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624 |
Djusad S., Nizomy I.R., Hakim S., Priyatini T., Moegni F., Meutia A.P., Imsantoso B. |
57192276788;57267769100;57192276095;57192265423;55450456100;57203368133;57431312700; |
Incidence and characteristics of de novo stress urinary incontinence after pelvic organ prolapse vaginal repair |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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245 |
249 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123677566&doi=10.13181%2fmji.oa.204163&partnerID=40&md5=9b2deb933d7d42f78f8cd27103bdad59 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia |
Djusad, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nizomy, I.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia; Hakim, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priyatini, T., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meutia, A.P., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Imsantoso, B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND Some patients who undergo pelvic floor reconstruction for pelvic organ prolapse (POP) may experience a de novo stress urinary incontinence (SUI) postoperatively. We aimed to investigate the incidence and characteristics of de novo SUI in patients who underwent pelvic floor reconstruction at the national referral hospital in Indonesia. METHODS This cross-sectional study evaluated 108 patients who underwent pelvic floor reconstruction due to POP between January 2016 and December 2017. Per the inclusion criteria, 75 women were enrolled using a consecutive sampling. The incidence of de novo SUI was determined 6–12 months postoperatively using the Indonesian version of the questionnaire for urinary incontinence diagnosis and objectively using the cough stress test during gynecologic examination after a negative preoperative prolapse reduction stress test. RESULTS The average age, parity, body mass index, and years since menopause onset were 56.17 (4.67) years, 3.17 (1.07), 28.58 (5.18) kg/m2, and 12.8 (7.0) years, respectively. De novo SUI was seen in 8.0% (6 of 75) patients at 6–7 months postoperatively, with 3 (50.0%) had severe POP and 3 (50.0%) had a mild POP. Most of these patients (4 of 6, 66.7%) had undergone procedures other than colpocleisis for POP reconstruction. CONCLUSIONS The incidence of de novo SUI after gynecologic surgery for POP at a national referral hospital in Indonesia is 8%. Most patients were aged <60 years, had a parity of <4, were nonobese, were menopausal, and had diabetes. © 2021 Authors. |
Gynecologic surgery; Pelvic organ prolapse; Tertiary referral center; Urinary stress incontinence |
adult; Article; bladder function test; body mass; cough stress test; cross-sectional study; diabetes mellitus; female; gynecological examination; human; incidence; major clinical study; middle aged; parity; pelvic organ prolapse; preoperative prolapse reduction stress test; stress incontinence; vagina reconstruction |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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627 |
Aninditha T., Pratama P.Y., Sofyan H.R., Imran D., Estiasari R., Octaviana F., Iskandar M.M., Odilo J., Werdhani R.A., Aman R.A., Ranakusuma T.A.S. |
57189611205;57450416000;57328366500;57203976849;55240204000;26029958700;57205414462;57450963600;57189088848;36848942500;7801656487; |
Adults brain tumor in Cipto Mangunkusumo General Hospital: A descriptive epidemiology |
2021 |
Romanian Journal of Neurology/ Revista Romana de Neurologie |
20 |
4 |
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480 |
484 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124554663&doi=10.37897%2fRJN.2021.4.13&partnerID=40&md5=b5302d49e5e258bb7f13476b33682fdc |
Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Pratama, P.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Sofyan, H.R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Imran, D., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Estiasari, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Octaviana, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Iskandar, M.M., Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Odilo, J., Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Ranakusuma, T.A.S., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Background. Brain tumor is a rare tumor with low incidence. Although it is a rare tumor, the mortality of brain tumor is disproportionately high. Many countries have already published epidemiology of brain tumor. However, the epidemiology of brain tumor in Indonesia remains to be investigated. This article aimed to provide descriptive epidemiology of brain tumor. Methods. The data of brain tumor acquired from Department of Neurology and Neurosurgery Cipto Mangunkusumo General Hospital from 2014 to 2016. The histopathology classification of primary intracranial tumors was based on WHO classification of CNS tumors 2016 while brain metastasis was classified based on other histopathological types. The vari-ables were analyzed and presented descriptively. Results. There were 316 subjects acquired in this study. Most of the subjects (68%) were women. The mean age of this study was 43.8 (11.7). Most of the subjects (86.1%) had primary histopathology. Lung cancer was the most commonly found brain metastasis in this study (34.1%). Conclusions. This is a pilot study of brain tumor epidemiology in Indonesia. Collaboration with other centers in Indonesia is needed to give a more representative insight of brain tumor in Indonesia. © 2021, Editura Medicala. All rights reserved. |
Brain tumor; Cancer; Descriptive study; Epidemiology |
adenoma; adult; Article; brain hemorrhage; brain metastasis; brain tumor; cancer grading; cancer localization; cancer staging; central nervous system tumor; cross-sectional study; female; general condition; general hospital; glioblastoma; glioma; histopathology; human; human tissue; immunohistochemistry; intracranial metastasis; intracranial tumor; lung cancer; major clinical study; male; meningioma; middle aged; neurosurgery; pilot study; retrospective study |
Editura Medicala |
20696094 |
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Article |
Q4 |
111 |
28569 |
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630 |
Indrasari M., Kusdhany L.S., Maharani D.A., Ismail R.I. |
57193349086;55301180900;32867911000;55996895500; |
Development of the Indonesian version of the Oral Health Impact Profile in Edentulous Prosthodontic Patients |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1531 |
1536 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123868913&partnerID=40&md5=29207b68d1256bd93f9c88f61071a0dd |
Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Indrasari, M., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusdhany, L.S., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Maharani, D.A., Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Oral Health Impact Profile in Edentulous (OHIP-EDENT) is an instrument that measures several aspects of oral health-related quality of life as it relates to edentulous patients. Numerous studies have shown that edentulous has an impact on an individual's quality of life. This instrument aids in detecting the impact of oral health on the quality of life of patients who wear prostheses. The purpose of this study was to develop the OHIP-EDENT in Indonesian version for edentulous patients. The questionnaire was translated into Indonesian, back-translated, pre-tested, and crossculturally adapted. The qualitative interviews were carried out of 12 subjects, 46-77 years old, with diverse levels of formal education. All subjects were undergoing complete or single complete denture treatments at Dental Hospital Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. Since an expert committee agreed upon the original version, the questionnaire was translated, back-translated, and the outcomes of the qualitative interviews were used to finalize the revised instrument. After the pretesting, the adapted Indonesian OHIP-EDENT can be used as an instrument that is easy to use by edentulous patients undergoing complete or single denture treatments. Further analyses of the questionnaire's psychometric properties are needed to confirm its validity and reliability in target settings. © 2021,Journal of International Dental and Medical Research.All Rights Reserved |
Complete denture; Cross-cultural adaptation; Edentulous; Oral health; Quality oflife |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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631 |
Siahaan P.E.A., Kusumawardhani A.A.A.A., Ismail R.I., Malik K. |
57435237600;14633768700;55996895500;57204114533; |
Effectiveness of the "Emotion Recognition" Music Therapy Module in Schizophrenia Patients: A Quasi Experimental Study |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1722 |
1726 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123861310&partnerID=40&md5=d39caa1cc0263ce0e3e32f24151e3bb2 |
Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
Siahaan, P.E.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Kusumawardhani, A.A.A.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Ismail, R.I., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Malik, K., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
One of the deficit domains of social cognition in schizophrenia patients is emotion recognition. Negative emotion recognition deficits, such as emotional deficits of fear, anger, and sadness already exist in the first episode of schizophrenia. Music as therapy is known to be beneficial for emotional improvement, as well as the emotional experience of patients with schizophrenia. This study was aimed to assess the validity and effectiveness of a music therapy module “emotion recognition” in improving recognition of basic emotions in patients with schizophrenia. This quasi experimental study was conducted at the adult outpatient clinic at Cipto Mangunkusumo Hospital. The research was conducted in 2 steps. The first step to assess the validity of the module by calculate the I-CVI, S-CVI, and CVR of validity test and the second step to implement the music therapy module to the patient. This study assessed 15 subjects of schizophrenic remission patients who attended music therapy for 10 sessions conducted from March 2020 to July 2020. Subjects were assessed pre and post music therapy test results to see the effectivity of the module as seen by improvements in recognition of 5 basic emotions (happy, sad, anger, fear, tender) using the Mcnemar statistical test. The results of the validity test of the module showed the I-CVI of 0.98, S-CVI of 0.95, and CVR of 0.97. There was a significant improvement in the emotional deficits of fear and anger, with an increase in the pre and post music therapy test scores with a p-value 0.016 in the anger emotion and 0.008 in fear emotion, but not significant in the happy, sad, and tender emotions (p-value> 0.05). The emotion recognition music therapy module has good content validity, and effectiveness in emotion recognition of some of the basic emotions of remission schizophrenia patients, especially the emotion recognition of fear and anger. © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Effectivity; Emotion recognition; Music therapy; Schizophrenia |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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632 |
Arozal W., Barinda A.J., Monayo E.R., Aulia R. |
32067462200;57196373933;56955565900;56955797500; |
Mangiferin Attenuates Doxorubicin-Induced Nephrotoxicity in Rats Through Reduction of Oxidative Stress |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1667 |
1674 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123841744&partnerID=40&md5=1da2ad818beb007235cddc77a1b487fe |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Barinda, A.J., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Monayo, E.R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Aulia, R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Doxorubicin (DOX) has been widely used in the clinical setting for malignancy treatment.However, it also induces toxicity in a vital organ such as the kidney. Several studies suggest theformation of an iron anthracycline complex which produces free radicals plays an important role innephrotoxicity.Mangiferin (MGF), a xanthone derivate, exhibits as an iron chelator and antioxidant activitythrough a free radical scavenger activity. We analyzed the effect of MGF to prevent DOX inducednephrotoxicity. Male Sprague-Dawley rats were administered MGF orally every day for five weeks,with 50 and 100 mg/kg BW together with DOX. Renal failure and dyslipidemia were detected in theDOX groups in association with increased malondialdehyde (MDA) levels in plasma and kidney anddecreased superoxide dismutase (SOD) and glutathione (GSH) levels in kidney. Of note, cotreatmentwith MGF improved renal dysfunction caused by doxorubicin as shown by theamelioration plasma albumin, urea and creatinine levels, and proteinuria. MGF also diminishedover-production of MDA levels, thus enhanced antioxidant activity such as SOD and GSH in thekidney.Our study opens the perspective to clinical studies for consideration of MGF as a potentialchemoprotectant nutraceutical in the combination chemotherapy with DOX to limit its nephrotoxicity © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Doxorubicin; Kidney; Mangiferin; Toxicity |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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633 |
Nadia Y.F., Syahrani R.A., Arumsari S., Sadikin M., Wanandi S.I. |
57428347800;57204103147;57193202336;36981411100;36099320700; |
Effect of Cell Culture Medium on the Proliferation and Stemness of CD24-/CD44+ Human Breast Cancer Stem Cells |
2021 |
Indonesian Biomedical Journal |
13 |
4 |
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355 |
363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123550895&doi=10.18585%2fINABJ.V13I4.1674&partnerID=40&md5=f0c363bff3a069d364bc71970a109469 |
Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
Nadia, Y.F., Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Syahrani, R.A., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Arumsari, S., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Wanandi, S.I., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
BACKGROUND: Cancer stem cells (CSCs) is defined as tumor initiating cells within tumor that maintain stemness properties and tumorigenicity. Extracellular pH of CSCs in in vitro condition is important for supporting cell proliferation which may also regulate the expression of stemness markers such as OCT4. This work aimed to examine the effect of cell culture media on the proliferation and stemness of human breast cancer stem cells (BCSCs). RESULTS: Our results showed a higher viable cell number and proliferation of BCSCs in DMEM/F-12 HEPES (-) compared to HEPES (+) medium until 4 day incubation. OCT4 mRNA and protein level, as well as MFU of BCSCs were significantly higher in HEPES (-) compared to HEPES (+) medium on day 2. CONCLUSION: DMEM/F-12 medium without HEPES facilitates CD24-/CD44+ BCSCs to have higher proliferation and stemness on day 2 incubation compared to those with HEPES. © 2021. All Rights Reserved. |
breast cancer; cancer stem cell; OCT4; proliferation; stemness |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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637 |
Tjoa K., Kusmardi K., Midoen Y.H. |
57222366705;56966625300;57197805109; |
Effects of Industrial Waste Fish Oil Administration on Interleukin-6 (Il-6) Expression at Mice Colon being Induced by Azoxymethane (AOM) and Dextran Sodium Sulphate (DSS) |
2021 |
Biomedical and Pharmacology Journal |
14 |
4 |
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2227 |
2233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122824976&doi=10.13005%2fbpj%2f2321&partnerID=40&md5=bc79b4fdfe0aaabc3c89256150a440fb |
Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tjoa, K., Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Kusmardi, K., Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Midoen, Y.H., Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Colorectal cancer (CRC) is the world's third most cancer and the second highest mortality rate. The searching for new anti-inflammation substances with less adverse effects than aspirin for chemoprevention and adjuvant chemotherapy of CRC is running. The most notable one is fish oil containing omega 3. Kusmardi, et al. studied that industrial waste fish oil omega-3 level comes close enough to conventional fish oil industry. Study aims to reducing the level IL-6 on mice colon tissue being induced CRC using AOM/DSS by fish oil administration. Thirty male Swiss Webster mice are grouped into six treatments: Positive control (aspirin), negative control (physiological saline), normal, high dose (fish oil 6mg/kgBW), medium dose (fish oil 3mg/kgBW), dan solvent control (corn oil). Colon tissue was stained using anti IL-6 antibody. Ten photos per slide were taken by microscope (400x), analyzed for the IL-6 expression by ImageJ®, and quantified for H-score. Data was analyzed using SPSS 24.0 (CI 95%) and p-value <0.05 is consider significant. Data are not normally distributed with median of 161.64 (119.4-260.67). Kruskal-Wallis test is significant in addition with Mann-Whitney test shows only high dose group has significant difference to negative control (p=0.008), medium dose (p=0.016) dan and solvent control (p=0.008). No significant difference reported between high dose and positive control group (p=0.69). High dose industrial waste fish oil can lower IL-6 expression in mice colon tissue induced CRC using AOM/DSS. © 2021 Oriental Scientific Publishing Company. |
Colitis Associated Cancer; Colorectal cancer; Interleukin-6; Omega-3 Fish Oil |
acetylsalicylic acid; CD34 antigen; cytochrome P450 2E1; fish oil; interleukin 6; microRNA; nonsteroid antiinflammatory agent; octamer transcription factor 4; probiotic agent; adjuvant chemotherapy; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; azoxymethane-induced colon carcinogenesis; carcinogenesis; cardiovascular disease; cell proliferation; chemoprophylaxis; colon cancer; colon tissue; colorectal cancer; controlled study; dextran sulfate sodium-induced colitis; DNA methylation; drug megadose; fat intake; genomic instability; histone modification; immunohistochemistry; industrial waste; male; mortality rate; mouse; nonhuman; obesity; peritoneum adhesion; protein expression; quantitative analysis; rheumatoid arthritis; ulcerative colitis |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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650 |
Jufri M., Vardhani A., Purwaningsih E. |
55542805100;57372533300;57186723500; |
Evaluating the efficacy of lotion containing black rice bran (Oryza sativa L. indica) extract as skin brightening agent: A clinical trial |
2021 |
Jundishapur Journal of Natural Pharmaceutical Products |
16 |
4 |
e114152 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121121214&doi=10.5812%2fjjnpp.114152&partnerID=40&md5=7475812ecd399617effa3198e4bc8700 |
Faculty of Pharmacy, Universitas Indonesia, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Indonesia |
Jufri, M., Faculty of Pharmacy, Universitas Indonesia, Indonesia; Vardhani, A., Faculty of Pharmacy, Universitas Indonesia, Indonesia; Purwaningsih, E., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Indonesia |
Background: Ultraviolet exposure is an extrinsic factor to initiate melanogenesis, the process of melanin formation in the skin. Nowadays, natural ingredients tend to be more prevalent in cosmetic formulations due to consumers’ concern about synthetic ingredients and the risks they may represent for human health. Rice bran, the outer layer of a rice grain, can be utilized as a skin-lightening agent. Objectives: This study aimed to determine the efficacy of a lotion containing black rice bran (Oryza sativa L. indica) ethanolic extract as a skin lightening agent. Methods: The black rice bran ethanolic extract was formulated into oil in water (o/w) lotion. In this study, 34 women applied the lotion at one side of the forearm and base placebo lotion as control at the other side of forearm. The results were tested with a paired t-test by GraphPad Prism 8.3.0 software. Results: There was a significant decrease in the melanin index and erythema index in the forearm with a lotion containing black rice bran extract (P-value < 0.0001). Conclusions: The lotion containing 10% black rice bran extract was effective as a skin lightener because it effectively reduced skin melanin production when applied topically. Copyright © 2021, Author(s). |
Black Rice Bran; Clinical Trials; Natural Product; Oryza sativa L. indica; Skin Lightening Agent |
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Kowsar Medical Institute |
17357780 |
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Article |
Q3 |
228 |
17746 |
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717 |
Kadharusman M.M., Antarianto R.D., Hardiany N.S. |
57222724597;57190862806;57192910605; |
A review of the impact of calorie restriction on stem cell potency |
2021 |
Malaysian Journal of Medical Sciences |
28 |
4 |
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5 |
13 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114744628&doi=10.21315%2fmjms2021.28.4.2&partnerID=40&md5=f082ca9d61a167cf3fec646a0e6012b7 |
Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kadharusman, M.M., Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Calorie restriction (CR) prolongs lifespan in various species and also minimises pathologies caused by aging. One of the characteristics seen in age-related pathologies is stem cell exhaustion. Here, we review the various impacts of CR on mammalian health mediated through stem cell potency in various tissues. This study comprised of a literature search through NCBI, Science Direct, Google Scholar and PubMed, focusing on the impact of CR on pluripotency. In the skeletal muscle, CR acts as an anti-inflammatory agent and increases the presence of satellite cells endogenously to improve regeneration, thus causing a metabolic shift to oxidation to meet oxygen demand. In the intestinal epithelium, CR suppresses the mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells to shift the stem cell equilibrium towards self-renewal at the cost of differentiation. In haematopoiesis, CR prevents deterioration or maintains the function of haematopoietic stem cells (HSCs) depending on the genetic variation of the mice. In skin and hair follicles, CR increases the thickness of the epidermis and hair growth and improves hair retention through stem cells. CR mediates the proliferation and self-renewal of stem cells in various tissues, thus increasing its regenerative ability. © Penerbit Universiti Sains Malaysia, 2021. |
Calorie restriction; Pluripotency; Stem cell |
apoptosis; caloric restriction; cell differentiation; cell proliferation; deterioration; epidermis; fluorescence activated cell sorting; gene expression; genetic variation; hair follicle; hematopoietic stem cell; insulin sensitivity; intestine epithelium; microenvironment; nonhuman; oxidative phosphorylation; oxidative stress; oxygen consumption; physical activity; regenerative ability; Review; signal transduction; skeletal muscle; stem cell; thermal conductivity; upregulation |
Penerbit Universiti Sains Malaysia |
1394195X |
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Review |
Q3 |
394 |
12287 |
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818 |
Sahar N., Birowo P., Kusmardi, Kristianty D., Rahmaningrum K., Miranda A.V., Rasyad A., Prasasty V.D. |
57212464367;6504153311;56966625300;57223024424;57223023016;57222664687;57223027205;56019989700; |
Mucin-1 expression in endometrial tissue of Macaca nemestrina during mid-luteal phase after controlled-ovarian hyperstimulation |
2021 |
Biodiversitas |
22 |
4 |
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1927 |
1933 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104548199&doi=10.13057%2fbiodiv%2fd220440&partnerID=40&md5=436be5fa1fbe0e2157ca68a386731018 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Departement Urology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Biotechnology, Universita Katolik Atma Jaya Indonesia, Jl. Jend. Sudirman No. 51, Jakarta Selatan, Jakarta, 12930, Indonesia |
Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Birowo, P., Departement Urology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Kusmardi, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Kristianty, D., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Rahmaningrum, K., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Rasyad, A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, Jakarta, 10430, Indonesia; Prasasty, V.D., Faculty of Biotechnology, Universita Katolik Atma Jaya Indonesia, Jl. Jend. Sudirman No. 51, Jakarta Selatan, Jakarta, 12930, Indonesia |
Endometrial receptivity is one of the factors for successful implantation in pregnancy. Controlled ovarian hyperstimulation (COH) is a required step of in vitro fertilization (IVF), one of the standard procedures to overcome infertility. Exogenous gonadotropin hormones from COH provoke the secretion of estrogen and progesterone from the ovaries in higher amounts. The supraphysiological environment could impact the endometrial receptivity of the implantation process. Mucin-1 (MUC1) can be used as a marker to indicate alterations in the endometrial tissue. Therefore, this study aimed to investigate the alteration of mucin-1 expression in endometrial tissue of Macaca nemestrina after COH protocol. This study used endometrium tissue of M. nemestrina embedded with paraffin as tissue blocks. The subjects were 15 female macaques in reproductive age (8-10 years old) with a history of producing offspring. These macaques were classified into four groups based on the COH protocols, which consist of administering gonadotropin-releasing hormone (GnRH) agonist and recombinant FSH (r-FSH) with dosages of 30 IU, 50 IU, 70 IU (intervention groups), and no r-FSH (control group). The stimulations were administered for 14 days during the mid-luteal phase. Moreover, tissue staining was done by using immunohistochemistry. Mucin-1 expression was analyzed manually for glandular and luminal compartments and automatically for the stromal compartment by Red Green Blue (RGB) measure plugin as a color image from ImageJ software. The expression of mucin-1 was counted semi-quantitatively as H-score. Mucin-1 expression differences in endometrial tissue were assessed by one-way ANOVA with a significant difference found in the glandular part and insignificant results found in luminal and stromal parts. Pearson correlation test was also performed to determine the relationship of steroidal hormones and mucin-1 expression in glandular and luminal compartments. Both correlations were statistically insignificant. However, a positive correlation was found with the glandular compartment and a negative correlation with luminal compartment. As the subject species, M. nemestrina is limited for research utilization in our country, small number of subjects becomes a limitation of this study. Further studies need to be conducted to deepen the understanding of the regulation of mucin-1 expression, particularly by the altered concentrations of steroidal hormones as a consequence of COH. © 2021, Society for Indonesian Biodiversity. All rights reserved. |
Controlled ovarian hyperstimulation; Endometrial receptivity; In vitro fertilization; Mucin-1 |
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Society for Indonesian Biodiversity |
1412033X |
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Article |
Q3 |
257 |
16376 |
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