce corrosion products, and improve the degradation rate. © 2021 Ahmad Jabir Rahyussalim et al. |
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Apatite; Biocompatibility; Biomechanics; Composite structures; Corrosion resistance; Degradation; Grain size and shape; Orthopedics; Powder metallurgy; Sintering; Tissue regeneration; Biodegradable implants; Biomechanical characteristics; Biomechanical properties; Fabrication parameters; Magnesium carbonate apatites; Structural characterization; Surrounding environment; Wound healing process; Magnesium metallurgy |
Hindawi Limited |
16874110 |
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Article |
Q2 |
463 |
10759 |
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843 |
Nelson B., Sitohang I.B.S., Marissa M., Indriatmi W., Wisnu W. |
57222619613;56734569200;57210795916;57189888041;57200425452; |
A comparative study of melasma severity after hyperthyroid therapy in hyperthyroid subjects with melasma |
2021 |
Acta Dermatovenerologica Alpina, Pannonica et Adriatica |
30 |
1 |
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31 |
34 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103497112&doi=10.15570%2factaapa.2021.7&partnerID=40&md5=12823fac55643be95fa3cbe943888df6 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Metabolic Endocrine Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Nelson, B., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wisnu, W., Metabolic Endocrine Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Melasma, and its variant chloasma, is an acquired and chronic disorder of hyperpigmentation, characterized by symmetrical hypermelanoses of the face. The exact pathogenesis of melasma remains unclear. Several hormones are thought to play a role, including thyroid hormones. The study’s objectives are to determine the proportion of melasma cases in hyperthyroid patients and to compare the severity of melasma before and after medications of hyperthyroid therapy. Methods: A quasi-experimental (pre-post intervention) study was conducted in Jakarta from August 2019 to February 2020. Twenty-three patients either newly diagnosed with hyperthyroidism or that had undergone hyperthyroid therapy for a maximum of 3 months and also had melasma were recruited. The severity of melasma was scored with the modified Melasma Area and Severity Index (mMASI), and dermoscopy of the lesions was performed. The evaluation was performed after 3 months of hyperthyroid therapy. Results: Among the 69 hyperthyroid patients, 45 (65%) had melasma. The mean difference in the mMASI score was 0.49 (p > 0.05). Dermoscopy features did not show any differences between the start and end of the study. Conclusions: There is no significant improvement of melasma severity in hyperthyroid patients after 3 months of hyperthyroid therapy. © 2021, Slovene Medical Society. All rights reserved. |
Chloasma; Hyperthyroid; Melasma; MMASI |
retinol derivative; thiamazole; thyrotropin; adult; anticonvulsant therapy; Article; chloasma; clinical article; clinical examination; comparative study; disease severity; disease severity assessment; epiluminescence microscopy; euthyroidism; female; free thyroxine index; hormonal contraception; hormone substitution; human; hyperpigmentation; hyperthyroidism; melasma area and severity index; prospective study; scoring system; skin defect; telangiectasia; thyroid function; thyroxine blood level; face; hyperthyroidism; melanosis; treatment outcome; Face; Humans; Hyperthyroidism; Melanosis; Treatment Outcome |
Slovene Medical Society |
13184458 |
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33765755 |
Article |
#N/A |
#N/A |
#N/A |
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844 |
Prihadi J.C., Putra A.C., Wahyudi Y. |
57204771911;36999310900;57215779247; |
Biopsy-confirmed genitourinary tuberculosis in a secondary health care hospital: An evidence-based clinical review |
2021 |
Research and Reports in Urology |
13 |
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133 |
137 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103294921&doi=10.2147%2fRRU.S286899&partnerID=40&md5=762300ffc5d15b605c193bb496ee96d9 |
Department of Surgery, Urology Division, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jakarta, Indonesia; Department of Urology, St. Carolus Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, St. Carolus Hospital, Jakarta, Indonesia |
Prihadi, J.C., Department of Surgery, Urology Division, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jakarta, Indonesia, Department of Urology, St. Carolus Hospital, Jakarta, Indonesia; Putra, A.C., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, St. Carolus Hospital, Jakarta, Indonesia; Wahyudi, Y., Department of Urology, St. Carolus Hospital, Jakarta, Indonesia |
Introduction: Tuberculosis (TB) is a worldwide disease and remains a major public health problem in developing countries, with 95% of cases occurring in developing countries, including Indonesia. It is caused by Mycobacterium tuberculosis, an acid-fast aerobic bacillus. When M. tuberculosis infects other than lung, it is called extrapulmonary tuberculosis (EPTB). Among other organs, genitourinary tuberculosis (GUTB) is responsible for 30– 40% of all EPTB cases. Methods: The study was conducted in a secondary health-care hospital in central Jakarta over a five-year period. We took data from hospital’s medical records and collected all the positive histopathological reports on biopsied tissue of the genitourinary tract from 2014– 2019. Results: Eleven patients showed positive histopathological results for TB on their biopsied genitourinary tissue. The genitourinary tracts involved were as follows: Prostate (n=2), kidney (n=1), ureter (n=2), epididymis (n=1), epididymo-orchitis (n=1), bladder (n=4). All of them presented with specific genitourinary symptoms, such as lower urinary tract symptoms (LUTS) (n=8), dysuria (n=9), urinary retention (n=2), flank pain (n=6), and incontinence (n=1). Nine of 11 patients (81.8%) exhibited systemic manifestations, with fever being the most common (n=8), followed by malaise (n=6), dyspepsia syndrome (n= 4), and weight loss (n=3). Discussion: Consistent with other studies, our research found that the prevalence of GUTB is substantially decreased with advancing age. Kidney is the most common site infected in GUTB infection. GUTB is easily overlooked, because its signs and symptoms are usually typical of a conventional bacterial cystitis. Conclusion: Because of its insidious nature and late-onset symptoms, diagnosis of GUTB is often late to approach, leading to higher morbidity and even mortality rate. This leads into further complications of the disease, which are largely preventable by a correct and timely diagnosis followed by appropriate therapy. © 2021 Prihadi et al. |
Extrapulmonary; Genitourinary; Tuberculosis |
albumin; esterase; abscess; adult; anemia; Article; bladder; body weight loss; clinical article; computer assisted tomography; cystitis; dyspepsia; dysuria; echography; electrolyte disturbance; epididymis; extrapulmonary tuberculosis; female; fever; flank pain; hematuria; histopathology; human; human tissue; hydrocele; hydronephrosis; hydroureter; incontinence; kidney; kidney failure; leukocytosis; leukocyturia; lower urinary tract symptom; malaise; male; morbidity; mortality rate; Mycobacterium tuberculosis; nephrolithiasis; orchitis; prevalence; prostate; proteinuria; public health; pyuria; retrospective study; secondary health care; ureter; urinalysis; urine retention; urogenital tuberculosis |
Dove Medical Press Ltd |
22532447 |
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Article |
Q2 |
506 |
9983 |
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845 |
Aggarwal B., Jones P.W., Yunus F., Lan L.T.T., Boonsawat W., Ismaila A., Ascioglu S. |
23007797900;26121204500;57194486277;55570089700;35608231000;15127439100;57222578443; |
Direct healthcare costs associated with management of asthma: comparison of two treatment regimens in Indonesia, Thailand and Vietnam |
2021 |
Journal of Asthma |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103248190&doi=10.1080%2f02770903.2021.1903915&partnerID=40&md5=24168d049c94d08b0ab06a00763e2d22 |
Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom; Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Value Evidence and Outcomes, GSK, Collegeville, PA, United States; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Clinical Sciences R&D, GSK, Singapore, Singapore |
Aggarwal, B., Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Jones, P.W., Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom, Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Lan, L.T.T., Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Boonsawat, W., Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Ismaila, A., Value Evidence and Outcomes, GSK, Collegeville, PA, United States, Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Ascioglu, S., Clinical Sciences R&D, GSK, Singapore, Singapore |
Objective: Daily inhaled corticosteroid (ICS) and long-acting beta-2-agonist (LABA) combinations comprising either regular maintenance therapy with ICS/LABA plus as-needed short-acting beta-2-agonist (SABA) or ICS-formoterol combinations used as maintenance and reliever therapy (MART) are recommended for moderate asthma. This analysis compares the direct costs of twice-daily fluticasone propionate/salmeterol (FP/salm) and budesonide/formoterol MART in three Southeast Asian countries. Methods: A literature review identified three randomized trials in patients with asthma (≥ 12 years) comparing regular twice-daily FP/salm with as-needed SABA versus MART in moderate asthma: AHEAD (NCT00242775/17 countries/2309 patients), COMPASS (AstraZeneca study SD-039-0735/16 countries/3335 patients), and COSMOS (AstraZeneca study SD-039-0691/16 countries/2143 patients). Economic analyses, conducted from a healthcare sector perspective (medication costs + healthcare utilization costs), applied unit costs from countries where healthcare costs are publicly available: Indonesia, Thailand and Vietnam. Results are expressed in British pound sterling (GBP/patient/year). Results: Annual exacerbation rates were low and differences between treatment strategies were small (range, FP/salm: 0.31–0.38, MART: 0.24–0.25) although statistically significant in favor of MART. Total average (minimum-maximum) direct costs (in GBP/patient/year) across the three studies were £187 (£137–£284), £158 (£125–£190), and £151 (£141–£164) for those who used FP/salm, and £242 (£217–£267), £284 (£237–£340) and £266 (£224–£315) for MART in Indonesia, Thailand and Vietnam, respectively. On average, total direct costs/patient/year with FP/salm were 22.8%, 44.6% and 43.0% lower than with MART for Indonesia, Thailand and Vietnam, respectively. Conclusions: In the three countries evaluated, total treatment costs with regular twice-daily FP/salm were consistently lower than with budesonide/formoterol MART due to lower direct healthcare costs. © 2021 GlaxoSmithKline. Published with license by Taylor & Francis Group, LLC. |
healthcare utilization; ICS/LABA; maintenance therapy; medication; Southeast Asia |
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Taylor and Francis Ltd. |
02770903 |
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Article |
Q2 |
687 |
7267 |
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846 |
Sitohang I.B.S. |
56734569200; |
Isotretinoin for treating acne vulgaris |
2021 |
International Journal of Applied Pharmaceutics |
13 |
2 |
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20 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103244010&doi=10.22159%2fijap.2021v13i2.40045&partnerID=40&md5=d324facccc1fd7db650538b96ff62380 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Acne vulgaris (AV) occurs in more than 80% of dermatological cases in adolescents and young adults and affects the quality of life. Oral isotretinoin, a metabolite product of vitamin A, is well-known to be the most effective treatment for severe nodulocystic AV and moderate AV that does not respond to other therapeutic modalities. Thus, this literature review was conducted to explain the mechanism of action, effectiveness, contraindications, side effects, and safety of oral isotretinoin in AV, which provided essential information for dermatologists. Furthermore, isotretinoin is the only treatment modality that has implications for the entire pathogenesis of acne. It contributes to decreasing corneocytes’ adhesion, supporting cellular proliferation and follicular renewal, induction of cell apoptosis, and immune regulation. The effectiveness of AV therapy with isotretinoin has expanded as it is also indicated for moderate to severe AV that does not respond well to topical combination therapy or systemic antibiotics. However, isotretinoin is included in Category X drugs and may induce many side effects from mucocutaneous effects to teratogenicity. From this extensive literature review, it can be concluded that isotretinoin is one of the treatment modalities for acne with good effectivity due to its mechanism of actions that affect the entire acne pathogenesis. Considering the various side effects of isotretinoin, its use requires adequate clinical assessment and monitoring by a dermatologist. © 2021 The Authors. |
Acne vulgaris; Contraindications; Effectiveness; Isotretinoin; Safety; Side effects |
antibiotic agent; isotretinoin; retinoic acid; acne vulgaris; algorithm; apoptosis; cell proliferation; cheilitis; clinical assessment; dermatologist; eczema; epistaxis; eye disease; fatigue; half life time; headache; human; immunoregulation; infection; minimum concentration; pathogenesis; pharmacokinetic parameters; prevalence; Review; skin fragility; teratogenicity |
Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Review |
Q3 |
238 |
17272 |
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847 |
Atmosudigdo I.S., Lim M.A., Radi B., Henrina J., Yonas E., Vania R., Pranata R. |
57222578186;57216039756;6603494019;57218482646;57201987097;57208328436;57201973901; |
Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression |
2021 |
Clinical Medicine Insights: Endocrinology and Diabetes |
14 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103239096&doi=10.1177%2f1179551421990675&partnerID=40&md5=f2529886c6cb74cf353635e1abd100c3 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia |
Atmosudigdo, I.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Radi, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association. Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study’s main outcome is a poor composite outcome, comprising of mortality and severe COVID-19. Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P =.010; I2: 56.7%, P =.018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P =.008; I2: 57.4%, P =.029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: −0.04, P =.033), male gender (coefficient: −0.03, P =.042), and hypertension (coefficient: −0.02, P =.033), but not diabetes (coefficient: −0.24, P =.135) and cardiovascular diseases (coefficient: −0.01, P =.506). Inverted funnel-plot was relatively symmetrical. Egger’s test indicates that the pooled analysis was not statistically significant for small-study effects (P =.206). Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension. PROSPERO Registration Number: CRD42020213491 © The Author(s) 2021. |
coronavirus; COVID-19; dyslipidemia; hyperlipidemia; prognosis |
Article; comorbidity; coronavirus disease 2019; diabetes mellitus; disease association; disease severity; dyslipidemia; human; hypertension; infection risk; mortality; prevalence; prognosis; risk assessment; systematic review |
SAGE Publications Ltd |
11795514 |
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Article |
Q3 |
527 |
9598 |
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848 |
Gunardi E.R., Susilo S.A. |
57192910998;57191052854; |
Menstrual Pattern and Characteristics of One-Rod and Two-Rod Levonorgestrel Implant Users |
2021 |
Obstetrics and Gynecology International |
2021 |
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2904542 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103051337&doi=10.1155%2f2021%2f2904542&partnerID=40&md5=9c88e8c5346ee41a0b8def57849e05c1 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia; Susilo, S.A., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Introduction. The maternal mortality ratio (MMR) in Indonesia reaches 359 per 100,000 live births. The long-acting reversible contraceptive (LARC) method is an effective contraceptive choice for reducing MMR. The contraceptive implant is one of the LARCs that has low usage due to lack of education about the side effects. This study aims to compare the menstrual pattern and characteristics between one-rod and two-rod levonorgestrel implant users. Methods. A prospective cohort study was performed in patients at Cipto Mangunkusumo Hospital (RSCM) from March 2016 to May 2018. Subject recruitment was done by consecutive sampling. This study was conducted from March 2016 until May 2019. Statistical analysis was performed on the data using the chi-square test to determine the relationship between menstrual pattern and characteristics, and the use of one-rod or two-rod levonorgestrel implants. Results. A total of 140 subjects participated in the study, comprising 70 (50%) one-rod users and 70 (50%) two-rod users. In the first month, 32.9% one-rod users experienced amenorrhea, 22.9% experienced shortened menstrual period, 30% experienced normal menstrual period, and 14,2 % experienced lengthened menstrual period. In comparison, in the first month, 41.4% two-rod users experienced amenorrhea, 15.7% experienced shortened menstrual period, 32.9% experienced normal menstrual period, and 10% experienced lengthened menstrual period. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Conclusion. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Implications. Menstrual patterns and characteristics from levonorgestrel implants user can help clinicians to reduce discontinuation rate from the acceptors. Further research should be conducted to know other side effects aside from menstrual bleeding patterns. © 2021 Eka Rusdianto Gunardi and Sulaeman Andrianto Susilo. |
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injectable contraceptive agent; levonorgestrel; oral contraceptive agent; adult; amenorrhea; Article; body mass; breast feeding; cohort analysis; comparative study; controlled study; data analysis software; female; human; long-acting reversible contraception; major clinical study; menstrual cycle; menstruation; obesity; prospective study; underweight |
Hindawi Limited |
16879589 |
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Article |
Q2 |
648 |
7760 |
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849 |
Pontoh L.A.P., Rahyussalim A.J., Widodo W., Fiolin J., Rhatomy S. |
57192907426;55212166100;57208941551;57194498274;57204509883; |
Anthropometric study as a predictor of anterior cruciate ligament sizes in Asian Indonesian population |
2021 |
Journal of Orthopaedic Surgery |
29 |
1 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102931782&doi=10.1177%2f23094990211000462&partnerID=40&md5=115eb91e8582294904d6485d349881e8 |
Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Pondok Indah General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Dr Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Pontoh, L.A.P., Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahyussalim, A.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widodo, W., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Fiolin, J., Department of Orthopaedics and Traumatology, Pondok Indah General Hospital, Jakarta, Indonesia; Rhatomy, S., Department of Orthopaedics and Traumatology, Dr Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Objectives: To evaluate whether anthropometric data can predict anterior cruciate ligament (ACL) sizes on magneti resonance imaging (MRI) in Asian population. Background: Reconstruction of ACL has been performed over a decade ago. Recently, more individualized ACL reconstruction is performed taking account of each patient’s ACL characteristics. However, there has been limited study regarding ACL sizes in Asian Indonesian population. This study aimed to evaluate the role of anthropometric data in ACL sizes using MRI in Asian Indonesian population. Study Design: Retrospective Study. Method: A series of 531 knees from 420 patients with knee pain and intact ACL confirmed by MRI study. Length, width and inclination angle of ACL were measured using a T2-weighted sagittal MRI 3.0 Tesla Magnetom Skyra. Height, weight, body mass index (BMI) and age were recorded. Multiple regression analysis was used to determine relationship between the anthropometric data and size of ACL measurements. Result: ACL length and width were significantly different between male and female, consecutively. Mean ACL length was 35.36 ± 3.63 mm, male was significantly longer (36.59 ± 3.24 mm) compared to female (32.77 ± 2.99 mm), p < 0.0001. Mean ACL width was 10.23 ± 1.84 mm, male was significantly wider (10.85 ± 1.59 mm) compared to female (8.93 ± 1.64 mm), p < 0.0001. The mean ACL inclination angle was 47.75° ± 3.07° (range 40.17°–57.12°). The strongest correlation for ACL length was height and weight (r = 0.437; r = 0.341 consecutively, p < 0.0001). Females had stronger correlation compared to males for ACL length (R2 = 0.489 vs R2 = 0.418). ACL width showed weak correlation with anthropometric data. The following regression analysis equation was obtained for ACL length: ACL length = 60.697 − 0.11*age + 0.461*weight (kg) − 16.522*height (meter) − 1.093*BMI (R2 = 0.539; p < 0.0001). Conclusion: Anthropometric data can be utilized as a predictor of ACL length in Asian Indonesian population. The ACL length in Asian Indonesian population is shorter than that in Western population study. © The Author(s) 2021. |
ACL sizes; anthropometric data; Asian population; magnetic resonance imaging |
adult; anterior cruciate ligament; anthropometry; Article; body height; body mass; body weight; clinical evaluation; female; human; Indonesian; knee pain; major clinical study; male; nuclear magnetic resonance imaging; population research; prediction; retrospective study; sex difference; adolescent; anatomy and histology; anterior cruciate ligament; Asian continental ancestry group; diagnostic imaging; epidemiology; Indonesia; knee; morphometry; organ size; pathology; procedures; young adult; Adolescent; Adult; Anterior Cruciate Ligament; Asian Continental Ancestry Group; Body Mass Index; Body Weights and Measures; Female; Humans; Indonesia; Knee; Knee Joint; Magnetic Resonance Imaging; Male; Organ Size; Retrospective Studies; Young Adult |
SAGE Publications Ltd |
10225536 |
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33745362 |
Article |
Q3 |
457 |
10873 |
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