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Sudibio S., Anton J., Handoko H., Permata T.B.M., Kodrat H., Nuryadi E., Sofyan H.R., Mulyadi R., Aman R.A., Gondhowiardjo S. |
57283461500;57328462500;57204105168;57197808751;57210639849;57197806814;57328366500;56403164500;36848942500;6508327402; |
Outcome analysis and prognostic factors in patients of glioblastoma multiforme: An indonesian single institution experience |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1410 |
1416 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119154241&doi=10.3889%2foamjms.2021.7502&partnerID=40&md5=9312ddc4112180679fb892c1d7cc2e79 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Neurology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Neurosurgery, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Sudibio, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Anton, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Handoko, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kodrat, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nuryadi, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sofyan, H.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Mulyadi, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aman, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurosurgery, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
AIM: This study was done to assess the survival of patients with glioblastoma multiforme (GBM) and to identify factors that can affect patient survival. MATERIALS AND METHODS: From January 2015 to December 2019, 55 patients with histopathologically confirmed GBM and received adjuvant radiation/chemoradiation in our department were retrospectively analyzed. RESULTS: The median overall survival (OS) for entire cohort was 13 months and 1-year OS and 2-year OS rate were 52.7% and 3.6% with the mean follow-up period was 12 months. In univariate analysis, age (≤50 years vs. >50 years, p = 0.02), performance status (≥90 vs. 70–80 vs. <70, p < 0.001), radiation therapy oncology group recursive partitioning analysis (RTOG-RPA) classification (Class III vs. Class IV vs. Class V-VI, p < 0.001), parietal lobes tumor site (vs. others, p = 0.02), residual tumor volume (≤20.4 cm3 vs. >20.4 cm3, p = 0.001), and time to initiate adjuvant therapy (<4 weeks vs. 4-6 weeks vs. >6 weeks, p = 0.01) were significantly affect OS. In multivariate analysis, RTOG-RPA classification and involvement of parietal lobes were independent prognostic factors for OS. CONCLUSIONS: RTOG-RPA classification that consisted of age and performance status is an independent prognostic factor for the clinical outcome of GBM. Besides this well-known factor, we also identified the involvement of parietal lobe gives a strong negative influence on survival of GBM patients. © 2021 Sudibio Sudibio, Jellyca Anton, Handoko Handoko, Tiara Bunga Mayang Permata, Henry Kodrat, Endang Nuryadi, Henry Riyanto Sofyan, Rahmad Mulyadi, Renindra Ananda Aman, Soehartati Gondhowiardjo. |
Glioblastoma multiforme; Prognostic factors; Radiotherapy; Survival |
methylated DNA protein cysteine methyltransferase; adjuvant chemotherapy; adult; Article; basal ganglion; cancer prognosis; cancer radiotherapy; cancer size; cancer surgery; cancer survival; chemoradiotherapy; clinical outcome; cohort analysis; controlled study; corpus callosum; female; follow up; frontal lobe; glioblastoma; histopathology; human; human tissue; major clinical study; male; outcome assessment; overall survival; parietal lobe; prospective study; radiation dose; recursive partitioning; retrospective study; temporal lobe; tumor volume |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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3 |
Taufiqa Z., Chandra D.N., Helmizar H., Lipoeto N.I., Hegar B. |
57295694500;57190861000;57193098406;6507795270;6506273944; |
Micronutrient content and total lactic acid bacteria of dadiah pudding as food supplementation for pregnant women |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1149 |
1155 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117031213&doi=10.3889%2foamjms.2021.6791&partnerID=40&md5=41ee51317717c3162ced81a45aa47265 |
Department of Nutrition, Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Education Unit, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Public Health, Universitas Andalas, Padang, 25144, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Taufiqa, Z., Department of Nutrition, Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Medical Education Unit, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Chandra, D.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Helmizar, H., Department of Nutrition, Faculty of Public Health, Universitas Andalas, Padang, 25144, Indonesia; Lipoeto, N.I., Department of Nutrition, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Hegar, B., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
BACKGROUND: Dadiah, traditional yogurt from Indonesia, which is known as a source of probiotics, also contains micronutrients. AIM: This descriptive study aimed to determine whether additional ingredients and processes during the manufacture of Dadiah pudding maintain the iron, zinc, calcium, and total lactic acid bacteria (LAB) contents. METHODS: Dadiah pudding was made using Dadiah originated from Bukittinggi, West Sumatra. Micronutrient levels were analyzed according to Indonesian National Standard 01-2896-1998. The total LAB were counted by inoculating samples on Man, Rogosa, and Sharpe agar with serial dilution, and morphological identification was carried out using gram stain. RESULTS: In 100 g of original Dadiah, mango and chocolate Dadiah pudding contained 347.98, 276.61, and 279.29 mg of calcium; 4.87, 3.75, and 6.31 mg of zinc; 6.53, 6.60, and 9.39 mg of iron; and 6.4 × 10⁹, 6.1 × 10⁹, and 2.4 × 10⁹ CFU/ml LAB, respectively. CONCLUSION: This study found that modifying the original Dadiah into Dadiah pudding has been proved to affect the concentration of calcium, zinc, and iron and to maintain total LAB. We suggest that consuming Dadiah pudding may be a good choice as a food supplementation for pregnant women to optimize the golden period outcomes. © 2021 Zuhrah Taufiqa, Dian Novita Chandra, Helmizar Helmizar, Nur Indrawaty Lipoeto, Badriul Hegar. |
Dadiah pudding; Lactic acid bacteria; Micronutrients; Pregnant women; Probiotic |
calcium; iron; probiotic agent; trace element; yoghurt; zinc; adult; Article; bacterial count; colony forming unit; controlled study; dietary supplement; double blind procedure; female; fermentation; fermented product; food frequency questionnaire; food industry; gestational age; Gram staining; health center; human; human experiment; Indonesia; informed consent; lactic acid bacterium; microbial morphology; micronutrient intake; middle aged; normal human; pregnancy outcome; pregnant woman; randomized controlled trial; young adult |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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4 |
Rinaldi I., Putri A., Louisa M., Koesnoe S. |
23475122400;57214826648;41461551400;26028015000; |
High stat5a expression is associated with major molecular response achievement failure of chronic phase chronic myeloid leukemia patients receiving hydroxyurea before imatinib: A cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1160 |
1167 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117030211&doi=10.3889%2foamjms.2021.6911&partnerID=40&md5=f2aaf46fdf0c34ecbeb60cc8e6d66cac |
Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Rinaldi, I., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Putri, A., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koesnoe, S., Department of Internal Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
BACKGROUND: STAT5 is a transcriptional factor which when highly expressed in chronic myeloid leukemia (CML) cells stimulate proliferation and mediate resistance from tyrosine kinase inhibitors, resulting in major molecular response (MMR) failure. STAT5 has two isoforms, STAT5A and STAT5B. However, prolonged use of imatinib appears to only upregulate STAT5A pathway. In addition, the resistance conferred by STAT5A does not extend to other drugs such as hydroxyurea. Hence, STAT5A and STAT5B might have different functions in CML cells. AIM: The objective of the study was to determine the association of STAT5A and STAT5B expression with MMR failure in CML patients. METHODS: This was a cross-sectional study of CML patients in chronic phase with age ≥ 18 years old, receiving IM therapy ≥ 12 months, and previously given hydroxyurea. MMR status was evaluated and patients were categorized as achieved or failed to achieve MMR. Expression levels of STAT5A and STAT5B were conducted using RT-PCR methods. Associations between STAT5A expression, STAT5B expression, hydroxyurea duration, and imatinib duration with MMR achievement were calculated using logistic regression. RESULTS: A total of 118 patients were analyzed; 71.1% failed to achieve MMR. Multivariate logistic regression analysis showed statistically significant association between high STAT5A expression (odds ratio [OR]: 3.852; 95% confidence interval [CI]: 1.420–10.452; p = 0.008), STAT5A/STAT5B interaction (OR: 0.150; 95% CI: 0.038–0.593; p = 0.007), longer hydroxyurea administration (OR: 3.882; 95% CI: 1.023–14.733; p = 0.046), and shorter imatinib administration (OR: 0.333; 95% CI: 0.132–0.840; p = 0.020) with MMR achievement failure. After adjusting STAT5A expression with STAT5A/STAT5B interaction, high STAT5A expression independently increased the likelihood of MMR achievement failure only in high expression STAT5B patients (OR: 3.852; 95% CI: 1.420–10.452; p = 0.008). CONCLUSION: High STAT5A expression which is induced by high STAT5B is associated with MMR achievement failure of chronic phase CML patients who received hydroxyurea before imatinib. Longer duration of hydroxyurea and shorter duration of IM confound of STAT5A expression to MMR achievement failure. © 2021 Ikhwan Rinaldi, Anastasia Putri, Melva Louisa, Sukamto Koesnoe. |
Breakpoint cluster region-ABL; Chronic myeloid leukemia; Imatinib; STAT5A; STAT5B |
eltrombopag; hemoglobin; hydroxyurea; imatinib; STAT5 protein; adult; age; Article; basophil; blood sampling; chronic myeloid leukemia; cross-sectional study; female; gene amplification; housekeeping gene; human; human cell; human experiment; leukocyte; lymphocyte; major clinical study; male; middle aged; neutrophil; overall survival; platelet count; protein expression; real time polymerase chain reaction; sex; thrombocyte |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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8 |
Sartika D., Nurrachmah E., Sukirman D.I., Mansyur M., Supartono B. |
57467276300;57466703100;57467568600;37085506800;57205286040; |
Ergonomic Risk-prone Activities toward Nurses in the Intensive Care and Emergency Room |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
T5 |
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48 |
53 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125269929&doi=10.3889%2fOAMJMS.2021.7851&partnerID=40&md5=e4f606505a7f1d2f7fa6498e532fb934 |
Health Polytechnic of Riau, Pekanbaru, Indonesia; Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia |
Sartika, D., Health Polytechnic of Riau, Pekanbaru, Indonesia; Nurrachmah, E., Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Sukirman, D.I., Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Supartono, B., Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia |
BACKGROUND: Nurses have the risk of ergonomic hazards in providing nursing care, especially with increasingly dynamic health services such as during Coronavirus disease-19 pandemic like today. AIM: The aim of the study was to evaluate activities prone to produce ergonomic risks during the implementation of nursing care in intensive care and emergency room (ER) of a hospital in Riau, Indonesia. METHODOLOGY: This study was conducted by observing the routine activities conducted by the nurses and using similar task group techniques equipped with Rapid Entire Body Assessment instrument. Those observed activities were obtained from 17 intensive care room nurses and ten ER nurses. There were six activities observed in the intensive care room: Bathing, transferring the patient, wounds dressing, taking blood samples for the AGDA examinations, as well as inserting the intravenous needle and electrocardiograms. Meanwhile, there were two activities observed in the ER: Transferring the patient and inserting the intravenous needle. RESULTS: The highest ergonomic risks activity in the intensive care room was bathing the patient with a total score of 13. At the ER, the highest risk score was transferring the patient with a total score of 12. Both activities were at level 4, indicating a high-risk condition. Thus, examinations and changes should be immediately initiated. CONCLUSION: The results are significant to be paid attention by the related parties at the hospital to facilitate some improvements immediately. In addition, the ergonomic approaches that can be suggested to the nurses are regular stretching, physical exercises, and applying ergonomic principles while working. © 2021 Dewi Sartika, Elly Nurrachmah, Dewi Irawaty Sukirman, Muchtaruddin Mansyur, Basuki Supartono. |
Emergency room; Ergonomic risk; Intensive care; Nurse’s activity; Nursing intervention |
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Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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136 |
Daulay R.S., Saragih R.A.C., Daulay R.M., Ganie R.A., Tann G., Supriyatno B. |
57201677329;57204321772;6504644320;57193788722;57213061716;37068046400; |
Role of interferon-gamma +874 a/t single-nucleotide polymorphism and tuberculosis susceptibility of pediatric population in north sumatera, indonesia |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1057 |
1060 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121721756&doi=10.3889%2foamjms.2021.7441&partnerID=40&md5=490f692392638585ec48409e7140509b |
Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Daulay, R.S., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Saragih, R.A.C., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Daulay, R.M., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Ganie, R.A., Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Tann, G., Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Supriyatno, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Tuberculosis (TB) remains to be a leading cause of morbidity and mortality worldwide. The immune defense against Mycobacterium tuberculosis is complicated. Interferon-gamma (IFN-γ) is the main cytokine involved in the immune response of TB. To date, the role of +874 A/T single-nucleotide polymorphism (SNP) and TB disease susceptibility continues to be controversial. AIM: The aim of this study was to investigate the role of +874 A/T SNP and TB disease susceptibility of pediatric population in North Sumatera, Indonesia. METHODS: A case–control study was conducted in Medan and Batubara, North Sumatera, Indonesia, from January to December 2016. A total of 51 children with TB and 51 healthy controls were enrolled in this study. Subjects were 2 months–14 years old age children diagnosed with TB and written informed consent from the parents or the caregivers to participate. Subjects were withdrawn from the study when immunodeficiency condition was found or suffered from other infection disease. DNA samples were obtained from all of the subjects. +874 A/T SNP was identified by performing the amplification refractory mutational system-polymerase chain reaction method. IFN-γ levels were measured using human enzyme-linked immunosorbent assay. Data analysis was performed using Chi-square and Mann–Whitney test. P < 0.05 was considered statistically significant. RESULTS: The result of this study reveals that the presence of AA, AT, and TT genotype in TB patients was 31 (60.8%), 20 (39.2%), and 0 (0%), respectively (p = 0.023). Significant decreased production of IFN-γ levels (p = 0.042) was found in TB patients 9.41 (1.10–28.06) pg/ml. CONCLUSION: Our study demonstrated significant evidence of the role of +874 A/T SNP and TB disease susceptibility of pediatric population in North Sumatera, Indonesia, predominantly AA genotype. Significant decreased production of IFN-γ reported among pediatric TB. © 2021 Rini Savitri Daulay, Rina Amalia C. Saragih, Ridwan Muchtar Daulay, Ratna Akbari Ganie, Gino Tann, Bambang Supriyatno. |
+874 A/T; Indonesia; Interferon-gamma; Pediatric; Single-nucleotide polymorphism; Tuberculosis |
gamma interferon; adolescent; amplification refractory mutation system polymerase chain reaction; Article; case control study; child; controlled study; cytokine production; disease predisposition; DNA isolation; enzyme linked immunosorbent assay; female; fine needle aspiration biopsy; gene frequency; genotype; human; immune deficiency; infant; major clinical study; male; newborn; preschool child; school child; single nucleotide polymorphism; thorax radiography; tuberculin test; tuberculosis |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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610 |
Lisnawati L., Billianti Y.D., Manatar A.F. |
57215311695;57398065300;57398065400; |
Association between foxp3 tumor infiltrating lymphocyte expression and response after chemoradiation in nasopharyngeal carcinoma |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1285 |
1291 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122331446&doi=10.3889%2foamjms.2021.7639&partnerID=40&md5=966b01cb054ca6692343d8dda3943b56 |
Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Lisnawati, L., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Billianti, Y.D., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Manatar, A.F., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a carcinoma originating from the surface epithelium of the nasopharynx with the highest incidence in China and South East Asia. Currently, many researchers are developing tumor microenvironment which can be assessed by tumor-infiltrating lymphochyte, and its association with treatment response in several tumors, including NPC. Foxp3, known as a regulatory T cell (Treg) marker, plays a role in the immunoregulatory environment of tumor cells and can be used as a prognostic factor. The relationship between Foxp3 expression and treatment response is considered as one of the factors affecting the prognosis of NPC. AIM: This study aims to determine the relationship between Foxp3 expression and treatment response in NPC. MATERIALS AND METHODS: A cross-sectional study was done to analyze the association between Foxp3 and treatment response in NPC. This study included 60 samples who were diagnosed with non-keratinizing NPC at the Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital from January 2018 until December 2020. Immunohistochemistry was done to evaluate the expression of Foxp3. Foxp3 expression was evaluated in the intratumoral and peritumoral areas. RESULTS: Among 60 patients, the number of males were more than females (66.7%, 33.3%, respectively) with a ratio of 2:1. There was statistically significant difference between intratumoral and total Foxp3 expression and treatment response (p < 0.05, p = 0.001, respectively); however, no significant differences found between peritumoral Foxp3 expression and treatment response (p = 0.114). CONCLUSION: Foxp3 expression had a statistically significant relationship with response therapy after chemoradiation. © 2021 Lisnawati Lisnawati, Yayi Dwina Billianti, Amelia Fossetta Manatar. |
Chemoradiation therapy; Foxp3; Nasopharyngeal carcinoma |
transcription factor FOXP3; adolescent; adult; Article; cancer infiltration; cancer prognosis; chemoradiotherapy; chemotherapy; child; complete response; computer assisted tomography; cross-sectional study; female; gene expression; histopathology; human; human tissue; immunohistochemistry; lymph vessel metastasis; lymphocytic infiltration; major clinical study; male; nasopharynx carcinoma; nuclear magnetic resonance imaging; partial response; pathologist; progressive response; protein expression; radiodiagnosis; regulatory T lymphocyte; rehydration; stable disease; treatment response; tumor associated leukocyte; tumor microenvironment; tumor volume |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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611 |
Indarti J., Surya R., Aditya R., Ikhsan M., Alda K., Antoniman M.A. |
39161587400;56986345100;57384331700;36518708700;57218391373;57385259100; |
Successfully pregnancy outcome after lletz in women with cervical intraepithelial neoplasia: A case series |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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308 |
312 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121712103&doi=10.3889%2foamjms.2021.7770&partnerID=40&md5=c8d73616847c9c707c197e7f03bfed5e |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Indarti, J., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aditya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ikhsan, M., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Alda, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Antoniman, M.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Human papillomavirus (HPV) has an important role in cervical cancer development and the incidence of cervical intraepithelial neoplasia (CIN) was 1.3–2.7/1000 pregnancies. The HPV and its treatments such as loop electrosurgical excisional procedure (LEEP) or large loop electrosurgical excisional procedure (LLETZ) have an association with poor obstetric outcomes. CASE REPORT: Here, we present four case studies of successful live birth after treatment of CIN. We reported that four patients had been performed LLETZ, with abnormal colposcopy results and liquidbased cytology results were one ASCUS, one ASCH, and two HSIL. The histopathology results were one CIN 1, one CIN 2, and two CIN 3. There was a higher rate of pregnancy for treated women than untreated women. The higher the CIN grades, the more prevalence of cesarean section rate. CONCLUSION: The HPV testing or cotesting at 3-year intervals is recommended after treatment due to the sensitivity of HPV testing. Although pregnancy could delay the progression of precancerous lesions, it is recommended to follow the individualized algorithm in the ASCCP guideline to reduce the risk of cervical cancer progression. © 2021 Junita Indarti, Raymond Surya, Reyhan Aditya, Muhammad Ikhsan, Kristian Alda, Mohammad Agassi Antoniman. |
Infant outcome; Precancerous lesion; Pregnancy profile |
adult; algorithm; Article; birth weight; cancer growth; case report; case study; cesarean section; clinical article; colposcopy; cytology; family planning; female; histopathology; human; live birth; loop electrosurgical excision; practice guideline; preeclampsia; pregnancy outcome; uterine cervix carcinoma in situ; Wart virus |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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612 |
Astuti S.W., Liem I.K., Ramli Y. |
57385798200;55802927800;57197869497; |
The effect of intravenously and intra-arterially delivered human umbilical cord blood mononuclear cell on cortical neurogenesis of post-ischemic stroke rat brain |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1245 |
1251 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121681681&doi=10.3889%2foamjms.2021.6555&partnerID=40&md5=33a2aafda87f7fa7e1e4defa3f943842 |
Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Gunadarma University, Depok, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Astuti, S.W., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Gunadarma University, Depok, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramli, Y., Stem Cell Medical Technology Integrated Service Unit, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
BACKGROUND: Stroke is the second most cause of death in the world. There are several treatments but they often end up with disabilities. Recently, cell therapy has become a new hope as an alternative treatment as it could improve the patients neurological deficits and daily living activities. Cord blood mononuclear cells (CB-MNCs) are one of the cell therapies for post-ischemic neurogenesis by intravenous or intra-arterial administration; however, it is not clear which one is better. AIM: This study aims to compare the effects of intra-arterial and intravenous administration of human CB-MNC on cortical neurogenesis of rat brain after ischemic stroke. METHODS: Twenty-four rats were divided into four groups, that is, control, middle cerebral artery obstruction (MCAO) without treatment, MCAO with intra-arterial CB-MNC injection (MCAO-IA), and MCAO with intravenous CB-MNC injection (MCAO-IV). Two weeks after injection, all rats were sacrificed, the brain was harvested, histologically process and stained with hematoxylin eosin (HE) to determine cellular and tissue morphology changes, and immunohistochemical staining, anti-NeuN antibody to determine the number of cortical neurons. The HE showed that MCAO rat brain had gliosis and shrunken cells. RESULTS: The results showed that MCAO-IA and MCAO-IV had fewer areas of gliosis and shrunken cells when compared to the MCAO group. The number of neurons also showed an increase. However, there was no difference between the MCAO-IA and MCAO-IV groups. It was concluded both of them could improve neurogenesis. CONCLUSION: CB-MNC administration can be an alternative for stroke ischemic therapy because it is proven to increase neurogenesis and reduce gliosis areas. However, there was no difference in neurogenesis in the brain tissue of mice injected with CB-MNC intravenously or intra-arterially. © 2021, Scientific Foundation SPIROSKI. All rights reserved. |
Cord blood mononuclear cells; Ischemic stroke; NeuN; Neurogenesis |
anti NeuN antibody; ketamine; neuron specific nuclear protein; unclassified drug; xylazine; animal experiment; animal model; animal tissue; Article; brain cell; cell therapy; controlled study; gliosis; immunohistochemistry; intraarterial drug administration; intravenous drug administration; ischemic stroke; male; middle cerebral artery occlusion; mononuclear cell; nervous system development; nonhuman; rat; umbilical cord blood |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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613 |
Margiana R., Alawiyah K., Ima K., Fitriana R., Widodo A.R., Wibowo T.D. |
56685900600;57212465522;57210444835;57377515100;57377515200;57377674000; |
Improvement of walking analysis using the sciatic function index for sciatic nerve function in injured rat model treated with low-intensity aerobics |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1162 |
1168 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121438837&doi=10.3889%2foamjms.2021.7289&partnerID=40&md5=16b490d881d3f49901d8a12bcb6ef892 |
Departement of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Salemba, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Margiana, R., Departement of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Salemba, Indonesia; Alawiyah, K., Departement of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Salemba, Indonesia; Ima, K., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitriana, R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widodo, A.R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wibowo, T.D., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Sciatica is a disease of the peripheral nerves. Sciatica shows that there is damage to the peripheral nerves in the sciatic nerves. Factors that can affect this disease include gender, posture, parity, age, genetic factors, and occupation. Some of the pathophysiological conditions of sciatica include the pathology of the intervertebral disc, dorsal root, and sciatic nerve itself. The results of standard therapy with surgery have not been effective and very expensive. Therefore, research on therapy in sciatica cases still needs to be done and evaluated. Physical exercise treatment (aerobic) is necessary for this therapy in sciatica cases due to promote the function of peripheral nerves. AIM: This study aimed to determine the effect of aerobic exercise treatment on peripheral nerve injury and its relationship to walking function during injury-induced peripheral nerve regeneration. METHODS: This study was an experimental study with a post-test. The study sample comprised male Sprague-Dawley rats with an age of about 2–3 months divided into three groups. The control group was conducted by surgery without clamping/injuring the peripheral nerves. The treatment for the second group (P1) was clamping/injury of peripheral nerve and given the treatment of physical exercise with aerobics. The treatment for the third group (P2) was clamping/injury of peripheral nerve and not given the treatment of physical exercise with aerobics. The intensity of giving physical exercise treatment with aerobic that is carried out is for 42 days. Nerve functional evaluation was carried out using the sciatic function index (SFI) method. Histological staining for sciatic was used for hematoxylin-eosin staining and immunohistochemistry with growth-associated protein 43 (GAP43) [Bioss, bs-0154R] and S100 antibody [ab52642]. This research was approved by the Animal Ethics Committee of the University of Indonesia protocol (No.19-07-0852). RESULTS: There was a significant change between the 7th and 14th days (p < 0.001; paired t-test) in the P1 treatment. Improvement in nerve function was found on the 14th day after being given aerobic treatment. This is showed by the data average change in SFI scores on days 7 and 4 was from −144 to 34. These data are also supported by footprint changes for injured hindfoot data. CONCLUSION: Low-intensity aerobics treatment improves the walking function and nerve function in sciatic nerve injury on day 14. This is due to the effect of physical exercise on the injured sciatic nerve. © 2021 Ria Margiana, Kamila Alawiyah, Khoirul Ima, Rizni Fitriana, Arif Rahmat Widodo, Theresa Devi Wibowo. |
Aerobics; Physical exercise; Sciatic fuction index; Sciatic nerve injury |
eosin; hematoxylin; neuromodulin; aerobic exercise; animal experiment; animal model; Article; controlled study; demyelination; histology; histopathology; immunohistochemistry; ischiadicus function index; kinesiotherapy; low intensity aerobics; male; muscle weakness; nerve function; nerve injury; nerve regeneration; nonhuman; parameters; peripheral nerve injury; physical activity; rat; rat model; sciatic function index; sciatic nerve; Sprague Dawley rat; walking function |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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614 |
Rhatomy S., Setyawan R., Romulo M.A. |
57204509883;57206249736;57221505201; |
Enhancement of chondrogenesis in hypoxic precondition culture: A systematic review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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492 |
504 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118498577&doi=10.3889%2foamjms.2021.5850&partnerID=40&md5=a767ee0e694f65e29d11b57b920b1f48 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Orthopaedics and Traumatology, Sport and Adult Reconstructive Division, Dr. Soeradji, Tirtonegoro General Hospital, Klaten, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Soeradji Tirtonegoro Sport Center and Research Unit, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia |
Rhatomy, S., Department of Orthopaedics and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia, Department of Orthopaedics and Traumatology, Sport and Adult Reconstructive Division, Dr. Soeradji, Tirtonegoro General Hospital, Klaten, Indonesia, Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Setyawan, R., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Romulo, M.A., Soeradji Tirtonegoro Sport Center and Research Unit, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia |
BACKGROUND: Cartilage tear has begun to be treated with stem cells. However, stem cell oxygen level culture has not been evaluated for the best environment to enhance chondrogenesis. AIM: The purpose of this review is to focus on the hypoxic oxygen level of stem cells culture as a treatment for cartilage tear. METHODS: A literature search was systemically conducted on PubMed (MEDLINE), OVID, EMBASE, the Cochrane Library, Scopus, Web of Science, Science Direct, Wiley Online Library, Google Scholar, and bibliography of selected articles with the terms (“culture”) AND (“stem cell” OR “mesenchymal stem cell” OR “MSC”) AND (“hypoxic” OR “hypoxia”) AND (“cartilage” OR “chondro*”) as the main keywords. A total of 438 articles were reviewed. Thirty-six articles were considered relevant for this systematic review. RESULTS: The result of this review supports stimulation effects of hypoxic oxygen level stem cell culture in chondrogenesis process. Most studies used 5% oxygen concentration for culture, both of in vivo and in vitro studies. Due to the heterogeneity nature of the included studies, meta-analysis was unable to be conducted. CONCLUSION: Hypoxia state seems to play an important role in chondrocytes proliferation, differentiation, and matrix production. © 2021 Sholahuddin Rhatomy,. |
Cartilage; Hypoxic; Oxygen level; Stem cell |
amphotericin; collagen type 1; collagen type 10; collagen type 2; elastin; glycosaminoglycan; hydroxyproline; oxygen; penicillin G; probiotic agent; streptomycin; stromal cell derived factor 1; Thy 1 membrane glycoprotein; adipose derived stem cell; biomechanics; cell culture technique; cell differentiation; cell isolation; cell proliferation; chondrogenesis; Cochrane Library; Embase; flow cytometry; gene expression; histology; human; human cell; hypoxia; hypoxic precondition culture; iliac crest; in vitro fertilization; in vitro study; in vivo study; mesenchymal stem cell; mesenchymal stem cell transplantation; natural killer cell; osteoblast; oxygen concentration; oxygen tension; phylogenetic tree; protein expression; quality control; Review; ScienceDirect; Scopus; search engine; stem ce |
Scientific Foundation SPIROSKI |
18579655 |
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Review |
Q3 |
288 |
15252 |
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