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615 |
Rahadiani N., Retnowulan I.A., Stephanie M., Handjari D.R., Krisnuhoni E. |
16426455700;57313230400;57192369336;56160657900;35310982200; |
β-Catenin Expression and Its Association with Prognostic Factors in Hepatocellular Carcinoma: A Study on Alpha-fetoprotein, Histologic Grade, and Microvascular Invasion |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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887 |
893 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117945095&doi=10.3889%2foamjms.2021.6123&partnerID=40&md5=76f7c7436e4af55617330cb33cb4138f |
Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Rahadiani, N., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Retnowulan, I.A., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Stephanie, M., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Handjari, D.R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver cancer. In addition to its high incidence, the disease burden is high due to its poor prognosis and high recurrence rate. Some of the currently known clinicopathologic prognostic factors include alpha-fetoprotein (AFP) level, histologic grade, and microvascular invasion. At the molecular level, β-catenin is one of the most common driver mutations found in HCC. The Wnt/β-catenin pathway regulates cellular processes related to initiation, growth, survival, migration, differentiation, and apoptosis. Although the underlying pathogenesis of hepatocarcinogenesis is known, clinical application warrants a greater understanding of the molecular characteristics and tumor phenotype, especially for determining the prognosis. AIM: This study aims to analyze the expression of β-catenin and its association with AFP, histologic grade, and microvascular invasion. METHODS: Thirty-five samples of surgically resected HCCs at Cipto Mangunkusumo National Referral Hospital were examined. Diagnoses were made based on histopathological and immunohistochemical findings followed by β-catenin staining. β-catenin expression was analyzed to determine difference between variables. RESULTS: Here, we show that β-catenin expression is significantly associated with low serum AFP and well to moderate differentiation implications. Strong nuclear β-catenin expression implies better prognosis in HCC. CONCLUSION: β-catenin expression is significantly associated with low serumAFP and well-to-moderate differentiation, but not with microvascular invasion. Strong nuclear β-catenin expression implies better prognosis in HCC. © 2021 Nur Rahadiani, Ignasia Andhini Retnowulan, Marini Stephanie, Diah Rini Handjari, Ening Krisnuhoni. |
Alpha-fetoprotein; Hepatocellular carcinoma; Microvascular invasion; Tumor grade; β-catenin |
alpha fetoprotein; beta catenin; adult; aged; alpha fetoprotein blood level; Article; cancer grading; cancer prognosis; cell invasion; clinical article; controlled study; female; hepatitis B; hepatitis C; histology; histopathology; human; human tissue; immunohistochemistry; liver cell carcinoma; liver cirrhosis; lymph vessel; male; microvasculature; prevalence; protein expression; risk factor; tumor growth; tumor volume |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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616 |
Soetandyo N., Rinaldi I., Sari R.M., Kosasih A.S., Setiawan L., Winston K. |
6505525162;23475122400;57208474079;55879389300;57053036100;57224165400; |
Rare case of multiple lineage dysplasia myelodysplastic syndrome presenting with only anemia: A case report |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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182 |
188 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117611464&doi=10.3889%2foamjms.2021.6969&partnerID=40&md5=690591c95626ca9c62d16cbf0e9616bb |
Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Soetandyo, N., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Rinaldi, I., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sari, R.M., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Kosasih, A.S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dharmais National Cancer Hospital, Jakarta, Indonesia; Winston, K., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
BACKGROUND: Myelodysplastic syndrome (MDS) is a heterogeneous group of hematopoietic stem cell disorders which is characterized by ineffective hematopoiesis and risk of progression into acute myeloid leukemia. The diagnosis and classification of MDS are determined from the findings of dysplasia in one or more cell lineage and the percentage of blast cell on bone marrow examination. However, it should be noted that an abnormality in one marrow cell lineage does not necessarily translate to the corresponding clinical phenotype. Here, we present a case of MDS with multilineage dysplasia (MLD) (erythrocyte, leukocyte, and thrombocyte) from bone marrow aspiration, but with anemia as the sole clinical manifestation (single cytopenia). CASE REPORT: A 78-year-old male patient came to our clinic on July 10, 2020, with chief complaint of worsening fatigue which started approximately 1 year before visit. His vital signs during the visit were stable and no other abnormalities observed other than pale conjunctivae. Complete blood count showed macrocytic anemia with no abnormalities in leukocyte count and thrombocyte count, which suggested a single cytopenia. Peripheral blood smear was negative for megaloblasts and hypersegmented neutrophils. The patient’s bone marrow examination showed MDS with MLD. This result was in contrast to complete blood count examination which only showed anemia (single cytopenia). CONCLUSION: This case showed that there could be discrepancy between clinical manifestations of the cytopenia with bone marrow dysplasia, which highlighted the importance of conducting bone marrow examination to properly classify MDS type. © 2021 Noorwati Soetandyo, Ikhwan Rinaldi, Resti Mulya Sari, Agus Susanto Kosasih, Lyana Setiawan, Kevin Winston. |
Anemia; Elderly; Lenalidomide; Leukemia; Myelodysplastic syndrome |
alanine aminotransferase; albumin; aspartate aminotransferase; creatinine; cyanocobalamin; erythropoietin; ferritin; globulin; hemoglobin; lenalidomide; protein; activated partial thromboplastin time; aged; anemia; Article; bleeding time; blood cell count; blood smear; bone marrow examination; case report; chromosome deletion; cytogenetics; cytopenia; dysplasia; erythrocyte concentrate; erythrocyte count; erythrocyte transfusion; estimated glomerular filtration rate; fatigue; granulopoiesis; hematocrit; human; human,clinical article; immunophenotyping; International Prognostic Scoring System; karyotype; leukocyte count; macrocytic anemia; male; mean corpuscular hemoglobin concentration; mean corpuscular volume; megakaryocyte; megakaryopoiesis; metamyelocyte; multiple lineage dysplasia; mye |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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617 |
Lestari H.M., Gustinanda J., Tejaputri N.A., Tumpu N.A., Radifan T., Louisa M. |
57223631169;57283903400;57212584722;57212585928;57283679000;41461551400; |
Stool antigen examination as a diagnostic tool for dyspeptic patient caused by helicobacter pylori infection: A case-based literature review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
F |
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305 |
309 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116395737&doi=10.3889%2foamjms.2021.5568&partnerID=40&md5=fab7a62274bf5e7787c0ca4a61924b0d |
Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lestari, H.M., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gustinanda, J., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tejaputri, N.A., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tumpu, N.A., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radifan, T., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Today, the gold standard for diagnosing Helicobacter pylori infection is by urea breath test (UBT). However, UBT tests are not widely available in several remote areas in Indonesia. Stool antigen test (SAT) is an alternative diagnostic test for H. pylori infection. However, it is unclear whether the performance of SAT to diagnose H. pylori infection can be comparable with UBT accuracy. This report was aimed to determine the accuracy of SAT to diagnose H. pylori infection as an alternative to UBT. Our case-based literature review indicates that SAT has high sensitivity (79–96.4%); therefore, SAT can help doctors in ruling out H. pylori infection. SAT also demonstrates remarkable specificity of stool antigen examination (98.6–100%), suggesting that SAT can help doctors in ruling in H. pylori infection. © 2021 Haifa Mayang Lestari, Jatmiko Gustinanda, Nadzila Anindya Tejaputri, Nur Afiahuddin Tumpu, Taris Radifan, Melva Louisa. |
Helicobacter pylori; Stool antigen test; Urea breath test |
antigen; adult; breath analysis; case report; clinical article; decreased appetite; diagnostic accuracy; dyspepsia; enzyme immunoassay; epigastric pain; feces analysis; Helicobacter infection; human; male; meta analysis; nausea and vomiting; predictive value; prevalence; Review; systematic review; urea breath test; validity |
Scientific Foundation SPIROSKI |
18579655 |
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Review |
Q3 |
288 |
15252 |
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618 |
Djusad S., Meutia A.P., Suastika A., Hidayah G.N., Surya I.U., Priangga M., Fadhly R., Harzif A.K. |
57192276788;57203368133;57226722016;57222671850;57226288663;56320839200;57226710149;57191493435; |
Maternal death caused by severe-critical covid-19 in jakarta: Case series |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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103 |
108 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112449077&doi=10.3889%2foamjms.2021.6250&partnerID=40&md5=e9b76ca77220d8ad24d7f5514bcc5d0d |
Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
Djusad, S., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Meutia, A.P., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Suastika, A., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Hidayah, G.N., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Surya, I.U., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Priangga, M., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Fadhly, R., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Harzif, A.K., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
BACKGROUND: As of January 2021, Indonesia had the 21st highest number of total COVID-19 cases and the 17th highest total deaths among all countries. COVID-19 infection in pregnant women seems to negatively affect both maternal and neonatal outcomes. CASE REPORT: We describe four cases of pregnant women confirmed with severe and critical COVID-19 that resulted in maternal death from November until December 2020. The first case was complicated with thrombocytopenia, her condition quickly deteriorated post-delivery. Pulmonary embolism was suspected as the cause of death. Second and third cases were complicated with preeclampsia, obesity, and advanced maternal age. Second case came in sepsis condition. Her SARS CoV-2 RTPCR swab test came out after her death. Third patient did not have COVID-19 symptoms at admission. She starts having symptoms on second day and was confirmed positive a day after. She falls in septic shock. Fourth patient has history of fever, cough, and dyspnea. She was confirmed positive on first day and her condition worsened, diagnosed with bacterial co-infection sepsis on day eight. All patients underwent cesarean section. CONCLUSION: Limited information and studies for COVID-19 management in pregnant women are challenging for obstetricians. Management should be individualized weighing the benefit and risks in presence of comorbidities or accompanying disease. © Suskhan Djusad, Alfa Putri Meutia, Arresta Suastika, Gita Nurul Hidayah, Ilham Utama Surya, Muhammad Priangga, Raden Fadhly, Achmad Kemal Harzif. |
Case Series; COVID-19; Indonesia; Maternal Death |
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Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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644 |
Immanuel S., Ginanjar E., Nurtyas F.I.P., Sukartini N., Yusra Y., Pasaribu M.M.B.R. |
12777341300;23472616600;57391656300;6505680329;57220998367;57391787700; |
The role of neutrophil lymphocyte ratio as a major adverse cardiac events predictor and its correlation with coronary severity in acute coronary syndrome patients with chronic kidney disease: A case control and cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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1758 |
1763 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122018503&doi=10.3889%2foamjms.2021.7488&partnerID=40&md5=f88a00ee4d9113e8e49425b6276d9400 |
Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ginanjar, E., Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nurtyas, F.I.P., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sukartini, N., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pasaribu, M.M.B.R., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Acute coronary syndrome (ACS) patients with chronic kidney disease (CKD) are known to have a higher risk of mortality compared to ACS patients without CKD. In ACS patients with CKD, chronic inflammation plays an important role in morphological and functional changes in endothelial cells, resulting in atherosclerosis acceleration associated with coronary severity that leads to an increase in major adverse cardiac events (MACE). AIM: Therefore, this study aims to determine the role of neutrophil lymphocyte ratio (NLR) as a predictor of MACE and its correlation with coronary severity in ACS patients with CKD. METHODS: The study was conducted at National General Hospital Cipto Mangunkusumo Jakarta, Indonesia in October to November 2019. We used quota sampling with two designs study. First, a nested case control study was conducted with a total of 59 ACS patients with CKD: 31 subjects who had experienced MACE as a case group and 28 subjects who had not experienced MACE as a control group. Second, a correlative study with a cross-sectional approach was undertaken. RESULTS: There was no significant difference or relationship between NLR and MACE (p > 0.05; OR = 2.16 [95% CI = 0.63–7.51]), also no correlation between NLR and coronary severity degree assessed using the Gensini score (r = 0.10; p = 0.474). CONCLUSION: NLR can not predict MACE in ACS patients with CKD nor be employed interchangeably with the Gensini score in assessing coronary severity in ACS patients with CKD. © 2021 Suzanna Immanuel, Eka Ginanjar, Fahrani Imanina Putri Nurtyas, Ninik Sukartini, Yusra Yusra, Merci Monica B. R. Pasaribu. |
Acute coronary syndrome; Chronic kidney disease; Major adverse cardiac events predictor; Neutrophil lymphocyte ratio |
beta 2 microglobulin; hemoglobin; acute coronary syndrome; adult; Article; basophil count; case control study; chronic kidney failure; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; disease severity; dyslipidemia; eosinophil count; female; Gensini score; human; hypertension; leukocyte count; leukocyte differential count; lymphocyte count; major adverse cardiac event; major clinical study; male; middle aged; monocyte count; neutrophil count; neutrophil lymphocyte ratio; non ST segment elevation myocardial infarction; platelet count; prediction; ST segment elevation myocardial infarction |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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649 |
Mukti A.I., Ilyas S., Warli S.M., Putra A., Rasyid N., Munir D., Siregar K.B., Ichwan M., Alif I., Hidayah N. |
57376899500;55980597400;57189610001;57197818079;56245069300;57039203600;57190863373;26040779000;57215218352;57377826800; |
Mesenchymal stem cells enhance vascular endothelial growth factor-A, endothelial nitric oxide synthetase, and HSP70 expression in improving erectile dysfunction in streptozotocin-induced diabetic rats |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1174 |
1180 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121417031&doi=10.3889%2foamjms.2021.7801&partnerID=40&md5=d2741187724b6c10a2d9b17fcabd3aad |
Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Department of Urology, Faculty of Medicine, Universitas Sumatera Utara Hospital, Medan, Indonesia; Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia; Department of Pathology, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Department of Postgraduate Biomedical Science, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Pusat Unggulan IPTEK Tissue Engineering, Universitas Sumatera Utara, Medan, Indonesia; Department of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia |
Mukti, A.I., Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Ilyas, S., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Warli, S.M., Department of Urology, Faculty of Medicine, Universitas Sumatera Utara Hospital, Medan, Indonesia; Putra, A., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia, Department of Pathology, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia, Department of Postgraduate Biomedical Science, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Munir, D., Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia, Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia, Pusat Unggulan IPTEK Tissue Engineering, Universitas Sumatera Utara, Medan, Indonesia; Siregar, K.B., Department of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia; Ichwan, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Alif, I., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia; Hidayah, N., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia |
AIM: This study investigated the therapeutic role of mesenchymal stem cells (MSCs) on erectile function in a diabetes mellitus erectile dysfunction (DMED) rat model by analyzing the expression of endothelial nitric oxide synthetase (eNOS), vascular endothelial growth factor A (VEGF-A), and the 70 kilodalton heat shock proteins (HSP70). METHODS: MSCs were isolated from umbilical cords (UCs), and their characteristics identified by flow cytometry and osteogenic differentiation analysis. Thirty 8-week-old rats were divided into four groups: Sham, control, T1, and T2. After a 16 h fast, 24 rats were randomly selected and intraperitoneally injected with streptozotocin (STZ) to induce diabetes mellitus. At 8 weeks after STZ injection, rats with DMED were classified into four groups, sham, control group (DMED rats received 500 μL phosphate buffer saline [PBS]); T1 (DMED rats treated with 500 μL PBS containing 1 × 106 UC-MSCs); and T2 (DMED rats treated with 500 μL PBS containing 2 × 106 UC-MSCs). Eight weeks after MSCs administration, the rats’ erectile function was measured by cavernous nerve stimulation. The blinded histological and gene expression assessment were used to analyze the eNOS, HSP70 content, and VEGF-A expression on the penile tissues. RESULTS: MSCs administration, rats in T1 and T2 groups showed a significant enhancement of erectile response that showed a trend of increase of VEGF-A mRNA level expression was 2.2 ± 0.61 in T2 Group supported with the optimum recovery of eNOS, in which the value of eNOS expression was 20.66% ± 2.32%. While optimum decrease of HSP70 content, the value of HSP70 expression was 15.50% ± 0.90%. IHC results showed that the DMED induction in rats caused a significant decrease of eNOS content in corpus cavernosum tissue. CONCLUSION: MSCs could ameliorate DMED in rats by increasing VEGF-A and decreasing HSP70 and eNOS, indicating these cells offer a potential application for DMED patients’ treatment. © 2021 Ade Indra Mukti, Syafruddin Ilyas, Syah Mirsya Warli, Agung Putra, Nur Rasyid, Delfitri Munir, Kamal Basri Siregar, Muhammad Ichwan, Iffan Alif, Nurul Hidayah. |
Endothelial nitric oxide synthetase; Erectile dysfunction; HSP70; Mesenchymal stem cells; Vascular endothelial growth factor A-A |
heat shock protein; heat shock protein 70; messenger RNA; nitric oxide synthase; vasculotropin A; animal cell; animal experiment; animal model; animal tissue; Article; cell differentiation; controlled study; corpus cavernosum; erectile dysfunction; female; flow cytometry; gene expression; glucose blood level; histology; hypoglycemia; immunohistochemistry; International Index of Erectile Function; lipid storage; male; mesenchymal stem cell; nerve stimulation; nonhuman; polymerase chain reaction; protein expression; rat; real time polymerase chain reaction; Sertoli cell; streptozotocin-induced diabetes mellitus |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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661 |
Andreas A.M., Djuwita R., Helda H., Sekartni R., Suradijono S.H.R., Wiguna T., Tulaar A.B.M., Kristianto Y., Hendrik H. |
57356220700;56586138300;57195467249;57355240300;57209473358;57356086800;24330360800;57356220800;57355801600; |
Massage therapy can prevent the risk of autism spectrum disorders in children |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1556 |
1560 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120032396&doi=10.3889%2foamjms.2021.7436&partnerID=40&md5=ca9744bb24e561c7ddfc3916dd11ecc2 |
Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Department of Pediatrics and Development, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Developmental Psychology, Faculty of Psychology, University of Indonesia, Jakarta, Indonesia; Department of Child Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Medical Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Health Polytechnic, Ministry of Health Jakarta 1, Jakarta, Indonesia; Department of Physiotherapy, Health Polytechnic, Ministry of Health Makassar, Makassar, Indonesia |
Andreas, A.M., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Djuwita, R., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Helda, H., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Sekartni, R., Department of Pediatrics and Development, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Suradijono, S.H.R., Department of Developmental Psychology, Faculty of Psychology, University of Indonesia, Jakarta, Indonesia; Wiguna, T., Department of Child Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tulaar, A.B.M., Department of Medical Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kristianto, Y., Health Polytechnic, Ministry of Health Jakarta 1, Jakarta, Indonesia; Hendrik, H., Department of Physiotherapy, Health Polytechnic, Ministry of Health Makassar, Makassar, Indonesia |
BACKGROUND: The prevalence of human beings with autism spectrum issues in some parts of the world tends to make bigger, in Indonesia alone, accurate and complete data and information from human beings with autism spectrum disorders (ASD) are nonetheless missing, so it is feared that many children with risk symptoms of ASD do not get treatment early. AIM: This research aims to prevent the risk of ASD in children through making use of massage therapy remedies based on evaluation of the Modified Checklist for Autism in Toddler (modified Chat [M-Chat]) ratings. METHODS: This research is a quasi-experimental study with a time series design which was carried out from May 2019 to March 2020 at three health centers in the city of Jakarta. The analysis was carried out before and after the application of massage in a time series of four periods on ten children aged 18–36 months with M-Chat scores, and then analyzed by receiver operating characteristics to obtain a cutoff point to determine the risk status of ASD. RESULTS: The results showed that there was an effect of massage therapy on the M-Chat score of children with ASD risk p = 0.004 < 0.05 and changes in the M-Chat score of children with ASD risk experienced significant changes after massage in the third and fourth therapy periods with p = 0.005 and p = 0.007 < 0.05. CONCLUSION: The results show that massage therapy can prevent of autism spectrum issues in children based on the Modified Checklist for Autism in Toddler (M-Chat). © 2021 Andy Martahan Andreas, Ratna Djuwita, Helda Helda, Rini Sekartni, Sri Hartati R. Suradijono, Thjin Wiguna, Angela B. M. Tulaar, Yusuf Kristianto, Hendrik Hendrik. |
Autism spectrum disorders; Babies; Massage therapy; Modified checklist for autism in toddler |
Article; autism; cesarean section; checklist; child; chromosome aberration; female; health center; human; human experiment; Indonesia; male; massage; pH; predictive value; preschool child; prevalence; prospective study; QT interval; quasi experimental study; receiver operating characteristic; scoring system; sensitivity and specificity; time series analysis; toddler |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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719 |
Habiburrahman M., Ariq H., Yusharyahya S.N. |
57204537114;57252668400;57211780941; |
The role of lipid and the benefit of statin in augmenting rifampicin effectivity for a better leprosy treatment |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
F |
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246 |
259 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114611520&doi=10.3889%2foamjms.2021.6263&partnerID=40&md5=1f7a547ae466b610bf3ce7e833b58a56 |
Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
BACKGROUND: Although leprosy remains as a serious disease of the skin and nervous system, the current treatment is still lacking in its effectiveness. AIM: This literature review will explore the association of lipid and leprosy, as well as the potential of statin and other lipid-lowering agents as adjunctive drugs to combat leprosy. MATERIALS AND METHODS: Articles were searched through the PubMed, EBSCOhost, and Google Scholar with the keywords: immunomodulation, lipid-body, lipids, leprosy, Mycobacterium leprae, pathogenesis, rifampin or rifampicin, and statins. A manual searching is also carried out to find an additional relevant information to make this literature review more comprehensive. RESULTS: The literatures showed that lipids are highly correlated with leprosy through alterations in serum lipid profile, metabolism, pathogenesis, and producing oxidative stress. Statins can diminish lipid utilization in the pathogenesis of leprosy and show a mycobactericidal effect by increasing the effectiveness of rifampicin and recover the function of macrophages. In addition, Statins have anti-inflammatory properties which may aid in preventing type I and II reactions in leprosy. Standard multidrug therapy might reduce the efficacy of statins, but the effect is not clinically significant. The statin dose-response curve also allows therapeutic response to be achieved with minimal dose. CONCLUSION: The various pleiotropic effects of statins make it a potential adjunct to standard treatment for leprosy in the future. © 2021 Muhammad Habiburrahman, Haekal Ariq, Shannaz Nadia Yusharyahya. |
Anti-inflammatory; Bactericidal; Leprosy; Lipids; Rifampicin; Statins |
hydroxymethylglutaryl coenzyme A reductase inhibitor; interleukin 10; mevalonic acid; rifampicin; Article; human; immunomodulation; inflammation; lepromatous leprosy; leprosy; lipid metabolism; macrophage; macrophage function; Mycobacterium leprae; oxidative stress; phagocytosis; physiological stress; pleiotropy; polypharmacy; sensitivity and specificity; systematic review; treatment response; tuberculoid leprosy |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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738 |
Ardinata D., Zain-Hamid R., Roesyanto-Mahadi I.D., Mihardja H. |
57201518818;8059724800;57222900126;57195721818; |
Interleukin-31 serum and pruritus dimension after acupuncture treatment in hemodialysis patients: A randomized clinical trial |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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196 |
201 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112120177&doi=10.3889%2foamjms.2021.5599&partnerID=40&md5=a48058e1ca315a987857bbabd6864b39 |
Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Ardinata, D., Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Zain-Hamid, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Roesyanto-Mahadi, I.D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Mihardja, H., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Interleukin (IL)-31 serum levels were significantly higher in hemodialysis patients with pruritus, whereas acupuncture in LI11 was shown to improve symptoms of pruritus. However, there is limited information that IL-31 serum levels that correlate with decreased dimensions of the pruritus after acupuncture in LI11 in a hemodialysis patient. AIM: The aim of the study was to demonstrate the impact of acupuncture in LI11 and IL-31 serum level and its correlation with dimensions of the pruritus in hemodialysis patients. METHODS: A randomized clinical trial has been carried out from August 2019 to December 2019 at H. Adam Malik General Hospital, Medan, Indonesia. Sixty patients underwent hemodialysis who were randomly allocated to two groups, one group got acupuncture in Quchi LI11 (intervention group), and the other group got a placebo (control group). IL-31 serum levels and pruritus were measured before and after 6 weeks of acupuncture in both groups. RESULTS: Acupuncture did not significantly reduce IL-31 (p = 0.931) and decreased dimensions: Degree, duration, disability, and distribution of the pruritus between the intervention group and the control group after 6 weeks of acupuncture in LI11. It can be shown that there is no significant correlation between IL-31 serum levels and dimensions of the pruritus. CONCLUSION: This study demonstrates the effect of acupuncture on reducing dimensions of the pruritus not related to IL-31 serum levels. Identifying the action mechanism of acupuncture to minimize pruritus considerably enhances knowledge of the impacts of acupuncture on reducing pruritus in hemodialysis patients. © 2021 Dedi Ardinata, Rozaimah Zain-Hamid, Irma. D. Roesyanto-Mahadi, Hasan Mihardja. |
Acupuncture; Hemodialysis; Interleukin 31; LI11 Quchi; Pruritus |
bicarbonate; C reactive protein; chemical compound; hemoglobin; interleukin 31; naltrexone; polysulphane; tumor necrosis factor; unclassified drug; acupuncture; adult; Article; atopic dermatitis; body mass; controlled study; data analysis; diabetic nephropathy; disability; disease severity; enzyme linked immunosorbent assay; female; hemodialysis; hemodialysis patient; histamine release; human; hypertension; iontophoresis; kidney disease; major clinical study; male; middle aged; percutaneous coronary intervention; protein blood level; pruritus; psoriasis; quchi acupoint; questionnaire; randomized controlled trial; scoring system; urticaria; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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759 |
Ertandri L., Hamid A.R.A.H., Saraswati M., Mochtar C.A., Umbas R. |
57226072007;57202054669;57208472364;6506558321;6602634832; |
Open versus percutaneous approach of renal tumor biopsy at cipto mangunkusumo hospital: A single-center experience |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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547 |
551 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110263491&doi=10.3889%2foamjms.2021.6038&partnerID=40&md5=1dba3a8b193172b4b556c059d687c1e8 |
Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Ertandri, L., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Saraswati, M., Department of Pathology Anatomy, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Umbas, R., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
BACKGROUND: Renal tumor biopsy is beneficial as it is capable of distinguishing between histological types of renal tumor; hence, it plays an important role in deciding the best therapy regimen. AIM: This study aims to evaluate the clinical experiences of renal biopsy in Cipto Mangunkusumo National Referral Hospital (RSCM), with both a percutaneous and open approach. It also aims to analyze the indications, results, intraoperative information, and complications of the two approaches. METHODS: This study was conducted using the retrospective cohort design; meanwhile, data were collected from RSCM from 1990 to 2019. The biopsy sample was taken using percutaneous and open renal biopsy, while comparative analysis was done between the two biopsy approaches. RESULTS: Data were collected from 33 patients that underwent renal biopsy from 1990 to 2019. Majority of the cases were diagnosed as unresectable renal tumor, while histological examination found clear cell carcinoma in most of the cases (73%). Furthermore, the open approach showed longer duration and higher blood loss compared to percutaneous technique with median 60 (30–120) versus 30 (5–60) min (p < 0.001) and 100 (5–650) versus 2 (1–5) ml (p < 0.001), respectively. In general, complications were reported to be low for both techniques. CONCLUSION: Based on the results, percutaneous renal biopsy has similar efficacy and complications rates in tumor sampling for histopathology together with open approach. However, there were significant differences in the duration and blood loss; hence, percutaneous biopsy is more favorable. © 2021 Luki Ertandri, Agus Rizal A. H. Hamid, Meilania Saraswati, Chaidir A. Mochtar, Rainy Umbas. |
Comparative analysis; Complications; Open approach; Percutaneous approach; Renal tumor biopsy |
cefoperazone plus sulbactam; ceftriaxone; adult; aged; Article; bleeding; blood transfusion; cancer staging; clear cell renal cell carcinoma; clinical article; clinical evaluation; cohort analysis; comparative study; female; fine needle aspiration biopsy; general anesthesia; hematuria; histology; histopathology; human; human tissue; kidney biopsy; kidney tumor; local anesthesia; male; needle biopsy; open biopsy; operation duration; operative blood loss; percutaneous biopsy; peroperative complication; real time echography; retrospective study; sepsis; squamous cell carcinoma; transitional cell carcinoma; tumor biopsy; urinary tract infection |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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