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No records
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559 |
Kesuma Y., Sekartini R., Timan I.S., Kurniawan A., Bardosono S., Firmansyah A., Vandenplas Y. |
57209278648;57224503576;6602793366;6506883360;21933841000;6602915502;57223670656; |
Irritable bowel syndrome in Indonesian adolescents |
2021 |
Jornal de Pediatria |
97 |
2 |
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197 |
203 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081734309&doi=10.1016%2fj.jped.2020.02.001&partnerID=40&md5=b8d2dcd5c96832dce29f4c05c71dd219 |
Sriwijaya University and Moh Hoesin Hospital, Faculty of Medicine, Department of Pediatrics, Palembang, Indonesia; University of Indonesia and Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Pediatrics, Jakarta, Indonesia; University of Indonesia Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Clinical Pathology, Jakarta, Indonesia; University of Indonesia, Faculty of Medicine, Department of Parasitology, Jakarta, Indonesia; University of Indonesia, Faculty of Medicine, Department of Nutrition, Jakarta, Indonesia; Free University of Brussels, UZ Brussel Hospital, KidZ Health Castle, Brussels, Belgium |
Kesuma, Y., Sriwijaya University and Moh Hoesin Hospital, Faculty of Medicine, Department of Pediatrics, Palembang, Indonesia; Sekartini, R., University of Indonesia and Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Pediatrics, Jakarta, Indonesia; Timan, I.S., University of Indonesia Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Clinical Pathology, Jakarta, Indonesia; Kurniawan, A., University of Indonesia, Faculty of Medicine, Department of Parasitology, Jakarta, Indonesia, University of Indonesia, Faculty of Medicine, Department of Nutrition, Jakarta, Indonesia; Bardosono, S., University of Indonesia, Faculty of Medicine, Department of Nutrition, Jakarta, Indonesia; Firmansyah, A., University of Indonesia and Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Pediatrics, Jakarta, Indonesia; Vandenplas, Y., Free University of Brussels, UZ Brussel Hospital, KidZ Health Castle, Brussels, Belgium |
Objective: Irritable bowel syndrome is a frequent functional gastrointestinal disorder. The aims of this study were to investigate its epidemiology, focusing on the role of intestinal mucosal integrity and to evaluate the impact on the quality of life. Methods: A community-based survey applying a comparative cross sectional approach was conducted in six high schools in Palembang. Subjects were recruited using multistage random sampling divided in two groups. Rome III criteria were used to establish a diagnosis of IBS in combination with a questionnaire to determine risk factors. Determination of fecal alpha-1-antitrypsin and calprotectin levels was performed to determine impaired intestinal mucosal integrity. A questionnaire was used to evaluate how quality of life was affected by irritable bowel syndrome. Results: The survey was performed in 454 14−18 years old adolescents, of whom 30.2% fulfilled the Rome III criteria for IBS, with the following subtypes: 36.5% diarrhea, 18.9% constipation, 21.9% mixed, and 22.6% unclassified. Major risk factors were female gender, bullying, age 14–16 years, history of constipation and diarrhea, eating nuts, and drinking coffee, tea, and soft drinks. There was a significant association with intestinal inflammation (p = 0.013). A significantly impaired quality of life was found (p = 0.001). Conclusions: The prevalence of irritable bowel syndrome in adolescents was high, with bullying, female gender, age 14–16 years, constipation and diarrhea, and dietary consumption of soft drinks, coffee, and tea as risk factors. A significant association with intestinal inflammation was found. © 2020 Sociedade Brasileira de Pediatria |
Adolescent; Intestinal integrity; Irritable bowel syndrome; Quality of life |
alpha 1 antitrypsin; calgranulin; adolescent; adult; age; Article; avoidance behavior; body image; bullying; clinical evaluation; coffee consumption; comparative study; constipation; controlled study; cross-sectional study; data analysis software; diarrhea; digestive system disease assessment; disease association; dysphoria; enteritis; feces level; female; gender; high school; human; human activities; human relation; Indonesia; Indonesian; intestine mucosa; Irritable Bowel Syndrome Quality of Life questionnaire; irritable colon; major clinical study; male; nut; patient worry; pediatric patient; prevalence; quality of life; quality of life assessment; risk factor; Rome III criteria; sexual behavior; social behavior; soft drink; tea consumption; constipation; irritable colon; questionnaire; |
Elsevier Editora Ltda |
00217557 |
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32156535 |
Article |
Q2 |
645 |
7804 |
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No records
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652 |
Indarti J., Ria S., Maulina F., Andardi B., Octavianti J., Santawi V.P.A. |
39161587400;57366269400;57365981600;57219905485;57365684400;57192917419; |
Maternal and Perinatal outcomes in pregnancies affected by maternal cardiovascular disease |
2021 |
Journal of Reproductive Medicine |
66 |
9-10 |
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298 |
302 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120797893&partnerID=40&md5=15870fc71073943a029b179358e65364 |
Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Indarti, J., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ria, S., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Maulina, F., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Andardi, B., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Octavianti, J., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Santawi, V.P.A., Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
OBJECTIVE: To investigate the incidence, profile, and maternal and perinatal outcomes in pregnancies affected by maternal cardiovascular disease. STUDY DESIGN: We performed a retrospective data collection from the database of pregnancies in which the mother had cardiovascular disease. Maternal age, parity, gestational age at delivery, type of cardiovascular disease, subsequent contraceptive method, mode of delivery, intensive care unit (ICU) admission, maternal death, APGAR scores, presence of acidosis, neonatal ICU (NICU) admission, and perinatal death were investigated. Medical records with incomplete variables were excluded. We obtained 70 cases of pregnant women with cardiovascular disease from 2014 to 2018 who were admitted to Cipto Mangunkusumo National Hospital. RESULTS: Out of 70 cases, 60% were acquired heart disease, while 40% were congenital heart disease. It was found that 74.3% of the pregnancies had preterm birth, and the cesarean section rate was 72.9%. While the ICU admission rate was 52.9%, the maternal mortality rate remained at 7.1%. We found that 11.4% of neonates suffered asphyxia, with a 5.0% rate of NICU admissions. CONCLUSION: This study shows that preterm delivery might be indicated in pregnancies affected by maternal cardiovascular disease to prevent maternal mortality at the expense of neonatal outcomes. © Journal of Reproductive Medicine Inc. |
Cardiovascular disease; Heart disease; Maternal and neonatal outcome; Maternal outcomes; Pregnancy; Pregnancy complications |
acidosis; adult; Apgar score; Article; asphyxia; cardiovascular disease; cesarean section; congenital heart disease; contraception; cross-sectional study; female; fetus; fetus death; gestational age; heart rate; hospital admission; hospital discharge; human; hypertension; intensive care unit; major clinical study; maternal age; maternal death; maternal hypertension; maternal mortality; maternal outcome; multicenter study; neonatal intensive care unit; newborn; parity; perinatal death; perinatal outcome; pregnancy complication; pregnancy outcome; pregnant woman; premature fetus membrane rupture; premature labor; prematurity; puerperium; retrospective study; vaginal delivery |
Journal of Reproductive Medicine, Inc. |
00247758 |
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Article |
#N/A |
#N/A |
#N/A |
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No records
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83 |
Triwidodo A., Rahyussalim A.J., Yulisa N.D., Pandelaki J., Huraiby L.S., Hadi I.A.N., Liosha F.Y., Dilogo I.H. |
57222626174;55212166100;57191033188;35759266900;57410470800;57345259600;57195941059;56161962800; |
Sacrum morphometry and spinopelvic parameters among the Indonesian population using computed tomography scans |
2021 |
Medicine (United States) |
100 |
47 |
e27955 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122758150&doi=10.1097%2fMD.0000000000027955&partnerID=40&md5=fcef27e030576bfa693c1f9a81c6abd9 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Triwidodo, A., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yulisa, N.D., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Huraiby, L.S., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hadi, I.A.N., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Liosha, F.Y., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
This is a cross-sectional study. This study aims to describe the characteristics of sacrum vertebrae and spinopelvic parameters among the Indonesian population and compare them with studies from other populations. This study also intends to determine the sexual dimorphism of sacrum vertebrae and find the correlations between spinopelvic parameters. Morphometry of the sacrum is necessary for designing sacral prosthesis and instrumentations. Knowledge of spinopelvic parameters further supports the prosthesis installation procedure to restore the physiological spinal alignment of the patients. However, previous studies showed varied results among different populations. This is the first study to be conducted among the Indonesian population. Morphometric dimensions of sacrum vertebrae and the spinopelvic parameters (pelvic incidence, pelvic tilt, sacral slope, lumbar lordosis) were analyzed using thin-cut (1 mm) computed tomography images in 150 males and 150 females, aged 25 to 50 years without any spinal pathology. Generally, the size of the sacrum vertebrae was greater in males (P < .05). The sacral index, curvature index, and corporo-basal index were statistically different between genders (P < .001). Lumbar lordosis was the only spinopelvic parameter found significantly greater in females (P < .001). Significant positive correlations between all spinopelvic parameters, except for lumbar lordosis and pelvic tilt, were found in the present study (P < .001). The study serves as the first large series database of sacrum morphometric characteristics and spinopelvic parameters of the Indonesian population. There was significant gender-associated differences in various dimensions of sacrum vertebrae. The sacral index was found to be the most useful parameter for sex determination. There were strong significant positive correlations between various spinopelvic parameters. A comparison of populations revealed morphometric characteristic differences, which is proved to be critical in surgical implications. Copyright © 2021 the Author(s). |
Computed tomography scans; Indonesian population; Morphometry; Sacrum vertebrae; Spinopelvic parameters |
adult; cross-sectional study; diagnostic imaging; female; human; Indonesia; lumbar vertebra; male; middle aged; pelvis; sacrum; sexual characteristics; x-ray computed tomography; Adult; Cross-Sectional Studies; Female; Humans; Indonesia; Lumbar Vertebrae; Male; Middle Aged; Pelvis; Sacrum; Sex Characteristics; Tomography, X-Ray Computed |
Lippincott Williams and Wilkins |
00257974 |
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34964781 |
Article |
Q2 |
590 |
8573 |
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No records
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114 |
Andrianto, Al-Farabi M.J., Nugraha R.A., Marsudi B.A., Azmi Y. |
57221812919;57210466548;57200701510;57201975146;57200278939; |
Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis |
2021 |
Microvascular Research |
138 |
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104224 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111341102&doi=10.1016%2fj.mvr.2021.104224&partnerID=40&md5=d5cc3fe2a0d5a70658ecff8ad7fa6f8b |
Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia |
Andrianto, Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Al-Farabi, M.J., Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Nugraha, R.A., Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Marsudi, B.A., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azmi, Y., Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia |
Background: Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). To better understand the prognostic values of endothelial dysfunction in COVID-19-associated coagulopathy, we conducted a systematic review and meta-analysis to assess biomarkers of endothelial cells in patients with COVID-19. Methods: A literature search was conducted on online databases for observational studies evaluating biomarkers of endothelial dysfunction and composite poor outcomes in COVID-19 patients. Results: A total of 1187 patients from 17 studies were included in this analysis. The estimated pooled means for von Willebrand Factor (VWF) antigen levels in COVID-19 patients was higher compared to healthy control (306.42 [95% confidence interval (CI) 291.37–321.48], p < 0.001; I2:86%), with the highest VWF antigen levels was found in deceased COVID-19 patients (448.57 [95% CI 407.20–489.93], p < 0.001; I2:0%). Meta-analysis showed that higher plasma levels of VWF antigen, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 antigen (PAI-1) antigen, and soluble thrombomodulin (sTM) were associated with composite poor outcome in COVID-19 patients ([standardized mean difference (SMD) 0.74 [0.33–1.16], p < 0.001; I2:80.4%], [SMD 0.55 [0.19–0.92], p = 0.003; I2:6.4%], [SMD 0.33 [0.04–0.62], p = 0.025; I2:7.9%], and [SMD 0.55 [0.10–0.99], p = 0.015; I2:23.6%], respectively). Conclusion: The estimated pooled means show increased levels of VWF antigen in COVID-19 patients. Several biomarkers of endothelial dysfunction, including VFW antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19. PROSPERO registration number: CRD42021228821 © 2021 Elsevier Inc. |
COVID-19; Endothelial dysfunction; Plasminogen activator inhibitor-1; Thrombomodulin; Tissue-type plasminogen activator; von Willebrand Factor |
biological marker; plasminogen activator inhibitor 1; thrombomodulin; tissue plasminogen activator; von Willebrand factor; biological marker; plasminogen activator inhibitor 1; SERPINE1 protein, human; THBD protein, human; thrombomodulin; tissue plasminogen activator; von Willebrand factor; adult; aged; Article; clinical outcome; controlled study; coronavirus disease 2019; endothelial dysfunction; female; human; major clinical study; male; publication bias; systematic review; blood; diagnosis; meta analysis; metabolism; middle aged; pathophysiology; predictive value; prognosis; therapy; vascular endothelium; very elderly; Adult; Aged; Aged, 80 and over; Biomarkers; COVID-19; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Predictive Value of Tes |
Academic Press Inc. |
00262862 |
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34273359 |
Article |
Q2 |
819 |
5848 |
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No records
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523 |
Octaviana F., Bestari A., Loho A., Indrawati L., Wiratman W., Kurniawan M., Sugiarto A., Budikayanti A. |
26029958700;57223262097;57223264641;57205117182;57191920526;57196001182;57189612291;57194713932; |
Nonconvulsive Status Epilepticus in Metabolic Encephalopathy in Indonesia Referral Hospital |
2021 |
Neurology India |
69 |
2 |
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354 |
359 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105413010&doi=10.4103%2f0028-3886.314533&partnerID=40&md5=41f369c55e5b08a8b0bd905ac5493afd |
Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Octaviana, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bestari, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Loho, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Indrawati, L., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wiratman, W., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kurniawan, M., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Budikayanti, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Nonconvulsive status epilepticus (NCSE) is often underdiagnosed in patients with metabolic encephalopathy (ME). The diagnosis of ME should be made specifically to recognize the underlying etiology. Delay in seizure identification and making a diagnosis of NCSE contributed to the poor outcome. Objective: This study aimed to find the incidence and outcome of NCSE in patients with ME. Methods and Material: This was an observational prospective cross-sectional study in patients with ME in emergency and critical care units in Cipto Mangunkusumo General Hospital. The diagnosis of NCSE was based on EEG using Salzburg Criteria for Nonconvulsive Status Epilepticus (SCNC). The outcome was assessed within 30 days after the NCSE diagnosis has been made. Results: A total of 50 patients with ME were involved in this study. NCSE was confirmed in 32 subjects (64%). The most common etiology of ME was sepsis (58%). The mortality rate in the NCSE and non-NCSE group was 40.6% vs 44.4%. Multiple aetiologies were risk factors to poor outcome in the NCSE group. Conclusions: The incidence of NCSE among patients with ME at our hospital was high. Despite the anti-epileptic treatment of the NCSE group, the underlying cause of ME is still the main factor that affected the outcome. Therefore, aggressive treatment of anti-epileptic drug (AED) should be very carefully considered knowing the possible side-effect that might worsen the outcome of patients with ME. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Metabolic encephalopathy; mortality; non-convulsive status epilepticus |
diazepam; levetiracetam; midazolam; phenobarbital; phenytoin; propofol; valproic acid; adult; Article; clinical article; cross-sectional study; electroencephalography; epileptic state; female; human; incidence; Indonesia; male; metabolic encephalopathy; mortality rate; nonconvulsive status epilepticus; observational study; prognosis; risk factor; sepsis; epileptic state; hospital; metabolic encephalopathy; patient referral; prospective study; Brain Diseases, Metabolic; Cross-Sectional Studies; Electroencephalography; Hospitals; Humans; Indonesia; Prospective Studies; Referral and Consultation; Status Epilepticus |
Wolters Kluwer Medknow Publications |
00283886 |
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33904451 |
Article |
Q3 |
339 |
13675 |
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No records
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563 |
Arozal W., Diliana D., Wikanendra G.B., Purwantyastuti P., Rusli A. |
32067462200;57225946044;57204105059;57205722372;57225950729; |
Clinical characteristics of recurrent tuberculosis patients from a Jakarta hospital-based survey |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S58 |
S61 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109803544&partnerID=40&md5=629bb068125f26ed38057da8c963846e |
Department of Pharmacology and Therapeutics Faculty of Medicine Universitas Indonesia, Indonesia; Clinical Pharmacology Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacy, Sanata Dharma University, Jogyakarta, Indonesia; Infection Disease Hospital, Prof. Dr Sulianti Saroso, Jakarta, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics Faculty of Medicine Universitas Indonesia, Indonesia; Diliana, D., Clinical Pharmacology Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wikanendra, G.B., Department of Pharmacy, Sanata Dharma University, Jogyakarta, Indonesia; Purwantyastuti, P., Department of Pharmacology and Therapeutics Faculty of Medicine Universitas Indonesia, Indonesia; Rusli, A., Infection Disease Hospital, Prof. Dr Sulianti Saroso, Jakarta, Indonesia |
Objective: To analyse factors affecting the recurrence of TB in a tertiary hospital in Jakarta, Indonesia. Methods: This is a hospital-based survey, located in Jakarta, in the period of January 2014-December 2018. All patients with recurrent TB were included in the study, while the samples with successful treatment in the same period were chosen by consecutive sampling. Statistical analysis of clinical characteristics of both study groups was conducted. Results: The medical records of 2322 TB patients who presented to Sulianti Saroso Hospital were analysed retrospectively. Ninety-four cases of recurrent TB that met inclusion and exclusion criteria were included in the study. It was observed that factors affecting recurrence of TB were medication compliance (p = .007, odds ratio (OR) 0.38 [CI 95% 0.19-0.76]) and appearance of lung cavity lesions in the first thorax x-ray examination (p < .001, OR 0.08 [CI 95% 0.03-0.20]). Conclusion: There was a relationship between recurrent TB and medication compliance and the appearance of lung cavity lesions in the first thorax x-ray examination. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-58 [Suppl. 2]; 2021); Clinical characteristics; Recurrent tb; Tuberculosis |
ethambutol; isoniazid; tuberculostatic agent; adult; clinical feature; clinical outcome; Conference Paper; diabetes mellitus; female; human; incidence; lung cavity; lung compliance; major clinical study; male; medication compliance; nutritional status; prospective study; tertiary care center; thorax radiography; treatment duration; tuberculosis |
Pakistan Medical Association |
00309982 |
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Conference Paper |
Q4 |
242 |
17081 |
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565 |
Stefani S., Andayani D.E. |
57205176413;57222706544; |
Nutritional medical therapy in cachexia patient with oesophageal adenocarcinoma metastases on dexamethasone therapy: A case report |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S143 |
S145 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103746346&partnerID=40&md5=919fefbd8857fb0a86a2a2c0b96e5cf1 |
Department of Clinical Nutrition, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Stefani, S., Department of Clinical Nutrition, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Andayani, D.E., Department of Clinical Nutrition, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gastroesophageal adenocarcinomas have a high risk of brain metastases. Patients with oesophageal cancer often present with symptoms of gastrointestinal (GI) obstruction and bleeding. On the other hand, high-dose steroids are used to supress brain oedema in cases of brain tumour, resulting in a drastic rise in appetite. Parenteral nutrition appears to reduce the appetite of humans, so it can be used in palliative patients who receive hypocaloric food to combat hunger. A man, 53 years old with intracranial metastasis space-occupying lesions (SOL) from oesophageal adenocarcinoma and cachexia, received 3x10 mg dexamethasone followed by tapering. Acute upper GI bleeding occurred during hospitalisation; thus, enteral feeding was delayed, and intravenous feeding was otherwise given. After two weeks of hospitalisation, we found that there was a decrease in hunger, change in clinical condition, tolerance to food, and functional ability. © 2021 Pakistan Medical Association. All rights reserved. |
Brain neoplasm.; Cachexia; Nutrition; Oesophageal adenocarcinoma |
dexamethasone; adenocarcinoma; cachexia; case report; complication; esophagus tumor; human; male; middle aged; parenteral nutrition; Adenocarcinoma; Cachexia; Dexamethasone; Esophageal Neoplasms; Humans; Male; Middle Aged; Parenteral Nutrition |
Pakistan Medical Association |
00309982 |
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33785960 |
Conference Paper |
Q4 |
242 |
17081 |
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566 |
Hariyanto N.I., Purwandhita R.P., Syahrani R.A., Louisa M., Wanandi S.I. |
57222706851;57202377042;57204103147;41461551400;36099320700; |
Role of TGF-?1 in human breast cancer stem cells |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
|
S84 |
S89 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103745958&partnerID=40&md5=425118184fecd5818a6435ec48e67ad8 |
Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia; Department of Molecular Biology and Proteomics, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Universitas Indonesia, Jakarta, Indonesia; Department of BioChemistry and Molecular Biology, Universitas Indonesia, Jakarta, Indonesia |
Hariyanto, N.I., Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia; Purwandhita, R.P., Department of Molecular Biology and Proteomics, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Syahrani, R.A., Department of Pharmacology, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of BioChemistry and Molecular Biology, Universitas Indonesia, Jakarta, Indonesia; Wanandi, S.I., Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia |
Objective: To investigate the auto-induction of transforming growth factor-b1 (TGF-?1) in breast cancer stem cells (BCSCs) and its effect on cell viability and stemness. Methods: Human BCSCs (aldehyde dehydrogenase positive; ALDH+) were grown in serum-free Dulbecco's Modified Eagle Medium/Nutrient Mixture F12 (DMEM/F12) and treated for periods of 1, 2 and 4 hours with 0.1 ng/ml recombinant human TGF-?1 protein (rhTGF-?1). The medium was then replaced with serum-free DMEM/F12 without rhTGF-?1 for 24 hours. Cell viability was determined using a trypan blue exclusion assay. Type 1 TGF-? receptor (T?R1), TGF-?1, octamer-binding transcription factor 4 (OCT4) and aldehyde dehydrogenase 1 family member A1 (ALDH1A1) messenger RNA (mRNA) expression levels were analysed using quantitative real-Time reverse-Transcriptase polymerase chain reaction (RT-qPCR). The TGF-? protein level in the culture medium was determined using an enzyme-linked immunosorbent assay (ELISA). Results: The expression levels of rhTGF-?1, TGF-?1 and T?R1 mRNA significantly increased in BCSCs compared to control after treatment for 1 and 2 hours but decreased after 4 hours. This is in line with alteration of stemness gene, OCT4 and ALDH1A1 mRNA expressions. However, the secretion of newly synthesised TGF-?1 significantly increased after 2 hours. In contrast, viable BCSCs decreased after 1 hour and then gradually increased 2.7 times compared to control after 4 hours. Conclusion: TGF-?1 treatment in low concentration and for short period of time triggers its auto-induction in BCSCs, leading to increased cell viability and stemness gene expression via autocrine signalling. © 2021 Pakistan Medical Association. All rights reserved. |
Aldehyde Dehydrogenase. (JPMA 71: S-84 [Suppl. 2]; 2021); Breast Neoplasms; Neoplastic Stem Cells; Octamer Transcription Factor-3; Transforming Growth Factor beta1 |
transforming growth factor; transforming growth factor beta; transforming growth factor beta1; breast tumor; cancer stem cell; human; Breast Neoplasms; Humans; Neoplastic Stem Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factors |
Pakistan Medical Association |
00309982 |
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33785948 |
Conference Paper |
Q4 |
242 |
17081 |
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567 |
Damayanti R., Natsir M.P.W., Annisa I., Trianto D.M., Sungkar S., Friska D. |
57215770702;57225897287;57221960863;57222707452;57016857300;57202805330; |
Protein intake and number of children associated with nutritional status |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
|
S99 |
S102 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103744835&partnerID=40&md5=2bb449c2ed5baffb1b8a0c1b7d2261af |
Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Damayanti, R., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Natsir, M.P.W., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Annisa, I., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Trianto, D.M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sungkar, S., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: This study aimed to evaluate the association between protein intake and number of children in a family, based on nutritional status of children aged 2 to 12 years of age. Methods: This was a cross-sectional study with consecutive sampling. Weight and height were measured, and the 24-hour food recall was gathered with a questionnaire. Nutritional status was assessed using weight-for-Age curve of Centers for Disease Control and Prevention (CDC) growth chart. Protein intake was assessed using NutriSurvey. Data were analysed with chi-square test. Results: There were 99 children, 52 girls and 47 boys. From these, 57 (57.6%) were undernourished and 42 (42.4%) subjects had a good nutritional status. Sixty-five (65.6%) children had poor protein intake, while 34 (34.3%) had adequate protein intake. There was no association between protein intake and nutritional status (p = 0.805) or number of children in the family and nutritional status (p = 0.414). The principal protein source was squid, but squid is often sold for additional income. Conclusion: The nutritional status of children in Pero Konda Village could be considered undernourished. There was no association between protein intake and number of children based on nutritional status. The villagers had poor dietary habits, so good dietary habits should be promoted. © 2021 Pakistan Medical Association. All rights reserved. |
Children; Diet; Nutritional status. (JPMA 71: S-99 [Suppl. 2]; 2021); Protein intake |
body weight; caloric intake; child; cross-sectional study; diet; feeding behavior; female; human; income; male; nutritional status; preschool child; Body Weight; Child; Child, Preschool; Cross-Sectional Studies; Diet; Energy Intake; Feeding Behavior; Female; Humans; Income; Male; Nutritional Status |
Pakistan Medical Association |
00309982 |
|
33785951 |
Conference Paper |
Q4 |
242 |
17081 |
|
|
|
568 |
Manggala S.K., Aditianingsih D., Harijanto E. |
57190962171;56312263600;56059081200; |
Diaphragm function in post-upper abdominal surgery: High-flow nasal cannula (HFNC) versus nasal cannula a pilot study |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
|
S4 |
S9 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103683600&partnerID=40&md5=f3b1bfe03f068ac7f5f515249ea589e8 |
Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Manggala, S.K., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aditianingsih, D., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Harijanto, E., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Objective: This pilot study was performed to identify the differences between the effectiveness of HFNC and conventional oxygen therapy. Methods: This study was a part of a more extensive ongoing study in a tertiary care hospital from January to April 2019. Criteria for inclusion were adult patients scheduled for upper-Abdominal surgery. Patients were randomised into two groups: conventional oxygen therapy (n=10) and HFNC therapy (n=10). The differences in (clinical parameters;Mean Arterial Pressure (MAP), heart rate, respiratory rate), diaphragm thickening on ultrasound, air lung distribution on Electrical Impedance Tomography (EIT), and blood gas analysis data between both groups were assessed at specific times. Adverse events were recorded and treated during the study. The data collected was analysed using SPSS software version 23.0. Results: During the recuritment of patients, no issues were indentified in this study. Therefore, no clinical or statistical differences in EIT and ultrasound diaphragm thickening between the two groups were observed; no clinical or statistical differences in patterns in clinical parameters were found. The mean arterial PO2 was particulary different at time 1: 137.10 mmHg for patients in the conventional therapy group and 93.95 mmHg in the HFNC group (p = 0.001). A patient in the HFNC group reported a feeling of discomfort. Conclusion: The aim of this study was to observe differences between HFNC and conventional oxygen therapy. Nonetheless, more data are needed in order to achieve a conclusive result. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-4 [Suppl. 2]; 2021); Blood gas analysis; Electric impedance; Oxygen inhalation therapy; Tomography; Ultrasonography |
abdominal surgery; adult; arterial oxygen tension; blood gas analysis; breathing rate; computer assisted impedance tomography; conference paper; controlled study; data analysis software; diaphragm; echography; female; heart rate; high flow nasal cannula therapy; human; lung; major clinical study; male; mean arterial pressure; oxygen therapy; pilot study; randomized controlled trial; surgery; tertiary care center; cannula; diagnostic imaging; diaphragm; oxygen therapy; pilot study; respiratory failure; oxygen; Adult; Cannula; Diaphragm; Humans; Oxygen; Oxygen Inhalation Therapy; Pilot Projects; Respiratory Insufficiency |
Pakistan Medical Association |
00309982 |
|
33785933 |
Conference Paper |
Q4 |
242 |
17081 |
|
|
