No records
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240 |
Nathania M., Sunardi D. |
57245860300;57192075078; |
The importance of balanced nutrition to fortify the immune system during the covid-19 outbreak [La importancia de una nutrición equilibrada para aumentar el sistema inmunológico durante el brote de covid-19] |
2021 |
Revista Chilena de Nutricion |
48 |
4 |
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620 |
629 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114246311&doi=10.4067%2fS0717-75182021000400620&partnerID=40&md5=c999acae5c75b659b516d0fbb8b1815b |
Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
Nathania, M., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia; Sunardi, D., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
COVID-19, first reported in December 2019 in Wuhan, China, quickly spread worldwide and was announced as a pandemic in March 2020. As symptoms and outcomes are varied, the elderly and those who have at least one comorbidity (diabetes, cardiovascular disorders or other chronic diseases) are considered to be at high risk and are generally have lower immunity. An optimal immune system is critical for survival, as it protects the body against infectious agents. Nutrition is an essential factor in the immune system, contributing to components in physical barriers, biochemical, innate and adaptive immunity. Research advances show that nutritional deficiencies, namely the inadequacy of energy, macronutrients and micronutrients, affect the immune system and increase infection risk. The following discussion explains the comprehensive role of nutrition in the immune system, nutrition recommendations that can be used as precautions and the need for supplementation during this outbreak. © 2021, Sociedad Chilena de Nutricion Bromatologia y Toxilogica. All rights reserved. |
COVID-19; Immune; Nutrition; Pandemic; Supplementation |
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Sociedad Chilena de Nutricion Bromatologia y Toxilogica |
07177518 |
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Review |
Q4 |
182 |
20570 |
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242 |
Bintoro D.A., Nareswari I. |
57237633100;57194336586; |
The Role of Electroacupuncture in the Regulation of Appetite-Controlling Hormone and Inflammatory Response in Obesity |
2021 |
Medical Acupuncture |
33 |
4 |
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264 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113821541&doi=10.1089%2facu.2020.1500&partnerID=40&md5=b4a919cddf828d9f0978d90ea651ac42 |
Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Bintoro, D.A., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Objective: Obesity, a condition with serious complications, needs special attention. It is a complex and multifactorial problem and regulation of calorie balance involving various humoral and central factors is the main key for managing obesity. In addition, there is an increase in various proinflammatory cytokines and an increase in oxidative stress. There is a need to discover a useful therapy for obesity management. The goal of this review was to examine the literature on electroacupuncture (EA) as a potential therapy. Methods: This review explores the literature on EA, which has proven to be effective for inducing weight loss in experimental human and animal studies. Both continuous and dense-disperse EA waves have their own roles in hormone regulation of obesity using ST 25, CV 9, CV 12, CV 4, SP 6, ST 36, and ST 44; this is discussed the associated mechanism related to this is through suppression of various orexigenic peptides, enhancement of anorexigenic peptides, suppression of inflammatory factors, and improvement in the balance of pro-oxidants and antioxidants. Conclusions: The absence of another definitive therapy for obesity and EA's minimal side-effects make it a potential therapy for managing obesity. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
electroacupuncture; inflammation; obesity; oxidative stress |
ghrelin; acupuncture; appetite; body weight loss; electroacupuncture; food intake; human; inflammation; nonhuman; obesity; oxidative stress; pathophysiology; Review |
Mary Ann Liebert Inc. |
19336586 |
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Review |
Q2 |
281 |
15498 |
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243 |
Nareswari I., Lestari S.W., Notonegoro C. |
57194336586;55980501200;57224857889; |
Acupuncture Therapy for Severe Oligoasthenoteratozoospermia |
2021 |
Medical Acupuncture |
33 |
4 |
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302 |
305 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113775889&doi=10.1089%2facu.2020.1513&partnerID=40&md5=04fcbc629e9b71da58c0b69ee5116b7c |
Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Anna Hospital, Pekayon, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nareswari, I., Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Anna Hospital, Pekayon, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lestari, S.W., Anna Hospital, Pekayon, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Notonegoro, C., Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Infertility affects ∼15%-20% of couples. Of the 16.7% infertility rate reported based on Word Health Organisation questionnaire data, 6.4% of cases are associated with male factors. Male infertility can result from abnormal semen parameters; oligoasthenoteratozoospermia (OAT) is the most common diagnosis. Acupuncture is an ancient method that has been used for centuries to treat and prevent various conditions. In modern medicine, it is gaining popularity as a complementary infertility therapy. Case: A 41-year-old male presented to the Medical Acupuncture Department of Dr. Cipto Mangunkusumo Hospital (in Jakarta, Indonesia) because he wanted to have a child. His semen was analyzed, and he was diagnosed with severe OAT. Manual acupuncture therapy was performed at CV 3, CV 4, CV 5, CV 6, CV 7, ST 29, SP 6, SP 3, ST 36, and KI 3, alternating with KI 7 5 days per week and at LR 8 once per week, for a total of 28 sessions. Results: Semen analysis after 2 series of manual acupuncture treatments revealed improvement, especially in sperm motility, from 25% to 33% and then to 67% after the first and second serial therapies, respectively, changing the diagnosis from severe OAT to severe oligoteratozoospermia. Conclusions: Manual acupuncture combined with medication improves male fertility, especially sperm motility. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
Acupuncture; Male Infertility; Oligoasthenoteratozoospermia |
alpha tocopherol; ascorbic acid; beta carotene; clomifene citrate; glutathione; lycopene; mineral; selenium; ubidecarenone; zinc; acupuncture; acupuncture point; adult; Article; case report; clinical article; follow up; high fiber diet; human; Indonesia; male; male infertility; oligoasthenoteratozoospermia; semen analysis; spermatozoon motility; Tribulus terrestris |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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244 |
Djaali W. |
57212479564; |
How Do You Treat Non-Insulin Dependent Diabetes in Your Practice? |
2021 |
Medical Acupuncture |
33 |
4 |
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306 |
308 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113733355&doi=10.1089%2facu.2021.29182.cpl&partnerID=40&md5=d5215d516a5077a554bb640392817b63 |
Universitas Negeri Jakarta Jl. Rawamangun Muka East Jakarta, Jakarta, 13220, Indonesia; Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Central Jakarta, Jakarta, Indonesia |
Djaali, W., Universitas Negeri Jakarta Jl. Rawamangun Muka East Jakarta, Jakarta, 13220, Indonesia, Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Central Jakarta, Jakarta, Indonesia |
[No abstract available] |
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hemoglobin A1c; acupuncture; acupuncture point; adult; Article; case report; clinical article; evaluation study; evidence based practice; fatigue; glucose blood level; histology; human; male; middle aged; non insulin dependent diabetes mellitus; Research Diagnostic Criteria; signal transduction; somnolence; treatment planning |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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252 |
Reksodiputro M.H., Hutauruk S.M., Widodo D.W., Fardizza F., Mutia D. |
35090488800;57205105620;56644646600;55091031700;57221630137; |
Response to Letter by Spartalis et al: Platelet-Rich Fibrin in Total Laryngectomy: Further Study Concerns |
2021 |
Facial Plastic Surgery |
37 |
4 |
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551 |
552 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111071840&doi=10.1055%2fs-0041-1729637&partnerID=40&md5=8aeb911188e8d4c1c7a3fd0986d70915 |
Department of Otorhinolaryngology-Head and Neck Surgery, Plastic Reconstructive Division, Faculty of Medicine, University of Indonesia, Jl Diponegoro No 71, DKI Jakarta, Jakarta, 10413, Indonesia; Division of Plastic Reconstructive, Department of Otorhinolaryngology-Head and Neck Surgery, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia |
Reksodiputro, M.H., Department of Otorhinolaryngology-Head and Neck Surgery, Plastic Reconstructive Division, Faculty of Medicine, University of Indonesia, Jl Diponegoro No 71, DKI Jakarta, Jakarta, 10413, Indonesia, Division of Plastic Reconstructive, Department of Otorhinolaryngology-Head and Neck Surgery, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia; Hutauruk, S.M., Department of Otorhinolaryngology-Head and Neck Surgery, Plastic Reconstructive Division, Faculty of Medicine, University of Indonesia, Jl Diponegoro No 71, DKI Jakarta, Jakarta, 10413, Indonesia, Division of Plastic Reconstructive, Department of Otorhinolaryngology-Head and Neck Surgery, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia; Widodo, D.W., Department of Otorhinolaryngology-Head and Neck Surgery, Plastic Reconstructive Division, Faculty of Medicine, University of Indonesia, Jl Diponegoro No 71, DKI Jakarta, Jakarta, 10413, Indonesia, Division of Plastic Reconstructive, Department of Otorhinolaryngology-Head and Neck Surgery, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia; Fardizza, F., Department of Otorhinolaryngology-Head and Neck Surgery, Plastic Reconstructive Division, Faculty of Medicine, University of Indonesia, Jl Diponegoro No 71, DKI Jakarta, Jakarta, 10413, Indonesia, Division of Plastic Reconstructive, Department of Otorhinolaryngology-Head and Neck Surgery, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia; Mutia, D., Department of Otorhinolaryngology-Head and Neck Surgery, Plastic Reconstructive Division, Faculty of Medicine, University of Indonesia, Jl Diponegoro No 71, DKI Jakarta, Jakarta, 10413, Indonesia |
[No abstract available] |
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platelet-rich fibrin; human; laryngectomy; Humans; Laryngectomy; Platelet-Rich Fibrin |
Thieme Medical Publishers, Inc. |
07366825 |
|
34284502 |
Letter |
Q3 |
435 |
11329 |
|
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264 |
Lesmana C.R.A., Mandasari B.K.D. |
8977683000;57223222627; |
The new era of endoscopic ultrasound in biliary disorders |
2021 |
Clinical Journal of Gastroenterology |
14 |
4 |
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923 |
931 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105339459&doi=10.1007%2fs12328-021-01419-1&partnerID=40&md5=e46386a86669ce1318bf2c07a7eeb843 |
Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia; Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia |
Lesmana, C.R.A., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia, Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia; Mandasari, B.K.D., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia |
Biliary obstruction is one of challenging biliary disorders in gastroenterology field, where this long-standing condition can also lead to portal hypertension and multi-disciplinary teamwork is usually needed to manage this problem. Biliary drainage is the primary management to prevent prolonged cholestasis. Biliary system with its thin-walled and tubular structure sometimes makes the diagnosis and therapeutic not easy to approach. Over the past 3 decades, numerous new and modern diagnostic and therapeutic modalities have been developed to manage the complex biliary problems. It is well known that endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), and surgical procedure are common procedures in managing biliary disorders. However, surgical therapy and ERCP are not always easy to perform due to several contraindications. Because of difficulty in performing these procedures or unavailability of these procedures in the facility, PTBD, as the primary non-surgical procedure of choice, has been popular due to its easy technique. Endoscopic ultrasound (EUS) has evolved significantly not only as a diagnostic tool for identification and staging, but also for interventional approaches, especially in management of biliary malignancy. Recently, EUS-guided biliary drainage (EUS-BD) and EUS-guided gallbladder drainage (EUS-GBD) are developed for managing biliary disorders. Whether EUS can be useful for managing biliary obstruction as a primary procedure is still controversial. Hence, a large number of further studies are required to validate. © 2021, Japanese Society of Gastroenterology. |
Biliary obstruction; Endoscopic ultrasound (EUS); EUS-guided biliary drainage (EUS-BD); EUS-guided gallbladder drainage (EUS-GBD); Portal hypertension |
biliary tract disease; biliary tract drainage; cholestasis; endoscopic retrograde cholangiopancreatography; endoscopic ultrasonography; examination; gallbladder drainage; history of medicine; human; interventional ultrasonography; nonhuman; percutaneous transhepatic drainage; portal hypertension; Review; screening; biliary tract tumor; cholestasis; diagnostic imaging; endoscopic ultrasonography; Biliary Tract Neoplasms; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Drainage; Endosonography; Humans |
Springer Japan |
18657257 |
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33895970 |
Review |
Q3 |
414 |
11779 |
|
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265 |
Yuliwulandari R., Shin J.G., Kristin E., Suyatna F.D., Prahasto I.D., Prayuni K., Mahasirimongkol S., Cavallari L.H., Mitropoulou C., Patrinos G.P., Hao J., Williams M.S., Snyder S.R. |
23098874600;56031235700;6504458442;56039633100;57222660319;57190022456;14632559000;8396168500;37001846100;6603726539;57194283820;57203332674;7401687524; |
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model |
2021 |
Pharmacogenomics Journal |
21 |
4 |
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476 |
483 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103643380&doi=10.1038%2fs41397-021-00225-9&partnerID=40&md5=927cb9a5fa739ff5a932d25eb4459bd0 |
Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia; Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; The Golden Helix Foundation, London, United Kingdom; Department of Pharmacy, University of Patras, Patras, Greece; Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Department of Population Health Sciences, Geisinger, Danville, PA, United States; Genomic Medicine Institute, Geisinger, Danville, PA, United States; Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Yuliwulandari, R., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia, Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Shin, J.G., Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea, Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Suyatna, F.D., Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Prahasto, I.D., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Prayuni, K., Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Mahasirimongkol, S., Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Cavallari, L.H., Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; Mitropoulou, C., The Golden Helix Foundation, London, United Kingdom; Patrinos, G.P., Department of Pharmacy, University of Patras, Patras, Greece, Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Hao, J., Department of Population Health Sciences, Geisinger, Danville, PA, United States; Williams, M.S., Genomic Medicine Institute, Geisinger, Danville, PA, United States; Snyder, S.R., Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Carbamazepine (CBZ)-induced Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele. Screening HLA-B*15:02 before CBZ administration might prevent CBZ-induced SJS/TEN by enabling clinicians to prescribe alternative therapy for positive patients. Similar to other Southeastern Asian countries, HLA-B*15:02 is highly prevalent in Indonesia. Therefore, we assessed the economic value of HLA-B*15:02 screening before CBZ prescription to patients with epilepsy in Indonesia. A generic cost-effectiveness model and decision support tool, developed to enable users to perform an initial cost-effectiveness analysis from a healthcare provider/payer perspective, were used to assess the value of HLA-B*15:02 genotyping. The incremental cost-effectiveness ratio of adopting universal HLA-B*15:02 screening was 656,444,671 Indonesian Rupiah (IDR)/quality-adjusted life year (QALY) gained for patients compared with 2,634,975,574 IDR/QALY gained for providing valproic acid (alternative drug) without screening. Thus, neither HLA-B*15:02 screening nor substitution with VPA meets the Indonesian threshold for cost effectiveness. However, the improved outcomes with this test in other Asian countries may inform the desirability of implementation in Indonesia even with suboptimal cost-effectiveness. © 2021, The Author(s), under exclusive licence to Springer Nature Limited. |
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anticonvulsive agent; carbamazepine; HLA B antigen; valproic acid; anticonvulsive agent; carbamazepine; HLA B15 antigen; aged; Article; cost effectiveness analysis; epilepsy; epileptic patient; female; genotyping; human; Indonesian; Javanese (people); major clinical study; male; predictive value; prevalence; quality adjusted life year; sensitivity analysis; sensitivity and specificity; Stevens Johnson syndrome; Sundanese (people); toxic epidermal necrolysis; adult; allele; Asian; cost benefit analysis; epilepsy; genetic predisposition; genetic screening; genetics; genotype; Indonesia; procedures; risk factor; Adult; Alleles; Anticonvulsants; Asians; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Female; Genetic Predisposition to Disease; Genetic Testing; Genotype; HLA-B15 Antigen; Humans; |
Springer Nature |
1470269X |
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33824430 |
Article |
Q2 |
804 |
6015 |
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268 |
Findyartini A., Ramani S., McKimm J., Fornari A. |
56543777300;56186462600;26433565200;6701517660; |
Collaborative writing for clinical educators: recommendations from a community of scholars |
2021 |
Clinical Teacher |
18 |
4 |
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330 |
335 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101865035&doi=10.1111%2ftct.13329&partnerID=40&md5=c416c9d2916367a128e14dacb48e7fc6 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; Swansea University Medical School, United Kingdom; Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States |
Findyartini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramani, S., Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; McKimm, J., Swansea University Medical School, United Kingdom; Fornari, A., Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States |
Clinical educators who wish to engage in scholarship in health professions’ education (HPE), are ideally poised at the intersection of educational theories and their application to educational practice. However, the burden of clinical practice does not often allow the time and space for scholarly writing. Being part of a collaborative writing team, incorporating members with varying levels of expertise, from different health care professions, and at different stages of their career, can provide valuable opportunities for clinicians to contribute to scholarship. Such collaborations can also bridge the gap between scholarship and educational practice in clinical settings. In this paper, we emphasise the benefits of collaborative writing, describe challenges for clinical educators in starting writing projects, and identify potential solutions. We outline a systematic approach to collaborative writing grounded in literature and our own experiences. Three key concepts underpin the provided recommendations: types and standards for scholarship, leadership and followership and communities of practice. Psychological safety, mentoring and a growth mindset are emphasised as integral to successful team projects. Finally, we argue that collaborative writing groups in clinical education can be powerful communities of practice where the overall contribution to the field can be greater than the sum of its parts. © 2021 John Wiley & Sons Ltd and The Association for the Study of Medical Education |
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article; clinical education; human; human experiment; leadership; mentoring; psychological safety; writing; medical education; mentor; Fellowships and Scholarships; Humans; Leadership; Mentors; Writing |
John Wiley and Sons Inc |
17434971 |
|
33655649 |
Article |
Q3 |
354 |
13257 |
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270 |
Smith O.J., Wicaksana A., Davidson D., Spratt D., Mosahebi A. |
54881691700;57211445559;55553306500;7004394482;55985666400; |
An evaluation of the bacteriostatic effect of platelet-rich plasma |
2021 |
International Wound Journal |
18 |
4 |
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448 |
456 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100215304&doi=10.1111%2fiwj.13545&partnerID=40&md5=1f9c16fc126205b4735c175e68af0b2e |
Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom; Division of Surgery and Interventional Science, University College London, London, United Kingdom; Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom |
Smith, O.J., Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom, Division of Surgery and Interventional Science, University College London, London, United Kingdom; Wicaksana, A., Division of Surgery and Interventional Science, University College London, London, United Kingdom, Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Davidson, D., Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom; Spratt, D., Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom; Mosahebi, A., Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom, Division of Surgery and Interventional Science, University College London, London, United Kingdom |
Chronic wounds are a considerable health burden with high morbidity and poor rates of healing. Colonisation of chronic wounds by bacteria can be a significant factor in their poor healing rate. These bacteria can develop antibiotic resistance over time and can lead to wound infections, systemic illness, and occasionally amputation. When a large number of micro-organisms colonise wounds, they can lead to biofilm formation, which are self-perpetuating colonies of bacteria closed within an extracellular matrix, which are poorly penetrated by antibiotics. Platelet-rich plasma (PRP) is an autologous blood product rich in growth factors and cytokines that are involved in an inflammatory response. PRP can be injected or applied to a wound as a topical gel, and there is some interest regarding its antimicrobial properties and whether this can improve wound healing. This study aimed to evaluate the in vitro bacteriostatic effect of PRP. PRP was collected from healthy volunteers and processed into two preparations: activated PRP—activated with calcium chloride and ethanol; inactivated PRP. The activity of each preparation against Staphylococcus aureus and Staphylococcus epidermis was evaluated against a control by three experiments: bacterial kill assay to assess planktonic bacterial growth; plate colony assay to assess bacterial colony growth; and colony biofilm assay to assess biofilm growth. Compared with control, both preparations of PRP significantly inhibited growth of planktonic S aureus and S epidermis. Activated PRP reduced planktonic bacterial concentration more than inactivated PRP in both bacteria. Both PRP preparations significantly reduced bacterial colony counts for both bacteria when compared with control; however, there was no difference between the two. There was no difference found between biofilm growth in either PRP against control or against the other preparation. This study demonstrates that PRP does have an inhibitory effect on the growth of common wound pathogens. Activation may be an important factor in increasing the antimicrobial effect of PRP. However, we did not find evidence of an effect against more complex bacterial colonies. © 2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. |
antimicrobial therapy; chronic wounds; platelet-rich plasma |
alcohol; calcium chloride; antiinfective agent; Article; bacterial count; bacterial growth; bacterial strain; bacteriostatic activity; bacterium colony; biofilm; controlled study; extracellular matrix; in vitro study; nonhuman; Staphylococcus aureus; Staphylococcus epidermidis; thrombocyte activation; thrombocyte rich plasma; human; Staphylococcus infection; wound healing; wound infection; Anti-Bacterial Agents; Humans; Platelet-Rich Plasma; Staphylococcal Infections; Wound Healing; Wound Infection |
John Wiley and Sons Inc |
17424801 |
|
33476481 |
Article |
Q1 |
867 |
5385 |
|
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297 |
Gozal F., Gondhowiardjo S.A., Kodrat H., Wibowo W.E. |
57272055100;6508327402;57210639849;57271503300; |
Dosimetric analysis of three-dimensional conformal radiotherapy, intensity-modulated radiotherapy-step and shoot, helical tomotherapy, and volumetric modulated arc therapy in prostate cancer radiotherapy |
2021 |
Journal of Cancer Research and Therapeutics |
17 |
4 |
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893 |
900 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115716207&doi=10.4103%2fjcrt.JCRT_57_19&partnerID=40&md5=dd9c0144cb3b9a97d6b48eed122e1ba2 |
Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Gozal, F., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Gondhowiardjo, S.A., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wibowo, W.E., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: There is limited study comparing dosimetry parameters in detail. In regard to prostate cancer, there are four different techniques, namely three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy-step and shoot (IMRT-SS), IMRT-helical tomotherapy (HT), and volumetric-modulated arc therapy (VMAT). Materials and Methods: Experimental study with intervention on ten prostate cancer patients’ computed tomography planning data. 78 Gy dose in 39 fractions was given for planning target volume. Results: The mean V75 Gy rectum and bladder between 3D-CRT and the other three abovementioned techniques all showed significant results (P < 0.05). V5 Gy remaining volume at risk (RVR) between 3D-CRT versus VMAT and HT, IMRT-SS versus HT, and VMAT versus HT is statistically significant (P < 0.0001). The longest radiation time was done with HT (mean 4.70 ± 0.84 min). Conclusion: V75 Gy rectum bladder between 3D-CRT techniques differ significantly compared to the three other techniques and may not be suitable to the implementation of escalation doses. The HT technique produced the highest V5 Gy RVR and needed the highest monitor unit amount and the longest radiation duration. The VMAT technique was considered capable of realizing dose escalation in prostate cancer radiotherapy by minimizing toxicity in the rectum and bladder with the shortest radiation duration. © 2020 Journal of Cancer Research and Therapeutics. |
Helical tomotherapy; Intensity-modulated radiotherapy-step and shoot; Prostate cancer; Three-dimensional conformal radiotherapy; Volumetric-modulated arc therapy |
adult; aged; anisotropic analytical algorithm; Article; bladder; bladder capacity; cancer radiotherapy; clinical article; clinical target volume; computer assisted tomography; conformal radiotherapy; controlled study; dosimetry; health care; human; intensity modulated radiation therapy; male; middle aged; planning; planning target volume; prostate cancer; radiotherapy dosage; rectum; tomotherapy; volumetric modulated arc therapy; conformal radiotherapy; diagnostic imaging; follow up; intensity modulated radiation therapy; organs at risk; pathology; procedures; prognosis; prostate tumor; radiation response; radiotherapy planning system; spiral computer assisted tomography; Aged; Follow-Up Studies; Humans; Male; Middle Aged; Organs at Risk; Prognosis; Prostatic Neoplasms; Radiotherapy Dosage |
Wolters Kluwer Medknow Publications |
09731482 |
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34528538 |
Article |
Q3 |
475 |
10526 |
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