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316 |
Widodo D.W., Dewi D.J., Ranakusuma R.W., Irawati Y. |
56644646600;57219323765;57189729404;57201260313; |
Evaluation of 3 and 2-point internal fixation in the management of zygomaticomaxillary complex fractures: Case report |
2021 |
Annals of Medicine and Surgery |
67 |
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102539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109176909&doi=10.1016%2fj.amsu.2021.102539&partnerID=40&md5=aa5581548a2394f973a5958f289f0999 |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dewi, D.J., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ranakusuma, R.W., Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Irawati, Y., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: The ZMC has a prominent shape compared to other parts in the midfacial region, thus small injuries will generate fractures in the ZMC. The management of ZMC fracture depends on the fracture deformity and the surgeon's considerations. Various studies have revealed the success of ZMC reconstruction with one fixation point to 4 fixation points fitting to the tetrapod shape. Case report: We report two cases of ZMC fractures which comparing the efficacy of 3- and 2-point internal fixations for improving clinical outcomes The first patient underwent ORIF which placed at 2 fixation points, the first point in the left ZF suture and the second point in the left ZMB. The second patient underwent ORIF reconstruction at 3 fixation points, the first point in the right inferior orbital rim, the second point in the right ZF suture, and the third point in the right ZMB. Discussion: The most common surgical approach for ZMC fractures is through a gingivobuccal groin incision. This approach is for body exposure of the ZMB, which is the main buttress. The 3-point internal fixation improved the postoperative clinical outcome of fracture fragment stability compared to two-point fixation, but the mean malar height projection, vertical dystopia, and enophthalmos were not different between the two fixation methods. Conclusion: Three-point internal fixation can improve the clinical outcome of fracture fragment stability compared to 2-point fixation; however, it has a mean operative duration 22.2 minutes longer than 2-point fixation, so its application must be considered during the COVID-19 pandemic. © 2021 The Authors |
Case report; Internal fixation; Zygomatic fracture; Zygomaticomaxillary fracture |
adult; Article; cartilage graft; case report; clinical article; comparative effectiveness; computer assisted tomography; coronavirus disease 2019; endotracheal intubation; enophthalmos; female; general anesthesia; heterotopia; human; inguinal region; maxilla fracture; maxillofacial surgery; nose cavity; open fracture reduction; osteosynthesis; pandemic; physical examination; visual acuity; zygoma arch fracture |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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317 |
Hutauruk S.M., Hermani B., Monasari P. |
57205105620;14325051100;57224812004; |
Role of chlorhexidine on tracheostomy cannula decontamination in relation to the growth of Biofilm-Forming Bacteria Colony- a randomized controlled trial study |
2021 |
Annals of Medicine and Surgery |
67 |
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102491 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108345034&doi=10.1016%2fj.amsu.2021.102491&partnerID=40&md5=a3d916bc24eff149d6342e51ea55083d |
ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Hutauruk, S.M., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Hermani, B., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Monasari, P., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Background: Regular cleaning of the cannula in the trachea is very important for infection prevention. How to wash the tracheal cannula which is good to reduce the possibility of colonies of biofilm-forming bacteria and the growth of bacterial and the pattern of bacterial on the tracheal cannula is still unknown. This study aims to evaluate the efficacy of decontamination of the tracheal cannula using chlorhexidine and NaCl 0.9% in patients using the tracheal cannula to decrease biofilm-forming bacterial colony. Methods: 40 subjects were grouped into 20 subjects in the control group washing the cannula using 0.9% NaCl and the interventional group washing cannula using and with 2.5% chlorhexidine solution and 0.9% NaCl. This study used a parallel randomized controlled trial of 2 groups with a single blinded. Results: 40 subjects studied, 17 subjects (85%) each group produced biofilm-forming bacteria prior to intervention. After intervention in the study group, 15 subjects were biofilm negative and 5 biofilm positive subjects p = 0.001. The most common bacteria found in the control group is Pseudomonas aeruginosa, while in the study group some bacteria such as Acinetobacter sp. and Proteus mirabilis. Amoxicilin-Clavulanate had the highest resistance to biofilm forming bacteria in both groups. Piperacillin, ceftazidime, ciprofloxacin and meropenem have the highest sensitivity to biofilm-forming bacteria. Conclusion: There was a significant decrease in the number of colonies that produced biofilm in the tracheal cannula in the study group compared to the control group in tracheal cannula washing. © 2021 The Authors |
Bacteria colony; Biofilms; Chlorhexidine; Tracheostomy cannulae |
amoxicillin plus clavulanic acid; ceftazidime; chlorhexidine; ciprofloxacin; meropenem; piperacillin; sultamicillin; adult; aged; antibacterial activity; antibiotic resistance; Article; bacterial growth; bacterium colony; biofilm; clinical article; controlled study; decontamination; diabetes mellitus; Escherichia coli; human; hypertension; malnutrition; Proteus mirabilis; Pseudomonas aeruginosa; randomized controlled trial; single blind procedure; Staphylococcus aureus; tracheostomy |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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318 |
Hafizar, Hamid A.R.A.H., Saraswati M. |
57224823578;57202054669;57208472364; |
Cystoscopy-assisted laparoscopic partial cystectomy for muscle-invasive bladder cancer: Initial experience in Cipto Mangunkusumo Hospital, Jakarta |
2021 |
International Journal of Surgery Case Reports |
84 |
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106083 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108324475&doi=10.1016%2fj.ijscr.2021.106083&partnerID=40&md5=5cb1198507ed3b79541fd99fb1fe97d8 |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Hafizar, Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saraswati, M., Department of Anatomical Pathology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: We report the experience with patients of urachal adenocarcinoma of the bladder, a rare malignancy in the urinary bladder, treated with laparoscopic partial cystectomy. Aim: Solitary transitional cell carcinoma (TCC) of the dome/anterior wall of the bladder in some cases. As compared to radical surgery, partial cystectomy has a lower morbidity rate and similar oncological outcomes. We present our experience with laparoscopic partial cystectomy (LPC) in patients with urachal adenocarcinoma. Case presentation: Until being admitted to the hospital, a 60-year-old woman had been suffering from painless, sporadic gross hematuria for the previous year. Her physical examination was undistinguished. Computed tomography revealed an enhancing firmly bordered mass on the anterior-superior aspect of the bladder wall. The patient then underwent cystoscopy and laparoscopic partial cystectomy simultaneously. Conclusion: Based on our first experience in LPC, we suggest that cystoscopy assisted LPC is a reasonable and safe procedure with fewer complications and does not extend the operating time. The procedure's effectiveness hinges on the patient's selection. However, many cases needed to emphasize the effectiveness and safety of LPC. © 2021 The Authors |
Bladder cancer; Cystoscopy; Laparoscopy |
cisplatin; doxorubicin; gemcitabine; abdominal radiography; adenocarcinoma; adjuvant chemotherapy; adult; Article; bladder tumor; bladder wall; bleeding; cancer chemotherapy; cancer patient; cancer surgery; case report; clinical article; colloid carcinoma; computer assisted tomography; cystectomy; cystography; cystoscopy; differential diagnosis; echography; female; general anesthesia; hematuria; histopathology; human; human tissue; laparoscopic surgery; lithotomy; lower abdominal pain; medical history; middle aged; multiple cycle treatment; muscle invasive bladder cancer; transitional cell carcinoma; urachus |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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319 |
Oesman I., Sari C.M. |
57203961169;57224515809; |
Neglected neurogenic clubfoot treated with Achilles tendon lengthening using Z-plasty, total talectomy, and tibiocalcaneal arthrodesis |
2021 |
International Journal of Surgery Case Reports |
84 |
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106051 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107734709&doi=10.1016%2fj.ijscr.2021.106051&partnerID=40&md5=551520e63137809a0d35da15c3df6ec0 |
Foot and Ankle Consultant, Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Oesman, I., Foot and Ankle Consultant, Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Sari, C.M., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Introduction: The most common foot and ankle deformity from injury to the nervous system is equinocavovarus. This deformity comprises of equinus, cavus, varus, and adduction of the forefoot which leads to pain and poor stability in stance phase of gait. Treatment for this condition is difficult regarding literature limitation of the neurogenic clubfoot management. We reported a 18-year-old female with neglected right neurogenic clubfoot treated with 2 stage deformity correction. Case report: A 18-year-old female presented with crooked right foot since birth. It caused pain, especially during walking and standing for a long time and resulted in occasional skin infection on the bottom of the foot. However, currently she could walk in limping gait without walking aid. The patient was born aterm 39 weeks through caesarean delivery due to severe preeclampsia. There was delayed development of walking at 2 years and 9 months. Previously, she had history of spina bifida and undergone surgery in 2001. Afterward, she underwent VP shunt surgery. Physical examination demonstrated cavus varus, tenderness of the right foot, and limited ankle motion. The patient was diagnosed with neglected right neurogenic clubfoot and underwent two stage deformity correction consisting of Achilles tendon lengthening using Z-plasty, total talectomy, and tibiocalcaneal arthrodesis followed by posteromedial release, tendon lengthening (Tibialis posterior, FDL, FDB) and plantar fascia release. Conclusions: Two stage deformity correction can be successful in patients with neglected neurogenic clubfoot. Further studies are required to investigate the safety and efficacy of such procedure in neurogenic clubfoot. © 2021 The Authors |
Achilles tendon lengthening; Neurogenic clubfoot; Tibiocalcaneal arthrodesis; Total talectomy |
cefoperazone plus sulbactam; polypropylene; achilles tendon; adult; arthrodesis; Article; bone graft; calcaneus; case report; clinical article; clubfoot; deformity; female; fibrosis; follow up; general anesthesia; human; limp (gait); motor development; neurologic disease; osteotomy; pain; physical examination; postoperative period; preoperative period; preoperative treatment; skin infection; spinal dysraphism; standing; surgical technique; talectomy; tibia; walking; X ray; young adult; Z plasty |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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320 |
Priyatini T., Roziana |
57192265423;57218684529; |
Modified Passerini-Glazel feminizing genitoplasty outcomes in adults: Two rare cases |
2021 |
International Journal of Surgery Case Reports |
84 |
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106086 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107634308&doi=10.1016%2fj.ijscr.2021.106086&partnerID=40&md5=1f174f5a5decf1024dcb84cf6d7d80f7 |
Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Priyatini, T., Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Roziana, Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Modified Passerini-Glazel feminizing genitoplasty is typically performed in children with atypical genitalia. In our article, we have performed the procedure in adults with genital anomalies. Case presentation: The first case was a 22 years old woman who was planning to get married. She presented with a chief complaint of having no vaginal canal. Gynecological examination showed no vaginal opening. The common channel was visible, and the size of the perineal body was 3 cm. The patient underwent vaginal reconstruction using a modified Passerini-Glazel technique without amnion graft. The second case was a 20 years old girl planning to get married, with a chief complaint of small vaginal introitus. Gynecology examination showed small minor labia with an introitus size of 1 cm. The patients underwent vaginal reconstruction and labioplasty using a modified Passerini-Glazel technique with an amnion graft. Both patients have undergone anal atresia surgery in childhood. Discussion: There was no difference in outcome between using amnion graft and without amnion graft following the modified Passerini-Glazel feminizing genitoplasty procedure. The first patient had been pregnant and had successful delivery by elective cesarean section. Moreover, the second patient had no complaint of sexual disorders after the procedure. No cases of dysuria, urinary tract infection, leukorrhea, hematocolpos, or malodorous vaginal discharge were reported in both cases. Conclusion: Modified Passerini-Glazel feminizing genitoplasty is a safe and effective procedure. Daily vaginal dilation in the postoperative period was unnecessary, and it allowed for an excellent cosmetic result. © 2021 The Authors |
Genitalia anomaly; Good outcome; Modified Passerini-Glazel feminizing genitoplasty |
polyglycolic acid; adult; amnion; anal mucosa; anus atresia; anus injury; anus surgery; bulbocavernosus muscle; case report; cesarean section; clinical article; clinical outcome; echography; female; follow up; gynecological examination; hematocolpos; high school graduate; human; hydrosalpinx; hysteroscopy; incision; labia minora; menstrual irregularity; menstruation; micturition; modified Passerini-Glazel feminizing genitoplasty; palpation; postoperative period; pregnancy; reconstructive surgery; scar; sexual dysfunction; sexual function; sexual intercourse; Short Survey; surgical technique; suture technique; tissue graft; unemployment; urine color; urogenital tract malformation; urologic surgery; uterus malformation; vagina; vagina aplasia; vagina mucosa; vaginoscopy; young adult |
Elsevier Ltd |
22102612 |
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Short Survey |
Q3 |
232 |
17549 |
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323 |
Rizka A., Setiati S., Sadikin M., Mansur I.G. |
57203243658;14325991900;57205093115;6603222374; |
Immunomodulatory effect of in vitro calcitriol in fit and frail elderly |
2021 |
International Immunopharmacology |
96 |
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107737 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105325886&doi=10.1016%2fj.intimp.2021.107737&partnerID=40&md5=bd310cacaf61c4b89ad48ac61ee52389 |
Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia |
Rizka, A., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia, Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Sadikin, M., Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Mansur, I.G., Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia |
Introduction: Effect of calcitriol on PBMCs of healthy adults have been well studied but not much is known about its effect on the PBMCs of elderly patients with various degree of frailty syndrome and immune senescence. This study was aimed to assess the effect of in vitro calcitriol immunomodulatory effect on IL-6, IL-10 and IFN-γ in elderly patients who were fit, pre-frail and frail to see which group of patients might get the most benefit of calcitriol. Methods: This study was an experimental study on the PBMCs of 24 elderly people, of which 8 subjects each were in fit, pre-frail and frail categories based on the Cardiovascular Health Study criteria. IL-6, IL-10, and IFN-γ were examined by ELISA, before and after administration of lipopolysaccharide and 100 pg/mL calcitriol into PBMC cultures in vitro. Result: The mean serum vitamin D level was 26.2 (2.4) ng/ml. Vitamin D level is decreasing along with worsening of frailty status. After LPS induction, calcitriol did not reduce IL-6 and IFN-γ in all the groups. Calcitriol increased IL-10 in all groups, with the most observed change in the pre-frail group. Conclusion: In vitro administration of calcitriol showed anti-inflammatory potential by increasing IL-10 mainly in pre-frail subjects. © 2021 Elsevier B.V. |
Calcitriol; Elderly; Frail; In vitro |
calcitriol; gamma interferon; interleukin 10; interleukin 6; lipopolysaccharide; vitamin D; calcitriol; gamma interferon; IFNG protein, human; IL10 protein, human; IL6 protein, human; interleukin 10; interleukin 6; vitamin D; aged; Article; cell culture; clinical article; controlled study; enzyme linked immunosorbent assay; experimental study; female; frail elderly; frailty; human; human cell; immunomodulation; in vitro study; male; peripheral blood mononuclear cell; priority journal; protein blood level; vitamin blood level; age; blood; drug effect; frail elderly; immunology; immunomodulation; metabolism; mononuclear cell; pharmacology; physiology; Age Factors; Aged; Calcitriol; Calcium-Regulating Hormones and Agents; Female; Frail Elderly; Humans; Immunomodulation; In Vitro Techniques; I |
Elsevier B.V. |
15675769 |
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33965881 |
Article |
Q1 |
1152 |
3523 |
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335 |
Anurogo D., Budi N.Y.P., Ngo M.-H.T., Huang Y.-H., Pawitan J.A. |
57224408026;57200656694;57222023578;57154840200;6508348067; |
Cell and gene therapy for anemia: Hematopoietic stem cells and gene editing |
2021 |
International Journal of Molecular Sciences |
22 |
12 |
6275 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107482996&doi=10.3390%2fijms22126275&partnerID=40&md5=fea16158471961b74a29fcf9cb158461 |
International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, 90221, Indonesia; Research Center of Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Center for Reproductive Medicine, Taipei Medical University Hospital, Taipei, 11031, Taiwan; Comprehensive Cancer Center, Taipei Medical University, Taipei, 11031, Taiwan; Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan; PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Anurogo, D., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, 90221, Indonesia; Budi, N.Y.P., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Ngo, M.-H.T., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Huang, Y.-H., International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Research Center of Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan, Center for Reproductive Medicine, Taipei Medical University Hospital, Taipei, 11031, Taiwan, Comprehensive Cancer Center, Taipei Medical University, Taipei, 11031, Taiwan, Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan, PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi anemia, glucose‐6‐phosphate dehydrogenase deficiency (G6PDD), and thalassemia. The available management strategies for these disorders are still unsatisfactory and do not eliminate the main causes. As genetic aberrations are the main causes of all forms of hereditary anemia, the optimal approach involves repairing the defective gene, possibly through the transplantation of normal hematopoietic stem cells (HSCs) from a normal matching donor or through gene therapy approaches (either in vivo or ex vivo) to correct the patient’s HSCs. To clearly illustrate the importance of cell and gene therapy in hereditary anemia, this paper provides a review of the genetic aberration, epidemiology, clinical features, current management, and cell and gene therapy en-deavors related to SCD, thalassemia, Fanconi anemia, and G6PDD. Moreover, we expound the future research direction of HSC derivation from induced pluripotent stem cells (iPSCs), strategies to edit HSCs, gene therapy risk mitigation, and their clinical perspectives. In conclusion, gene‐corrected hematopoietic stem cell transplantation has promising outcomes for SCD, Fanconi anemia, and thalassemia, and it may overcome the limitation of the source of allogenic bone marrow transplantation. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cell therapy; Gene editing; Gene therapy; Hematopoietic stem cells |
antisickling agent; BRCA1 protein; BRCA2 protein; Fanconi anemia group A protein; Fanconi anemia group b protein; Fanconi anemia group C protein; Fanconi anemia group D2 protein; Fanconi anemia group E protein; Fanconi anemia group F protein; Fanconi anemia group G protein; Fanconi anemia group i protein; Fanconi anemia group j protein; Fanconi anemia group L protein; hematologic agent; hemoglobin beta chain; hemoglobin F; nuclear protein; partner and localizer of BRCA2; Rad51 protein; Rad51c protein; unclassified drug; acute chest syndrome; anemia; aplastic anemia; arm malformation; Article; asplenia; blood transfusion; cafe au lait spot; cell therapy; cerebrovascular accident; chromosome aberration; chronic nonspherocytic hemolytic anemia; clinical feature; clinical outcome; congenital d |
MDPI |
16616596 |
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34200975 |
Article |
Q1 |
1455 |
2384 |
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347 |
Moegni F., Ocsilia Wengkang I.F. |
55450456100;57226112377; |
Correlation of levator ani muscle strength measurement between Modified Oxford Grading Scale and perineometer on pelvic organ prolapse patient |
2021 |
Urogynaecologia International Journal |
33 |
1 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110513972&doi=10.4081%2fUIJ.2021.268&partnerID=40&md5=f4aa2afc9d600b8716b8e0217ad613a6 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ocsilia Wengkang, I.F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pelvic Organ Prolapse (POP) is a debilitating condition affecting about half of all women aged of more than 60 years globally. Reduced levator ani muscle strength in POP is associated with worse symptoms and prognosis. Measurement of levator ani muscle strength can be done with several tools such as perineometer and digital palpation. However, there is currently no study regarding conformity between tests. The aim of this study is to determine the correlation between tests in POP patients. An analytic observational study using cross sectional design was done to determine conformity between perineometer and digital examination using Modified Oxford Grading Scale (MOS) in Dr Cipto Mangunkusumo National General Hospital, Indonesia during the period of July, 2018 to June, 2020. Correlation between tests was determined using Spearman test. Cut-off of perineometer reading for each MOS score was also determined. A total of 110 subjects examined with both perineometer and digital palpation were recruited to the study. Positive correlation was observed between perineometer reading and Modified Oxford Grading Scale (r = 0.790, p < 0.001). According to the result, values between 0.01 – 9.64 cmH2O correspond to very weak pressure (MOS 1); 9.65 – 22.49 cmH2O represent weak pressure (MOS 2); 22.5 – 35.24 cmH2O represent moderate pressure (MOS 3); ≥ 35.25 cmH2O represent good pressure (MOS 4). There was a strong correlation between MOS and perineometer result for measuring levator ani strength in POP patients. Non ©Copyright: the Author(s), 2021 Licensee PAGEPress, Italy |
Levator ani muscle strength; Modified Oxford Grading Scale, pelvic organ prolapse; Perineometer |
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Page Press Publications |
20388314 |
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Article |
Q4 |
103 |
30394 |
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348 |
Djuardi Y., Lazarus G., Stefanie D., Fahmida U., Ariawan I., Supali T. |
6507800820;57214599425;57193121018;14420783500;8840573400;6602742029; |
Soil-transmitted helminth infection, anemia, and malnutrition among preschool-age children in nangapanda subdistrict, indonesia |
2021 |
PLoS Neglected Tropical Diseases |
15 |
6 |
e0009506 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110433985&doi=10.1371%2fjournal.pntd.0009506&partnerID=40&md5=acf6b372e3919f6422f75ae7d13a1c91 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Djuardi, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stefanie, D., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fahmida, U., Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Ariawan, I., Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background Soil-transmitted helminth (STH) infections are still prevalent in Indonesia, with roughly one-third of infected population being preschool-age children (PSC), which are generally at higher risk of morbidity such as malnutrition and anemia. This study aimed to investigate the association of STH infections with nutritional status and anemia among PSC in Nangapanda subdistrict, Ende, East Nusa Tenggara. Methods A cross-sectional survey involving PSC ranging from 12 to 59 months old from Nangapanda subdistrict, Ende district, East Nusa Tenggara was performed. Socio-demographic, breastfeeding, and complementary feeding information was obtained from structured questionnaires, while nutritional and anemia status was determined from anthropometry and hemoglobin measurements, respectively. Anthropometric z-scores were calculated based on the World Health Organization 2006 standards and stool samples were examined using Kato-Katz method. Results A total of 393 PSC randomly selected from 22 villages were examined. The prevalence of underweight, stunting, wasting, and anemia were 33.1%, 40.2%, 17.1%, and 60.3%, respectively. STH infection, predominated by Ascaris lumbricoides, was found in 160 (58.8%) PSC. Single STH infection, but not multiple infection, was independently associated with a lower risk of anemia (odds ratio [OR] 0.320, 95% confidence interval [CI]: 0.126– 0.809, p = 0.016). Similar association with anemia was also found on mild STH infection (OR 0.318 [95% CI: 0.114–0.887], p = 0.029). On the other hand, younger children were found to have a higher risk of anemia and stunting. None of the examined variables were independently associated with underweight and wasting. Conclusion STH infection as well as anemia and malnutrition were prevalent in this region. However in this study, current STH infections seemed to have minimal negative impact on children’s nutritional status. © 2021 Djuardi et al. |
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edetic acid; hemoglobin; hemoglobin; anemia; anthropometry; antiretroviral therapy; Article; body mass; breast feeding; child; complementary feeding; controlled study; cross-sectional study; disorder of sex development; endoscopic retrograde cholangiopancreatography; feces analysis; female; flotation; food frequency questionnaire; food intake; helminthiasis; human; major clinical study; male; malnutrition; mass spectrometry; morbidity; nutritional status; obesity; preschool child; questionnaire; randomized controlled trial; risk factor; Strongyloides stercoralis; structured questionnaire; stunting; underweight; vitamin intake; vitamin supplementation; World Health Organization; anemia; animal; Ascaris lumbricoides; growth disorder; helminthiasis; Indonesia; infant; malnutrition; parasitolo |
Public Library of Science |
19352727 |
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34138863 |
Article |
Q1 |
1990 |
1322 |
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350 |
Herawati F., Jaelani A.K., Wijono H., Rahem A., Setiasih, Yulia R., Andrajati R., Soemantri D. |
57194722742;57372559200;57222260570;57204655643;57209025002;56768083700;9940247700;36640659100; |
Antibiotic stewardship knowledge and belief differences among healthcare professionals in hospitals: A survey study |
2021 |
Heliyon |
7 |
6 |
e07377 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109492428&doi=10.1016%2fj.heliyon.2021.e07377&partnerID=40&md5=5c399c28320a996c1e4e405a6c2d8169 |
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacy, RSUD Bangil, Pasuruan, 67153, Indonesia; Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Community Pharmacy Department, Faculty of Pharmacy, Airlangga University, Surabaya, 60115, Indonesia; Laboratory for Developmental Psychology, Faculty of Psychology, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Herawati, F., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Jaelani, A.K., Department of Pharmacy, RSUD Bangil, Pasuruan, 67153, Indonesia; Wijono, H., Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Rahem, A., Community Pharmacy Department, Faculty of Pharmacy, Airlangga University, Surabaya, 60115, Indonesia; Setiasih, Laboratory for Developmental Psychology, Faculty of Psychology, Universitas Surabaya, Surabaya, 60293, Indonesia; Yulia, R., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Andrajati, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Background: Collaborative practice in healthcare has been recommended to improve the quality of antimicrobial stewardship interventions, a behavioral change in antimicrobial use. Insufficient knowledge regarding antibiotic resistance, the fear of complications from infections, and how providers perceive antibiotic use and resistance are likely to influence prescribing behavior. This study's objective was to identify the knowledge and belief healthcare professionals' differences about antibiotic stewardship. Methods: This cross-sectional survey study of three hospitals in the East Java province, Indonesia utilized a 43-item questionnaire to assess antimicrobial stewardship knowledge and belief. There were 12 knowledge questions (total possible score: 12) and 31 belief questions (total possible score: 155). The Kuder Richardson 20 (KR-20) and Cronbach alpha values of the questionnaire were 0.54 and 0.92, respectively. Results: Out of the 257 respondents, 19% (48/257) had a low scores of knowledge, and 39% (101/257) had low scores on belief about antibiotic stewardship (101/257). Most midwives had a low scores on knowledge (25/61) and low scores on belief (46/61). Respondents with high scores on belief were 17% (10/59) physicians, 15% (4/27) pharmacists, 8% (5/65) nurses, and 3% (2/61) midwives. Conclusion: Among healthcare professionals, knowledge and belief differences concerning antibiotic stewardship vary widely. These differences will affect their capability, behavior, and contribution to the healthcare team collaboration and performance. Further studies are needed to evaluate the correlation between the level of inter-professional collaboration and the quality of the antibiotic stewardship implementation. © 2021 The Author(s) |
Antibiotic stewardship; Belief; Knowledge |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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