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223 |
Razeghian E., Margiana R., Chupradit S., Bokov D.O., Abdelbasset W.K., Marofi F., Shariatzadeh S., Tosan F., Jarahian M. |
57223052224;56685900600;57211329338;56845561300;57208873763;57199650994;57225946579;57216155951;16241593900; |
Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy |
2021 |
Frontiers in Medicine |
8 |
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721174 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114747651&doi=10.3389%2ffmed.2021.721174&partnerID=40&md5=eb488365f37edbafb0ec0a51d29dbfc9 |
Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Razeghian, E., Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Shariatzadeh, S., Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Tosan, F., Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Pro-inflammatory cytokines can effectively be used for tumor immunotherapy, affecting every step of the tumor immunity cycle. Thereby, they can restore antigen priming, improve the effector immune cell frequencies in the tumor microenvironment (TME), and eventually strengthen their cytolytic function. A renewed interest in the anticancer competencies of cytokines has resulted in a substantial promotion in the number of trials to address the safety and efficacy of cytokine-based therapeutic options. However, low response rate along with the high toxicity associated with high-dose cytokine for reaching desired therapeutic outcomes negatively affect their clinical utility. Recently, mesenchymal stem/stromal cells (MSCs) due to their pronounced tropism to tumors and also lower immunogenicity have become a promising vehicle for cytokine delivery for human malignancies. MSC-based delivery of the cytokine can lead to the more effective immune cell-induced antitumor response and provide sustained release of target cytokines, as widely evidenced in a myriad of xenograft models. In the current review, we offer a summary of the novel trends in cytokine immunotherapy using MSCs as a potent and encouraging carrier for antitumor cytokines, focusing on the last two decades' animal reports. © Copyright © 2021 Razeghian, Margiana, Chupradit, Bokov, Abdelbasset, Marofi, Shariatzadeh, Tosan and Jarahian. |
cytokine; cytokine delivery; gene therapy; mesenchymal stem/stromal cells; tumor-immunotherapy |
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Frontiers Media S.A. |
2296858X |
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Review |
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1388 |
2608 |
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227 |
Hamid A.R.A.H., Luna-Velez M.V., Dudek A.M., Jansen C.F.J., Smit F., Aalders T.W., Verhaegh G.W., Schaafsma E., Sedelaar J.P.M., Schalken J.A. |
57202054669;56667692600;48761226600;8515960200;7005490663;6603571474;6603760728;6603552898;6602103585;7101847178; |
Molecular Phenotyping of AR Signaling for Predicting Targeted Therapy in Castration Resistant Prostate Cancer |
2021 |
Frontiers in Oncology |
11 |
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721659 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114356605&doi=10.3389%2ffonc.2021.721659&partnerID=40&md5=cd27bd052cb98d77c92f1b93868f2c4f |
Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Department of Urology, Ciptomangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; NovioGendix, Nijmegen, Netherlands; Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands |
Hamid, A.R.A.H., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands, Department of Urology, Ciptomangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Luna-Velez, M.V., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Dudek, A.M., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Jansen, C.F.J., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Smit, F., NovioGendix, Nijmegen, Netherlands; Aalders, T.W., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Verhaegh, G.W., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Schaafsma, E., Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands; Sedelaar, J.P.M., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Schalken, J.A., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands |
Castration-resistant prostate cancer (CRPC) is defined by resistance of the tumor to androgen deprivation therapy (ADT). Several molecular changes, particularly in the AR signaling cascade, have been described that may explain ADT resistance. The variety of changes may also explain why the response to novel therapies varies between patients. Testing the specific molecular changes may be a major step towards personalized treatment of CRPC patients. The aim of our study was to evaluate the molecular changes in the AR signaling cascade in CRPC patients. We have developed and validated several methods which are easy to use, and require little tissue material, for exploring AR signaling pathway changes simultaneously. We found that the AR signaling pathway is still active in the majority of our CRPC patients, due to molecular changes in AR signaling components. There was heterogeneity in the molecular changes observed, but we could classify the patients into 4 major subgroups which are: AR mutation, AR amplification, active intratumoral steroidogenesis, and combination of AR amplification and active intratumoral steroidogenesis. We suggest characterizing the AR signaling pathway in CRPC patients before beginning any new treatment, and a recent fresh tissue sample from the prostate or a metastatic site should be obtained for the purpose of this characterization. © Copyright © 2021 Hamid, Luna-Velez, Dudek, Jansen, Smit, Aalders, Verhaegh, Schaafsma, Sedelaar and Schalken. |
androgen receptor; castration-resistant prostate cancer; gene amplification; gene mutation; splice variant; steroidogenic enzymes |
aldo keto reductase family 1 member C3; androgen receptor; antiandrogen; estrogen; genomic DNA; gonadorelin agonist; Article; castration resistant prostate cancer; cell culture; controlled study; gene amplification; gene expression; gene mutation; human; human tissue; immunohistochemistry; male; molecularly targeted therapy; mRNA expression level; orchiectomy; phenotype; prostate hypertrophy; real time polymerase chain reaction; RNA extraction; signal transduction |
Frontiers Media S.A. |
2234943X |
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Article |
Q1 |
1834 |
1574 |
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228 |
Reksodiputro M.H., Harahap A.R., Setiawan L., Yosia M. |
35090488800;6507325543;57053036100;57204933098; |
A Modified Preparation Method of Ideal Platelet-Rich Fibrin Matrix From Whole Blood |
2021 |
Frontiers in Medicine |
8 |
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724488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114628863&doi=10.3389%2ffmed.2021.724488&partnerID=40&md5=2a784dc8d442d97efac9d34d1c6769cc |
Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Reksodiputro, M.H., Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
One bioproduct that is widely used in the wound healing process is platelet-rich plasma (PRP). PRP is a liquid solution with high autologous platelet concentration, making it a good source of growth factors to accelerate wound healing. Recent development in PRP had created a new product called platelet-rich fibrin matrix (PRFM), which has a denser and more flexible structure. PRFM is the newest generation of platelet concentrate with a fibrin matrix that holds platelet in it. The key concept in creating PRFM from PRP is the addition of CaCl2 followed by centrifugation, which converts fibrinogen to fibrin, and the fibrin cross-links to form a matrix that contains viable platelets. There are many commercially available kits to create PRFM, but they are often expensive and uneconomical. This research will test a modified method of making ideal PRFM from PRP without any commercial kits. The modified method will include determining the minimum level of CaCl2 used, the type of centrifuge, and the speed and duration of centrifugation. By performing a modified preparation method on five samples of whole blood, it was found that the ideal PRFM could be made by mixing PRP with 25 mM CaCl2 and centrifuging it at a speed of 2,264 × g for 25 min at room temperature. The PRP and PRFM platelet counts of this method tend to be lower than the platelet counts found in other studies. Although visually comparable, further study is needed to compare the performance of PRFMs made with this method and PRFMs made with commercial kits. © Copyright © 2021 Reksodiputro, Harahap, Setiawan and Yosia. |
CaCl2; centrifugation; fibrin matrix; platelet concentrate; platelet rich fibrin matrix; platelet rich plasma |
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Frontiers Media S.A. |
2296858X |
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Article |
Q1 |
1388 |
2608 |
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229 |
Nadhif M.H., Irsyad M., Rahyussalim A.J., Utomo M.S. |
57189057498;57220935587;55212166100;56180933900; |
Geometrical evaluation of CAM-configured thermoplastic polyurethane lattices for intervertebral disc replacements |
2021 |
AIP Conference Proceedings |
2382 |
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030006 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114011637&doi=10.1063%2f5.0060049&partnerID=40&md5=894c1cbce6bdc985a2b86b40dcf80e06 |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Central Hospital, Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Rahyussalim, A.J., Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Central Hospital, Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia |
Intervertebral discs (IVD) are prone to deformation due to higher stress that the discs can endure. Treatments for deformed IVDs include total disc replacements. Some studies concluded the superiority of spinal fusion compared to total disc replacement devices, either in the lumbar or cervical region. In current study, cuboid scaffolds made of thermoplastic polyurethane with lattice architecture were designed and configured using computer-aided manufacturing (CAM). The scaffolds were fabricated using fused filament fabrication. Process parameters were characterized and optimized to obtain scaffolds with uniform cells distribution. The struts at the top surface had average width values closer to the setpoints than the struts at the bottom surface, indicated by lower RMSE values for the struts at the top surface. However, the printing consistency in the same extrusion ratio at the bottom surface was higher than at the top surface, indicated by lower standard deviation values. Statistical analysis using standard deviation, RMSE, and Tukey's test showed that current scaffolds had non-uniform distribution between layers, which required further improvement. © 2021 Author(s). |
Computer-aided manufacturing; intervertebral disc; lattice structure; polyurethane |
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American Institute of Physics Inc. |
0094243X |
9780735441156 |
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Conference Paper |
- |
177 |
20880 |
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230 |
Agustina R., Syam A.F., Wirawan F., Widyahening I.S., Rahyussalim A.J., Yusra Y., Rianda D., Burhan E., Salama N., Daulay R., Halim A.R.V., Shankar A.H. |
57214141404;8443384400;57205313463;54893154400;55212166100;57220998367;57214119630;36058554600;57219411020;57226811488;57226806443;7005442634; |
Integration of symptomatic, demographical and diet-related comorbidities data with SARS-CoV-2 antibody rapid diagnostic tests during epidemiological surveillance: A cross-sectional study in Jakarta, Indonesia |
2021 |
BMJ Open |
11 |
8 |
e047763 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112745267&doi=10.1136%2fbmjopen-2020-047763&partnerID=40&md5=1e972251c248b0cfbea89e8c34d44b24 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syam, A.F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wirawan, F., Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widyahening, I.S., Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Rianda, D., Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Salama, N., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Daulay, R., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Halim, A.R.V., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Shankar, A.H., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Affordable options for COVID-19 epidemiological surveillance are needed. Virus detection by reverse transcription-PCR (RT-PCR) is sensitive but costly, and antigen-based rapid diagnostic tests (RDTs) are cheap but with reduced sensitivity; both detect current infection but not exposure. RDT-IgM/IgG antibodies to SARS-CoV-2 detect exposure but have poor sensitivity for current infection. We investigated if the integration of symptomatic, demographical and diet-related comorbidities data with antibody RDTs improves their potential to assess infection rates in addition to exposure, thereby broadening their utility for surveillance. We conducted a cross-sectional study using data from community surveillance for SARS-CoV-2. Health workers collected nasopharyngeal swabs for RT-PCR and RDT antigen assessments and venous blood for RDT-IgM/IgG from symptomatic and asymptomatic persons. Data on age, gender, contact history, symptoms (ie, fever, cough, runny nose, sore throat, headache, dyspnoea and diarrhoea), diet-related comorbidities (ie, diabetes and hypertension) and chest radiology were collected. High-risk communities in Jakarta, Indonesia, in May 2020. 343 community members’ data were included. RDT-IgM/IgG sensitivity, specificity and predictive values and area under receiver operating characteristic curve for RT-PCR positivity using RDT results alone and in combination with other predictors, including symptom components derived from principal component analysis. There were 24 PCR-confirmed infections. RDT-IgM/IgG-positive tests were associated with infection (OR 10.8, 95% CI 4.43 to 26.4, p<0.001) with an area under the curve (AUC) of 0.708% and 50% sensitivity, 91.5% specificity, 30.8% positive predictive value (PPV) and 96.1% negative predictive value (NPV). RDT results combined with age, gender, contact history, symptoms and comorbidities increased the AUC to 0.787 and yielded 62.5% sensitivity, 87.0% specificity, 26.6% PPV and 96.9% NPV. SARS-CoV-2 RDT-IgM/IgG results integrated with other predictors may be an affordable tool for epidemiological surveillance for population-based COVID-19 exposure and current infection, especially in groups with outbreaks or high transmission. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
COVID-19; epidemiology; public health |
immunoglobulin G; immunoglobulin M; SARS-CoV-2 antibody; virus antibody; adolescent; adult; aged; area under the curve; Article; child; community; comorbidity; coronavirus disease 2019; coughing; cross-sectional study; demography; diagnostic test; diagnostic test accuracy study; diet; female; health care personnel; human; Indonesia; major clinical study; male; nasopharyngeal swab; predictive value; receiver operating characteristic; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat; thorax radiography; diagnostic test; diet; epidemiology; Antibodies, Viral; COVID-19; Cross-Sectional Studies; Diagnostic Tests, Routine; Diet; Humans; Indonesia; SARS-CoV-2; Sensitivity and Specificity |
BMJ Publishing Group |
20446055 |
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34376448 |
Article |
Q1 |
1132 |
3624 |
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231 |
Farhoudian A., Radfar S.R., Ardabili H.M., Rafei P., Ebrahimi M., Zonoozi A.K., De Jong C.A.J., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Hansen H., Brady K.T., Potenza M.N., Baldacchino A.M., Ekhtiari H., Abagiu A.O., Abouna F.D.N., Ahmed M.H., Al-Ansari B., Al-Khair F.M.A., Almaqbali M.H., Ambekar A., Arya S., Asebikan V.O., Ayasreh M.A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Busse A., Butner J.L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., Cherpitel J.J.E.N., Clark K.J., Cyders M.A., de Bernardis E., Deilamizade A., Derry J.E., Dhagudu N.K., Dolezalova P., Dom G., Dunlop A.J., Elhabiby M.M., Elkholy H., Essien N.F., Farah G.I., Ferri M., Floros G.D., Friedman C., Fuderanan C.H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I.A., Grandinetti P., Guirguis A., Gutnisky D., Haber P.S., Hassani-Abharian P., Hooshyari Z., Ibrahim I.I.M., Ieong H.F.-H., Indradewi R.N., Iskandar S., Isra T.N., Jain S., James S., Javadi S.M.H., Joe K.H., Jokubonis D., Jovanova A.T., Kamal R.M., Kantchelov A.I., Kathiresan P., Katzman G., Kawale P., Kern A.M., Kessler F.H.P., Kim S.-G.S., Kimball A.M., Kljucevic Z., Kurniasanti K.S., Lev R., Lee H.K., Lengvenyte A., Lev-Ran S., Mabelya G.S., Mahi M.A.E., Maphisa J.M., Maremmani I., Masferrer L., Massah O., McCambridge O., McGovern G.G., Min A.K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I.U.K., Mukherjee D., Munira P.M., Myers B., Menon T. N. J., Narasimha V.L., Ndionuka N., Nejatisafa A.-A., Niaz K., Nizami A.T., Nuijens J.H., Orsolini L., Oum V., Oyemade A.A., Palavra I.R., Pant S.B., Paredes J., Peyron E., Quirós R.A., Qurishi R., Rafiq N.U.Z., Raghavendra Rao R., Ratta-Apha W., Raymond K.-L., Reimer J., Renaldo E., Rezapour T., Robertson J.R., Roncero C., Roub F., Rubenstein E.J., Rupp C.I., Saenz E., Salehi M., Samartzis L., Sarubbo L.B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F.M., Sosa V.A., Subata E., Sztycberg N., Taghizadeh F., Wee Teck J.B.T., Tjagvad C., Torrens M., Twala J.M., Vadivel R., Volpicelli J.R., Weijs J., Wintoniw S.M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., ISAM Global Survey Consortium (ISAM-GSC) |
25631625900;36019651400;55658200400;57218199674;57218203004;57218205554;55394697400;57203060812;14622058700;6602323007;55912287400;57221996850;7101818468;7006591634;6603786612;26632924600;55021572500;57221605725;57221411272;56996118200;55549232500;57221411355;35749590300;35463222300;57221410006;57221410448;18833291700;57219202850;55789741800;6603894892;15135243700;57189041459;7003868723;57196510693;56816710600;57221410155;56400851700;7003818736;24176502200;26026739900;54936844000;57358665500;57221410761;6504408224;55604104700;56059025100;57221409824;57203836122;6603422138;12768470700;57219674374;26767656700;55086535500;57191041815;57221411550;8871569800;12768168000;57221411410;57210375852;55578764500;36833820900;57205763778;27367905800;55487378900;55496109900;57221411047;7004422180;54892046900;36607951600;57216708013;57193806115;57221410095;37004580200;57221604184;57207211289;57216621884;57207842636;15062725000;57188646762;57221411023;36996943600;24468101500;57023935300;57221410517;55928375400;55031071400;57202970264;57221410531;35420584800;57203155640;57209262171;8913859800;8600274900;57189340754;23019092700;57221410613;57223919852;57200792839;7003948428;6507438528;57044778200;56527137000;57221410507;57221411329;56059054800;6506077151;57214574855;57197364393;57221410358;7202684194;57200567557;56272241600;57221410263;55666521300;57194102646;12144358600;7004198198;55376767200;57217227990;16234058300;57225265059;36114863900;57221411223;57205355338;57221409971;55735687800;57221410341;57358663600;35604346900;56783754400;56000939600;57221410809;56968163500;57205640157;7003524112;57191926633;57221411128;7006106435;26656074800;57226311750;36633076300;57221409908;24476669600;57219874143;57216762422;7005625709;7003465287;57221409902;57221409982;56616079200;57221410011;55802145800;57221409677;57188537200;7006681890;57221411350;57219874702;57209053124;57221410085;57221410695;55151590700;6701757799;57221410275;57204013732;55185317400; |
A Global Survey on Changes in the Supply, Price, and Use of Illicit Drugs and Alcohol, and Related Complications During the 2020 COVID-19 Pandemic |
2021 |
Frontiers in Psychiatry |
12 |
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646206 |
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6 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113236018&doi=10.3389%2ffpsyt.2021.646206&partnerID=40&md5=583fc4953970f4d964584bcd9a7d5b02 |
Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroscience and Addiction, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran; Integrated Substance Abuse Programs Department, University of California, Los Angeles, Los Angeles, CA, United States; Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Behavioral Science Institute, Radboud University, Nijmegen, Netherlands; School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Surrey and Borders Partnership National Health Service Foundation Trust, Leatherhead, United Kingdom; Turning Point, Eastern Health, Box Hill, VIC, Australia; Departments of Anthropology and Psychiatry, New York University, New York, NY, United States; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States; Yale School of Medicine, Connecticut Council on Problem Gambling and Connecticut Mental Health Center, New Haven, CT, United States; Division of Population and Behavior Sciences, Medical School, University of St Andrews, St Andrews, United Kingdom; Laureate Institute for Brain Research, Tulsa, OK, United States; National Institute for Infectious Diseases, Prof. Dr. Matei Bals-Arena OMT Department, Romania; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon; Alamal psychiatric hospital, Dubai, United Arab Emirates; Sydney Medical School, University of SydneyNSW, Australia; Al Ahliyya Amman University, Amman, Jordan; Ministry of Health, Muscat, Oman; Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; State Drug Dependence Treatment Centre, Institute of Mental Health, Pt BDS University of Health Sciences, India; Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria; Addiction Medicine Clinic, Jordan; Drug De-addiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Addiction Medicine Clinic, Mila, Algeria; Centre medical Marmottan, France; Réseau de Prévention des Addictions (RESPADD), France; Department of Psychiatry and Behavioural Neurosciences, Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Geneva University Hospitals, Switzerland; United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; CUNY School of Medicine, New York, United States; Agenzija Sedqa, Malta; Department of Medicine and Surgery, University Milan-Bicocca, Italy; University Psychiatric Hospital Vrapce-Zagreb, Croatia; Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; Addiction Medicine Clinic, Mexico; Addiction Crisis Solutions, United States; Department of Psychology, Indiana University Purdue University-Indianapolis, United States; SerT Lentini, ASP Siracusa, Italy; Rebirth Charity Society NGO, Tehran, Iran; Serenity Vista Addiction Treatment Center, Panama; Department of Psychiatry, ESIC Medical College, Hyderabad, Telangana, India; National Institute of Mental Health, Czech Republic; Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp University (UA), Belgium; Drug & Alcohol Clinical Services, Hunter New England Local Health District, Australia; Ain Shams University, Cairo, Egypt; Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Centre for Research and Information on Substance Abuse, Nigeria; Addiction Medicine Clinic, Syrian Arab Republic; European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Italy; Department of Psychiatry, Aristotle University of Thessaloniki, Greece; Brown University and Lifespan Health System, Providence, RI, United States; Fuderanan Mental Health Clinic, Philippines; Drug De-addiction & Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Georgian Harm Reduction Network, Georgia; Organization Against Drugs, Primary Care Health Center, Veria, Greece; Addictions Services (Ser.D.), Department of Territorial Services, ASL Teramo, Italy; Swansea University Medical School, Institute of Life Sciences 2, Singleton CampusSA2 8PP, United Kingdom; Universidad de Buenos Aires, Argentina; University of Sydney, Australia; Institutes for Cognitive Science Studies (IRICSS), Brain and Cognition Clinic, Tehran, Iran; Tehran University of Medical Sciences, Tehran, Iran; Department of Anesthesiology, Yale University, United States; Drugs Rehabilitation Center, National Narcotics Board of Indonesia, Indonesia; Department of Psychiatry, Universitas Padjadjaran, Bandung, West Java, Indonesia; National Institute of Education, Sri Lanka; Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; Univeristi Malaysia Sabah, Malaysia; Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; National Center for Mental Health of Korea, South Korea; Republican Center for Addictive Disorders, Lithuania; Addiction Medicine Clinic, North Macedonia; Naufar Institute, Doha, Qatar; The Kantchelov Clinic, Sofia, Bulgaria; Mount Sinai Medical Center, New York, United States; African Institute for Development Policy, Malawi; Sobriety Centers of New Hampshire, United States; Federal University of Rio Grande do Sul, Brazil; Pusan National University Yangsan Hospital, Department of Neuropsychiatry, Yangsan, South Korea; Chatham House, United States; Institute for Public Health of Split-Dalmatia County, Croatia; Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Indonesia; Scripps Mercy Hospital, San Diego, United States; Department of Psychiatry, The Catholic University of Korea, Seoul, South Korea; Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania; Israel Center on Addiction, Netanya, Israel; Community Health Work, Tanzania; Hayat Center for Treatment and Psycho-social Rehabilitation, Khartoum, Sudan; University of Botswana, Botswana; V.P. Dole, Dual Disorder Unit, Santa Chiara University Hospital, University of Pisa, Italy; CAS Girona, Department of Psychology, University of Girona, Spain; Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; Community addiction team, Southern Health and Social Care Trust, United Kingdom; Priority Medical Clinic, Dublin, Ireland; Save the Children International Organization, Burma; Dirección de Investigaciones Epidemiológicas y Sociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, United States; Department of Psychiatry, Faculty of Medicine, Sir John Kotelawala Defence University, Sri Lanka; Centre for Addiction Medicine, NIMHANS, Bangalore, India; Kleopatra Kodric, Irena Nisic, Slovenia; Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, South Africa; NIMHANS, Bangalore, India; Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India; Federal Neuropsychiatric Hospital, Calabar, Nigeria; Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, Iran; Institute of Psychiatry, WHO Collaborating Center for Mental Health, Pakistan; Brijder Addiction Care, Zaandam, Netherlands; Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy; Koh Kong Provincial Hospital, Cambodia; Kaiser Permanente, United States; Psychiatric hospital Sveti Ivan, Zagreb, Croatia; Department of Psychiatry and mental health, Institute of Medicine, Tribhuvan University, Nepal; Universidad de El Salvador, El Salvador; AddiPsy, Lyon, France; Addiction Medicine Clinic, Costa Rica; Novadic-Kentron Addiction Care Network, Vught, Netherlands; Phoenix Foundation for Research and Development, Pakistan; Barwon Health, Geelong, Australia; Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand; University of the Sunshine Coast (USC)QLD, Australia; Center for Interdisciplinary Addiction Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Drugs Rehabilitation Center, National Narcotics Board of Indonesia; Department of Cognitive Psychology, Institute for Cognitive Science Studies, Tehran, Iran; Usher Institute, University of Edinburgh, United Kingdom; Psychiatry Service, University of Salamanca Health Care Complex, Salamanca, Spain; PGIMER, Chandigarh, India; Street Health Centre, Canada; Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck, Austria; Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Medical School, University of Cyprus, Cyprus; Clínica Psiquiátrica de la Facultad de Medicina, Uruguay; Center for Treatment of Drug addiction, University Psychiatric Clinic, Ljubljana, Slovenia; Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lagankhel, Nepal; Department of Psychiatry, Second Xiangya Hospital, Central South University, China; Department of Psychiatry, Teine Keijinkai Medical Center, Japan; David Geffen School of Medicine at UCLA, Department of Family Medicine, United States; Health Professions Councils of Namibia, Namibia; Addiction Medicine Clinic, Uruguay; Asociasion Programa Andres Argentina, Argentina; Mazandaran University of Medical Sciences, Mazandaran, Iran; MRC/CSO SPHSU, University of Glasgow, United Kingdom; Gladsaxe Substance Use Disorder Treatment Centre, Denmark; Institut de Neuropsiquiatria i Addiccions, IMIM-Hospital del Mar, Medical Research, Barcelona, Spain; NACADA, Kenya; Waikato District Health Board (WDHB, Hamilton, New Zealand; Institute of Addiction Medicine, United States; Jellinek, Amsterdam, Netherlands; Addictions Foundation of Manitoba, Canada; Thanyarak Chiangmai Hospital, Thailand; Medical University of Warsaw, Warsaw, Poland; Jimma University, Ethiopia; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China |
Farhoudian, A., Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Radfar, S.R., Department of Neuroscience and Addiction, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran, Integrated Substance Abuse Programs Department, University of California, Los Angeles, Los Angeles, CA, United States; Ardabili, H.M., Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Rafei, P., Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran, Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Ebrahimi, M., Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Zonoozi, A.K., Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; De Jong, C.A.J., Behavioral Science Institute, Radboud University, Nijmegen, Netherlands; Vahidi, M., Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Yunesian, M., School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Kouimtsidis, C., Surrey and Borders Partnership National Health Service Foundation Trust, Leatherhead, United Kingdom; Arunogiri, S., Turning Point, Eastern Health, Box Hill, VIC, Australia; Hansen, H., Departments of Anthropology and Psychiatry, New York University, New York, NY, United States; Brady, K.T., Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States; Potenza, M.N., Yale School of Medicine, Connecticut Council on Problem Gambling and Connecticut Mental Health Center, New Haven, CT, United States; Baldacchino, A.M., Division of Population and Behavior Sciences, Medical School, University of St Andrews, St Andrews, United Kingdom; Ekhtiari, H., Laureate Institute for Brain Research, Tulsa, OK, United States; Abagiu, A.O., National Institute for Infectious Diseases, Prof. Dr. Matei Bals-Arena OMT Department, Romania; Abouna, F.D.N., Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon; Ahmed, M.H., Alamal psychiatric hospital, Dubai, United Arab Emirates; Al-Ansari, B., Sydney Medical School, University of SydneyNSW, Australia; Al-Khair, F.M.A., Al Ahliyya Amman University, Amman, Jordan; Almaqbali, M.H., Ministry of Health, Muscat, Oman; Ambekar, A., Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Arya, S., State Drug Dependence Treatment Centre, Institute of Mental Health, Pt BDS University of Health Sciences, India; Asebikan, V.O., Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria; Ayasreh, M.A., Addiction Medicine Clinic, Jordan; Basu, D., Drug De-addiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Benmebarek, Z., Addiction Medicine Clinic, Mila, Algeria; Bhad, R., Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Blaise, M., Centre medical Marmottan, France; Bonnet, N., Réseau de Prévention des Addictions (RESPADD), France; Brasch, J., Department of Psychiatry and Behavioural Neurosciences, Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Broers, B., Geneva University Hospitals, Switzerland; Busse, A., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Butner, J.L., CUNY School of Medicine, New York, United States; Camilleri, M., Agenzija Sedqa, Malta; Campello, G., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Carra, G., Department of Medicine and Surgery, University Milan-Bicocca, Italy; Celic, I., University Psychiatric Hospital Vrapce-Zagreb, Croatia; Chalabianloo, F., Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; Chaturvedi, A., Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; Cherpitel, J.J.E.N., Addiction Medicine Clinic, Mexico; Clark, K.J., Addiction Crisis Solutions, United States; Cyders, M.A., Department of Psychology, Indiana University Purdue University-Indianapolis, United States; de Bernardis, E., SerT Lentini, ASP Siracusa, Italy; Deilamizade, A., Rebirth Charity Society NGO, Tehran, Iran; Derry, J.E., Serenity Vista Addiction Treatment Center, Panama; Dhagudu, N.K., Department of Psychiatry, ESIC Medical College, Hyderabad, Telangana, India; Dolezalova, P., National Institute of Mental Health, Czech Republic; Dom, G., Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp University (UA), Belgium; Dunlop, A.J., Drug & Alcohol Clinical Services, Hunter New England Local Health District, Australia; Elhabiby, M.M., Ain Shams University, Cairo, Egypt; Elkholy, H., Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Essien, N.F., Centre for Research and Information on Substance Abuse, Nigeria; Farah, G.I., Addiction Medicine Clinic, Syrian Arab Republic; Ferri, M., European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Italy; Floros, G.D., Department of Psychiatry, Aristotle University of Thessaloniki, Greece; Friedman, C., Brown University and Lifespan Health System, Providence, RI, United States; Fuderanan, C.H., Fuderanan Mental Health Clinic, Philippines; Gerra, G., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Ghosh, A., Drug De-addiction & Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Gogia, M., Georgian Harm Reduction Network, Georgia; Grammatikopoulos, I.A., Organization Against Drugs, Primary Care Health Center, Veria, Greece; Grandinetti, P., Addictions Services (Ser.D.), Department of Territorial Services, ASL Teramo, Italy; Guirguis, A., Swansea University Medical School, Institute of Life Sciences 2, Singleton CampusSA2 8PP, United Kingdom; Gutnisky, D., Universidad de Buenos Aires, Argentina; Haber, P.S., University of Sydney, Australia; Hassani-Abharian, P., Institutes for Cognitive Science Studies (IRICSS), Brain and Cognition Clinic, Tehran, Iran; Hooshyari, Z., Tehran University of Medical Sciences, Tehran, Iran; Ibrahim, I.I.M., Ain Shams University, Cairo, Egypt; Ieong, H.F.-H., Department of Anesthesiology, Yale University, United States; Indradewi, R.N., Drugs Rehabilitation Center, National Narcotics Board of Indonesia, Indonesia; Iskandar, S., Department of Psychiatry, Universitas Padjadjaran, Bandung, West Java, Indonesia; Isra, T.N., National Institute of Education, Sri Lanka; Jain, S., Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; James, S., Univeristi Malaysia Sabah, Malaysia; Javadi, S.M.H., Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; Joe, K.H., National Center for Mental Health of Korea, South Korea; Jokubonis, D., Republican Center for Addictive Disorders, Lithuania; Jovanova, A.T., Addiction Medicine Clinic, North Macedonia; Kamal, R.M., Naufar Institute, Doha, Qatar; Kantchelov, A.I., The Kantchelov Clinic, Sofia, Bulgaria; Kathiresan, P., Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Katzman, G., Mount Sinai Medical Center, New York, United States; Kawale, P., African Institute for Development Policy, Malawi; Kern, A.M., Sobriety Centers of New Hampshire, United States; Kessler, F.H.P., Federal University of Rio Grande do Sul, Brazil; Kim, S.-G.S., Pusan National University Yangsan Hospital, Department of Neuropsychiatry, Yangsan, South Korea; Kimball, A.M., Chatham House, United States; Kljucevic, Z., Institute for Public Health of Split-Dalmatia County, Croatia; Kurniasanti, K.S., Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Indonesia; Lev, R., Scripps Mercy Hospital, San Diego, United States; Lee, H.K., Department of Psychiatry, The Catholic University of Korea, Seoul, South Korea; Lengvenyte, A., Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania; Lev-Ran, S., Israel Center on Addiction, Netanya, Israel; Mabelya, G.S., Community Health Work, Tanzania; Mahi, M.A.E., Hayat Center for Treatment and Psycho-social Rehabilitation, Khartoum, Sudan; Maphisa, J.M., University of Botswana, Botswana; Maremmani, I., V.P. Dole, Dual Disorder Unit, Santa Chiara University Hospital, University of Pisa, Italy; Masferrer, L., CAS Girona, Department of Psychology, University of Girona, Spain; Massah, O., Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; McCambridge, O., Community addiction team, Southern Health and Social Care Trust, United Kingdom; McGovern, G.G., Priority Medical Clinic, Dublin, Ireland; Min, A.K., Save the Children International Organization, Burma; Moghanibashi-Mansourieh, A., Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; Mora-Rios, J., Dirección de Investigaciones Epidemiológicas y Sociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, United States; Mudalige, I.U.K., Department of Psychiatry, Faculty of Medicine, Sir John Kotelawala Defence University, Sri Lanka; Mukherjee, D., Centre for Addiction Medicine, NIMHANS, Bangalore, India; Munira, P.M., Kleopatra Kodric, Irena Nisic, Slovenia; Myers, B., Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, South Africa; Menon T. N., J., NIMHANS, Bangalore, India; Narasimha, V.L., Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India; Ndionuka, N., Federal Neuropsychiatric Hospital, Calabar, Nigeria; Nejatisafa, A.-A., Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, Iran; Niaz, K., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Nizami, A.T., Institute of Psychiatry, WHO Collaborating Center for Mental Health, Pakistan; Nuijens, J.H., Brijder Addiction Care, Zaandam, Netherlands; Orsolini, L., Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy; Oum, V., Koh Kong Provincial Hospital, Cambodia; Oyemade, A.A., Kaiser Permanente, United States; Palavra, I.R., Psychiatric hospital Sveti Ivan, Zagreb, Croatia; Pant, S.B., Department of Psychiatry and mental health, Institute of Medicine, Tribhuvan University, Nepal; Paredes, J., Universidad de El Salvador, El Salvador; Peyron, E., AddiPsy, Lyon, France; Quirós, R.A., Addiction Medicine Clinic, Costa Rica; Qurishi, R., Novadic-Kentron Addiction Care Network, Vught, Netherlands; Rafiq, N.U.Z., Phoenix Foundation for Research and Development, Pakistan; Raghavendra Rao, R., Barwon Health, Geelong, Australia; Ratta-Apha, W., Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand; Raymond, K.-L., University of the Sunshine Coast (USC)QLD, Australia; Reimer, J., Center for Interdisciplinary Addiction Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Renaldo, E., Drugs Rehabilitation Center, National Narcotics Board of Indonesia; Rezapour, T., Department of Cognitive Psychology, Institute for Cognitive Science Studies, Tehran, Iran; Robertson, J.R., Usher Institute, University of Edinburgh, United Kingdom; Roncero, C., Psychiatry Service, University of Salamanca Health Care Complex, Salamanca, Spain; Roub, F., PGIMER, Chandigarh, India; Rubenstein, E.J., Street Health Centre, Canada; Rupp, C.I., Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck, Austria; Saenz, E., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Salehi, M., Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Samartzis, L., Medical School, University of Cyprus, Cyprus; Sarubbo, L.B., Clínica Psiquiátrica de la Facultad de Medicina, Uruguay; Segrec, N., Center for Treatment of Drug addiction, University Psychiatric Clinic, Ljubljana, Slovenia; Shah, B., Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lagankhel, Nepal; Shen, H., Department of Psychiatry, Second Xiangya Hospital, Central South University, China; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Japan; Shoptaw, S., David Geffen School of Medicine at UCLA, Department of Family Medicine, United States; Sintango, F.M., Health Professions Councils of Namibia, Namibia; Sosa, V.A., Addiction Medicine Clinic, Uruguay; Subata, E., Republican Center for Addictive Disorders, Lithuania; Sztycberg, N., Asociasion Programa Andres Argentina, Argentina; Taghizadeh, F., Mazandaran University of Medical Sciences, Mazandaran, Iran; Wee Teck, J.B.T., MRC/CSO SPHSU, University of Glasgow, United Kingdom; Tjagvad, C., Gladsaxe Substance Use Disorder Treatment Centre, Denmark; Torrens, M., Institut de Neuropsiquiatria i Addiccions, IMIM-Hospital del Mar, Medical Research, Barcelona, Spain; Twala, J.M., NACADA, Kenya; Vadivel, R., Waikato District Health Board (WDHB, Hamilton, New Zealand; Volpicelli, J.R., Institute of Addiction Medicine, United States; Weijs, J., Jellinek, Amsterdam, Netherlands; Wintoniw, S.M., Addictions Foundation of Manitoba, Canada; Wittayanookulluk, A., Thanyarak Chiangmai Hospital, Thailand; Wojnar, M., Medical University of Warsaw, Warsaw, Poland; Yasir, S., Institute of Psychiatry, WHO Collaborating Center for Mental Health, Pakistan; Yitayih, Y., Jimma University, Ethiopia; Zhao, M., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China; ISAM Global Survey Consortium (ISAM-GSC) |
Background and Aims: COVID-19 has infected more than 77 million people worldwide and impacted the lives of many more, with a particularly devastating impact on vulnerable populations, including people with substance use disorders (SUDs). Quarantines, travel bans, regulatory changes, social distancing, and “lockdown” measures have affected drug and alcohol supply chains and subsequently their availability, price, and use patterns, with possible downstream effects on presentations of SUDs and demand for treatment. Given the lack of multicentric epidemiologic studies, we conducted a rapid global survey within the International Society of Addiction Medicine (ISAM) network in order to understand the status of substance-use patterns during the current pandemic. Design: Cross-sectional survey. Setting: Worldwide. Participants: Starting on April 4, 2020 during a 5-week period, the survey received 185 responses from 77 countries. Measurements: To assess addiction medicine professionals' perceived changes in drug and alcohol supply, price, use pattern, and related complications during the COVID-19 pandemic. Findings: Participants reported (among who answered “decreased” or “increased”) a decrease in drug supply (69.0%) and at the same time an increase in price (95.3%) globally. With respect to changes in use patterns, an increase in alcohol (71.7%), cannabis (63.0%), prescription opioids (70.9%), and sedative/hypnotics (84.6%) use was reported, while the use of amphetamines (59.7%), cocaine (67.5%), and opiates (58.2%) was reported to decrease overall. Conclusions: The global report on changes in the availability, use patterns, and complications of alcohol and drugs during the COVID-19 pandemic should be considered in making new policies and in developing mitigating measures and guidelines during the current pandemic (and probable future ones) in order to minimize risks to people with SUD. © Copyright © 2021 Farhoudian, Radfar, Mohaddes Ardabili, Rafei, Ebrahimi, Khojasteh Zonoozi, De Jong, Vahidi, Yunesian, Kouimtsidis, Arunogiri, Hansen, Brady, ISAM Global Survey Consortium (ISAM-GSC), Potenza, Baldacchino and Ekhtiari. |
addiction; behavioral addiction; COVID-19; global survey; illicit drug market; substance use disorder |
alcohol; cannabis; illicit drug; addiction medicine; adult; Article; coronavirus disease 2019; drug bioavailability; drug industry; female; gambling; health care personnel; health service; human; male; pandemic; pharmacist; prescription; questionnaire; substance use |
Frontiers Media S.A. |
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Raharjanti N.W., Wiguna T., Purwadianto A., Soemantri D., Bardosono S., Poerwandari E.K., Mahajudin M.S., Ramadianto A.S., Alfonso C.A., Findyartini A., Nugrahadi N.R., Lazuardi M.Q., Subroto P.A.M., Saroso O.J.D.A., Levania M.K. |
57226872499;24367785700;18635479200;36640659100;21933841000;25628305200;57218600581;57226862690;7004331573;56543777300;57221694462;57226862998;57208444972;57226865761;57226868672; |
Clinical Reasoning in Forensic Psychiatry: Concepts, Processes, and Pitfalls |
2021 |
Frontiers in Psychiatry |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113172545&doi=10.3389%2ffpsyt.2021.691377&partnerID=40&md5=a63e42686ad595c41e376dfb2ea2ffc6 |
Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Department of Forensic and Medicolegal, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Airlangga University, Surabaya, Indonesia; Department of Psychiatry, Columbia University, New York, NY, United States |
Raharjanti, N.W., Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Wiguna, T., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Purwadianto, A., Department of Forensic and Medicolegal, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Poerwandari, E.K., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Mahajudin, M.S., Department of Psychiatry, Airlangga University, Surabaya, Indonesia; Ramadianto, A.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Alfonso, C.A., Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Psychiatry, Columbia University, New York, NY, United States; Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nugrahadi, N.R., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Lazuardi, M.Q., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Subroto, P.A.M., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Saroso, O.J.D.A., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Levania, M.K., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Forensic psychiatrists are often sought by the court of law to provide professional opinion on specific legal matters that have a major impact on the evaluee and possibly society at large. The quality of that opinion and recommendations rely on the quality of the analysis from the assessment results conducted by the psychiatrist. However, the definition and scope of a forensic psychiatric analysis is not clear. While existing literature on forensic psychiatric analysis generally includes organizing information, identifying relevant details, and formulating a set of forensic psychiatric opinions as components, there is no explicit and unified definition of these terms and process. This lack of clarity and guidelines may hinder forensic psychiatry from achieving its goal of providing objective information to the court or other relevant parties. Forensic psychiatric analysis exhibits numerous parallels to clinical reasoning in other fields of medicine. Therefore, this review aims to elaborate forensic psychiatric analysis through the lens of clinical reasoning, which has been developed by incorporating advances in cognitive sciences. We describe forensic psychiatric analysis through three prominent clinical reasoning theories: hypothetico-deductive model, illness script theory, and dual process theory. We expand those theories to elucidate how forensic psychiatrists use clinical reasoning not only to diagnose mental disorders, but also to determine mental capacities as requested by law. Cognitive biases are also described as potential threat to the accuracy of the assessment and analysis. Additionally, situated cognition theory helps elucidate how contextual factors influence risk of errors. Understanding the processes involved in forensic psychiatric analysis and their pitfalls can assist forensic psychiatrists to be aware of and try to mitigate their bias. Debiasing strategies that have been implemented in other fields of medicine to mitigate errors in clinical reasoning can be adapted for forensic psychiatry. This may also shape the training program of general psychiatrists and forensic psychiatrists alike. © Copyright © 2021 Raharjanti, Wiguna, Purwadianto, Soemantri, Bardosono, Poerwandari, Mahajudin, Ramadianto, Alfonso, Findyartini, Nugrahadi, Lazuardi, Subroto, Saroso and Levania. |
clinical reasoning; cognitive bias; debiasing strategy; dual process theory; forensic psychiatry; hypothetico-deductive model; illness-script theory; psychomedicolegal analysis |
clinical reasoning; cognitive bias; court; forensic psychiatry; human; mental capacity; practice guideline; psychiatrist; review; theoretical study; training |
Frontiers Media S.A. |
16640640 |
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Review |
Q1 |
1363 |
2668 |
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233 |
Sunarno S., Puspandari N., Sariadji K., Febriyana D., Saraswati T.F.R.D., Maha M.S., Handayani S., Lestari C.S.W., Fitriana V.S.F., Yuniar Y., Pracoyo N.E., Pradono J., Siswanto S., Multihartina P., Anggraeni N.D., Hidayati L.N., Sukandar A., Safaat H., Karyanti M.R. |
57441531200;56786591900;57199654249;57222530233;57462625600;6603127192;26023188400;57194534757;57462459800;57219339473;57273150400;57462947000;56613530000;56708801900;57218324975;57463104500;57463428900;57462459900;56290680800; |
Microbiological and Clinical Aspects of Diphtheria-Confirmed Cases from Capital City of Indonesia, Jakarta, and Surrounding Areas in 2017 |
2021 |
Jundishapur Journal of Microbiology |
14 |
8 |
e118751 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125038649&doi=10.5812%2fJJM.118751&partnerID=40&md5=cd6599282018ea61a451d60e8fe3eb1a |
Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; World Health Organization, South-East Asia Regional Office, New Delhi, India; Jakarta Provincial Health Office, Jakarta, Indonesia; West Java Provincial Health Office, Bandung, Indonesia; Banten Provincial Health Office, Serang, Indonesia; Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia |
Sunarno, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Sariadji, K., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Febriyana, D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Saraswati, T.F.R.D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Maha, M.S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Handayani, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Lestari, C.S.W., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Fitriana, V.S.F., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Yuniar, Y., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Pracoyo, N.E., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Pradono, J., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Siswanto, S., World Health Organization, South-East Asia Regional Office, New Delhi, India; Multihartina, P., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Anggraeni, N.D., Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Hidayati, L.N., Jakarta Provincial Health Office, Jakarta, Indonesia; Sukandar, A., West Java Provincial Health Office, Bandung, Indonesia; Safaat, H., Banten Provincial Health Office, Serang, Indonesia; Karyanti, M.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia |
Background: The World Health Organization reported Indonesia as one of the countries with the most prevalent cases of diphtheria worldwide. The microbiological aspects of diphtheria-inducing bacteria are of great significance in tracing disease transmission and case management. However, clinical aspects are critical for updating clinical features and case management in the field, which may sometimes differ from theoretical foundations. Objectives: This study aimed to identify the microbiological and clinical aspects, including molecular typing and case fatality rates, in diphtheria-confirmed cases from the capital city of Indonesia, Jakarta, and surrounding areas in 2017. Methods: The microbiological aspect of 40 diphtheria-confirmed cases were obtained by re-identify diphtheria-inducing bacteria isolated from the samples, while the clinical aspects of the cases were obtained from the medical records and epidemiological data. The chi-square test was used to examine the correlation between fatal cases and myocarditis and diphtheria antitoxin administra-tion delay. In this study, P ≤ 0.05 was set as the significance level. Results: All 40 diphtheria confirmed cases were induced by toxigenic Corynebacterium diphtheriae with two biotypes, namely inter-medius (60.0%) and mitis (40.0%). There are six sequence types of bacteria with two main sequence types, ie, ST534 (46.4%) and ST377 (35.7%). The proportions of cases that had a fever and sore throat were 72.5% and 77.5%, respectively; however, the prevalence rates of the cases with pseudomembrane and bull neck were 100% and 47%, respectively. Most cases were administered a combination of penicillin or erythromycin with other antibiotics (40%), and 22.5% of the cases only received penicillin. Myocarditis was noticed in three fatal cases, and their relationship was statistically significant (P = 0.000). All five fatal cases (12.5% of cases) received diphtheria antitoxin (DAT) lately or had not received it yet. Conclusions: Toxigenic C. diphtheriae with two biotypes (namely mitis and intermedius) and two main sequence types (ie, ST534 and ST377) was the causative agent of diphtheria-confirmed cases from Jakarta and surrounding areas in 2017. It was also concluded that those fatal cases were correlated with myocarditis complications. © 2021, Author(s). |
Corynebacterium diphtheriae; Diphtheria; Indonesia; Jakarta |
antibiotic agent; antitoxin; erythromycin; glycerol; penicillin G; adolescent; airway obstruction; Article; bacterium identification; bull neck; case fatality rate; child; clinical assessment; clinical feature; conceptual framework; controlled study; correlation analysis; Corynebacterium diphtheriae; Corynebacterium pseudotuberculosis; descriptive research; diphtheria; disease transmission; female; fever; headache; human; Indonesia; intermedius; major clinical study; male; medical record; microbiology; microscopy; mitis; molecular typing; multilocus sequence typing; polymerase chain reaction; preschool child; pseudomembrane; school child; sequence analysis; sore throat; toxicity testing; vaccination; World Health Organization |
Kowsar Medical Institute |
20083645 |
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Article |
Q3 |
281 |
15495 |
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234 |
Nugroho S.W., Pradhana I., Gunawan K. |
57460519700;57373805000;57195935319; |
New adaptation of neurosurgical practice and residency programs during the Covid-19 pandemic and their effects on neurosurgery resident satisfaction and welfare at the National General Hospital, Jakarta, Indonesia |
2021 |
Heliyon |
7 |
8 |
e07757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121271314&doi=10.1016%2fj.heliyon.2021.e07757&partnerID=40&md5=09cbd414f0eefb36b6d98b642efa84cf |
Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nugroho, S.W., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradhana, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Many institutions in numerous countries have made changes in their health care services during the COVID-19 pandemic. One change has been to reduce elective neurosurgery cases, which has impacted neurosurgery education. Published literature is lacking about the healthcare services, education, and residents’ well-being during adaptation to the pandemic, especially in national referral hospitals in developing countries. Methods: We conducted a cross-sectional study on current neurosurgical services during 2020. We evaluated 34 neurosurgery residents in Cipto Mangunkusumo National General Hospital using a self-made questionnaire to determine the effects of the COVID-19 pandemic on their surroundings, education process, and satisfaction with the currently adapted education program. We used the modified Maslach Burnout Inventory to assess burnout in the residents before and during the pandemic. Results: Neurosurgical residents spent more time studying neurosurgical theory (Mode 1–1.5h/day, p < 0.05) but spent less time learning neurosurgical skills (Mode 30 min–1 h/day, p < 0.05) compared to before the pandemic. The resident satisfaction mean score (scale 0–10) was 7.58 for live surgery and 8.53 for the microsurgical skills lab training program. On a scale of 1–10, the residents’ stress level increased after the pandemic but the change was not statistically significant (6.61 ± 1.87, p > 0.05). The Modified Maslach Burnout inventory score was 3.02 ± 3.74 during the pandemic, and increased from before the pandemic (2.41 ± 3.18), but the difference was not statistically significant. Conclusion: The COVID-19 pandemics have reduced the working hours and the clinical exposure of neurosurgical residents. Fortunately, this pandemic has led to a new opportunity to find many suitable learning methods which may decrease the risk of burnout. The psychological burden of residents is still worrisome, and planned management is necessary to sustain resident performance. © 2021 |
COVID-19; Education; Neurosurgery; Neurosurgical residency; Pandemic; Residency |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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236 |
Lancaster K.E., Mollan K.R., Hanscom B.S., Shook-Sa B.E., Ha T.V., Dumchev K., Djoerban Z., Rose S.M., Latkin C.A., Metzger D.S., Go V.F., Dvoriak S., Reifeis S.A., Piwowar-Manning E.M., Richardson P., Hudgens M.G., Hamilton E.L., Eshleman S.H., Susami H., Chu V.A., Djauzi S., Kiriazova T., Nhan D.T., Burns D.N., Miller W.C., Hoffman I.F. |
55503210000;26659057900;6603650318;55990940100;36988527800;8923601900;23472548200;12544917400;57235096800;35944632400;7102536801;57205192774;57193208279;35783326900;57203639655;6603567044;56450237600;7004740977;57202642757;57195576444;23495847800;55757875500;57317058700;7403171278;7406061778;7006682600; |
Engaging People Who Inject Drugs Living with HIV in Antiretroviral Treatment and Medication for Opioid Use Disorder: Extended Follow-up of HIV Prevention Trials Network (HPTN) 074 |
2021 |
Open Forum Infectious Diseases |
8 |
8 |
ofab281 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118242331&doi=10.1093%2fofid%2fofab281&partnerID=40&md5=6133eea6e10cff9e76240789c9b5b783 |
Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; UNC Vietnam, Hanoi, Viet Nam; Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Science Facilitation Department, FHI 360, Durham, NC, United States; Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; HIV Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Academy of Labor, Social Relations and Tourism, Kyiv, Ukraine; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Vietnam Administration of HIV/AIDS Control, Hanoi, Viet Nam; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
Lancaster, K.E., Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Mollan, K.R., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Hanscom, B.S., Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Shook-Sa, B.E., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Ha, T.V., Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, UNC Vietnam, Hanoi, Viet Nam; Dumchev, K., Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Djoerban, Z., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rose, S.M., Science Facilitation Department, FHI 360, Durham, NC, United States; Latkin, C.A., Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; Metzger, D.S., HIV Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Go, V.F., Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Dvoriak, S., Academy of Labor, Social Relations and Tourism, Kyiv, Ukraine; Reifeis, S.A., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Piwowar-Manning, E.M., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Richardson, P., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Hudgens, M.G., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Hamilton, E.L., Science Facilitation Department, FHI 360, Durham, NC, United States; Eshleman, S.H., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Susami, H., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Chu, V.A., UNC Vietnam, Hanoi, Viet Nam; Djauzi, S., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kiriazova, T., Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Nhan, D.T., Vietnam Administration of HIV/AIDS Control, Hanoi, Viet Nam; Burns, D.N., Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Miller, W.C., Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Hoffman, I.F., Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
Background: People who inject drugs (PWID) living with HIV experience inadequate access to antiretroviral treatment (ART) and medication for opioid use disorders (MOUD). HPTN 074 showed that an integrated intervention increased ART use and viral suppression over 52 weeks. To examine durability of ART, MOUD, and HIV viral suppression, participants could re-enroll for an extended follow-up period, during which standard-of-care (SOC) participants in need of support were offered the intervention. Methods: Participants were recruited from Ukraine, Indonesia and Vietnam and randomly allocated 3:1 to SOC or intervention. Eligibility criteria included: HIV-positive; active injection drug use; 18-60 years of age; ≥1 HIV-uninfected injection partner; and viral load ≥1,000 copies/mL. Re-enrollment was offered to all available intervention and SOC arm participants, and SOC participants in need of support (off-ART or off-MOUD) were offered the intervention. Results: The intervention continuation group re-enrolled 89 participants, and from week 52 to 104, viral suppression (<40 copies/mL) declined from 41% to 29% (estimated 9.4% decrease per year, 95% CI-17.0%;-1.8%). The in need of support group re-enrolled 94 participants and had increased ART (re-enrollment: 55%, week 26: 69%) and MOUD (re-enrollment: 16%, week 26: 25%) use, and viral suppression (re-enrollment: 40%, week 26: 49%). Conclusions: Viral suppression declined in year 2 for those who initially received the HPTN 074 intervention and improved maintenance support is warranted. Viral suppression and MOUD increased among in need participants who received intervention during the study extension. Continued efforts are needed for widespread implementation of this scalable, integrated intervention. © 2021 The Author(s). |
antiretroviral therapy; HIV infection; injection drug use; methadone/therapeutic use; viral load |
antiretrovirus agent; buprenorphine; methadone; adult; Article; CD4 lymphocyte count; Consolidated Standards of Reporting Trial; controlled study; disease transmission; epidemic; evaluation and follow up; female; health care quality; health education; hepatitis C; human; Human immunodeficiency virus infection; incidence; injection drug user; integrated health care system; intervention study; interview; major clinical study; male; medication compliance; medication for opioid use disorder; medication for opioid use disorder; middle aged; opiate addiction; outcome assessment; paramedical personnel; practice guideline; psychosocial development; randomized controlled trial; telephone interview; viral suppression; virus load; World Health Organization; young adult |
Oxford University Press |
23288957 |
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Article |
Q1 |
1546 |
2161 |
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